DGIdb - PLA2G7 Gene Record

PLA2G7 7941 Druggable Genome

Alternate Names:

7941
PHOSPHOLIPASE A2 GROUP VII
PLA2G7
LDL-PLA2
LP-PLA2
PAFAD
PAFAH
601690
9040
ENSG00000146070
OTTHUMG00000014789
Q13093
BE0002409
LDL-PLA(2)
Platelet-activating factor acetylhydrolase
1-alkyl-2-acetylglycerophosphocholine esterase
2-acetyl-1-alkylglycerophosphocholine esterase
Group-VIIA phospholipase A2
LDL-associated phospholipase A2
PAF 2-acylhydrolase
PAF acetylhydrolase
gVIIA-PLA2
1432
NP_005075
NM_005084
PLA<sub>2</sub>-G7
T69912

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.1.1.47
GuideToPharmacology Gene Category Name	Phospholipase A<sub>2</sub>
GuideToPharmacology Gene Category ID	275
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Hydrolases
GuideToPharmacology Gene Category ID	799

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Papavasiliou et al., 2006, PAF-acetylhydrolase activity in plasma of patients with chronic kidney disease. Effect of long-term therapy with erythropoietin., Nephrol. Dial. Transplant.

DARAPLADIB PLA2G7

Interaction Score: 28.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In an assay using whole human plasma and recombinant hPLA2-G7, that approximates the physiological environment of the enzyme.

Direct Interaction? False

Details of the Assay for Interaction In a biochemical assay, measuring fluorescence intensity and using Thio-Paf.

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions

RILAPLADIB PLA2G7

Interaction Score: 25.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction LDL-associated phospholipase A2 inhibitor

Direct Interaction? True

PMIDs:
None found

Sources:
TTD DrugBank GuideToPharmacology ChemblInteractions
EPOETIN BETA PLA2G7

Interaction Score: 2.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16421163

Sources:
NCI

Ensembl: ENSG00000146070
- Version: 101_38
Alternate Names:

PLA2G7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q13093
- Version: January-2014
Alternate Names:

PLA2G7 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.1.47

Publications:
GuideToPharmacology: 7941
- Version: 29-September-2020
Alternate Names:

9040 HUGO Gene ID

9040 HUGO Gene Symbol

phospholipase A2 group VII HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Hydrolases

GuideToPharmacology Gene Category ID 799

GuideToPharmacology Gene Category Name Phospholipase A<sub>2</sub>

Gene Categories:

ENZYME

Publications:
DrugBank: BE0002409
- Version: 5.1.7
Alternate Names:

PLA2G7 DrugBank Gene Name

Q13093 UniProt Accession

7941 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
NCI: PLA2G7
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Papavasiliou et al., 2006, PAF-acetylhydrolase activity in plasma of patients with chronic kidney disease. Effect of long-term therapy with erythropoietin., Nephrol. Dial. Transplant.
ChemblInteractions: PAFAH
- Version: chembl_23
Alternate Names:

gVIIA-PLA2 UNIPROT

PAFAH GENE_SYMBOL

PLA2G7 GENE_SYMBOL

Gene Info:

Publications:
HingoraniCasas: ENSG00000146070
- Version: 31-May-2017
Alternate Names:

ENSG00000146070 Gene Symbol

PLA2G7 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: PLA2G7
- Version: 19.3
Alternate Names:

ENSG00000146070 Ensembl Gene ID

LDL-PLA2 Human Protein Atlas Gene Synonym

PAFAH Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: PLA2G7
- Version: 03-September-2020
Alternate Names:

Platelet-activating factor acetylhydrolase Gene Name

Q13093 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Platelet-activating factor acetylhydrolase
- Version: 2020.06.01
Alternate Names:

PLA2G7 TTD Gene Abbreviation

T69912 TTD Target ID

Gene Info:

Publications:

Details of the Assay for Interaction	In an assay using whole human plasma and recombinant hPLA2-G7, that approximates the physiological environment of the enzyme.
Direct Interaction?	False
Details of the Assay for Interaction	In a biochemical assay, measuring fluorescence intensity and using Thio-Paf.

