DGIdb - PLA2G1B Gene Record

PLA2G1B 5319 Druggable Genome

Alternate Names:

5319
PHOSPHOLIPASE A2 GROUP IB
PLA2G1B
PLA2
PLA2A
PPLA2
172410
9030
ENSG00000170890
OTTHUMG00000169343
P04054
PHOSPHOLIPASE A2
PHOSPHOLIPASE A2 PRECURSOR (EC 3.1.1.4) (PHOSPHATIDYLCHOLINE 2- ACYLHYDROLASE) (GROUP IB PHOSPHOLIPASE A2). [SOURCE:UNIPROT/SWISSPROT;ACC:P04054]
PA21B_HUMAN
1416
sPLA<sub>2</sub>-1B
BE0003997
T31479

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:3.1.1.4
Interpro Name	Phospholipase A2, eukaryotic
Interpro Type	Family
Human Readable Name	PHOSPHOLIPASE
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001211
Uniprot Status	Swiss-Prot
Interpro Short Name	PLipase_A2_euk
GuideToPharmacology Gene Category Name	Phospholipase A<sub>2</sub>
GuideToPharmacology Gene Category ID	275
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

CELL SURFACE
PHOSPHOLIPASE
DRUGGABLE GENOME
ENZYME

Publications:

Seiler et al., 1995, Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na+/H+ exchange by a thrombin receptor antagonist., Biochem. Pharmacol.
Yu BZ et al., 2009, Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia., J Nat Prod
Ottlecz et al., 1999, Effect of ranitidine bismuth citrate on the phospholipase A2 activity of Naja naja venom and Helicobacter pylori: a biochemical analysis., Aliment. Pharmacol. Ther.
Pruzanski et al., 1997, Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity., Biochem. Pharmacol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Jabeen et al., 2005, Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution., Acta Crystallogr. D Biol. Crystallogr.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Zhang et al., 1998, Regulation of membrane release in apoptosis., Biochem. J.
Mustonen et al., 1991, Activation of phospholipase A2 by adriamycin in vitro. Role of drug-lipid interactions., J. Biol. Chem.
Kucia et al., Effect of antidepressants on the phospholipase A2 activity in plasma membranes of the rat brain cortex., Pol J Pharmacol
Hamasaki Y et al., 1996, Inhibition of leukotriene synthesis by azelastine., Ann Allergy Asthma Immunol

CHEMBL1159973 PLA2G1B

Interaction Score: 7.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
HEPTANOATE PLA2G1B

Interaction Score: 3.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
P-ANISIC ACID PLA2G1B

Interaction Score: 3.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
DEOXY CHOLATE PLA2G1B

Interaction Score: 3.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19102680

Sources:
DTC
METHYLGLYOXAL PLA2G1B

Interaction Score: 3.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
1,6-HEXANEDIOL PLA2G1B

Interaction Score: 2.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHOLIC ACID PLA2G1B

Interaction Score: 1.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19102680

Sources:
DTC
TRIDECANOATE PLA2G1B

Interaction Score: 1.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
AZELASTINE PLA2G1B

Interaction Score: 0.92

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8630722

Sources:
DrugBank
CONTEZOLID ACEFOSAMIL PLA2G1B

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MANOALIDE PLA2G1B

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CLOCORTOLONE PLA2G1B

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL605084 PLA2G1B

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIFLORASONE PLA2G1B

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NIFLUMIC ACID PLA2G1B

Interaction Score: 0.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235 16301791

Sources:
DrugBank
RILAPLADIB PLA2G1B

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHENODIOL PLA2G1B

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19102680

Sources:
DTC
CLOBETASOL PLA2G1B

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MILTEFOSINE PLA2G1B

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL528181 PLA2G1B

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RANITIDINE PLA2G1B

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10383521

Sources:
NCI
ADRIAMYCIN PLA2G1B

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2007582

Sources:
NCI
TOLFENAMIC ACID PLA2G1B

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BIFONAZOLE PLA2G1B

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CETYLPYRIDINIUM BROMIDE PLA2G1B

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SULFASALAZINE PLA2G1B

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
9256165

Sources:
DrugBank
ALEXIDINE HYDROCHLORIDE PLA2G1B

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENTICLOR PLA2G1B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMITRIPTYLINE PLA2G1B

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12856820

Sources:
NCI
ETOPOSIDE PLA2G1B

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9716508

Sources:
NCI
PROGESTERONE PLA2G1B

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7872957

Sources:
NCI

Ensembl: ENSG00000170890
- Version: 101_38
Alternate Names:

PLA2G1B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000170890

Version: 26-July-2011

Alternate Names:

ENSG00000170890 Ensembl Gene Id

PLA2G1B Display Id

PHOSPHOLIPASE A2 PRECURSOR (EC 3.1.1.4) (PHOSPHATIDYLCHOLINE 2- ACYLHYDROLASE) (GROUP IB PHOSPHOLIPASE A2). [SOURCE:UNIPROT/SWISSPROT;ACC:P04054] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P04054
- Version: January-2014
Alternate Names:

PLA2G1B Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.1.4

Publications:
HopkinsGroom: P04054
- Version: 11-September-2012
Alternate Names:

PA21B_HUMAN Uniprot Id

ENSG00000170890 Ensembl Gene Id

5319 Entrez Gene Id

Gene Info:

Interpro Name Phospholipase A2, eukaryotic

Interpro Type Family

Human Readable Name PHOSPHOLIPASE

Gene Categories:

PHOSPHOLIPASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5319
- Version: 29-September-2020
Alternate Names:

9030 HUGO Gene ID

9030 HUGO Gene Symbol

phospholipase A2 group IB HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Phospholipase A<sub>2</sub>

GuideToPharmacology Gene Category ID 275

Gene Categories:

ENZYME

Publications:

DrugBank: BE0003997

Version: 5.1.7

Alternate Names:

PLA2G1B DrugBank Gene Name

P04054 UniProt Accession

5319 Entrez Gene Id

Gene Info:

Publications:

Pruzanski et al., 1997, Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity., Biochem. Pharmacol.

Hamasaki Y et al., 1996, Inhibition of leukotriene synthesis by azelastine., Ann Allergy Asthma Immunol

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: PLA2G1B

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Rosenthal et al., 2001, Developmental maturation of primate placental trophoblast: placental cytosolic and secretory phospholipase A2 expression after estrogen suppression of baboons., Prostaglandins Other Lipid Mediat.

Mustonen et al., 1991, Activation of phospholipase A2 by adriamycin in vitro. Role of drug-lipid interactions., J. Biol. Chem.

Seiler et al., 1995, Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na+/H+ exchange by a thrombin receptor antagonist., Biochem. Pharmacol.

DTC: PLA2G1B
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Yu BZ et al., 2009, Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia., J Nat Prod
HingoraniCasas: ENSG00000170890
- Version: 31-May-2017
Alternate Names:

ENSG00000170890 Gene Symbol

PLA2G1B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: PLA2G1B
- Version: 03-September-2020
Alternate Names:

Phospholipase A2 Gene Name

P04054 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: PLA2G1B
- Version: 05-September-2020
Alternate Names:

PLA2 GO Gene Synonym

PLA2A GO Gene Synonym

PPLA2 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
TTD: Phospholipase A2
- Version: 2020.06.01
Alternate Names:

PLA2G1B TTD Gene Abbreviation

T31479 TTD Target ID

Gene Info:

Publications:

ENSG00000170890	Ensembl Gene Id
PLA2G1B	Display Id
PHOSPHOLIPASE A2 PRECURSOR (EC 3.1.1.4) (PHOSPHATIDYLCHOLINE 2- ACYLHYDROLASE) (GROUP IB PHOSPHOLIPASE A2). [SOURCE:UNIPROT/SWISSPROT;ACC:P04054]	Description

PA21B_HUMAN	Uniprot Id
ENSG00000170890	Ensembl Gene Id
5319	Entrez Gene Id

9030	HUGO Gene ID
9030	HUGO Gene Symbol
phospholipase A2 group IB	HUGO Gene Name

PLA2G1B	DrugBank Gene Name
P04054	UniProt Accession
5319	Entrez Gene Id

PLA2G1B Gene Record

PLA2G1B 5319 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19102680

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19102680

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 8630722

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10592235 16301791

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19102680

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
19102680

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
19102680

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
8630722

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10592235 16301791

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
19102680

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10383521

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2007582

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
9256165

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found