DGIdb - PIM1 Gene Record

PIM1 5292 Druggable GenomeClinically Actionable

Alternate Names:

5292
PIM-1 PROTO-ONCOGENE, SERINE/THREONINE KINASE
PIM1
PIM
164960
8986
ENSG00000137193
OTTHUMG00000016426
2158
P11309
PIM1_HUMAN
SERINE/THREONINE-PROTEIN KINASE PIM-1
PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 (EC 2.7.1.37). [SOURCE:UNIPROT/SWISSPROT;ACC:P11309]
NM_001243186
NP_002639
T50594
Serine/threonine-protein kinase pim
T74073

Gene Info:

Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Acc	IPR002290
Human Readable Name	KINASE
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Target Class	Enzymes
Target Subclass	EC:2.7.11.1
GuideToPharmacology Gene Category Name	PIM family
GuideToPharmacology Gene Category ID	600
Gene Biotype	PROTEIN_CODING

(14 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Olla S et al., 2009, Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors., Bioorg Med Chem Lett
Wan X et al., 2013, A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling., J Med Chem
Fox et al., 2005, The Pim kinases control rapamycin-resistant T cell survival and activation., J. Exp. Med.

CHEMBL478510 PIM1

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19179076

Sources:
DTC
CHEMBL478141 PIM1

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19179076

Sources:
DTC
CHEMBL478323 PIM1

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19179076

Sources:
DTC
CHEMBL478324 PIM1

Interaction Score: 1.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19179076

Sources:
DTC
CHEMBL515495 PIM1

Interaction Score: 1.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19179076

Sources:
DTC
CHEMBL500812 PIM1

Interaction Score: 1.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19179076

Sources:
DTC
CHEMBL476025 PIM1

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19179076

Sources:
DTC
SGI-1776 PIM1

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor

Direct Interaction? False

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology
AZD-1208 PIM1

Interaction Score: 0.63

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LGH-447 PIM1

Interaction Score: 0.63

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NORHARMANE PIM1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL399530 PIM1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SILMITASERTIB PIM1

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
RUBOXISTAURIN PIM1

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL365617 PIM1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZAKENPAULLONE PIM1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VORUCICLIB PIM1

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
MITOXANTRONE PIM1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23442188

Sources:
DTC
CHEMBL578061 PIM1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LY-2090314 PIM1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LAUROGUADINE PIM1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SIROLIMUS PIM1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15642745

Sources:
NCI
SB-220025 PIM1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL546797 PIM1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RUCAPARIB PIM1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 PIM1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL379975 PIM1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-269962A PIM1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE PIM1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE PIM1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SOTRASTAURIN PIM1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X PIM1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEFITINIB PIM1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 PIM1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000137193
- Version: 101_38
Alternate Names:

PIM1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000137193
- Version: 26-July-2011
Alternate Names:

ENSG00000137193 Ensembl Gene Id

PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 (EC 2.7.1.37). [SOURCE:UNIPROT/SWISSPROT;ACC:P11309] Description

PIM1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P11309
- Version: January-2014
Alternate Names:

PIM1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:
HopkinsGroom: P11309
- Version: 11-September-2012
Alternate Names:

P11309 Uniprot Accession

5292 Entrez Gene Id

PIM1_HUMAN Uniprot Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5292
- Version: 29-September-2020
Alternate Names:

8986 HUGO Gene ID

8986 HUGO Gene Symbol

Pim-1 proto-oncogene, serine/threonine kinase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name PIM family

GuideToPharmacology Gene Category ID 600

Gene Categories:

ENZYME

Publications:
NCI: PIM1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Fox et al., 2005, The Pim kinases control rapamycin-resistant T cell survival and activation., J. Exp. Med.

DTC: PIM1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Olla S et al., 2009, Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors., Bioorg Med Chem Lett

Wan X et al., 2013, A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling., J Med Chem

HingoraniCasas: ENSG00000137193
- Version: 31-May-2017
Alternate Names:

ENSG00000137193 Gene Symbol

PIM1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PIM1
- Version: chembl_23
Alternate Names:

PIM1 GENE_SYMBOL

Serine/threonine-protein kinase pim-1 UNIPROT

Gene Info:

Publications:
Tempus: PIM1
- Version: 11-November-2018
Alternate Names:

PIM1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: PIM1
- Version: 27-Jun-2013
Alternate Names:

5292 Gene ID

PIM dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Serine/threonine-protein kinase pim-1
- Version: 2020.06.01
Alternate Names:

PIM1 TTD Gene Abbreviation

T50594 TTD Target ID

Gene Info:

Publications:
TTD: Serine/threonine-protein kinase pim
- Version: 2020.06.01
Alternate Names:

PIM TTD Gene Abbreviation

T74073 TTD Target ID

Gene Info:

Publications:
Pharos: PIM1
- Version: 01-May-2021
Alternate Names:

Serine/threonine-protein kinase pim-1 Gene Name

P11309 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: PIM1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: PIM1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: PIM1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: PIM1
- Version: 01-May-2021
Alternate Names:

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, TRANSCRIPTION FACTOR BINDING

Publications:

Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase PIM inhibitor
Direct Interaction?	False

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

ENSG00000137193	Ensembl Gene Id
PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 (EC 2.7.1.37). [SOURCE:UNIPROT/SWISSPROT;ACC:P11309]	Description
PIM1	Display Id

P11309	Uniprot Accession
5292	Entrez Gene Id
PIM1_HUMAN	Uniprot Id

8986	HUGO Gene ID
8986	HUGO Gene Symbol
Pim-1 proto-oncogene, serine/threonine kinase	HUGO Gene Name

Serine/threonine-protein kinase pim-1	Gene Name
P11309	UniProt ID

PIM1 Gene Record

PIM1 5292 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19179076

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19179076

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19179076

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19179076

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19179076

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19179076

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19179076

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor Direct Interaction? False

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23442188

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
19179076

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19179076

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19179076

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19179076

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19179076

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19179076

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19179076

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor

Direct Interaction? False

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase PIM inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23442188

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15642745

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found