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PLG 5340 Druggable Genome
Alternate Names:
5340 PLASMINOGEN PLG 173350 9071 ENSG00000122194 OTTHUMG00000015957 P00747 P02671 2243 ENSG00000171560 FIBA_HUMAN PLASMINOGEN PRECURSOR (EC 3.4.21.7) [CONTAINS: ANGIOSTATIN]. [SOURCE:UNIPROT/SWISSPROT;ACC:P00747] PLMN_HUMAN 2394 NP_000292 NM_000301 Plasmin light chain B Plasmin heavy chain A, short form Angiostatin Activation peptide Plasmin heavy chain A P07355 302 ANXA2_HUMAN ENSG00000182718 BE0000211 T89034 - Gene Info:
Target Class Miscellaneous Target Subclass StructuralAndAdhesion Target Subclass Fibrinogen Target Class Enzymes Target Subclass EC:3.4.21.7 Target Main Class Other Human Readable Name DRUGGABLE GENOME GuideToPharmacology Gene Category Name S1: Chymotrypsin GuideToPharmacology Gene Category ID 751 Human Readable Name PROTEASE Target Subclass 3.4.21.7 Target Main Class Enzymes Target Subclass Enzyme Inhibitor Uniprot Evidence 1: Evidence at protein level Interpro Short Name Peptidase_S1_S6 Interpro Type Domain Interpro Acc IPR001254 Interpro Name Peptidase S1/S6, chymotrypsin/Hap Uniprot Status Swiss-Prot Gene Biotype PROTEIN_CODING Gene Categories: Category Details
CELL SURFACE PROTEASE DRUGGABLE GENOME ENZYME Publications:
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Interaction Score: 10.08
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Interaction Score: 9.16
Interaction Types & Directionality:
activator (activating) Interaction Info:
Trial Name desmoteplase Novel drug target Established target Mechanism of Interaction Plasminogen activator -
Interaction Types & Directionality:
activator (activating) Interaction Info:
Trial Name reteplase,Retavase, Rapilysin Novel drug target Established target Mechanism of Interaction Plasminogen activator
Sources:
TEND TdgClinicalTrial TTD DrugBank ChemblInteractions -
Interaction Score: 4.89
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Interaction Score: 3.66
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Interaction Score: 1.83
Interaction Types & Directionality:
activator (activating) Interaction Info:
Mechanism of Interaction Plasminogen activator Direct Interaction yes -
Interaction Score: 1.83
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Plasminogen inhibitor Direct Interaction yes -
Interaction Types & Directionality:
activator (activating) Interaction Info:
Mechanism of Interaction Plasminogen activator Direct Interaction yes Trial Name urokinase for injection,Kinlytic
Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions -
Interaction Score: 1.37
Interaction Types & Directionality:
activator (activating) Interaction Info:
Mechanism of Interaction Plasminogen activator Direct Interaction yes Trial Name -
Sources:
TEND TdgClinicalTrial TTD DrugBank ChemblInteractions -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Binding -
Interaction Score: 1.1
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Interaction Types & Directionality:
activator (activating) Interaction Info:
Novel drug target Established target Trial Name alteplase,Activase, Actilyse Mechanism of Interaction Plasminogen activator -
Interaction Score: 0.92
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Plasminogen inhibitor Direct Interaction yes -
Interaction Score: 0.92
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name amediplase, K2tu-PA Novel drug target Established target -
Interaction Score: 0.37
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Interaction Score: 0.37
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Interaction Score: 0.31
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Interaction Score: 0.31
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name Plasmin Novel drug target Established target -
Interaction Score: 0.15
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Interaction Score: 0.14
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Interaction Score: 0.1
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Interaction Score: 0.04
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- Version: 101_38
Alternate Names:
PLG Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: January-2014
Alternate Names:
PLG Gene Symbol Gene Info:
Target Class Miscellaneous Target Subclass StructuralAndAdhesion Target Subclass Fibrinogen Publications:
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Alternate Names:
ENSG00000182718 Ensembl Gene Id ANXA2_HUMAN Uniprot Id 302 Entrez Gene Id Gene Info:
Target Subclass Enzyme Inhibitor Target Main Class Other Publications:
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Alternate Names:
PLMN_HUMAN Uniprot Id PLG Gene Symbol 5340 Entrez Gene Id Gene Info:
Target Subclass 3.4.21.7 Target Main Class Enzymes Publications:
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Alternate Names:
P02671 Uniprot Accession 2243 Entrez Gene Id PLG Gene Symbol Gene Info:
Target Subclass Fibrinogen Target Main Class Other Target Subclass StructuralAndAdhesion Publications:
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- Version: 26-July-2011
Alternate Names:
PLASMINOGEN PRECURSOR (EC 3.4.21.7) [CONTAINS: ANGIOSTATIN]. [SOURCE:UNIPROT/SWISSPROT;ACC:P00747] Description ENSG00000122194 Ensembl Gene Id PLG Display Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 11-September-2012
Alternate Names:
P00747 Uniprot Accession ENSG00000122194 Ensembl Gene Id 5340 Entrez Gene Id Gene Info:
Human Readable Name PROTEASE Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Gene Categories:
PROTEASE, DRUGGABLE GENOME Publications:
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- Version: 29-September-2020
Alternate Names:
9071 HUGO Gene ID 9071 HUGO Gene Symbol plasminogen HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name S1: Chymotrypsin GuideToPharmacology Gene Category ID 751 Gene Categories:
ENZYME Publications:
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Alternate Names:
PLG DrugBank Gene Name P00747 UniProt Accession 5340 Entrez Gene Id Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Publications:
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Alternate Names:
Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000122194 Gene Symbol PLG Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
PLG GENE_SYMBOL Plasminogen UNIPROT Plasmin heavy chain A UNIPROT Gene Info:
Publications:
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Alternate Names:
5340 Gene ID - dGene Synonym Gene Info:
Gene Categories:
PROTEASE Publications:
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- Version: 2020.06.01
Alternate Names:
PLG TTD Gene Abbreviation T89034 TTD Target ID Gene Info:
Publications:
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Alternate Names:
Gene Info:
Gene Categories:
CELL SURFACE Publications: