DGIdb - PDE4C Gene Record

PDE4C 5143 Druggable Genome

Alternate Names:

5143
PHOSPHODIESTERASE 4C
PDE4C
DPDE1
PDE21
600128
8782
ENSG00000105650
OTTHUMG00000183353
Q08493
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
1302
PDE4C_HUMAN
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C (EC 3.1.4.17) (DPDE1) (PDE21). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08493]
BE0002353
T12081

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.1.4.17
Target Main Class	Enzymes
Target Subclass	3.1.4.17
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002073
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Short Name	PDEase_catalytic_dom
Interpro Name	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)
GuideToPharmacology Gene Category ID	260

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Hariton, 1994, Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors., Eur. J. Pharmacol.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Iancu et al., 1979, Trials with xanthine derivatives in systemic treatment of psoriasis., Dermatologica
Barone et al., 2008, Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and mice., Pharmacology
Freund YR et al., 2012, Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center., FEBS Lett
Huang et al., 2006, Preferential inhibition of human phosphodiesterase 4 by ibudilast., Life Sci.
Schermuly et al., 2003, Zardaverine and aerosolised iloprost in a model of acute respiratory failure., Eur. Respir. J.
Wilkens et al., 2001, Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension., Circulation
Ghofrani et al., 2002, Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension., Crit. Care Med.
Grant et al., 1988, cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity., Proc. Natl. Acad. Sci. U.S.A.
Beeh et al., 2004, Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients., Lung

DYPHYLLINE PDE4C

Interaction Score: 2.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Novel drug target Established target

PMIDs:
7925603 17139284 17016423 225216

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
ROFLUMILAST PDE4C

Interaction Score: 2.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
17726343

Sources:
DrugBank ChemblInteractions
PICLAMILAST PDE4C

Interaction Score: 1.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15765929

Sources:
DrugBank
CRISABOROLE PDE4C

Interaction Score: 1.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
22841723

Sources:
DrugBank ChemblInteractions
IBUDILAST PDE4C

Interaction Score: 1.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ibudilast, MN-166, AV411

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
16313925

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
ILOPROST PDE4C

Interaction Score: 1.0

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank
APREMILAST PDE4C

Interaction Score: 1.0

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Potency against recombinant human PDE4C1 isoform in a TR-FRET assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
CDP840 PDE4C

Interaction Score: 0.75

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
ROLIPRAM PDE4C

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
FLAVOXATE HYDROCHLORIDE PDE4C

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EXISULIND PDE4C

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
THEOPHYLLINE SODIUM GLYCINATE PDE4C

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE PDE4C

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE PDE4C

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETAZOLATE PDE4C

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name EHT 0202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AMLEXANOX PDE4C

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE PDE4C

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE4C

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE4C

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000105650
- Version: 101_38
Alternate Names:

PDE4C Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q08493
- Version: January-2014
Alternate Names:

PDE4C Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.4.17

Publications:
TEND: Q08493
- Version: 01-August-2011
Alternate Names:

PDE4C_HUMAN Uniprot Id

Q08493 Uniprot Accession

ENSG00000105650 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 3.1.4.17

Publications:
HopkinsGroom: Q08493
- Version: 11-September-2012
Alternate Names:

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C Uniprot Protein Name

Q08493 Uniprot Accession

5143 Entrez Gene Id

Gene Info:

Interpro Acc IPR002073

Uniprot Status Swiss-Prot

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000105650
- Version: 26-July-2011
Alternate Names:

PDE4C Display Id

ENSG00000105650 Ensembl Gene Id

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C (EC 3.1.4.17) (DPDE1) (PDE21). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08493] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5143
- Version: 29-September-2020
Alternate Names:

8782 HUGO Gene ID

8782 HUGO Gene Symbol

phosphodiesterase 4C HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)

GuideToPharmacology Gene Category ID 260

Gene Categories:

ENZYME

Publications:

DrugBank: BE0002353

Version: 5.1.7

Alternate Names:

PDE4C DrugBank Gene Name

Q08493 UniProt Accession

5143 Entrez Gene Id

Gene Info:

Publications:

Hariton, 1994, Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors., Eur. J. Pharmacol.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

HingoraniCasas: ENSG00000105650
- Version: 31-May-2017
Alternate Names:

ENSG00000105650 Gene Symbol

PDE4C Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: DPDE1
- Version: chembl_23
Alternate Names:

DPDE1 GENE_SYMBOL

PDE4C GENE_SYMBOL

cAMP-specific 3',5'-cyclic phosphodiesterase 4C UNIPROT

Gene Info:

Publications:
TTD: Phosphodiesterase 4C
- Version: 2020.06.01
Alternate Names:

PDE4C TTD Gene Abbreviation

T12081 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Phosphodiesterase 4 inhibitor
Novel drug target	Established target

Trial Name	ibudilast, MN-166, AV411
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

Details of the Assay for Interaction	Potency against recombinant human PDE4C1 isoform in a TR-FRET assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Mechanism of Interaction	3',5'-cyclic phosphodiesterase inhibitor
Direct Interaction	yes

PDE4C_HUMAN	Uniprot Id
Q08493	Uniprot Accession
ENSG00000105650	Ensembl Gene Id

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C	Uniprot Protein Name
Q08493	Uniprot Accession
5143	Entrez Gene Id

PDE4C	Display Id
ENSG00000105650	Ensembl Gene Id
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C (EC 3.1.4.17) (DPDE1) (PDE21). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08493]	Description

8782	HUGO Gene ID
8782	HUGO Gene Symbol
phosphodiesterase 4C	HUGO Gene Name

PDE4C	DrugBank Gene Name
Q08493	UniProt Accession
5143	Entrez Gene Id

DPDE1	GENE_SYMBOL
PDE4C	GENE_SYMBOL
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	UNIPROT

PDE4C Gene Record

PDE4C 5143 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 4 inhibitor Novel drug target Established target

PMIDs: 7925603 17139284 17016423 225216

Sources: TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: 17726343

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15765929

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: 22841723

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ibudilast, MN-166, AV411 Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 16313925

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: inducer (activating)

Interaction Info:

PMIDs: 12952271 11551870 12441759 2461561

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Potency against recombinant human PDE4C1 isoform in a TR-FRET assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name EHT 0202 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Novel drug target Established target

PMIDs:
7925603 17139284 17016423 225216

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
17726343

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15765929

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
22841723

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ibudilast, MN-166, AV411

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
16313925

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

inducer (activating)

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Potency against recombinant human PDE4C1 isoform in a TR-FRET assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name EHT 0202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

PDE4C Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PDE4C Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.4.17

Alternate Names:

PDE4C_HUMAN Uniprot Id

Q08493 Uniprot Accession

ENSG00000105650 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 3.1.4.17

Alternate Names:

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C Uniprot Protein Name

Q08493 Uniprot Accession

5143 Entrez Gene Id