DGIdb - PDK1 Gene Record

PDK1 5163 Druggable GenomeClinically Actionable

Alternate Names:

5163
PYRUVATE DEHYDROGENASE KINASE 1
PDK1
602524
8809
ENSG00000152256
OTTHUMG00000132285
PDK1_HUMAN
PDHK1
Q15118
PA33154
[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL
PDPK1
3-phosphoinositide-dependent protein kinase 1
hPDK1
[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL PRECURSOR (EC 2.7.1.99) (PYRUVATE DEHYDROGENASE KINASE ISOFORM 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15118]
T15776
-
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

Gene Info:

Interpro Name	ATPase-like, ATP-binding domain
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Acc	IPR003594
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Interpro Short Name	ATPase-like_ATP-bd
Target Class	Enzymes
Target Subclass	EC:2.7.11.2
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Hayashi T et al., 2007, 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis., Proc Natl Acad Sci U S A
Meng T et al., 2014, Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90., J Med Chem
Stacpoole, 1989, The pharmacology of dichloroacetate., Metab. Clin. Exp.
Kim EJ et al., 2010, OGA inhibition by GlcNAc-selenazoline., Bioorg Med Chem

DICHLOROACETIC ACID PDK1

Interaction Score: 30.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25383915 2554095

Sources:
DTC
AR-12 PDK1

Interaction Score: 10.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3-phosphoinositide dependent protein kinase-1 inhibitor

Trial Name AR-12

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CHEMBL257158 PDK1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20822912

Sources:
DTC
CHEMBL445304 PDK1

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18003900

Sources:
DTC
UCN-01 PDK1

Interaction Score: 0.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3-phosphoinositide dependent protein kinase-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CELECOXIB PDK1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB

Ensembl: ENSG00000152256
- Version: 101_38
Alternate Names:

PDK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000152256

Version: 26-July-2011

Alternate Names:

PDK1 Display Id

ENSG00000152256 Ensembl Gene Id

[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL PRECURSOR (EC 2.7.1.99) (PYRUVATE DEHYDROGENASE KINASE ISOFORM 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15118] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q15118
- Version: 11-September-2012
Alternate Names:

PDK1 Uniprot Gene Name

5163 Entrez Gene Id

[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL Uniprot Protein Name

Gene Info:

Interpro Name ATPase-like, ATP-binding domain

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q15118
- Version: January-2014
Alternate Names:

PDK1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.2

Publications:
PharmGKB: PDK1
- Version: 18-August-2020
Alternate Names:

PA33154 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DTC: PDK1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Hayashi T et al., 2007, 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis., Proc Natl Acad Sci U S A

Meng T et al., 2014, Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90., J Med Chem

Kim EJ et al., 2010, OGA inhibition by GlcNAc-selenazoline., Bioorg Med Chem

HingoraniCasas: ENSG00000152256
- Version: 31-May-2017
Alternate Names:

ENSG00000152256 Gene Symbol

PDK1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PDK1
- Version: chembl_23
Alternate Names:

PDK1 GENE_SYMBOL

PDPK1 GENE_SYMBOL

3-phosphoinositide-dependent protein kinase 1 UNIPROT

Gene Info:

Publications:
Tempus: PDK1
- Version: 11-November-2018
Alternate Names:

PDK1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: PDK1
- Version: 27-Jun-2013
Alternate Names:

5163 Gene ID

- dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Pyruvate dehydrogenase kinase 1
- Version: 2020.06.01
Alternate Names:

PDHK1 TTD Gene Abbreviation

T15776 TTD Target ID

Gene Info:

Publications:
Pharos: PDK1
- Version: 01-February-2022
Alternate Names:

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Gene Name

Q15118 UniProt ID

Gene Info:

Gene Categories:

KINASE, ENZYME

Publications:
FoundationOneGenes: PDK1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: PDK1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Direct Interaction	yes
Mechanism of Interaction	3-phosphoinositide dependent protein kinase-1 inhibitor
Trial Name	AR-12

PDK1	Display Id
ENSG00000152256	Ensembl Gene Id
[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL PRECURSOR (EC 2.7.1.99) (PYRUVATE DEHYDROGENASE KINASE ISOFORM 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15118]	Description

PDK1	Uniprot Gene Name
5163	Entrez Gene Id
[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL	Uniprot Protein Name

PDK1	GENE_SYMBOL
PDPK1	GENE_SYMBOL
3-phosphoinositide-dependent protein kinase 1	UNIPROT

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	Gene Name
Q15118	UniProt ID

PDK1 Gene Record

PDK1 5163 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DICHLOROACETIC ACID PDK1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 25383915 2554095

Sources: DTC

AR-12 PDK1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3-phosphoinositide dependent protein kinase-1 inhibitor Trial Name AR-12

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

CHEMBL257158 PDK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20822912

Sources: DTC

CHEMBL445304 PDK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18003900

Sources: DTC

UCN-01 PDK1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3-phosphoinositide dependent protein kinase-1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

CELECOXIB PDK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Ensembl: ENSG00000152256

Alternate Names: PDK1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000152256

Alternate Names: PDK1 Display Id ENSG00000152256 Ensembl Gene Id [PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL PRECURSOR (EC 2.7.1.99) (PYRUVATE DEHYDROGENASE KINASE ISOFORM 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15118] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: Q15118

Alternate Names: PDK1 Uniprot Gene Name 5163 Entrez Gene Id [PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL Uniprot Protein Name

Gene Info: Interpro Name ATPase-like, ATP-binding domain Human Readable Name DRUGGABLE GENOME Uniprot Status Swiss-Prot

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q15118

Alternate Names: PDK1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.7.11.2

Publications:

PharmGKB: PDK1

Alternate Names: PA33154 PharmGKB ID

Gene Info:

Publications: Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DTC: PDK1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000152256

Alternate Names: ENSG00000152256 Gene Symbol PDK1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: PDK1

Alternate Names: PDK1 GENE_SYMBOL PDPK1 GENE_SYMBOL 3-phosphoinositide-dependent protein kinase 1 UNIPROT

Gene Info:

Publications:

Tempus: PDK1

Alternate Names: PDK1 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

dGene: PDK1

Alternate Names: 5163 Gene ID - dGene Synonym

Gene Info:

Gene Categories: KINASE, SERINE THREONINE KINASE

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
25383915 2554095

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3-phosphoinositide dependent protein kinase-1 inhibitor

Trial Name AR-12

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20822912

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18003900

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3-phosphoinositide dependent protein kinase-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Alternate Names:

PDK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PDK1 Display Id

ENSG00000152256 Ensembl Gene Id

[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL PRECURSOR (EC 2.7.1.99) (PYRUVATE DEHYDROGENASE KINASE ISOFORM 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15118] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PDK1 Uniprot Gene Name

5163 Entrez Gene Id

[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1, MITOCHONDRIAL Uniprot Protein Name

Gene Info:

Interpro Name ATPase-like, ATP-binding domain

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PDK1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.2

Alternate Names:

PA33154 PharmGKB ID

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

ENSG00000152256 Gene Symbol

PDK1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PDK1 GENE_SYMBOL

PDPK1 GENE_SYMBOL

3-phosphoinositide-dependent protein kinase 1 UNIPROT

Alternate Names:

PDK1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

5163 Gene ID

- dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

PDHK1 TTD Gene Abbreviation

T15776 TTD Target ID

Alternate Names:

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Gene Name

Q15118 UniProt ID

Gene Categories:

KINASE, ENZYME

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE