• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

PRKAA2 Gene Record

  • Summary
  • Interactions
  • Claims
  • PRKAA2 5563 Druggable Genome

    Alternate Names:

    5563
    PROTEIN KINASE AMP-ACTIVATED CATALYTIC SUBUNIT ALPHA 2
    PRKAA2
    AMPK
    AMPK2
    AMPKa2
    PRKAA
    600497
    9377
    ENSG00000162409
    OTTHUMG00000008282
    P54646
    5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-2 CHAIN (EC 2.7.1.-) (AMPK ALPHA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P54646]
    AAPK2_HUMAN
    5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
    PA33745

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name KINASE
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Acc IPR002290
    Interpro Type Domain
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett
    Koh M et al., 2013, A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells., Bioorg Med Chem
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
  • CHEMBL2348411   PRKAA2

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23490148


    Sources:
    DTC

  • SAPONARIN   PRKAA2

    Interaction Score: 3.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26471090


    Sources:
    DTC

  • METFORMIN   PRKAA2

    Interaction Score: 1.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22722338 26471090


    Sources:
    DTC PharmGKB

  • METFORMIN HYDROCHLORIDE   PRKAA2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23490148


    Sources:
    DTC

  • HESPERADIN   PRKAA2

    Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Ensembl: ENSG00000162409

    • Version: 101_38

    Alternate Names:
    PRKAA2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000162409

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000162409 Ensembl Gene Id
    PRKAA2 Display Id
    5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-2 CHAIN (EC 2.7.1.-) (AMPK ALPHA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P54646] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P54646

    • Version: 11-September-2012

    Alternate Names:
    5563 Entrez Gene Id
    P54646 Uniprot Accession
    ENSG00000162409 Ensembl Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name KINASE

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • PharmGKB: PRKAA2

    • Version: 18-August-2020

    Alternate Names:
    PA33745 PharmGKB ID

    Gene Info:

    Publications:
    Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • DTC: PRKAA2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett
    Koh M et al., 2013, A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells., Bioorg Med Chem
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

  • HingoraniCasas: ENSG00000162409

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000162409 Gene Symbol
    PRKAA2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: PRKAA2

    • Version: 01-February-2022

    Alternate Names:
    AMPK GO Gene Synonym
    AMPK2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: PRKAA2

    • Version: 27-Jun-2013

    Alternate Names:
    5563 Gene ID
    AMPK dGene Synonym
    AMPK2 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Pharos: PRKAA2

    • Version: 01-February-2022

    Alternate Names:
    5'-AMP-activated protein kinase catalytic subunit alpha-2 Gene Name
    P54646 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER, KINASE, ENZYME

    Publications:

  • ClearityFoundationClinicalTrial: PRKAA2

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21