DGIdb - PPARD Gene Record

PPARD 5467 Druggable Genome

Alternate Names:

5467
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA
PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
600409
9235
ENSG00000112033
OTTHUMG00000014567
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA (PPAR-DELTA) (PPAR- BETA) (NUCLEAR HORMONE RECEPTOR 1) (NUC1) (NUCI). [SOURCE:UNIPROT/SWISSPROT;ACC:Q03181]
BE0001007
Q03181
PA33557
peroxisome proliferator-activated receptor delta
PPAR-beta
Nuclear hormone receptor 1
Nuclear receptor subfamily 1 group C member 2
Peroxisome proliferator-activated receptor beta
PPAR-delta
PPARD_HUMAN
594
Peroxisome proliferator-activated receptor-β/δ
NP_006229
NM_177435
T36557

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Initial Gene Query	NR1C2
Counted Citations from 1950-2000	900
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Target Class	Receptors
Target Subclass	Nuclear receptor
Interpro Acc	IPR000536
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
GuideToPharmacology Gene Category Name	1C. Peroxisome proliferator-activated receptors
GuideToPharmacology Gene Category ID	86
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR BINDING
NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Ciocoiu CC et al., 2010, Synthesis and dual PPARalpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516., Eur J Med Chem
Buhrke T et al., 2013, In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths., Toxicol Lett
Sato A et al., 2013, Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists., Bioorg Med Chem Lett
Sarath Josh MK et al., 2014, Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach., J Appl Toxicol
Lalloyer F et al., 2010, Fibrates, glitazones, and peroxisome proliferator-activated receptors., Arterioscler Thromb Vasc Biol
Kasuga J et al., 2008, SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail., Bioorg Med Chem Lett
Leisewitz et al., 2003, Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells., J. Neurochem.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Lieber S et al., 2012, (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties., J Med Chem
Planavila et al., 2005, Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells., Biochim. Biophys. Acta
Ali et al., 2006, Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts., Am. J. Respir. Cell Mol. Biol.
Kaupang Å et al., 2015, Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618., Eur J Med Chem
Caldari-Torres et al., 2006, Differential effects of n-3 and n-6 fatty acids on prostaglandin F2alpha production by bovine endometrial cells., J. Dairy Sci.
Iwata et al., 2001, Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione., J. Mol. Graph. Model.
Inoue et al., 1998, Expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary cultures of human vascular endothelial cells., Biochem. Biophys. Res. Commun.
Xu et al., 1999, Molecular recognition of fatty acids by peroxisome proliferator-activated receptors., Mol. Cell
Kondo et al., Ligand-dependent transcriptional activities of four torafugu pufferfish Takifugu rubripes peroxisome proliferator-activated receptors., Gen. Comp. Endocrinol.
Kim et al., 2006, Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta)., Carcinogenesis
Babbar et al., 2003, Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer., J. Biol. Chem.
Liou et al., 2007, Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon., Cancer Res.
Jarvis et al., 2005, Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line., Oncogene
He et al., 1999, PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs., Cell
Gathiaka S et al., 2013, Design, development and evaluation of novel dual PPARδ/PPARγ agonists., Bioorg Med Chem Lett
Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J
Bhurruth-Alcor Y et al., 2010, Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR alpha selective., Bioorg Med Chem Lett
Tenenbaum et al., 2005, Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons., Cardiovasc Diabetol
Inoue et al., 2002, Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB., Biochem. Biophys. Res. Commun.
Rodríguez-Cruz M et al., 2017, Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors., Nutrition
Vanden Heuvel JP et al., 2006, Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha., Toxicol Sci

KD3010 PPARD

Interaction Score: 1.57

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

Direct Interaction yes

Trial Name KD3010

PMIDs:
None found

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions
CER-002 PPARD

Interaction Score: 1.57

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

Direct Interaction yes

Trial Name CER-002

PMIDs:
20393155

Sources:
TdgClinicalTrial TTD ChemblInteractions
MBX-8025 PPARD

Interaction Score: 1.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MBX-8025

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
CHEMBL592652 PPARD

Interaction Score: 1.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
22369181

