DGIdb - PRKAA2 Gene Record

PRKAA2 5563 Druggable Genome

Alternate Names:

5563
PROTEIN KINASE AMP-ACTIVATED CATALYTIC SUBUNIT ALPHA 2
PRKAA2
AMPK
AMPK2
AMPKa2
PRKAA
600497
9377
ENSG00000162409
OTTHUMG00000008282
P54646
5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-2 CHAIN (EC 2.7.1.-) (AMPK ALPHA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P54646]
AAPK2_HUMAN
5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
PA33745

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	KINASE
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Acc	IPR002290
Interpro Type	Domain
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

TRANSPORTER
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett
Koh M et al., 2013, A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells., Bioorg Med Chem
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

CHEMBL2348411 PRKAA2

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23490148

Sources:
DTC
SAPONARIN PRKAA2

Interaction Score: 3.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26471090

Sources:
DTC
METFORMIN PRKAA2

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22722338 26471090

Sources:
DTC PharmGKB
METFORMIN HYDROCHLORIDE PRKAA2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23490148

Sources:
DTC
HESPERADIN PRKAA2

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC

Ensembl: ENSG00000162409
- Version: 101_38
Alternate Names:

PRKAA2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000162409

Version: 26-July-2011

Alternate Names:

ENSG00000162409 Ensembl Gene Id

PRKAA2 Display Id

5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-2 CHAIN (EC 2.7.1.-) (AMPK ALPHA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P54646] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P54646
- Version: 11-September-2012
Alternate Names:

5563 Entrez Gene Id

P54646 Uniprot Accession

ENSG00000162409 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Human Readable Name KINASE

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
PharmGKB: PRKAA2
- Version: 18-August-2020
Alternate Names:

PA33745 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DTC: PRKAA2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett

Koh M et al., 2013, A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells., Bioorg Med Chem

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

HingoraniCasas: ENSG00000162409
- Version: 31-May-2017
Alternate Names:

ENSG00000162409 Gene Symbol

PRKAA2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: PRKAA2
- Version: 01-February-2022
Alternate Names:

AMPK GO Gene Synonym

AMPK2 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: PRKAA2
- Version: 27-Jun-2013
Alternate Names:

5563 Gene ID

AMPK dGene Synonym

AMPK2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
Pharos: PRKAA2
- Version: 01-February-2022
Alternate Names:

5'-AMP-activated protein kinase catalytic subunit alpha-2 Gene Name

P54646 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER, KINASE, ENZYME

Publications:
ClearityFoundationClinicalTrial: PRKAA2
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

ENSG00000162409	Ensembl Gene Id
PRKAA2	Display Id
5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-2 CHAIN (EC 2.7.1.-) (AMPK ALPHA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P54646]	Description

5563	Entrez Gene Id
P54646	Uniprot Accession
ENSG00000162409	Ensembl Gene Id

5'-AMP-activated protein kinase catalytic subunit alpha-2	Gene Name
P54646	UniProt ID

5563	Gene ID
AMPK	dGene Synonym
AMPK2	dGene Synonym

PRKAA2 Gene Record

PRKAA2 5563 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL2348411 PRKAA2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23490148

Sources: DTC

SAPONARIN PRKAA2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26471090

Sources: DTC

METFORMIN PRKAA2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22722338 26471090

Sources: DTC PharmGKB

METFORMIN HYDROCHLORIDE PRKAA2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23490148

Sources: DTC

HESPERADIN PRKAA2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19035792

Sources: DTC

Ensembl: ENSG00000162409

Alternate Names: PRKAA2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000162409

Alternate Names: ENSG00000162409 Ensembl Gene Id PRKAA2 Display Id 5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-2 CHAIN (EC 2.7.1.-) (AMPK ALPHA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P54646] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P54646

Alternate Names: 5563 Entrez Gene Id P54646 Uniprot Accession ENSG00000162409 Ensembl Gene Id

Gene Info: Uniprot Status Swiss-Prot Uniprot Evidence 1: Evidence at protein level Human Readable Name KINASE

Gene Categories: KINASE, DRUGGABLE GENOME

Publications:

PharmGKB: PRKAA2

Alternate Names: PA33745 PharmGKB ID

Gene Info:

Publications: Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DTC: PRKAA2

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000162409

Alternate Names: ENSG00000162409 Gene Symbol PRKAA2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: PRKAA2

Alternate Names: AMPK GO Gene Synonym AMPK2 GO Gene Synonym

Gene Info:

Gene Categories: SERINE THREONINE KINASE

Publications:

dGene: PRKAA2

Alternate Names: 5563 Gene ID AMPK dGene Synonym AMPK2 dGene Synonym

Gene Info:

Gene Categories: KINASE, SERINE THREONINE KINASE

Publications:

Pharos: PRKAA2

Alternate Names: 5'-AMP-activated protein kinase catalytic subunit alpha-2 Gene Name P54646 UniProt ID

Gene Info:

Gene Categories: TRANSPORTER, KINASE, ENZYME

Publications:

ClearityFoundationClinicalTrial: PRKAA2

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
23490148

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26471090

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22722338 26471090

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23490148

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Alternate Names:

PRKAA2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000162409 Ensembl Gene Id

PRKAA2 Display Id

5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-2 CHAIN (EC 2.7.1.-) (AMPK ALPHA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P54646] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

5563 Entrez Gene Id

P54646 Uniprot Accession

ENSG00000162409 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Human Readable Name KINASE

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

PA33745 PharmGKB ID

Publications:

Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

ENSG00000162409 Gene Symbol

PRKAA2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

AMPK GO Gene Synonym

AMPK2 GO Gene Synonym

Gene Categories:

SERINE THREONINE KINASE

Alternate Names:

5563 Gene ID

AMPK dGene Synonym

AMPK2 dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

5'-AMP-activated protein kinase catalytic subunit alpha-2 Gene Name

P54646 UniProt ID

Gene Categories:

TRANSPORTER, KINASE, ENZYME