• PLA2G7 7941 Druggable Genome

    Alternate Names:

    7941
    PHOSPHOLIPASE A2 GROUP VII
    PLA2G7
    LDL-PLA2
    LP-PLA2
    PAFAD
    PAFAH
    601690
    9040
    ENSG00000146070
    OTTHUMG00000014789
    Q13093
    BE0002409
    LDL-PLA(2)
    Platelet-activating factor acetylhydrolase
    1-alkyl-2-acetylglycerophosphocholine esterase
    2-acetyl-1-alkylglycerophosphocholine esterase
    Group-VIIA phospholipase A2
    LDL-associated phospholipase A2
    PAF 2-acylhydrolase
    PAF acetylhydrolase
    gVIIA-PLA2
    1432
    NP_005075
    NM_005084
    PLA<sub>2</sub>-G7
    T69912

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.1.1.47
    GuideToPharmacology Gene Category Name Phospholipase A<sub>2</sub>
    GuideToPharmacology Gene Category ID 275
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Hydrolases
    GuideToPharmacology Gene Category ID 799
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME
  • Interaction Score: 28.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction In an assay using whole human plasma and recombinant hPLA2-G7, that approximates the physiological environment of the enzyme.
    Direct Interaction? False
    Details of the Assay for Interaction In a biochemical assay, measuring fluorescence intensity and using Thio-Paf.

  • Interaction Score: 25.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction LDL-associated phospholipase A2 inhibitor
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16421163


    Sources:
    NCI