DGIdb - PDE4B Gene Record

PDE4B 5142 Druggable Genome

Alternate Names:

5142
PHOSPHODIESTERASE 4B
PDE4B
DPDE4
PDEIVB
600127
8781
ENSG00000184588
OTTHUMG00000009088
PDE4B_HUMAN
Q07343
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC 3.1.4.17) (DPDE4) (PDE32). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07343]
PDE32
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
PA33129
T10265

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.1.4.17
Human Readable Name	DRUGGABLE GENOME
Target Main Class	Enzymes
Target Subclass	3.1.4.17
Interpro Acc	IPR002073
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	PDEase_catalytic_dom
Interpro Name	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Iancu et al., 1979, Trials with xanthine derivatives in systemic treatment of psoriasis., Dermatologica
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Hariton, 1994, Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors., Eur. J. Pharmacol.
Bäumer et al., 2007, Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis., Inflamm Allergy Drug Targets
Abdulrahim et al., 2015, Apremilast: a PDE4 inhibitor for the treatment of psoriatic arthritis., Expert Opin Pharmacother
Freund YR et al., 2012, Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center., FEBS Lett
Lipworth, Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease., Lancet
Zhou H et al., 2020, Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits., Nat Neurosci
Daly, 2007, Caffeine analogs: biomedical impact., Cell. Mol. Life Sci.
Xin et al., 2003, Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities., Asian J. Androl.
Zhu et al., 2009, The measurement of cyclic nucleotide phosphodiesterase 4 activities via the quantification of inorganic phosphate with malachite green., Anal. Chim. Acta
Barone et al., 2008, Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and mice., Pharmacology
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Giembycz MA, 2008, Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?, Br J Pharmacol
Monteiro JP et al., 2016, Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks., Molecules
Ukena D et al., 1993, Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes., Biochem Pharmacol
Beeh et al., 2004, Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients., Lung
Huang et al., 2006, Preferential inhibition of human phosphodiesterase 4 by ibudilast., Life Sci.

ENPROFYLLINE PDE4B

Interaction Score: 5.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 27472311 7680859

Sources:
TdgClinicalTrial TEND
PICLAMILAST PDE4B

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 15765929

Sources:
TTD
OGLEMILAST PDE4B

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Oglemilast, GRC 3886

Novel drug target Established target

PMIDs:
18660832

Sources:
TdgClinicalTrial TTD
DYPHYLLINE PDE4B

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
225216 17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND
ROLIPRAM PDE4B

Interaction Score: 1.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235 17016423 17139284

Sources:
TTD
ROFLUMILAST PDE4B

Interaction Score: 1.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Trial Name roflumilast,Daxas

PMIDs:
17726343

Sources:
TdgClinicalTrial ChemblInteractions
CRISABOROLE PDE4B

Interaction Score: 1.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

Novel drug target Established target

PMIDs:
22841723

Sources:
TdgClinicalTrial ChemblInteractions
APREMILAST PDE4B

Interaction Score: 1.29

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name apremilast, CC-10004

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17352685 25864487

Sources:
TdgClinicalTrial ChemblInteractions
CHEMBL535714 PDE4B

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAPAVERINE PDE4B

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12646997 19231363 17016423 17139284

Sources:
TdgClinicalTrial TEND
REVAMILAST PDE4B

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MK-0873 PDE4B

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DENBUFYLLINE PDE4B

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TOFIMILAST PDE4B

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GSK-356278 PDE4B

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LIRIMILAST PDE4B

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
HT-0712 PDE4B

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
IBUDILAST PDE4B

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ibudilast, MN-166, AV411

Novel drug target Established target

PMIDs:
16313925

Sources:
TdgClinicalTrial
CDC-801 PDE4B

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
INAMRINONE PDE4B

Interaction Score: 0.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
CAFFEINE PDE4B

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17514358 17016423 17139284

Sources:
TdgClinicalTrial TEND
THEOPHYLLINE PDE4B

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ADC4022, low-dose inhaled theophylline

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
15639300

Sources:
TdgClinicalTrial ChemblInteractions TEND
PENTOXIFYLLINE PDE4B

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name pentoxifylline, EHT0201

Novel drug target Established target

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
FLAVOXATE HYDROCHLORIDE PDE4B

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE PDE4B

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE PDE4B

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE SODIUM GLYCINATE PDE4B

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMLEXANOX PDE4B

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETAZOLATE PDE4B

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name EHT 0202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ALCOHOL PDE4B

