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PIM1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PIM1 5292 Druggable GenomeClinically Actionable

    Alternate Names:

    5292
    PIM-1 PROTO-ONCOGENE, SERINE/THREONINE KINASE
    PIM1
    PIM
    164960
    8986
    ENSG00000137193
    OTTHUMG00000016426
    2158
    P11309
    PIM1_HUMAN
    SERINE/THREONINE-PROTEIN KINASE PIM-1
    BE0001277
    PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 (EC 2.7.1.37). [SOURCE:UNIPROT/SWISSPROT;ACC:P11309]
    NM_001243186
    NP_002639
    T50594
    Serine/threonine-protein kinase pim
    T74073

    Gene Info:

    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Acc IPR002290
    Human Readable Name KINASE
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    GuideToPharmacology Gene Category Name PIM family
    GuideToPharmacology Gene Category ID 600
    Gene Biotype PROTEIN_CODING
    (15 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Olla S et al., 2009, Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors., Bioorg Med Chem Lett
    Wan X et al., 2013, A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling., J Med Chem
    Fox et al., 2005, The Pim kinases control rapamycin-resistant T cell survival and activation., J. Exp. Med.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
  • CHEMBL200528   PIM1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL409038   PIM1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1231605   PIM1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL406652   PIM1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL494360   PIM1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL391586   PIM1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL478510   PIM1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19179076


    Sources:
    DTC

  • CHEMBL478141   PIM1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19179076


    Sources:
    DTC

  • CHEMBL478323   PIM1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19179076


    Sources:
    DTC

  • CHEMBL478324   PIM1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19179076


    Sources:
    DTC

  • CHEMBL515495   PIM1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19179076


    Sources:
    DTC

  • CHEMBL500812   PIM1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19179076


    Sources:
    DTC

  • CHEMBL476025   PIM1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19179076


    Sources:
    DTC

  • SGI-1776   PIM1

    Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions GuideToPharmacology

  • GF-109203   PIM1

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423 10592235


    Sources:
    DrugBank

  • LY-294002   PIM1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423 10592235


    Sources:
    DrugBank

  • IMIDAZOLE   PIM1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • AZD-1208   PIM1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LGH-447   PIM1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NORHARMANE   PIM1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DEXFOSFOSERINE   PIM1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • TRICETIN   PIM1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • SILMITASERTIB   PIM1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • RUBOXISTAURIN   PIM1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL399530   PIM1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL365617   PIM1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZAKENPAULLONE   PIM1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VORUCICLIB   PIM1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • STAUROSPORINE   PIM1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17016423 17139284


    Sources:
    DrugBank

  • MITOXANTRONE   PIM1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23442188


    Sources:
    DTC

  • CHEMBL578061   PIM1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LY-2090314   PIM1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LAUROGUADINE   PIM1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SIROLIMUS   PIM1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15642745


    Sources:
    NCI

  • SB-220025   PIM1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL546797   PIM1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RUCAPARIB   PIM1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GO-6976   PIM1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL379975   PIM1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GSK-269962A   PIM1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KENPAULLONE   PIM1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALSTERPAULLONE   PIM1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • QUERCETIN   PIM1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • SOTRASTAURIN   PIM1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   PIM1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GEFITINIB   PIM1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   PIM1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FOSTAMATINIB   PIM1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26516587


    Sources:
    DrugBank

  • Ensembl: ENSG00000137193

    • Version: 101_38

    Alternate Names:
    PIM1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000137193

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000137193 Ensembl Gene Id
    PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 (EC 2.7.1.37). [SOURCE:UNIPROT/SWISSPROT;ACC:P11309] Description
    PIM1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P11309

    • Version: January-2014

    Alternate Names:
    PIM1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

  • HopkinsGroom: P11309

    • Version: 11-September-2012

    Alternate Names:
    P11309 Uniprot Accession
    5292 Entrez Gene Id
    PIM1_HUMAN Uniprot Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 5292

    • Version: 29-September-2020

    Alternate Names:
    8986 HUGO Gene ID
    8986 HUGO Gene Symbol
    Pim-1 proto-oncogene, serine/threonine kinase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name PIM family
    GuideToPharmacology Gene Category ID 600

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0001277

    • Version: 5.1.7

    Alternate Names:
    PIM1 DrugBank Gene Name
    P11309 UniProt Accession
    5292 Entrez Gene Id

    Gene Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

  • NCI: PIM1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Fox et al., 2005, The Pim kinases control rapamycin-resistant T cell survival and activation., J. Exp. Med.

  • DTC: PIM1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Olla S et al., 2009, Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors., Bioorg Med Chem Lett
    Wan X et al., 2013, A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling., J Med Chem

  • HingoraniCasas: ENSG00000137193

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000137193 Gene Symbol
    PIM1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: PIM1

    • Version: chembl_23

    Alternate Names:
    PIM1 GENE_SYMBOL
    Serine/threonine-protein kinase pim-1 UNIPROT

    Gene Info:

    Publications:

  • Pharos: PIM1

    • Version: 03-September-2020

    Alternate Names:
    Serine/threonine-protein kinase pim-1 Gene Name
    P11309 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • Tempus: PIM1

    • Version: 11-November-2018

    Alternate Names:
    PIM1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: PIM1

    • Version: 27-Jun-2013

    Alternate Names:
    5292 Gene ID
    PIM dGene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE, KINASE

    Publications:

  • TTD: Serine/threonine-protein kinase pim-1

    • Version: 2020.06.01

    Alternate Names:
    PIM1 TTD Gene Abbreviation
    T50594 TTD Target ID

    Gene Info:

    Publications:

  • TTD: Serine/threonine-protein kinase pim

    • Version: 2020.06.01

    Alternate Names:
    PIM TTD Gene Abbreviation
    T74073 TTD Target ID

    Gene Info:

    Publications:

  • MskImpact: PIM1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: PIM1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: PIM1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: PIM1

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE, TRANSCRIPTION FACTOR BINDING

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21