Sources:
DTC GuideToPharmacology
GW501516 PPARD

Interaction Score: 1.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
20403648 23391484 23566516 23843199

Sources:
DTC TdgClinicalTrial DrugBank GuideToPharmacology
CHEMBL202609 PPARD

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL523395 PPARD

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL598608 PPARD

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25768705

Sources:
DTC
DB959 PPARD

Interaction Score: 0.59

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name DB-959

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
VACCENIC ACID PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
CYCLOHEXANONE OXIME PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOCAPRAMINE PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPHENYLSULFANE PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FTORMETAZINE PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL31020 PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOXABEN PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROGLUMETACIN PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORPHRIFOS OXON PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MOSAPRAMINE PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL435278 PPARD

Interaction Score: 0.39

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
INDEGLITAZAR PPARD

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor agonist

PMIDs:
10592235

Sources:
DrugBank ChemblInteractions
CLINOFIBRATE PPARD

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11779144

Sources:
DrugBank
FENOFIBRIC ACID PPARD

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23566516

Sources:
DTC
ELAFIBRANOR PPARD

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD DrugBank
CHEMBL153057 PPARD

Interaction Score: 0.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10592235

Sources:
DTC DrugBank GuideToPharmacology
CINACALCET HYDROCHLORIDE PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOLPET PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OCTYL_GALLATE PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL172988 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SERATRODAST PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EMETINE HYDROCHLORIDE PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2392553 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ASCORBYL PALMITATE PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL592305 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
L-796449 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL1257022 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ETOXAZOLE PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VITAMIN K3H2 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THIOSEMICARBAZIDE PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOFLUCARBAN PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL594772 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ICOSAPENT PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16507691 11552681 9610365 10198642 17632107

Sources:
DrugBank
CHEMBL610767 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AVE0847 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

PMIDs:
None found

Sources:
ChemblInteractions
TROVAFLOXACIN MESYLATE PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL292352 PPARD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BEZAFIBRATE PPARD

Interaction Score: 0.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16168052

Sources:
DTC DrugBank
ELAIDIC ACID PPARD

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16731579

Sources:
DrugBank
PROSTAGLANDIN D2 PPARD

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23566516

Sources:
DTC
PROPRANOLOL HYDROCHLORIDE PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IPCONAZOLE PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BIFENAZATE PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CIGLITAZONE PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23566516

Sources:
DTC
SODELGLITAZAR PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ABAMECTIN PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BIOALLETHRIN S-CYCLOPENTENYL ISOMER PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROSIGLITAZONE MALEATE PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIPARANOL PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BAZEDOXIFENE ACETATE PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL333177 PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ORYZALIN PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PENFLURIDOL PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-9578 PPARD

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL38508 PPARD

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23273519

Sources:
DTC
SULINDAC PPARD

Interaction Score: 0.11

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

PMIDs:
16418176 14506281 17409426 16091736 10555149

Sources:
DrugBank
ALPHA-TERTHIENYL PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TETRADECYLTHIOACETIC ACID PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20036122

Sources:
DTC
ENCLOMIPHENE PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DINOSEB PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SALINAZID PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL118417 PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IDEBENONE PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DESLORATADINE PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIBROMSALAN PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRAMETHYLNON PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1606 PPARD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TREPROSTINIL PPARD

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16239641

Sources:
DrugBank
PHTHALIC ACID PPARD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23843199

Sources:
DrugBank
FISH OIL TRIGLYCERIDES PPARD

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
28760435

Sources:
DrugBank
ISOCONAZOLE PPARD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIBUTYLTIN-OXIDE PPARD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYMECROMONE PPARD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIFENOCONAZOLE PPARD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIBUTYLDICHLOROSTANNANE PPARD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BISPHENOL A PPARD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MURAGLITAZAR PPARD

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUOXETINE HYDROCHLORIDE PPARD

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE HYDROCHLORIDE PPARD

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IDAZOXAN PPARD

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICLOCARBAN PPARD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RETINAL PPARD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPACHLOR PPARD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROMETHAZINE HYDROCHLORIDE PPARD

