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PIK3R1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PIK3R1 5295 Druggable GenomeClinically Actionable

    Alternate Names:

    5295
    PHOSPHOINOSITIDE-3-KINASE REGULATORY SUBUNIT 1
    PIK3R1
    AGM7
    GRB1
    IMD36
    p85
    p85-ALPHA
    171833
    8979
    ENSG00000145675
    OTTHUMG00000131251
    PI3K
    2503
    P27986
    NP_852664
    NM_181523
    PtdIns-3-kinase regulatory subunit p85-alpha
    PI3-kinase subunit p85-alpha
    PtdIns-3-kinase regulatory subunit alpha
    PI3K regulatory subunit alpha
    PI3-kinase regulatory subunit alpha
    Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
    Phosphatidylinositol 3-kinase regulatory subunit alpha
    BE0000955
    PA33312

    Gene Info:

    GuideToPharmacology Gene Category Name Phosphatidylinositol kinases
    GuideToPharmacology Gene Category ID 781
    Gene Biotype PROTEIN_CODING
    (13 More Sources)

    Gene Categories: Category Details

    KINASE
    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    PHOSPHATIDYLINOSITOL 3 KINASE
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Slomiany et al., 2004, Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation., Biochem. Biophys. Res. Commun.
    Machida et al., 2005, Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils., Am. J. Physiol. Lung Cell Mol. Physiol.
    Słomiany et al., 2005, Gastric mucin secretion in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation., J. Physiol. Pharmacol.
    Slomiany et al., 2004, Secretion of gastric mucus phospholipids in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation., J. Physiol. Pharmacol.
    Slomiany et al., 2004, Src-kinase-dependent epidermal growth factor receptor transactivation in salivary mucin secretion in response to beta-adrenergic G-protein-coupled receptor activation., Inflammopharmacology
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
  • COPANLISIB   PIK3R1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers MyCancerGenomeClinicalTrial MyCancerGenome ChemblInteractions

  • SONOLISIB   PIK3R1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


    Sources:
    MyCancerGenomeClinicalTrial MyCancerGenome ChemblInteractions

  • PF-04691502   PIK3R1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers MyCancerGenome ChemblInteractions

  • ISOPROTERENOL   PIK3R1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    15110780 15618457 15985706 15381832 15527548


    Sources:
    DrugBank

  • DS-7423   PIK3R1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers ChemblInteractions

  • OMIPALISIB   PIK3R1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers MyCancerGenomeClinicalTrial ChemblInteractions

  • PILARALISIB   PIK3R1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers MyCancerGenome ChemblInteractions

  • GEDATOLISIB   PIK3R1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers MyCancerGenomeClinicalTrial MyCancerGenome ChemblInteractions

  • ZSTK-474   PIK3R1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RECILISIB   PIK3R1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GSK-1059615   PIK3R1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • WX-037   PIK3R1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BGT-226   PIK3R1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VOXTALISIB   PIK3R1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions

  • PWT-33587   PIK3R1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SF-1126   PIK3R1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RG-7666   PIK3R1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SAMOTOLISIB   PIK3R1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TASELISIB   PIK3R1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALPELISIB   PIK3R1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers MyCancerGenomeClinicalTrial MyCancerGenome

  • PUQUITINIB   PIK3R1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DACTOLISIB   PIK3R1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers MyCancerGenomeClinicalTrial MyCancerGenome ChemblInteractions

  • AZD-6482   PIK3R1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • APITOLISIB   PIK3R1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions

  • BUPARLISIB   PIK3R1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions

  • PA-799   PIK3R1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PANULISIB   PIK3R1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VS-5584   PIK3R1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PICTILISIB   PIK3R1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions

  • ENZASTAURIN   PIK3R1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • GSK-2636771   PIK3R1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • WORTMANNIN   PIK3R1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • PI-103   PIK3R1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • INFIGRATINIB   PIK3R1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • EVEROLIMUS   PIK3R1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • QUERCETIN   PIK3R1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • Ensembl: ENSG00000145675

    • Version: 101_38

    Alternate Names:
    PIK3R1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • GuideToPharmacology: 5295

    • Version: 29-September-2020

    Alternate Names:
    8979 HUGO Gene ID
    8979 HUGO Gene Symbol
    phosphoinositide-3-kinase regulatory subunit 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Phosphatidylinositol kinases
    GuideToPharmacology Gene Category ID 781

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0000955

    • Version: 5.1.7

    Alternate Names:
    PIK3R1 DrugBank Gene Name
    P27986 UniProt Accession
    5295 Entrez Gene Id

    Gene Info:

    Publications:
    Slomiany et al., 2004, Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation., Biochem. Biophys. Res. Commun.
    Machida et al., 2005, Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils., Am. J. Physiol. Lung Cell Mol. Physiol.
    Słomiany et al., 2005, Gastric mucin secretion in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation., J. Physiol. Pharmacol.

  • ChemblInteractions: GRB1

    • Version: chembl_23

    Alternate Names:
    GRB1 GENE_SYMBOL
    PIK3R1 GENE_SYMBOL
    Phosphatidylinositol 3-kinase regulatory subunit alpha UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000145675

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000145675 Gene Symbol
    PIK3R1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • MyCancerGenome: PIK3R1

    • Version: 20-Jun-2017

    Alternate Names:
    5295 Entrez Gene Id
    PIK3R1 MyCancerGenome Gene Symbol
    PI3K MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • PharmGKB: PIK3R1

    • Version: 18-August-2020

    Alternate Names:
    PA33312 PharmGKB ID

    Gene Info:

    Publications:

  • Pharos: PIK3R1

    • Version: 03-September-2020

    Alternate Names:
    Phosphatidylinositol 3-kinase regulatory subunit alpha Gene Name
    P27986 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ENZYME

    Publications:

  • GO: PIK3R1

    • Version: 05-September-2020

    Alternate Names:
    GRB1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR BINDING

    Publications:

  • Tempus: PIK3R1

    • Version: 11-November-2018

    Alternate Names:
    PIK3R1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: PIK3R1

    • Version: 27-Jun-2013

    Alternate Names:
    5295 Gene ID
    GRB1 dGene Synonym
    p85 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, PHOSPHATIDYLINOSITOL 3 KINASE

    Publications:

  • ClearityFoundationBiomarkers: PIK3R1

    • Version: 26-July-2013

    Alternate Names:

    Gene Info:

    Publications:

  • MyCancerGenomeClinicalTrial: PIK3R1

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: PIK3R1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: PIK3R1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: PIK3R1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: PIK3R1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21