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PRKAA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PRKAA1 5562 Druggable Genome

    Alternate Names:

    5562
    PROTEIN KINASE AMP-ACTIVATED CATALYTIC SUBUNIT ALPHA 1
    PRKAA1
    AMPK
    AMPKa1
    602739
    9376
    ENSG00000132356
    OTTHUMG00000162269
    BE0004907
    Q13131
    AAPK1_HUMAN
    BE0000677
    1541
    NP_006242
    NM_006251
    5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-1 CHAIN (EC 2.7.1.-) (AMPK ALPHA-1 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13131]
    AMPK1
    5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
    PA33744

    Gene Info:

    Target Subclass 2.7.11.1
    Target Main Class Enzymes
    GuideToPharmacology Gene Category Name AMPK subfamily
    GuideToPharmacology Gene Category ID 474
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002290
    Interpro Type Domain
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name KINASE
    Uniprot Status Swiss-Prot
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.
    Park et al., 2002, Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle., J. Appl. Physiol.
    Zhang et al., 2007, Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration., Am. J. Physiol. Heart Circ. Physiol.
    Chen et al., 2008, Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators., Biochem. J.
    Woollhead et al., 2007, Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells., Br. J. Pharmacol.
    Namkoong et al., 2005, Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats., Diabetes
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett
    Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Sviripa V et al., 2013, Fluorinated N,N'-diarylureas as AMPK activators., Bioorg Med Chem Lett
    Hahn-Windgassen et al., 2005, Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity., J. Biol. Chem.
    Marín-Aguilar F et al., 2017, Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds., Int J Mol Sci
    Mayes et al., 2007, Adenosine 5'-monophosphate kinase-activated protein kinase (PRKA) activators delay meiotic resumption in porcine oocytes., Biol. Reprod.
    Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • CHEMBL587615   PRKAA1

    Interaction Score: 3.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23414799


    Sources:
    DTC

  • PHENFORMIN   PRKAA1

    Interaction Score: 2.94

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17369473 17995453 17603555


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PENTOSTATIN   PRKAA1

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11969266


    Sources:
    NCI

  • SAPONARIN   PRKAA1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26471090


    Sources:
    DTC

  • ADENOSINE PHOSPHATE   PRKAA1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    28146060 17167165


    Sources:
    DrugBank

  • THYROXINE   PRKAA1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12433937


    Sources:
    NCI

  • METFORMIN   PRKAA1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26471090 22722338


    Sources:
    DTC PharmGKB

  • ADENOSINE TRIPHOSPHATE   PRKAA1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • STREPTOZOCIN   PRKAA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15616011


    Sources:
    NCI

  • LY-2090314   PRKAA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SIROLIMUS   PRKAA1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16027121


    Sources:
    NCI

  • HESPERADIN   PRKAA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • CHEMBL1997335   PRKAA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL379975   PRKAA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PALBOCICLIB   PRKAA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PD-0166285   PRKAA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • JNJ-7706621   PRKAA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SOTRASTAURIN   PRKAA1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ENTRECTINIB   PRKAA1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   PRKAA1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TOZASERTIB   PRKAA1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   PRKAA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOVITINIB   PRKAA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   PRKAA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   PRKAA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   PRKAA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   PRKAA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CENISERTIB   PRKAA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FOSTAMATINIB   PRKAA1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26516587


    Sources:
    DrugBank

  • Ensembl: ENSG00000132356

    • Version: 101_38

    Alternate Names:
    PRKAA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q13131

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000132356 Ensembl Gene Id
    5562 Entrez Gene Id
    AAPK1_HUMAN Uniprot Id

    Gene Info:
    Target Subclass 2.7.11.1
    Target Main Class Enzymes

    Publications:

  • HopkinsGroom: Q13131

    • Version: 11-September-2012

    Alternate Names:
    AAPK1_HUMAN Uniprot Id
    ENSG00000132356 Ensembl Gene Id
    5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 Uniprot Protein Name

    Gene Info:
    Interpro Acc IPR002290
    Interpro Type Domain
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q13131

    • Version: January-2014

    Alternate Names:
    PRKAA1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

  • RussLampel: ENSG00000132356

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000132356 Ensembl Gene Id
    PRKAA1 Display Id
    5'-AMP-ACTIVATED PROTEIN KINASE, CATALYTIC ALPHA-1 CHAIN (EC 2.7.1.-) (AMPK ALPHA-1 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13131] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 5562

    • Version: 29-September-2020

    Alternate Names:
    9376 HUGO Gene ID
    9376 HUGO Gene Symbol
    protein kinase AMP-activated catalytic subunit alpha 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name AMPK subfamily
    GuideToPharmacology Gene Category ID 474

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: PRKAA1

    • Version: 18-August-2020

    Alternate Names:
    PA33744 PharmGKB ID

    Gene Info:

    Publications:
    Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • DrugBank: BE0000677

    • Version: 5.1.7

    Alternate Names:
    PRKAA1 DrugBank Gene Name
    Q13131 UniProt Accession
    5562 Entrez Gene Id

    Gene Info:

    Publications:
    Mayes et al., 2007, Adenosine 5'-monophosphate kinase-activated protein kinase (PRKA) activators delay meiotic resumption in porcine oocytes., Biol. Reprod.
    Zhang et al., 2007, Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration., Am. J. Physiol. Heart Circ. Physiol.
    Chen et al., 2008, Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators., Biochem. J.

  • DrugBank: BE0004907

    • Version: 5.1.7

    Alternate Names:
    PRKAA1 DrugBank Gene Name
    Q13131 UniProt Accession
    5562 Entrez Gene Id

    Gene Info:

    Publications:
    Marín-Aguilar F et al., 2017, Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds., Int J Mol Sci
    Steinberg GR et al., 2013, AMPK: mediating the metabolic effects of salicylate-based drugs?, Trends Endocrinol Metab
    Hawley et al., 2012, The ancient drug salicylate directly activates AMP-activated protein kinase., Science

  • NCI: PRKAA1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.
    Gills et al., 2005, Effect of deguelin on UVB-induced skin carcinogenesis., J Chemother
    Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.

  • DTC: PRKAA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Sviripa V et al., 2013, Fluorinated N,N'-diarylureas as AMPK activators., Bioorg Med Chem Lett
    Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000132356

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000132356 Gene Symbol
    PRKAA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: PRKAA1

    • Version: 03-September-2020

    Alternate Names:
    5'-AMP-activated protein kinase catalytic subunit alpha-1 Gene Name
    Q13131 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER, KINASE, ENZYME, TRANSCRIPTION FACTOR

    Publications:

  • GO: PRKAA1

    • Version: 05-September-2020

    Alternate Names:
    AMPK1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: PRKAA1

    • Version: 27-Jun-2013

    Alternate Names:
    5562 Gene ID
    AMPK dGene Synonym
    AMPKa1 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • ClearityFoundationClinicalTrial: PRKAA1

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21