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PON1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PON1 5444 Druggable Genome

    Alternate Names:

    5444
    PARAOXONASE 1
    PON1
    ESA
    MVCD5
    PON
    168820
    9204
    ENSG00000005421
    OTTHUMG00000153894
    BE0000930
    P27169
    PA33529
    Serum paraoxonase/arylesterase 1
    3052

    Gene Info:

    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Paraoxonase (PON) family
    GuideToPharmacology Gene Category ID 1018
    (4 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Sinan et al., 2006, Novel purification strategy for human PON1 and inhibition of the activity by cephalosporin and aminoglikozide derived antibiotics., Biochimie
    Fu R et al., 2008, Effect of statin therapy on plasma high-density lipoprotein-cholesterol levels is modified by paraoxonase 1 in Chinese patients with coronary heart disease., Clin Exp Pharmacol Physiol
    Himbergen TM et al., 2005, The effect of statin therapy on plasma high-density lipoprotein cholesterol levels is modified by paraoxonase-1 in patients with familial hypercholesterolaemia., J Intern Med
    Nagila A et al., 2009, Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status., Pharmacol Rep
    Atrahimovich D et al., 2013, The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study., Bioorg Med Chem
    Wang F et al., 2013, Immobilized metal affinity chromatography and human serum proteomics., J Chromatogr B Analyt Technol Biomed Life Sci
  • CEFAZOLIN   PON1

    Interaction Score: 2.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16600468


    Sources:
    DrugBank

  • SIMVASTATIN   PON1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18430057 16238680 19904013


    Sources:
    PharmGKB

  • ATORVASTATIN   PON1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18430057 16238680 19904013


    Sources:
    PharmGKB

  • EPIRUBICIN   PON1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • OXALIPLATIN   PON1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ZINC CHLORIDE   PON1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • QUERCETIN   PON1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23623675


    Sources:
    DTC

  • COPPER   PON1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • METHYLDOPA   PON1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • FLUOROURACIL   PON1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000005421

    • Version: 101_38

    Alternate Names:
    PON1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • GuideToPharmacology: 5444

    • Version: 29-September-2020

    Alternate Names:
    9204 HUGO Gene ID
    9204 HUGO Gene Symbol
    paraoxonase 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Paraoxonase (PON) family
    GuideToPharmacology Gene Category ID 1018

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: PON1

    • Version: 18-August-2020

    Alternate Names:
    PA33529 PharmGKB ID

    Gene Info:

    Publications:
    Fu R et al., 2008, Effect of statin therapy on plasma high-density lipoprotein-cholesterol levels is modified by paraoxonase 1 in Chinese patients with coronary heart disease., Clin Exp Pharmacol Physiol
    Himbergen TM et al., 2005, The effect of statin therapy on plasma high-density lipoprotein cholesterol levels is modified by paraoxonase-1 in patients with familial hypercholesterolaemia., J Intern Med
    Nagila A et al., 2009, Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status., Pharmacol Rep

  • DrugBank: BE0000930

    • Version: 5.1.7

    Alternate Names:
    PON1 DrugBank Gene Name
    P27169 UniProt Accession
    5444 Entrez Gene Id

    Gene Info:

    Publications:
    Sinan et al., 2006, Novel purification strategy for human PON1 and inhibition of the activity by cephalosporin and aminoglikozide derived antibiotics., Biochimie
    Wang F et al., 2013, Immobilized metal affinity chromatography and human serum proteomics., J Chromatogr B Analyt Technol Biomed Life Sci

  • DTC: PON1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Atrahimovich D et al., 2013, The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study., Bioorg Med Chem

  • HingoraniCasas: ENSG00000005421

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000005421 Gene Symbol
    PON1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: PON1

    • Version: 19.3

    Alternate Names:
    ENSG00000005421 Ensembl Gene ID
    ESA Human Protein Atlas Gene Synonym
    PON Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER, ENZYME

    Publications:

  • Pharos: PON1

    • Version: 03-September-2020

    Alternate Names:
    Serum paraoxonase/arylesterase 1 Gene Name
    P27169 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21