DGIdb - PRKAA1 Gene Record

PRKAA1 5562 Druggable Genome

Alternate Names:

5562
PROTEIN KINASE AMP-ACTIVATED CATALYTIC SUBUNIT ALPHA 1
PRKAA1
AMPK
AMPKa1
602739
9376
ENSG00000132356
OTTHUMG00000162269
Q13131
AAPK1_HUMAN
1541
NP_006242
NM_006251
5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-1 CHAIN (EC 2.7.1.-) (AMPK ALPHA-1 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13131]
5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
PA33744
AMPK alpha 1
AMPK1

Gene Info:

Target Subclass	2.7.11.1
Target Main Class	Enzymes
GuideToPharmacology Gene Category Name	AMPK subfamily
GuideToPharmacology Gene Category ID	474
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002290
Interpro Type	Domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	KINASE
Uniprot Status	Swiss-Prot
Target Class	Enzymes
Target Subclass	EC:2.7.11.1
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

TRANSPORTER
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.
Park et al., 2002, Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle., J. Appl. Physiol.
Zhang et al., 2007, Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration., Am. J. Physiol. Heart Circ. Physiol.
Chen et al., 2008, Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators., Biochem. J.
Woollhead et al., 2007, Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells., Br. J. Pharmacol.
Namkoong et al., 2005, Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats., Diabetes
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett
Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Sviripa V et al., 2013, Fluorinated N,N'-diarylureas as AMPK activators., Bioorg Med Chem Lett
Hahn-Windgassen et al., 2005, Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity., J. Biol. Chem.

CHEMBL587615 PRKAA1

Interaction Score: 4.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23414799

Sources:
DTC
PHENFORMIN PRKAA1

Interaction Score: 4.09

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17369473 17995453 17603555

Sources:
TdgClinicalTrial TEND
PENTOSTATIN PRKAA1

Interaction Score: 2.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11969266

Sources:
NCI
SAPONARIN PRKAA1

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26471090

Sources:
DTC
THYROXINE PRKAA1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12433937

Sources:
NCI
METFORMIN PRKAA1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26471090 22722338

Sources:
DTC PharmGKB
STREPTOZOCIN PRKAA1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15616011

Sources:
NCI
LY-2090314 PRKAA1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SIROLIMUS PRKAA1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16027121

Sources:
NCI
HESPERADIN PRKAA1

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
CHEMBL1997335 PRKAA1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL379975 PRKAA1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PALBOCICLIB PRKAA1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 PRKAA1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 PRKAA1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SOTRASTAURIN PRKAA1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENTRECTINIB PRKAA1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X PRKAA1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB PRKAA1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 PRKAA1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB PRKAA1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 PRKAA1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 PRKAA1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 PRKAA1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB PRKAA1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB PRKAA1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000132356
- Version: 101_38
Alternate Names:

PRKAA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q13131
- Version: 01-August-2011
Alternate Names:

ENSG00000132356 Ensembl Gene Id

5562 Entrez Gene Id

AAPK1_HUMAN Uniprot Id

Gene Info:

Target Subclass 2.7.11.1

Target Main Class Enzymes

Publications:
HopkinsGroom: Q13131
- Version: 11-September-2012
Alternate Names:

AAPK1_HUMAN Uniprot Id

ENSG00000132356 Ensembl Gene Id

5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 Uniprot Protein Name

Gene Info:

Interpro Acc IPR002290

Interpro Type Domain

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q13131
- Version: January-2014
Alternate Names:

PRKAA1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:

RussLampel: ENSG00000132356

Version: 26-July-2011

Alternate Names:

ENSG00000132356 Ensembl Gene Id

PRKAA1 Display Id

5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-1 CHAIN (EC 2.7.1.-) (AMPK ALPHA-1 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13131] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 5562
- Version: 29-September-2020
Alternate Names:

9376 HUGO Gene ID

9376 HUGO Gene Symbol

protein kinase AMP-activated catalytic subunit alpha 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name AMPK subfamily

GuideToPharmacology Gene Category ID 474

Gene Categories:

ENZYME

Publications:
PharmGKB: PRKAA1
- Version: 18-August-2020
Alternate Names:

PA33744 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

NCI: PRKAA1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.

Gills et al., 2005, Effect of deguelin on UVB-induced skin carcinogenesis., J Chemother

Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.

DTC: PRKAA1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Sviripa V et al., 2013, Fluorinated N,N'-diarylureas as AMPK activators., Bioorg Med Chem Lett

Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000132356
- Version: 31-May-2017
Alternate Names:

ENSG00000132356 Gene Symbol

PRKAA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: PRKAA1
- Version: 27-Jun-2013
Alternate Names:

5562 Gene ID

AMPK dGene Synonym

AMPKa1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
GO: PRKAA1
- Version: 01-May-2021
Alternate Names:

AMPK1 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
Pharos: PRKAA1
- Version: 01-May-2021
Alternate Names:

5'-AMP-activated protein kinase catalytic subunit alpha-1 Gene Name

Q13131 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER, KINASE, ENZYME, TRANSCRIPTION FACTOR

Publications:
ClearityFoundationClinicalTrial: PRKAA1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

ENSG00000132356	Ensembl Gene Id
5562	Entrez Gene Id
AAPK1_HUMAN	Uniprot Id

9376	HUGO Gene ID
9376	HUGO Gene Symbol
protein kinase AMP-activated catalytic subunit alpha 1	HUGO Gene Name

5'-AMP-activated protein kinase catalytic subunit alpha-1	Gene Name
Q13131	UniProt ID

PRKAA1 Gene Record

PRKAA1 5562 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23414799

Sources: DTC

Interaction Types & Directionality: activator (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17369473 17995453 17603555

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11969266

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26471090

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12433937

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26471090 22722338

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15616011

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16027121

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19035792

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
23414799

Sources:
DTC

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17369473 17995453 17603555

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
11969266

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26471090

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12433937

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26471090 22722338

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15616011

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16027121

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PRKAA1 Ensembl Gene Name