DGIdb - POR Gene Record

POR 5447 Druggable Genome

Alternate Names:

5447
CYTOCHROME P450 OXIDOREDUCTASE
POR
CPR
CYPOR
P450R
124015
9208
ENSG00000127948
OTTHUMG00000130413
PA33532
NADPH--CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) (P450R). [SOURCE:UNIPROT/SWISSPROT;ACC:P16435]
NCPR_HUMAN
P16435
NADPH--CYTOCHROME P450 REDUCTASE
FLJ26468

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Name	Oxidoreductase FAD/NAD(P)-binding
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001433
Interpro Short Name	OxRdtase_FAD/NAD-bd
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Woillard JB et al., 2013, Effect of CYP3A422, POR28, and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients., Clin Chem
Elens L et al., 2013, Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin., Pharmacogenet Genomics
Oneda B et al., 2009, The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test., Pharmacogenet Genomics
Cvetković M et al., 2017, Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia., Ther Drug Monit
Lunde I et al., 2014, The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients., Eur J Clin Pharmacol
Elens L et al., 2014, Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients., Ther Drug Monit
Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
Drogari E et al., 2014, POR*28 SNP is associated with lipid response to atorvastatin in children and adolescents with familial hypercholesterolemia., Pharmacogenomics
Si S et al., 2019, Impact of single nucleotide polymorphisms on P450 oxidoreductase and peroxisome proliferator-activated receptor alpha on tacrolimus pharmacokinetics in renal transplant recipients., Pharmacogenomics J
Phupradit A et al., 2018, Impact of POR and CYP3A5 Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in the Early Post-operative Period Following Kidney Transplantation., Ther Drug Monit
Lancia P et al., 2018, Pharmacogenetics of post-transplant diabetes mellitus in children with renal transplantation treated with tacrolimus., Pediatr Nephrol
Almeida-Paulo GN et al., 2018, Weight of ABCB1 and POR genes on oral tacrolimus exposure in CYP3A5 nonexpressor pediatric patients with stable kidney transplant., Pharmacogenomics J
Jannot AS et al., 2016, A Lack of Significant Effect of POR*28 Allelic Variant on Tacrolimus Exposure in Kidney Transplant Recipients., Ther Drug Monit
Zhang JJ et al., 2015, The genetic polymorphisms of POR28 and CYP3A53 significantly influence the pharmacokinetics of tacrolimus in Chinese renal transplant recipients., Int J Clin Pharmacol Ther
Kuypers DR et al., 2014, Combined effects of CYP3A51, POR28, and CYP3A4*22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients., Pharmacogenet Genomics
Bruckmueller H et al., 2015, Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus., Ther Drug Monit
Kurzawski M et al., 2014, Impact of PPARA and POR polymorphisms on tacrolimus pharmacokinetics and new-onset diabetes in kidney transplant recipients., Pharmacogenet Genomics
Lesche D et al., 2014, CYP3A53 and POR28 genetic variants influence the required dose of tacrolimus in heart transplant recipients., Ther Drug Monit
Elens L et al., 2013, Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus., Pharmacogenet Genomics
Zhang JJ et al., 2013, Effect of the P450 oxidoreductase 28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers., Eur J Clin Pharmacol
de Jonge H et al., 2011, The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients., Pharmacogenomics
Kloth JSL et al., 2018, Genetic polymorphisms as predictive biomarker of survival in patients with gastrointestinal stromal tumors treated with sunitinib., Pharmacogenomics J

TACROLIMUS POR

Interaction Score: 3.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30323313 29878980 29399716 28094348 26829596 26227094 25322286 25271728 24921414 24739669 24113216 24061445 23097010 21770725

Sources:
PharmGKB
MIDAZOLAM POR

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23324807 19801957

Sources:
PharmGKB
ZIDOVUDINE POR

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22960662

Sources:
PharmGKB
CYCLOSPORINE POR

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29135906 24658827 24061445

Sources:
PharmGKB
SUNITINIB POR

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28117434

Sources:
PharmGKB
SIROLIMUS POR

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23974086

Sources:
PharmGKB
ATORVASTATIN POR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25521355

Sources:
PharmGKB
NICOTINE POR

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000127948
- Version: 101_38
Alternate Names:

POR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000127948
- Version: 26-July-2011
Alternate Names:

ENSG00000127948 Ensembl Gene Id

NADPH--CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) (P450R). [SOURCE:UNIPROT/SWISSPROT;ACC:P16435] Description

POR Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P16435
- Version: 11-September-2012
Alternate Names:

NADPH--CYTOCHROME P450 REDUCTASE Uniprot Protein Name

POR Uniprot Gene Name

P16435 Uniprot Accession

Gene Info:

Interpro Name Oxidoreductase FAD/NAD(P)-binding

Interpro Type Domain

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: POR

Version: 18-August-2020

Alternate Names:

PA33532 PharmGKB ID

Gene Info:

Publications:

Woillard JB et al., 2013, Effect of CYP3A422, POR28, and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients., Clin Chem

Cvetković M et al., 2017, Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia., Ther Drug Monit

Lunde I et al., 2014, The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients., Eur J Clin Pharmacol

HingoraniCasas: ENSG00000127948
- Version: 31-May-2017
Alternate Names:

ENSG00000127948 Gene Symbol

POR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: POR
- Version: 19.3
Alternate Names:

ENSG00000127948 Ensembl Gene ID

CYPOR Human Protein Atlas Gene Synonym

FLJ26468 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: POR
- Version: 01-February-2022
Alternate Names:

NADPH--cytochrome P450 reductase Gene Name

P16435 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ENSG00000127948	Ensembl Gene Id
NADPH--CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) (P450R). [SOURCE:UNIPROT/SWISSPROT;ACC:P16435]	Description
POR	Display Id

NADPH--CYTOCHROME P450 REDUCTASE	Uniprot Protein Name
POR	Uniprot Gene Name
P16435	Uniprot Accession

POR Gene Record

POR 5447 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30323313 29878980 29399716 28094348 26829596 26227094 25322286 25271728 24921414 24739669 24113216 24061445 23097010 21770725

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23324807 19801957

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22960662

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29135906 24658827 24061445

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28117434

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23974086

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25521355

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000127948

Alternate Names: POR Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000127948

Alternate Names: ENSG00000127948 Ensembl Gene Id NADPH--CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) (P450R). [SOURCE:UNIPROT/SWISSPROT;ACC:P16435] Description POR Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P16435

Alternate Names: NADPH--CYTOCHROME P450 REDUCTASE Uniprot Protein Name POR Uniprot Gene Name P16435 Uniprot Accession

Gene Info: Interpro Name Oxidoreductase FAD/NAD(P)-binding Interpro Type Domain Uniprot Evidence 1: Evidence at protein level

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: POR

Alternate Names: PA33532 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000127948

Alternate Names: ENSG00000127948 Gene Symbol POR Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: POR

Alternate Names: ENSG00000127948 Ensembl Gene ID CYPOR Human Protein Atlas Gene Synonym FLJ26468 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

Pharos: POR

Alternate Names: NADPH--cytochrome P450 reductase Gene Name P16435 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
30323313 29878980 29399716 28094348 26829596 26227094 25322286 25271728 24921414 24739669 24113216 24061445 23097010 21770725

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23324807 19801957

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22960662

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29135906 24658827 24061445

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28117434

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23974086

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25521355

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

POR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000127948 Ensembl Gene Id

NADPH--CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) (P450R). [SOURCE:UNIPROT/SWISSPROT;ACC:P16435] Description

POR Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NADPH--CYTOCHROME P450 REDUCTASE Uniprot Protein Name

POR Uniprot Gene Name

P16435 Uniprot Accession

Gene Info:

Interpro Name Oxidoreductase FAD/NAD(P)-binding

Interpro Type Domain

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA33532 PharmGKB ID

Alternate Names:

ENSG00000127948 Gene Symbol

POR Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000127948 Ensembl Gene ID

CYPOR Human Protein Atlas Gene Synonym

FLJ26468 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

NADPH--cytochrome P450 reductase Gene Name

P16435 UniProt ID

Gene Categories:

ENZYME