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BIS(DIMETHYLAMINETHIOCARBONYL)MONOSULFIDE PPARD

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL220845 PPARD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
3R14S-OCHRATOXIN A PPARD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOXYQUIN PPARD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GLYCERIN PPARD

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
E319 PPARD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BIFONAZOLE PPARD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZIRAM PPARD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NITROXOLINE PPARD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IDARUBICIN HYDROCHLORIDE PPARD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOHEXIMIDE PPARD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROTENONE PPARD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW7647 PPARD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18162399

Sources:
DTC
LINOLENIC ACID PPARD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16731579

Sources:
DrugBank
ASTEMIZOLE PPARD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORANIL PPARD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROSIGLITAZONE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11779144

Sources:
DrugBank
TROGLITAZONE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11779144

Sources:
DrugBank
CLOMIPRAMINE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DACTINOMYCIN PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORPROMAZINE HYDROCHLORIDE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THALIDOMIDE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20038957

Sources:
PharmGKB
TRIAMTERENE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICHLOROPHEN PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORHEXIDINE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENTICLOR PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAMOXIFEN CITRATE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENYLMERCURIC ACETATE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENANTHROLINE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VANOXERINE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYCANTHONE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THIORIDAZINE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RALOXIFENE HYDROCHLORIDE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUSPIRILENE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BITHIONOL PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SANGUINARIUM PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APIGENIN PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MENADIONE PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HOMIDIUM BROMIDE PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ATORVASTATIN PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16139565

Sources:
NCI
MITOXANTRONE HYDROCHLORIDE PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOXORUBICIN HYDROCHLORIDE PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOCETAXEL PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20038957

Sources:
PharmGKB
HEXACHLOROPHENE PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRETINOIN PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Full agonist

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PAZOPANIB PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALCOHOL PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12641735

Sources:
NCI
DASATINIB PPARD

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000112033
- Version: 101_38
Alternate Names:

PPARD Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000112033

Version: 26-July-2011

Alternate Names:

PPARD Display Id

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA (PPAR-DELTA) (PPAR- BETA) (NUCLEAR HORMONE RECEPTOR 1) (NUC1) (NUCI). [SOURCE:UNIPROT/SWISSPROT;ACC:Q03181] Description

ENSG00000112033 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: PPARD
- Version: February-2014
Alternate Names:

5467 Entrez Gene ID

Gene Info:

Initial Gene Query NR1C2

Counted Citations from 1950-2000 900

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
HopkinsGroom: Q03181
- Version: 11-September-2012
Alternate Names:

5467 Entrez Gene Id

PPARD_HUMAN Uniprot Id

ENSG00000112033 Ensembl Gene Id

Gene Info:

Interpro Acc IPR000536

Human Readable Name NUCLEAR HORMONE RECEPTOR

Interpro Name Nuclear hormone receptor, ligand-binding, core

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q03181
- Version: January-2014
Alternate Names:

PPARD Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
GuideToPharmacology: 5467
- Version: 29-September-2020
Alternate Names:

9235 HUGO Gene ID

9235 HUGO Gene Symbol

peroxisome proliferator activated receptor delta HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1C. Peroxisome proliferator-activated receptors

GuideToPharmacology Gene Category ID 86

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
PharmGKB: PPARD
- Version: 18-August-2020
Alternate Names:

PA33557 PharmGKB ID

Gene Info:

Publications:

Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J

DrugBank: BE0001007

Version: 5.1.7

Alternate Names:

PPARD DrugBank Gene Name

Q03181 UniProt Accession

5467 Entrez Gene Id

Gene Info:

Publications:

Vanden Heuvel JP et al., 2006, Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha., Toxicol Sci

Caldari-Torres et al., 2006, Differential effects of n-3 and n-6 fatty acids on prostaglandin F2alpha production by bovine endometrial cells., J. Dairy Sci.

Iwata et al., 2001, Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione., J. Mol. Graph. Model.

