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PPARA Gene Record

  • Summary
  • Interactions
  • Claims
  • PPARA 5465 Druggable Genome

    Alternate Names:

    5465
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA
    PPARA
    NR1C1
    PPAR
    PPARalpha
    hPPAR
    170998
    9232
    ENSG00000186951
    OTTHUMG00000150443
    peroxisome proliferator-activated receptor alpha
    Q07869
    PPAR-alpha
    Nuclear receptor subfamily 1 group C member 1
    PPARA_HUMAN
    PA280
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA (PPAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07869]
    T86591

    Gene Info:

    Target Class Receptors
    Target Subclass Nuclear receptor
    Target Main Class Receptors
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Acc IPR000536
    Uniprot Status Swiss-Prot
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Initial Gene Query NR1C1
    Counted Citations from 1950-2000 8485
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Hu B et al., 2010, Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist., J Med Chem
    Dana et al., 2001, Peroxisome proliferator-activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the Zucker diabetic fatty rat., Metab. Clin. Exp.
    Bouly et al., 2001, Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate., J. Biol. Chem.
    Guerre-Millo et al., 2000, Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity., J. Biol. Chem.
    Clavey et al., 1999, Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells., Cell. Physiol. Biochem.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Casas et al., 2000, New molecular aspects of regulation of mitochondrial activity by fenofibrate and fasting., FEBS Lett.
    Chaput et al., 2000, Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight., Biochem. Biophys. Res. Commun.
    Foucher C et al., 2004, Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes., Pharmacogenetics
    Tsamandouras N et al., 2014, Identification of the effect of multiple polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid using a population-modeling approach., Clin Pharmacol Ther
    de Keyser CE et al., 2013, Genetic variation in the PPARA gene is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study., Pharmacogenomics
    Hu M et al., 2013, Associations between the genotypes and phenotype of CYP3A and the lipid response to simvastatin in Chinese patients with hypercholesterolemia., Pharmacogenomics
    Laghezza A et al., 2013, New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression., J Med Chem
    Giampietro L et al., 2012, Synthesis and structure-activity relationships of fibrate-based analogues inside PPARs., Bioorg Med Chem Lett
    Kasuga J et al., 2008, SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail., Bioorg Med Chem Lett
    Felts AS et al., 2008, Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition., J Med Chem
    Li J et al., 2010, Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453)., J Med Chem
    Cabrero et al., 2000, Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes., Arch. Biochem. Biophys.
    Pedraza et al., 2000, Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene., Diabetes
    Goldenberg et al., 2008, Update on the use of fibrates: focus on bezafibrate., Vasc Health Risk Manag
    Fruchart et al., 2006, Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism., Drugs Today
    Inoue et al., 2001, The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells., Metab. Clin. Exp.
    Bonilla et al., 2001, Effect of a pharmacological activation of PPAR on the expression of RAR and TR in rat liver., J. Physiol. Biochem.
    Guan et al., 2001, Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease., Kidney Int.
    Vanden Heuvel JP et al., 2006, Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha., Toxicol Sci
    Egerod FL et al., 2005, Biomarkers for early effects of carcinogenic dual-acting PPAR agonists in rat urinary bladder urothelium in vivo., Biomarkers
    Chakrabarti et al., 2003, Ragaglitazar: a novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models., Br. J. Pharmacol.
    Pahan et al., 2002, Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes., J. Biol. Chem.
    Shoji et al., 2003, Preparation of antiserum against rat delta6-desaturase and its use to evaluate the desaturase protein levels in rats treated with gemfibrozil, a ligand for peroxisome proliferator-activated receptor alpha., Biosci. Biotechnol. Biochem.
    Bossé et al., Influences of the PPAR alpha-L162V polymorphism on plasma HDL(2)-cholesterol response of abdominally obese men treated with gemfibrozil., Genet. Med.
    Rizvi et al., 2003, Beneficial effects of fish liver preparations of sea bass (Lates calcarifer) versus gemfibrozil in high fat diet-induced lipid-intolerant rats., J Med Food
    De Filippis et al., 2011, Discovery of gemfibrozil analogues that activate PPARα and enhance the expression of gene CPT1A involved in fatty acids catabolism., Eur J Med Chem
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Cavender et al., 2010, Therapeutic potential of aleglitazar, a new dual PPAR-α/γ agonist: implications for cardiovascular disease in patients with diabetes mellitus., Am J Cardiovasc Drugs
    Casas et al., 2000, A 45 kDa protein related to PPARgamma2, induced by peroxisome proliferators, is located in the mitochondrial matrix., FEBS Lett.
    Palkar et al., 2010, Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development., Toxicology
    Kömüves et al., 2000, Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo., J. Invest. Dermatol.
    Gelosa et al., 2010, Peroxisome proliferator-activated receptor {alpha} agonism prevents renal damage and the oxidative stress and inflammatory processes affecting the brains of stroke-prone rats., J. Pharmacol. Exp. Ther.
    Murata et al., 2000, Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro., Biochem. Biophys. Res. Commun.
    Barclay et al., 1999, Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent., J. Pharmacol. Exp. Ther.
    Hunt et al., 2000, Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases., J. Lipid Res.
    Lancia P et al., 2018, Pharmacogenetics of post-transplant diabetes mellitus in children with renal transplantation treated with tacrolimus., Pediatr Nephrol
    Lunde I et al., 2014, The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients., Eur J Clin Pharmacol
    Elens L et al., 2013, Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus., Pharmacogenet Genomics
    Jia Y et al., 2011, Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism., Bioorg Med Chem Lett
    Bhurruth-Alcor Y et al., 2010, Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR alpha selective., Bioorg Med Chem Lett
    Sato A et al., 2013, Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists., Bioorg Med Chem Lett
    Hoang MH et al., 2012, Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells., Bioorg Med Chem Lett
    Goswami S et al., 2014, Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin., Clin Pharmacol Ther
    Sarath Josh MK et al., 2014, Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach., J Appl Toxicol
    Asano M et al., 2012, Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists., Bioorg Med Chem Lett
    Piemontese L et al., 2015, Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175., Eur J Med Chem
    Cano C et al., 2007, Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation., J Med Chem
    Kajita D et al., 2015, Design and synthesis of silicon-containing fatty acid amide derivatives as novel peroxisome proliferator-activated receptor (PPAR) agonists., Bioorg Med Chem Lett
    Tenenbaum et al., 2005, Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons., Cardiovasc Diabetol
    van Eekeren IC et al., 2013, Fibrates as therapy for osteoarthritis and rheumatoid arthritis? A systematic review., Ther Adv Musculoskelet Dis
    Murakami et al., 1999, Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha., Biochem. Biophys. Res. Commun.
    Botton MR et al., 2015, PPARA gene and phenprocoumon: a new predictor of response variability., Pharmacogenet Genomics
  • BEZAFIBRATE   PPARA

    Interaction Score: 5.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name CRx-401
    Novel drug target Established target

    PMIDs:
    10933891 10909982 18629356 16511610 11172467 11519881 11422732 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • LY-518674   PPARA

    Interaction Score: 3.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name LY-674
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • MYRISTIC ACID   PPARA

    Interaction Score: 2.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10403814


    Sources:
    DTC

  • GW590735   PPARA

    Interaction Score: 2.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    10592235


    Sources:
    ChemblInteractions

  • ROMAZARIT   PPARA

    Interaction Score: 2.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23515070


    Sources:
    TTD

  • CHEMBL107518   PPARA

    Interaction Score: 2.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22487179


    Sources:
    DTC

  • ALEGLITAZAR   PPARA

    Interaction Score: 2.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes
    Trial Name aleglitazar, R1439

    PMIDs:
    10592235 20653327


    Sources:
    TdgClinicalTrial ChemblInteractions

  • CHEMBL1089501   PPARA

    Interaction Score: 2.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20218621


    Sources:
    DTC

  • K-877   PPARA

    Interaction Score: 2.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • FENOFIBRIC ACID   PPARA

    Interaction Score: 1.81

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    23566516 21855333 22579484


    Sources:
    DTC ChemblInteractions

  • TESAGLITAZAR   PPARA

    Interaction Score: 1.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    16168052


    Sources:
    ChemblInteractions TTD

  • RAGAGLITAZAR   PPARA

    Interaction Score: 1.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16240504 12970088


    Sources:
    TTD

  • NAVEGLITAZAR   PPARA

    Interaction Score: 1.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name LY519818 , LY818
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • GW501516   PPARA

    Interaction Score: 1.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name GW501516
    Novel drug target Established target

    PMIDs:
    23566516 23843199


    Sources:
    DTC TdgClinicalTrial

  • DRF-10945   PPARA

    Interaction Score: 1.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHOLINE FENOFIBRATE   PPARA

    Interaction Score: 1.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OLEOYLETHANOLAMIDE   PPARA

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17228882 26071639


    Sources:
    DTC

  • ZYH7   PPARA

    Interaction Score: 1.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GEMFIBROZIL   PPARA

    Interaction Score: 1.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    12244038 12834305 10494028 12172398 12935323 21889235


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • CP-778875   PPARA

    Interaction Score: 1.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AVE8134   PPARA

    Interaction Score: 1.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IMIGLITAZAR   PPARA

    Interaction Score: 1.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CIPROFIBRATE   PPARA

    Interaction Score: 1.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16731579


    Sources:
    DTC TTD

  • PIRINIXIC ACID   PPARA

    Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25497132 23171045 17228882


    Sources:
    DTC

  • INDEGLITAZAR   PPARA

    Interaction Score: 0.72

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor agonist
    Direct Interaction yes

    PMIDs:
    10592235


    Sources:
    ChemblInteractions

  • PROSTAGLANDIN D2   PPARA

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23566516


    Sources:
    DTC

  • LXR-623   PPARA

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20350005


    Sources:
    DTC

  • CLOFIBRATE   PPARA

    Interaction Score: 0.72

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist

    PMIDs:
    10922459 20637823 10951268 20671072 10753628 10454501 10787442


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • MURAGLITAZAR   PPARA

    Interaction Score: 0.54

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name muraglitazar, BMS-298585
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • LACTOFEN   PPARA

