DGIdb - PDPK1 Gene Record

PDPK1 5170 Druggable GenomeClinically Actionable

Alternate Names:

5170
3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1
PDPK1
PDK1
PDPK2
PDPK2P
PRO0461
605213
8816
ENSG00000140992
OTTHUMG00000128874
O15530
PDPK1_HUMAN
3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1
1519
NP_002604
NM_001261816
3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1 (EC 2.7.1.37) (HPDK1). [SOURCE:UNIPROT/SWISSPROT;ACC:O15530]
BE0001193
Phosphoinositide dependent protein kinase-1
T20891

Gene Info:

Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Type	Domain
Interpro Acc	IPR002290
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Human Readable Name	KINASE
GuideToPharmacology Gene Category Name	PDK1 family
GuideToPharmacology Gene Category ID	604
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Zhu et al., 2004, From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors., Cancer Res.
Kulp et al., 2004, 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells., Cancer Res.
Li et al., 2006, A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth., J. Gastrointest. Surg.
Tseng et al., 2006, Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor., Mol. Pharmacol.
Tong et al., 2005, Neutrophil gelatinase-associated lipocalin as a survival factor., Biochem. J.
Arico et al., 2002, Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line., J. Biol. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

CHEMBL235157 PDPK1

Interaction Score: 3.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL571159 PDPK1

Interaction Score: 3.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL270875 PDPK1

Interaction Score: 3.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL269264 PDPK1

Interaction Score: 3.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 10592235

Sources:
DrugBank
AR-12 PDPK1

Interaction Score: 1.72

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD
CHEMBL23552 PDPK1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1236539 PDPK1

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
17016423 17139284

Sources:
DrugBank GuideToPharmacology
DEXFOSFOSERINE PDPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
GF-109203 PDPK1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
BX-795 PDPK1

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL1765740 PDPK1

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
CELECOXIB PDPK1

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15205346 14973075 16455452 16887935 16060857 12000750

Sources:
DrugBank NCI
DIMETHYLADENINE PDPK1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STAUROSPORINE PDPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17016423 17139284

Sources:
DrugBank
CHEMBL578061 PDPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LY-2090314 PDPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MLN-8054 PDPK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALISERTIB PDPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 PDPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE PDPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE PDPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SOTRASTAURIN PDPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB PDPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 PDPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 PDPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 PDPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB PDPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 PDPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 PDPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 PDPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB PDPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB PDPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOSTAMATINIB PDPK1

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000140992
- Version: 101_38
Alternate Names:

PDPK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000140992
- Version: 26-July-2011
Alternate Names:

3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1 (EC 2.7.1.37) (HPDK1). [SOURCE:UNIPROT/SWISSPROT;ACC:O15530] Description

PDPK1 Display Id

ENSG00000140992 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: O15530
- Version: 11-September-2012
Alternate Names:

PDPK1 Uniprot Gene Name

5170 Entrez Gene Id

O15530 Uniprot Accession

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5170
- Version: 29-September-2020
Alternate Names:

8816 HUGO Gene ID

8816 HUGO Gene Symbol

3-phosphoinositide dependent protein kinase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name PDK1 family

GuideToPharmacology Gene Category ID 604

Gene Categories:

ENZYME

Publications:

DrugBank: BE0001193

Version: 5.1.7

Alternate Names:

PDPK1 DrugBank Gene Name

O15530 UniProt Accession

5170 Entrez Gene Id

Gene Info:

Publications:

Zhu et al., 2004, From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors., Cancer Res.

Li et al., 2006, A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth., J. Gastrointest. Surg.

Kulp et al., 2004, 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells., Cancer Res.

NCI: PDPK1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Arico et al., 2002, Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line., J. Biol. Chem.
HingoraniCasas: ENSG00000140992
- Version: 31-May-2017
Alternate Names:

ENSG00000140992 Gene Symbol

PDPK1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: PDPK1
- Version: 03-September-2020
Alternate Names:

3-phosphoinositide-dependent protein kinase 1 Gene Name

O15530 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: PDPK1
- Version: 05-September-2020
Alternate Names:

PDK1 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
Tempus: PDPK1
- Version: 11-November-2018
Alternate Names:

PDPK1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: PDPK1
- Version: 27-Jun-2013
Alternate Names:

5170 Gene ID

PDK1 dGene Synonym

PRO0461 dGene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, KINASE

Publications:
TTD: Phosphoinositide dependent protein kinase-1
- Version: 2020.06.01
Alternate Names:

PDPK1 TTD Gene Abbreviation

T20891 TTD Target ID

Gene Info:

Publications:
MskImpact: PDPK1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
DTC: PDPK1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1 (EC 2.7.1.37) (HPDK1). [SOURCE:UNIPROT/SWISSPROT;ACC:O15530]	Description
PDPK1	Display Id
ENSG00000140992	Ensembl Gene Id

PDPK1	Uniprot Gene Name
5170	Entrez Gene Id
O15530	Uniprot Accession

8816	HUGO Gene ID
8816	HUGO Gene Symbol
3-phosphoinositide dependent protein kinase 1	HUGO Gene Name

PDPK1	DrugBank Gene Name
O15530	UniProt Accession
5170	Entrez Gene Id

3-phosphoinositide-dependent protein kinase 1	Gene Name
O15530	UniProt ID

PDPK1 Gene Record

PDPK1 5170 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423 10592235

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 17016423 17139284

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15205346 14973075 16455452 16887935 16060857 12000750

Sources: DrugBank NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17016423 17139284

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423 10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
17016423 17139284

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15205346 14973075 16455452 16887935 16060857 12000750

Sources:
DrugBank NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17016423 17139284

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a