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PLG Gene Record

  • Summary
  • Interactions
  • Claims
  • PLG 5340 Druggable Genome

    Alternate Names:

    5340
    PLASMINOGEN
    PLG
    173350
    9071
    ENSG00000122194
    OTTHUMG00000015957
    P00747
    P02671
    2243
    ENSG00000171560
    FIBA_HUMAN
    PLASMINOGEN PRECURSOR (EC 3.4.21.7) [CONTAINS: ANGIOSTATIN]. [SOURCE:UNIPROT/SWISSPROT;ACC:P00747]
    PLMN_HUMAN
    Plasmin light chain B
    Plasmin heavy chain A, short form
    Angiostatin
    Activation peptide
    Plasmin heavy chain A
    P07355
    302
    ANXA2_HUMAN
    ENSG00000182718
    T89034
    -
    HAE4

    Gene Info:

    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion
    Target Subclass Fibrinogen
    Target Class Enzymes
    Target Subclass EC:3.4.21.7
    Target Main Class Other
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name PROTEASE
    Target Subclass 3.4.21.7
    Target Main Class Enzymes
    Target Subclass Enzyme Inhibitor
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Peptidase_S1_S6
    Interpro Type Domain
    Interpro Acc IPR001254
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    PROTEASE
    DRUGGABLE GENOME

    Publications:

    Zhang et al., 2002, Study on the mechanism of the annexin II-mediated co-assembly of t-PA and plasminogen., J. Huazhong Univ. Sci. Technol. Med. Sci.
    Hashimoto et al., 2003, Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model., Thromb. Haemost.
    López-Alemany et al., 2003, Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase., Am. J. Hematol.
    Guda et al., 2003, Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors., Mol. Carcinog.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Chang et al., Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells., Cell Commun. Adhes.
    Melandri et al., 2009, Review of tenecteplase (TNKase) in the treatment of acute myocardial infarction., Vasc Health Risk Manag
    Longstaff et al., 2008, Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy., Cardiovasc Hematol Agents Med Chem
    Hilleman et al., 2007, Fibrinolytic agents for the management of ST-segment elevation myocardial infarction., Pharmacotherapy
    Ellis et al., 2002, Plasminogen activation is stimulated by prion protein and regulated in a copper-dependent manner., Biochemistry
    Dafer et al., 2007, Desmoteplase in the treatment of acute ischemic stroke., Expert Rev Neurother
    Stahl et al., 1995, The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae., J. Cell Biol.
    Mahdy et al., 2004, Perioperative systemic haemostatic agents., Br J Anaesth
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
    Shepherd, 1995, Danazol and plasma lipoprotein metabolism., Int J Gynaecol Obstet
    Bower et al., Failure of the synthetic androgen, danazol, to increase protein S levels and prevent thrombosis in a patient with severe protein S deficiency., Haemostasis
    Cugno et al., 1988, Haemostasis contact system and fibrinolysis in hereditary angioedema (C1-inhibitor deficiency)., J. Clin. Chem. Clin. Biochem.
    Bannach et al., 2004, Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta)., J. Thromb. Haemost.
    Parry et al., 2000, Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues., Trends Biochem. Sci.
    Alessi et al., 1999, [Thrombolytics and their use]., Rev Prat
    Korol'chuk et al., [Plasminogen binding with decapeptide and polypeptide fragments of streptokinase]., Ukr Biokhim Zh (1999)
    Chaudhary et al., 1999, Function of the central domain of streptokinase in substrate plasminogen docking and processing revealed by site-directed mutagenesis., Protein Sci.
    Caballero et al., 1999, Cloning, expression, sequence analysis, and characterization of streptokinases secreted by porcine and equine isolates of Streptococcus equisimilis., Infect. Immun.
    Ueda, 1990, Effect of corticosteroids on some hemostatic parameters in children with minimal change nephrotic syndrome., Nephron
    Notelovitz et al., 1992, Changes in coagulation and anticoagulation in women taking low-dose triphasic oral contraceptives: a controlled comparative 12-month clinical trial., Am. J. Obstet. Gynecol.
    Coleman JE et al., 2001, Radiosumin B, an unusual dipeptide from the cyanobacterium Microcystis aeruginosa., J Nat Prod
    Horne et al., 2005, Plasminogen interaction with platelets: the importance of carboxyterminal lysines., Thromb. Res.
    Silverstein et al., 1985, Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation., J. Biol. Chem.
    Liepkalns et al., 1991, Cell signalling associated with fibrinolytic ligand binding to human colorectal carcinoma cells., J. Cancer Res. Clin. Oncol.
    Fukao et al., 2007, Antithrombotic effects of odorless garlic powder both in vitro and in vivo., Biosci. Biotechnol. Biochem.
    Ahmed et al., 2002, Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer., J. Cell. Biochem.
    Politis et al., 1990, Effect of somatotropin on the plasminogen and plasmin system in the mammary gland: proposed mechanism of action for somatotropin on the mammary gland., J. Dairy Sci.
    Rose et al., 2005, Correlation of blood and milk components with the milk yield response to bovine somatotropin in dairy cows., Domest. Anim. Endocrinol.
    Shibuya et al., 1988, Oxymetholone therapy in patients with familial antithrombin III deficiency., Thromb. Haemost.
  • STREPTOKINASE   PLG