Direct Interaction	yes
Mechanism of Interaction	LDL-associated phospholipase A2 inhibitor
Direct Interaction?	True

9040	HUGO Gene ID
9040	HUGO Gene Symbol
phospholipase A2 group VII	HUGO Gene Name

PLA2G7	DrugBank Gene Name
Q13093	UniProt Accession
7941	Entrez Gene Id

ENSG00000146070	Ensembl Gene ID
LDL-PLA2	Human Protein Atlas Gene Synonym
PAFAH	Human Protein Atlas Gene Synonym

Platelet-activating factor acetylhydrolase	Gene Name
Q13093	UniProt ID

gVIIA-PLA2	UNIPROT
PAFAH	GENE_SYMBOL
PLA2G7	GENE_SYMBOL

PLA2G7 Gene Record

PLA2G7 7941 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DARAPLADIB PLA2G7

Interaction Types & Directionality: inhibitor (inhibitory)

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology ChemblInteractions

RILAPLADIB PLA2G7

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction LDL-associated phospholipase A2 inhibitor Direct Interaction? True

PMIDs: None found

Sources: TTD DrugBank GuideToPharmacology ChemblInteractions

EPOETIN BETA PLA2G7

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16421163

Sources: NCI

Ensembl: ENSG00000146070

Alternate Names: PLA2G7 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q13093

Alternate Names: PLA2G7 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.1.1.47

Publications:

GuideToPharmacology: 7941

Alternate Names: 9040 HUGO Gene ID 9040 HUGO Gene Symbol phospholipase A2 group VII HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Hydrolases GuideToPharmacology Gene Category ID 799 GuideToPharmacology Gene Category Name Phospholipase A<sub>2</sub>

Gene Categories: ENZYME

Publications:

DrugBank: BE0002409

Alternate Names: PLA2G7 DrugBank Gene Name Q13093 UniProt Accession 7941 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: PLA2G7

Alternate Names:

Gene Info:

Publications: Papavasiliou et al., 2006, PAF-acetylhydrolase activity in plasma of patients with chronic kidney disease. Effect of long-term therapy with erythropoietin., Nephrol. Dial. Transplant.

ChemblInteractions: PAFAH

Alternate Names: gVIIA-PLA2 UNIPROT PAFAH GENE_SYMBOL PLA2G7 GENE_SYMBOL

Gene Info:

Publications:

HingoraniCasas: ENSG00000146070

Alternate Names: ENSG00000146070 Gene Symbol PLA2G7 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: PLA2G7

Alternate Names: ENSG00000146070 Ensembl Gene ID LDL-PLA2 Human Protein Atlas Gene Synonym PAFAH Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

Pharos: PLA2G7

Alternate Names: Platelet-activating factor acetylhydrolase Gene Name Q13093 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

TTD: Platelet-activating factor acetylhydrolase

Alternate Names: PLA2G7 TTD Gene Abbreviation T69912 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction LDL-associated phospholipase A2 inhibitor

Direct Interaction? True

PMIDs:
None found

Sources:
TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16421163

Sources:
NCI

Alternate Names:

PLA2G7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PLA2G7 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.1.47

Alternate Names:

9040 HUGO Gene ID

9040 HUGO Gene Symbol

phospholipase A2 group VII HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Hydrolases

GuideToPharmacology Gene Category ID 799

GuideToPharmacology Gene Category Name Phospholipase A<sub>2</sub>

Gene Categories:

ENZYME

Alternate Names:

PLA2G7 DrugBank Gene Name

Q13093 UniProt Accession

7941 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Publications:

Papavasiliou et al., 2006, PAF-acetylhydrolase activity in plasma of patients with chronic kidney disease. Effect of long-term therapy with erythropoietin., Nephrol. Dial. Transplant.

Alternate Names:

gVIIA-PLA2 UNIPROT

PAFAH GENE_SYMBOL

PLA2G7 GENE_SYMBOL

Alternate Names:

ENSG00000146070 Gene Symbol

PLA2G7 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000146070 Ensembl Gene ID

LDL-PLA2 Human Protein Atlas Gene Synonym

PAFAH Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

Platelet-activating factor acetylhydrolase Gene Name

Q13093 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

PLA2G7 TTD Gene Abbreviation

T69912 TTD Target ID