TTD: Peroxisome proliferator-activated receptor delta

Version: 2020.06.01

Alternate Names:

PPARD TTD Gene Abbreviation

T36557 TTD Target ID

Gene Info:

Publications:

Mittermayer F et al., 2015, Addressing unmet medical needs in type 2 diabetes: a narrative review of drugs under development., Curr Diabetes Rev

Lalloyer F et al., 2010, Fibrates, glitazones, and peroxisome proliferator-activated receptors., Arterioscler Thromb Vasc Biol

NCI: PPARD

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Planavila et al., 2005, Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells., Biochim. Biophys. Acta

Leisewitz et al., 2003, Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells., J. Neurochem.

DTC: PPARD

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kaupang Å et al., 2015, Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618., Eur J Med Chem

Sato A et al., 2013, Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists., Bioorg Med Chem Lett

Gathiaka S et al., 2013, Design, development and evaluation of novel dual PPARδ/PPARγ agonists., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000112033
- Version: 31-May-2017
Alternate Names:

ENSG00000112033 Gene Symbol

PPARD Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: NR1C2
- Version: chembl_23
Alternate Names:

PPARB GENE_SYMBOL

PPARD GENE_SYMBOL

Peroxisome proliferator-activated receptor delta UNIPROT

Gene Info:

Publications:
Pharos: PPARD
- Version: 03-September-2020
Alternate Names:

Peroxisome proliferator-activated receptor delta Gene Name

Q03181 UniProt ID

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

Publications:
GO: PPARD
- Version: 05-September-2020
Alternate Names:

NR1C2 GO Gene Synonym

PPARB GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR BINDING, NUCLEAR HORMONE RECEPTOR

Publications:
dGene: PPARD
- Version: 27-Jun-2013
Alternate Names:

5467 Gene ID

FAAR dGene Synonym

NR1C2 dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:

Mechanism of Interaction	Peroxisome proliferator-activated receptor delta agonist
Direct Interaction	yes
Trial Name	KD3010

Trial Name	MBX-8025
Novel drug target	Established target
Mechanism of Interaction	Peroxisome proliferator-activated receptor delta agonist

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	DB-959
Novel drug target	Established target
Mechanism of Interaction	Peroxisome proliferator-activated receptor delta agonist

Endogenous Drug?	True
Specific Action of the Ligand	Full agonist
Direct Interaction?	False

PPARD	Display Id
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA (PPAR-DELTA) (PPAR- BETA) (NUCLEAR HORMONE RECEPTOR 1) (NUC1) (NUCI). [SOURCE:UNIPROT/SWISSPROT;ACC:Q03181]	Description
ENSG00000112033	Ensembl Gene Id

5467	Entrez Gene Id
PPARD_HUMAN	Uniprot Id
ENSG00000112033	Ensembl Gene Id

9235	HUGO Gene ID
9235	HUGO Gene Symbol
peroxisome proliferator activated receptor delta	HUGO Gene Name

PPARD	DrugBank Gene Name
Q03181	UniProt Accession
5467	Entrez Gene Id

PPARB	GENE_SYMBOL
PPARD	GENE_SYMBOL
Peroxisome proliferator-activated receptor delta	UNIPROT

Peroxisome proliferator-activated receptor delta	Gene Name
Q03181	UniProt ID

PPARD Gene Record

PPARD 5467 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist Direct Interaction yes Trial Name KD3010

PMIDs: None found

Sources: TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist Direct Interaction yes Trial Name CER-002

PMIDs: 20393155

Sources: TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name MBX-8025 Novel drug target Established target Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

PMIDs: None found

Sources: TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 22369181

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? False

PMIDs: 20403648 23391484 23566516 23843199

Sources: DTC TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25768705

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name DB-959 Novel drug target Established target Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

PMIDs: None found

Sources: TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

Direct Interaction yes

Trial Name KD3010

PMIDs:
None found

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

Direct Interaction yes

Trial Name CER-002

PMIDs:
20393155

Sources:
TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MBX-8025

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
22369181

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
20403648 23391484 23566516 23843199

Sources:
DTC TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
25768705

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name DB-959

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor agonist

PMIDs:
10592235

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
11779144

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23566516

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD DrugBank