    Interaction Score: 21.32

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Plasminogen activator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    10664583 10581996 10726310 10631997 11752352 10569766


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • TENECTEPLASE   PLG

    Interaction Score: 8.53

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Plasminogen activator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    19436656 18673235 11752352 17963464


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • RETEPLASE   PLG

    Interaction Score: 8.53

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Trial Name reteplase,Retavase, Rapilysin
    Novel drug target Established target
    Mechanism of Interaction Plasminogen activator

    PMIDs:
    18673235 17963464 11752352 19436656


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • DESMOTEPLASE   PLG

    Interaction Score: 8.53

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Trial Name desmoteplase
    Novel drug target Established target
    Mechanism of Interaction Plasminogen activator

    PMIDs:
    17425487


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • ANISTREPLASE   PLG

    Interaction Score: 7.46

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    19436656 18673235 11752352 17963464


    Sources:
    TdgClinicalTrial TEND TTD

  • RADIOSUMIN B   PLG

    Interaction Score: 4.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11374973


    Sources:
    DTC

  • UROKINASE   PLG

    Interaction Score: 3.2

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Plasminogen activator
    Direct Interaction yes
    Trial Name urokinase for injection,Kinlytic

    PMIDs:
    12658774 12719778 12666133 12720300 11752352 12745435


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DEFIBROTIDE SODIUM   PLG

    Interaction Score: 2.13

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Plasminogen activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HUMAN GROWTH HORMONE   PLG

    Interaction Score: 2.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2143511 15760670


    Sources:
    NCI

  • TRANEXAMIC ACID   PLG

    Interaction Score: 2.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Plasminogen inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LEPIRUDIN   PLG

    Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15894352


    Sources:
    NCI

  • APROTININ   PLG

    Interaction Score: 1.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Plasminogen inhibitor
    Direct Interaction yes

    PMIDs:
    15277296


    Sources:
    ChemblInteractions

  • NYSTATIN   PLG

    Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7721938


    Sources:
    NCI

  • ALTEPLASE   PLG

    Interaction Score: 1.12

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name alteplase,Activase, Actilyse
    Mechanism of Interaction Plasminogen activator

    PMIDs:
    19436656 18673235 11752352 17963464 12033920


    Sources:
    TdgClinicalTrial ChemblInteractions NCI TEND TTD

  • AMINOCAPROIC ACID   PLG

    Interaction Score: 1.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Plasminogen inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMEDIPLASE   PLG

    Interaction Score: 1.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name amediplase, K2tu-PA
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • FIBRINOLYSIN, HUMAN   PLG

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Plasmin
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • DANAZOL   PLG

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8529771 7607583 3146615


    Sources:
    NCI

  • OXYMETHOLONE   PLG

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3238652


    Sources:
    NCI

  • NORETHINDRONE   PLG

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1442974


    Sources:
    NCI

  • GARLIC   PLG

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17213677


    Sources:
    NCI

  • MELAGATRAN   PLG

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • COUMARIN   PLG

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3160707


    Sources:
    NCI

  • INOSITOL   PLG

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1648562


    Sources:
    NCI

  • RANOLAZINE   PLG

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PREDNISOLONE   PLG

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2079995


    Sources:
    NCI

  • CHEMBL35482   PLG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15613028


    Sources:
    NCI

  • GENISTEIN   PLG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11835393


    Sources:
    NCI

  • BORTEZOMIB   PLG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20875739


    Sources:
    DTC

  • Ensembl: ENSG00000122194

    • Version: 101_38

    Alternate Names:
    PLG Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P00747

    • Version: January-2014

    Alternate Names:
    PLG Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion
    Target Subclass Fibrinogen

    Publications:

  • TEND: P07355

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000182718 Ensembl Gene Id
    ANXA2_HUMAN Uniprot Id
    302 Entrez Gene Id

    Gene Info:
    Target Subclass Enzyme Inhibitor
    Target Main Class Other

    Publications:

  • TEND: P00747

    • Version: 01-August-2011

    Alternate Names:
    PLMN_HUMAN Uniprot Id
    PLG Gene Symbol
    5340 Entrez Gene Id

    Gene Info:
    Target Subclass 3.4.21.7
    Target Main Class Enzymes

    Publications:

  • TEND: P02671

    • Version: 01-August-2011

    Alternate Names:
    P02671 Uniprot Accession
    2243 Entrez Gene Id
    PLG Gene Symbol

    Gene Info:
    Target Subclass Fibrinogen
    Target Main Class Other
    Target Subclass StructuralAndAdhesion

    Publications:

  • RussLampel: ENSG00000122194

    • Version: 26-July-2011

    Alternate Names:
    PLASMINOGEN PRECURSOR (EC 3.4.21.7) [CONTAINS: ANGIOSTATIN]. [SOURCE:UNIPROT/SWISSPROT;ACC:P00747] Description
    ENSG00000122194 Ensembl Gene Id
    PLG Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P00747

    • Version: 11-September-2012

    Alternate Names:
    P00747 Uniprot Accession
    ENSG00000122194 Ensembl Gene Id
    5340 Entrez Gene Id

    Gene Info:
    Human Readable Name PROTEASE
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • NCI: PLG

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Fukao et al., 2007, Antithrombotic effects of odorless garlic powder both in vitro and in vivo., Biosci. Biotechnol. Biochem.
    Shibuya et al., 1988, Oxymetholone therapy in patients with familial antithrombin III deficiency., Thromb. Haemost.
    Tsai, 2007, The P11, tPA/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants., Med. Hypotheses

  • DTC: PLG

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Coleman JE et al., 2001, Radiosumin B, an unusual dipeptide from the cyanobacterium Microcystis aeruginosa., J Nat Prod
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000122194

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000122194 Gene Symbol
    PLG Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: PLG

    • Version: chembl_23

    Alternate Names:
    PLG GENE_SYMBOL
    Plasminogen UNIPROT
    Plasmin heavy chain A UNIPROT

    Gene Info:

    Publications:

  • dGene: PLG

    • Version: 27-Jun-2013

    Alternate Names:
    5340 Gene ID
    - dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Plasminogen

    • Version: 2020.06.01

    Alternate Names:
    PLG TTD Gene Abbreviation
    T89034 TTD Target ID

    Gene Info:

    Publications:

  • GO: PLG

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21