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ELAFIBRANOR   PPARA

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OXEGLITAZAR   PPARA

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LOBEGLITAZONE   PPARA

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL292352   PPARA

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FENOFIBRATE   PPARA

    Interaction Score: 0.49

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist
    Direct Interaction yes
    Trial Name ABT-335, choline fenofibrate,TriLipix

    PMIDs:
    11474486 11342537 10828060 10494028 11752352 11018525 10799317 15608561


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • CHEMBL220087   PPARA

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CIGLITAZONE   PPARA

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23566516


    Sources:
    DTC

  • SODELGLITAZAR   PPARA

    Interaction Score: 0.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IOXYNIL   PPARA

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL259327   PPARA

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENPROCOUMON   PPARA

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25461249


    Sources:
    PharmGKB

  • BROMOXYNIL   PPARA

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENFORMIN HYDROCHLORIDE   PPARA

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TETRADECYLTHIOACETIC ACID   PPARA

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20036122


    Sources:
    DTC

  • ILOPROST   PPARA

    Interaction Score: 0.27

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • CHEMBL118417   PPARA

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW7647   PPARA

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    23171045 23102891 18162399 18665581


    Sources:
    DTC

  • LINOLEIC ACID   PPARA

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • URSOLIC ACID   PPARA

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21855333


    Sources:
    DTC

  • CHEMBL153057   PPARA

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • T091317   PPARA

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20350005


    Sources:
    DTC

  • CHEMBL38508   PPARA

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OLEIC ACID   PPARA

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TACROLIMUS   PPARA

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29399716 24658827 24113216


    Sources:
    PharmGKB

  • SIMVASTATIN   PPARA

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24598718 23930676 23252946


    Sources:
    PharmGKB

  • METFORMIN   PPARA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24853734


    Sources:
    PharmGKB

  • BITHIONOL   PPARA

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000186951

    • Version: 101_38

    Alternate Names:
    PPARA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q07869

    • Version: January-2014

    Alternate Names:
    PPARA Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • HopkinsGroom: Q07869

    • Version: 11-September-2012

    Alternate Names:
    5465 Entrez Gene Id
    PPARA_HUMAN Uniprot Id
    ENSG00000186951 Ensembl Gene Id

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: Q07869

    • Version: 01-August-2011

    Alternate Names:
    PPARA_HUMAN Uniprot Id
    PPARA Gene Symbol
    5465 Entrez Gene Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • RussLampel: ENSG00000186951

    • Version: 26-July-2011

    Alternate Names:
    PPARA Display Id
    ENSG00000186951 Ensembl Gene Id
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA (PPAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07869] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: PPARA

    • Version: February-2014

    Alternate Names:
    5465 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1C1
    Counted Citations from 1950-2000 8485

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • PharmGKB: PPARA

    • Version: 18-August-2020

    Alternate Names:
    PA280 PharmGKB ID

    Gene Info:

    Publications:
    de Keyser CE et al., 2013, Genetic variation in the PPARA gene is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study., Pharmacogenomics
    Tsamandouras N et al., 2014, Identification of the effect of multiple polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid using a population-modeling approach., Clin Pharmacol Ther
    Hu M et al., 2013, Associations between the genotypes and phenotype of CYP3A and the lipid response to simvastatin in Chinese patients with hypercholesterolemia., Pharmacogenomics

  • TTD: Peroxisome proliferator-activated receptor alpha

    • Version: 2020.06.01

    Alternate Names:
    PPARA TTD Gene Abbreviation
    T86591 TTD Target ID

    Gene Info:

    Publications:
    van Eekeren IC et al., 2013, Fibrates as therapy for osteoarthritis and rheumatoid arthritis? A systematic review., Ther Adv Musculoskelet Dis

  • DTC: PPARA

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Laghezza A et al., 2013, New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression., J Med Chem
    Cano C et al., 2007, Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation., J Med Chem
    Piemontese L et al., 2015, Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175., Eur J Med Chem

  • HingoraniCasas: ENSG00000186951

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000186951 Gene Symbol
    PPARA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: PPAR

    • Version: 12-May-2016

    Alternate Names:
    PPAR Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: NR1C1

    • Version: chembl_23

    Alternate Names:
    PPAR GENE_SYMBOL
    PPARA GENE_SYMBOL
    Peroxisome proliferator-activated receptor alpha UNIPROT

    Gene Info:

    Publications:

  • GO: PPARA

    • Version: 01-February-2022

    Alternate Names:
    NR1C1 GO Gene Synonym
    PPAR GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: PPARA

    • Version: 27-Jun-2013

    Alternate Names:
    5465 Gene ID
    NR1C1 dGene Synonym
    PPAR dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • Pharos: PPARA

    • Version: 01-February-2022

    Alternate Names:
    Peroxisome proliferator-activated receptor alpha Gene Name
    Q07869 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21