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
32451486

Sources:
PharmGKB
RESVERATROL PDE4B

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SRT501

Novel drug target Established target

Trial Name Resveratrol

PMIDs:
None found

Sources:
TdgClinicalTrial
DIPYRIDAMOLE PDE4B

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000184588
- Version: 101_38
Alternate Names:

PDE4B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q07343
- Version: 01-August-2011
Alternate Names:

PDE4B_HUMAN Uniprot Id

5142 Entrez Gene Id

Q07343 Uniprot Accession

Gene Info:

Target Main Class Enzymes

Target Subclass 3.1.4.17

Publications:
TdgClinicalTrial: Q07343
- Version: January-2014
Alternate Names:

PDE4B Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.4.17

Publications:
RussLampel: ENSG00000184588
- Version: 26-July-2011
Alternate Names:

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC 3.1.4.17) (DPDE4) (PDE32). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07343] Description

ENSG00000184588 Ensembl Gene Id

PDE4B Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: Q07343
- Version: 11-September-2012
Alternate Names:

PDE4B_HUMAN Uniprot Id

5142 Entrez Gene Id

PDE4B Uniprot Gene Name

Gene Info:

Interpro Acc IPR002073

Human Readable Name DRUGGABLE GENOME

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: PDE4B
- Version: 18-August-2020
Alternate Names:

PA33129 PharmGKB ID

Gene Info:

Publications:

Zhou H et al., 2020, Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits., Nat Neurosci

TTD: Phosphodiesterase 4B

Version: 2020.06.01

Alternate Names:

PDE4B TTD Gene Abbreviation

T10265 TTD Target ID

Gene Info:

Publications:

Giembycz MA, 2008, Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?, Br J Pharmacol

Stocchi F, 2014, Therapy for Parkinson's disease: what is in the pipeline?, Neurotherapeutics

ChemblInteractions: DPDE4
- Version: chembl_23
Alternate Names:

DPDE4 GENE_SYMBOL

PDE4B GENE_SYMBOL

cAMP-specific 3',5'-cyclic phosphodiesterase 4B UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000184588
- Version: 31-May-2017
Alternate Names:

ENSG00000184588 Gene Symbol

PDE4B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
DTC: PDE4B
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Trial Name	Oglemilast, GRC 3886
Novel drug target	Established target

Direct Interaction	yes
Mechanism of Interaction	Phosphodiesterase 4 inhibitor
Trial Name	roflumilast,Daxas

Trial Name	apremilast, CC-10004
Novel drug target	Established target
Mechanism of Interaction	Phosphodiesterase 4 inhibitor

Trial Name	ibudilast, MN-166, AV411
Novel drug target	Established target

Trial Name	pentoxifylline, EHT0201
Novel drug target	Established target
Mechanism of Interaction	3',5'-cyclic phosphodiesterase inhibitor

Trial Name	SRT501
Novel drug target	Established target
Trial Name	Resveratrol

PDE4B_HUMAN	Uniprot Id
5142	Entrez Gene Id
Q07343	Uniprot Accession

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC 3.1.4.17) (DPDE4) (PDE32). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07343]	Description
ENSG00000184588	Ensembl Gene Id
PDE4B	Display Id

DPDE4	GENE_SYMBOL
PDE4B	GENE_SYMBOL
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	UNIPROT

antagonist (inhibitory)
inhibitor (inhibitory)

PDE4B Gene Record

PDE4B 5142 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 27472311 7680859

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 15765929

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Oglemilast, GRC 3886 Novel drug target Established target

PMIDs: 18660832

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 225216 17016423 17139284 7925603

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10592235 17016423 17139284

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 4 inhibitor Trial Name roflumilast,Daxas

PMIDs: 17726343

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes Novel drug target Established target

PMIDs: 22841723

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name apremilast, CC-10004 Novel drug target Established target Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 17352685 25864487

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12646997 19231363 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ibudilast, MN-166, AV411 Novel drug target Established target

PMIDs: 16313925

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 27472311 7680859

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
10592235 15765929

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Oglemilast, GRC 3886

Novel drug target Established target

PMIDs:
18660832

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
225216 17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10592235 17016423 17139284

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Trial Name roflumilast,Daxas

PMIDs:
17726343

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

Novel drug target Established target

PMIDs:
22841723

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name apremilast, CC-10004

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17352685 25864487

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12646997 19231363 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ibudilast, MN-166, AV411

Novel drug target Established target

PMIDs:
16313925

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17514358 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ADC4022, low-dose inhaled theophylline

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
15639300

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name pentoxifylline, EHT0201

Novel drug target Established target

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
17016423 17139284