• PLK4 10733 Druggable Genome

    Alternate Names:

    10733
    POLO LIKE KINASE 4
    PLK4
    MCCRP2
    SAK
    STK18
    605031
    11397
    ENSG00000142731
    OTTHUMG00000133301
    PLK-4
    Serine/threonine-protein kinase Sak
    Serine/threonine-protein kinase 18
    Polo-like kinase 4
    Serine/threonine-protein kinase PLK4
    2171
    O00444
    PLK4_HUMAN
    SERINE/THREONINE-PROTEIN KINASE PLK4 (EC 2.7.1.37) (POLO-LIKE KINASE 4) (PLK-4) (SERINE/THREONINE PROTEIN KINASE SAK) (SERINE/THREONINE- PROTEIN KINASE 18). [SOURCE:UNIPROT/SWISSPROT;ACC:O00444]
    NP_055079
    NM_001190799

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name Polo-like kinase (PLK) family
    GuideToPharmacology Gene Category ID 602
    Uniprot Status Swiss-Prot
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Acc IPR002290
    Interpro Type Domain
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME
  • Interaction Score: 1.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase PLK4 inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

    • Version: 101_38

    Alternate Names:
    PLK4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000142731 Ensembl Gene Id
    PLK4_HUMAN Uniprot Id
    SERINE/THREONINE-PROTEIN KINASE PLK4 Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000142731 Ensembl Gene Id
    PLK4 Display Id
    SERINE/THREONINE-PROTEIN KINASE PLK4 (EC 2.7.1.37) (POLO-LIKE KINASE 4) (PLK-4) (SERINE/THREONINE PROTEIN KINASE SAK) (SERINE/THREONINE- PROTEIN KINASE 18). [SOURCE:UNIPROT/SWISSPROT;ACC:O00444] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    11397 HUGO Gene Symbol
    11397 HUGO Gene ID
    polo like kinase 4 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category ID 602
    GuideToPharmacology Gene Category Name Polo-like kinase (PLK) family

    Gene Categories:
    ENZYME

    Publications:

    • Version: 02-September-2020
    • Version: chembl_23

    Alternate Names:
    STK18 GENE_SYMBOL
    PLK4 GENE_SYMBOL
    Serine/threonine-protein kinase PLK4 UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000142731 Gene Symbol
    PLK4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000142731 Ensembl Gene ID
    Sak Human Protein Atlas Gene Synonym
    STK18 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    10733 Gene ID
    SAK dGene Synonym
    STK18 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • GO: PLK4

    • Version: 01-May-2021

    Alternate Names:
    SAK GO Gene Synonym
    STK18 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Serine/threonine-protein kinase PLK4 Gene Name
    O00444 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications: