• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

PPARD Gene Record

  • Summary
  • Interactions
  • Claims
  • PPARD 5467 Druggable Genome

    Alternate Names:

    5467
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA
    PPARD
    FAAR
    NR1C2
    NUC1
    NUCI
    NUCII
    PPARB
    600409
    9235
    ENSG00000112033
    OTTHUMG00000014567
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA (PPAR-DELTA) (PPAR- BETA) (NUCLEAR HORMONE RECEPTOR 1) (NUC1) (NUCI). [SOURCE:UNIPROT/SWISSPROT;ACC:Q03181]
    BE0001007
    Q03181
    PA33557
    peroxisome proliferator-activated receptor delta
    PPAR-beta
    Nuclear hormone receptor 1
    Nuclear receptor subfamily 1 group C member 2
    Peroxisome proliferator-activated receptor beta
    PPAR-delta
    PPARD_HUMAN
    594
    Peroxisome proliferator-activated receptor-β/δ
    NP_006229
    NM_177435
    T36557

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Initial Gene Query NR1C2
    Counted Citations from 1950-2000 900
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Target Class Receptors
    Target Subclass Nuclear receptor
    Interpro Acc IPR000536
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    GuideToPharmacology Gene Category Name 1C. Peroxisome proliferator-activated receptors
    GuideToPharmacology Gene Category ID 86
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR BINDING
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Ciocoiu CC et al., 2010, Synthesis and dual PPARalpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516., Eur J Med Chem
    Buhrke T et al., 2013, In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths., Toxicol Lett
    Sato A et al., 2013, Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists., Bioorg Med Chem Lett
    Sarath Josh MK et al., 2014, Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach., J Appl Toxicol
    Lalloyer F et al., 2010, Fibrates, glitazones, and peroxisome proliferator-activated receptors., Arterioscler Thromb Vasc Biol
    Kasuga J et al., 2008, SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail., Bioorg Med Chem Lett
    Leisewitz et al., 2003, Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells., J. Neurochem.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Lieber S et al., 2012, (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties., J Med Chem
    Planavila et al., 2005, Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells., Biochim. Biophys. Acta
    Ali et al., 2006, Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts., Am. J. Respir. Cell Mol. Biol.
    Kaupang Å et al., 2015, Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618., Eur J Med Chem
    Caldari-Torres et al., 2006, Differential effects of n-3 and n-6 fatty acids on prostaglandin F2alpha production by bovine endometrial cells., J. Dairy Sci.
    Iwata et al., 2001, Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione., J. Mol. Graph. Model.
    Inoue et al., 1998, Expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary cultures of human vascular endothelial cells., Biochem. Biophys. Res. Commun.
    Xu et al., 1999, Molecular recognition of fatty acids by peroxisome proliferator-activated receptors., Mol. Cell
    Kondo et al., Ligand-dependent transcriptional activities of four torafugu pufferfish Takifugu rubripes peroxisome proliferator-activated receptors., Gen. Comp. Endocrinol.
    Kim et al., 2006, Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta)., Carcinogenesis
    Babbar et al., 2003, Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer., J. Biol. Chem.
    Liou et al., 2007, Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon., Cancer Res.
    Jarvis et al., 2005, Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line., Oncogene
    He et al., 1999, PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs., Cell
    Gathiaka S et al., 2013, Design, development and evaluation of novel dual PPARδ/PPARγ agonists., Bioorg Med Chem Lett
    Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J
    Bhurruth-Alcor Y et al., 2010, Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR alpha selective., Bioorg Med Chem Lett
    Tenenbaum et al., 2005, Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons., Cardiovasc Diabetol
    Inoue et al., 2002, Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB., Biochem. Biophys. Res. Commun.
    Rodríguez-Cruz M et al., 2017, Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors., Nutrition
    Vanden Heuvel JP et al., 2006, Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha., Toxicol Sci
  • KD3010   PPARD

    Interaction Score: 1.57

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist
    Direct Interaction yes
    Trial Name KD3010

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank ChemblInteractions

  • CER-002   PPARD

    Interaction Score: 1.57

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist
    Direct Interaction yes
    Trial Name CER-002

    PMIDs:
    20393155


    Sources:
    TdgClinicalTrial TTD ChemblInteractions

  • MBX-8025   PPARD

    Interaction Score: 1.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MBX-8025
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD ChemblInteractions

  • CHEMBL592652   PPARD

    Interaction Score: 1.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    22369181


    Sources:
    DTC GuideToPharmacology

  • GW501516   PPARD

    Interaction Score: 1.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    20403648 23391484 23566516 23843199


    Sources:
    DTC TdgClinicalTrial DrugBank GuideToPharmacology

  • CHEMBL202609   PPARD

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL523395   PPARD

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL598608   PPARD

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25768705


    Sources:
    DTC

  • DB959   PPARD

    Interaction Score: 0.59

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name DB-959
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD ChemblInteractions

  • VACCENIC ACID   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CYCLOHEXANONE OXIME   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOCAPRAMINE   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIPHENYLSULFANE   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FTORMETAZINE   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL31020   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ISOXABEN   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROGLUMETACIN   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORPHRIFOS OXON   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MOSAPRAMINE   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL435278   PPARD

    Interaction Score: 0.39

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • INDEGLITAZAR   PPARD

    Interaction Score: 0.29

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor agonist

    PMIDs:
    10592235


    Sources:
    DrugBank ChemblInteractions

  • CLINOFIBRATE   PPARD

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11779144


    Sources:
    DrugBank

  • FENOFIBRIC ACID   PPARD

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23566516


    Sources:
    DTC

  • ELAFIBRANOR   PPARD

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD DrugBank

  • CHEMBL153057   PPARD

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    10592235


    Sources:
    DTC DrugBank GuideToPharmacology

  • CINACALCET HYDROCHLORIDE   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FOLPET   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OCTYL_GALLATE   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL172988   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SERATRODAST   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EMETINE HYDROCHLORIDE   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2392553   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ASCORBYL PALMITATE   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL592305   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • L-796449   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL1257022   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ETOXAZOLE   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VITAMIN K3H2   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOSEMICARBAZIDE   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOFLUCARBAN   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL594772   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ICOSAPENT   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16507691 11552681 9610365 10198642 17632107


    Sources:
    DrugBank

  • CHEMBL610767   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AVE0847   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TROVAFLOXACIN MESYLATE   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL292352   PPARD

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BEZAFIBRATE   PPARD

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16168052


    Sources:
    DTC DrugBank

  • ELAIDIC ACID   PPARD

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16731579


    Sources:
    DrugBank

  • PROSTAGLANDIN D2   PPARD

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23566516


    Sources:
    DTC

  • PROPRANOLOL HYDROCHLORIDE   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IPCONAZOLE   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BIFENAZATE   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CIGLITAZONE   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23566516


    Sources:
    DTC

  • SODELGLITAZAR   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ABAMECTIN   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BIOALLETHRIN S-CYCLOPENTENYL ISOMER   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ROSIGLITAZONE MALEATE   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIPARANOL   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BAZEDOXIFENE ACETATE   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL333177   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ORYZALIN   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PENFLURIDOL   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GSK-9578   PPARD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL38508   PPARD

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23273519


    Sources:
    DTC

  • SULINDAC   PPARD

    Interaction Score: 0.11

    Interaction Types & Directionality:
    negative modulator (inhibitory)

    Interaction Info:

    PMIDs:
    16418176 14506281 17409426 16091736 10555149


    Sources:
    DrugBank

  • ALPHA-TERTHIENYL   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TETRADECYLTHIOACETIC ACID   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20036122


    Sources:
    DTC

  • ENCLOMIPHENE   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DINOSEB   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SALINAZID   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL118417   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IDEBENONE   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DESLORATADINE   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIBROMSALAN   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRAMETHYLNON   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1606   PPARD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TREPROSTINIL   PPARD

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16239641


    Sources:
    DrugBank

  • PHTHALIC ACID   PPARD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23843199


    Sources:
    DrugBank

  • FISH OIL TRIGLYCERIDES   PPARD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:

    PMIDs:
    28760435


    Sources:
    DrugBank

  • ISOCONAZOLE   PPARD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIBUTYLTIN-OXIDE   PPARD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYMECROMONE   PPARD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIFENOCONAZOLE   PPARD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIBUTYLDICHLOROSTANNANE   PPARD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BISPHENOL A   PPARD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MURAGLITAZAR   PPARD

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUOXETINE HYDROCHLORIDE   PPARD

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRALAZINE HYDROCHLORIDE   PPARD

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IDAZOXAN   PPARD

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRICLOCARBAN   PPARD

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RETINAL   PPARD

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPACHLOR   PPARD

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROMETHAZINE HYDROCHLORIDE   PPARD

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BIS(DIMETHYLAMINETHIOCARBONYL)MONOSULFIDE   PPARD

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL220845   PPARD

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 3R14S-OCHRATOXIN A   PPARD

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOXYQUIN   PPARD

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GLYCERIN   PPARD

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • E319   PPARD

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BIFONAZOLE   PPARD

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZIRAM   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NITROXOLINE   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IDARUBICIN HYDROCHLORIDE   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYCLOHEXIMIDE   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ROTENONE   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW7647   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18162399


    Sources:
    DTC

  • LINOLENIC ACID   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16731579


    Sources:
    DrugBank

  • ASTEMIZOLE   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORANIL   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ROSIGLITAZONE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11779144


    Sources:
    DrugBank

  • TROGLITAZONE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11779144


    Sources:
    DrugBank

  • CLOMIPRAMINE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DACTINOMYCIN   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORPROMAZINE HYDROCHLORIDE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THALIDOMIDE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20038957


    Sources:
    PharmGKB

  • TRIAMTERENE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DICHLOROPHEN   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORHEXIDINE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FENTICLOR   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAMOXIFEN CITRATE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENYLMERCURIC ACETATE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENANTHROLINE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VANOXERINE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYCANTHONE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIORIDAZINE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RALOXIFENE HYDROCHLORIDE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUSPIRILENE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BITHIONOL   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SANGUINARIUM   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • APIGENIN   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MENADIONE   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HOMIDIUM BROMIDE   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PIMOZIDE   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ATORVASTATIN   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16139565


    Sources:
    NCI

  • MITOXANTRONE HYDROCHLORIDE   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOXORUBICIN HYDROCHLORIDE   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DISULFIRAM   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOCETAXEL   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20038957


    Sources:
    PharmGKB

  • HEXACHLOROPHENE   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRETINOIN   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? True
    Specific Action of the Ligand Full agonist
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PAZOPANIB   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GOSSYPOL   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALCOHOL   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12641735


    Sources:
    NCI

  • DASATINIB   PPARD

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000112033

    • Version: 101_38

    Alternate Names:
    PPARD Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000112033

    • Version: 26-July-2011

    Alternate Names:
    PPARD Display Id
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA (PPAR-DELTA) (PPAR- BETA) (NUCLEAR HORMONE RECEPTOR 1) (NUC1) (NUCI). [SOURCE:UNIPROT/SWISSPROT;ACC:Q03181] Description
    ENSG00000112033 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: PPARD

    • Version: February-2014

    Alternate Names:
    5467 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1C2
    Counted Citations from 1950-2000 900

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • HopkinsGroom: Q03181

    • Version: 11-September-2012

    Alternate Names:
    5467 Entrez Gene Id
    PPARD_HUMAN Uniprot Id
    ENSG00000112033 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR000536
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Name Nuclear hormone receptor, ligand-binding, core

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q03181

    • Version: January-2014

    Alternate Names:
    PPARD Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • GuideToPharmacology: 5467

    • Version: 29-September-2020

    Alternate Names:
    9235 HUGO Gene ID
    9235 HUGO Gene Symbol
    peroxisome proliferator activated receptor delta HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 1C. Peroxisome proliferator-activated receptors
    GuideToPharmacology Gene Category ID 86

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • PharmGKB: PPARD

    • Version: 18-August-2020

    Alternate Names:
    PA33557 PharmGKB ID

    Gene Info:

    Publications:
    Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J

  • DrugBank: BE0001007

    • Version: 5.1.7

    Alternate Names:
    PPARD DrugBank Gene Name
    Q03181 UniProt Accession
    5467 Entrez Gene Id

    Gene Info:

    Publications:
    Vanden Heuvel JP et al., 2006, Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha., Toxicol Sci
    Caldari-Torres et al., 2006, Differential effects of n-3 and n-6 fatty acids on prostaglandin F2alpha production by bovine endometrial cells., J. Dairy Sci.
    Iwata et al., 2001, Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione., J. Mol. Graph. Model.

  • TTD: Peroxisome proliferator-activated receptor delta

    • Version: 2020.06.01

    Alternate Names:
    PPARD TTD Gene Abbreviation
    T36557 TTD Target ID

    Gene Info:

    Publications:
    Mittermayer F et al., 2015, Addressing unmet medical needs in type 2 diabetes: a narrative review of drugs under development., Curr Diabetes Rev
    Lalloyer F et al., 2010, Fibrates, glitazones, and peroxisome proliferator-activated receptors., Arterioscler Thromb Vasc Biol

  • NCI: PPARD

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Planavila et al., 2005, Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells., Biochim. Biophys. Acta
    Leisewitz et al., 2003, Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells., J. Neurochem.

  • DTC: PPARD

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kaupang Å et al., 2015, Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618., Eur J Med Chem
    Sato A et al., 2013, Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists., Bioorg Med Chem Lett
    Gathiaka S et al., 2013, Design, development and evaluation of novel dual PPARδ/PPARγ agonists., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000112033

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000112033 Gene Symbol
    PPARD Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: NR1C2

    • Version: chembl_23

    Alternate Names:
    PPARB GENE_SYMBOL
    PPARD GENE_SYMBOL
    Peroxisome proliferator-activated receptor delta UNIPROT

    Gene Info:

    Publications:

  • Pharos: PPARD

    • Version: 03-September-2020

    Alternate Names:
    Peroxisome proliferator-activated receptor delta Gene Name
    Q03181 UniProt ID

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

    Publications:

  • GO: PPARD

    • Version: 05-September-2020

    Alternate Names:
    NR1C2 GO Gene Synonym
    PPARB GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR BINDING, NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: PPARD

    • Version: 27-Jun-2013

    Alternate Names:
    5467 Gene ID
    FAAR dGene Synonym
    NR1C2 dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21