5468 |
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA |
PPARG |
CIMT1 |
GLM1 |
NR1C3 |
PPARG1 |
PPARG2 |
PPARgamma |
601487 |
9236 |
ENSG00000132170 |
OTTHUMG00000129764 |
P37231 |
Peroxisome proliferator-activated receptor gamma |
PPAR-gamma |
Nuclear receptor subfamily 1 group C member 3 |
PA281 |
BE0000215 |
PPARG_HUMAN |
595 |
NP_056953|NP_619725 |
Peroxisome proliferator-activated receptor-γ |
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR-GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P37231] |
T58921 |
NM_015869|NM_138712|NM_138711|NM_005037 |
Target Class | Receptors |
Target Subclass | Nuclear receptor |
Initial Gene Query | NR1C3 |
Counted Citations from 1950-2000 | 8212 |
Human Readable Name | NUCLEAR HORMONE RECEPTOR |
Target Main Class | Receptors |
GuideToPharmacology Gene Category Name | 1C. Peroxisome proliferator-activated receptors |
GuideToPharmacology Gene Category ID | 86 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR000536 |
Interpro Type | Domain |
Interpro Short Name | Nucl_hrmn_rcpt_lig-bd_core |
Uniprot Status | Swiss-Prot |
Interpro Name | Nuclear hormone receptor, ligand-binding, core |
Uniprot Evidence | 1: Evidence at protein level |
Gene Biotype | PROTEIN_CODING |
DRUG RESISTANCE |
TRANSCRIPTION FACTOR BINDING |
NUCLEAR HORMONE RECEPTOR |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
Novel drug target | Established target |
modulator |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma modulator |
Direct Interaction | yes |
Trial Name | MBX-2044 |
agonist (activating) |
modulator |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma modulator |
partial agonist (activating) |
modulator |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma modulator |
Direct Interaction | yes |
Trial Name | INT-131, AMG-131, T131 |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
modulator |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma modulator |
Direct Interaction | yes |
partial agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma partial agonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
agonist (activating) |
Trial Name | LY519818 , LY818 |
Novel drug target | Established target |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
agonist (activating) |
Novel drug target | Established target |
Trial Name | CS-7017 |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
modulator |
Direct Interaction | yes |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma modulator |
agonist (activating) |
Trial Name | aleglitazar, R1439 |
Novel drug target | Established target |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
agonist (activating) |
Trial Name | DB-959 |
Novel drug target | Established target |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
agonist (activating) |
Notes |
n/a |
Trial Name | metaglidasen, JNJ-39659100, MBX-102 |
Novel drug target | Established target |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
n/a |
Trial Name | GW501516 |
Novel drug target | Established target |
agonist (activating) |
Details of the Assay for Interaction | Measuring PPARγ transactivation in response to compound binding directly to the receptor's ligand binding domain. |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
Specific Action of the Ligand | Partial agonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
modulator |
Direct Interaction | yes |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma modulator |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Peroxisome proliferator-activated receptor agonist |
agonist (activating) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
Trial Name | muraglitazar, BMS-298585 |
n/a |
Trial Name | MSDC-0160 |
Novel drug target | Established target |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Details of the Assay for Interaction | Measuring agonist-induced cofactor recruitment. |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
agonist (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Full agonist |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
agonist (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Full agonist |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
agonist (activating) |
Novel drug target | Established target |
Trial Name | MAX-002 |
Direct Interaction? | True |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Irreversible inhibition |
Endogenous Drug? | False |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Mechanism of Interaction | Peroxisome proliferator-activated receptor gamma agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
Direct Interaction | yes |
n/a |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Details of the Assay for Interaction | Measured using a TR-FRET competitive displacement assay. |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
activator (activating) |
agonist (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Partial agonist |
agonist (activating) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Agonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
PPARG | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
PPARG | Gene Symbol |
Target Class | Receptors |
Target Subclass | Nuclear receptor |
5468 | Entrez Gene ID |
Initial Gene Query | NR1C3 |
Counted Citations from 1950-2000 | 8212 |
NUCLEAR HORMONE RECEPTOR |
PPARG_HUMAN | Uniprot Id |
ENSG00000132170 | Ensembl Gene Id |
PPARG | Uniprot Gene Name |
Interpro Acc | IPR000536 |
Interpro Type | Domain |
Human Readable Name | DRUGGABLE GENOME |
NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME |
ENSG00000132170 | Ensembl Gene Id |
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR-GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P37231] | Description |
PPARG | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
PPARG | Gene Symbol |
P37231 | Uniprot Accession |
ENSG00000132170 | Ensembl Gene Id |
Target Subclass | Nuclear receptor |
Target Main Class | Receptors |
9236 | HUGO Gene ID |
9236 | HUGO Gene Symbol |
peroxisome proliferator activated receptor gamma | HUGO Gene Name |
GuideToPharmacology Gene Category Name | 1C. Peroxisome proliferator-activated receptors |
GuideToPharmacology Gene Category ID | 86 |
NUCLEAR HORMONE RECEPTOR |
PA281 | PharmGKB ID |
PPARG | DrugBank Gene Name |
P37231 | UniProt Accession |
5468 | Entrez Gene Id |
PPARG | Gene Symbol |
NR1C3 | GENE_SYMBOL |
PPARG | GENE_SYMBOL |
Peroxisome proliferator-activated receptor gamma | UNIPROT |
ENSG00000132170 | Gene Symbol |
PPARG | Ensembl Id |
DRUGGABLE GENOME |
Peroxisome proliferator-activated receptor gamma | Gene Name |
P37231 | UniProt ID |
NUCLEAR HORMONE RECEPTOR |
NR1C3 | GO Gene Synonym |
DRUG RESISTANCE, TRANSCRIPTION FACTOR BINDING, NUCLEAR HORMONE RECEPTOR |
PPARG | Gene Symbol |
CLINICALLY ACTIONABLE |
5468 | Gene ID |
CIMT1 | dGene Synonym |
GLM1 | dGene Synonym |
NUCLEAR HORMONE RECEPTOR |
PPAR-gamma | TTD Gene Abbreviation |
T58921 | TTD Target ID |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |