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PDE4B Gene Record

  • Summary
  • Interactions
  • Claims
  • PDE4B 5142 Druggable Genome

    Alternate Names:

    5142
    PHOSPHODIESTERASE 4B
    PDE4B
    DPDE4
    PDEIVB
    600127
    8781
    ENSG00000184588
    OTTHUMG00000009088
    PDE4B_HUMAN
    Q07343
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC 3.1.4.17) (DPDE4) (PDE32). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07343]
    PDE32
    cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    PA33129
    T10265

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.1.4.17
    Human Readable Name DRUGGABLE GENOME
    Target Main Class Enzymes
    Target Subclass 3.1.4.17
    Interpro Acc IPR002073
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name PDEase_catalytic_dom
    Interpro Name 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Iancu et al., 1979, Trials with xanthine derivatives in systemic treatment of psoriasis., Dermatologica
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Hariton, 1994, Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors., Eur. J. Pharmacol.
    Bäumer et al., 2007, Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis., Inflamm Allergy Drug Targets
    Abdulrahim et al., 2015, Apremilast: a PDE4 inhibitor for the treatment of psoriatic arthritis., Expert Opin Pharmacother
    Freund YR et al., 2012, Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center., FEBS Lett
    Lipworth, Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease., Lancet
    Zhou H et al., 2020, Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits., Nat Neurosci
    Daly, 2007, Caffeine analogs: biomedical impact., Cell. Mol. Life Sci.
    Xin et al., 2003, Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities., Asian J. Androl.
    Zhu et al., 2009, The measurement of cyclic nucleotide phosphodiesterase 4 activities via the quantification of inorganic phosphate with malachite green., Anal. Chim. Acta
    Barone et al., 2008, Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and mice., Pharmacology
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Giembycz MA, 2008, Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?, Br J Pharmacol
    Monteiro JP et al., 2016, Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks., Molecules
    Ukena D et al., 1993, Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes., Biochem Pharmacol
    Beeh et al., 2004, Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients., Lung
    Huang et al., 2006, Preferential inhibition of human phosphodiesterase 4 by ibudilast., Life Sci.
  • ENPROFYLLINE   PDE4B

    Interaction Score: 5.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 27472311 7680859


    Sources:
    TdgClinicalTrial TEND

  • PICLAMILAST   PDE4B

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 15765929


    Sources:
    TTD

  • OGLEMILAST   PDE4B

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Oglemilast, GRC 3886
    Novel drug target Established target

    PMIDs:
    18660832


    Sources:
    TdgClinicalTrial TTD

  • DYPHYLLINE   PDE4B

    Interaction Score: 1.93

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Phosphodiesterase 4 inhibitor

    PMIDs:
    225216 17016423 17139284 7925603


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ROLIPRAM   PDE4B

    Interaction Score: 1.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10592235 17016423 17139284


    Sources:
    TTD

  • ROFLUMILAST   PDE4B

    Interaction Score: 1.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Trial Name roflumilast,Daxas

    PMIDs:
    17726343


    Sources:
    TdgClinicalTrial ChemblInteractions

  • CRISABOROLE   PDE4B

    Interaction Score: 1.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    22841723


    Sources:
    TdgClinicalTrial ChemblInteractions

  • APREMILAST   PDE4B

    Interaction Score: 1.29

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name apremilast, CC-10004
    Novel drug target Established target
    Mechanism of Interaction Phosphodiesterase 4 inhibitor

    PMIDs:
    17352685 25864487


    Sources:
    TdgClinicalTrial ChemblInteractions

  • CHEMBL535714   PDE4B

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PAPAVERINE   PDE4B

    Interaction Score: 0.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12646997 19231363 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • REVAMILAST   PDE4B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MK-0873   PDE4B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DENBUFYLLINE   PDE4B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TOFIMILAST   PDE4B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GSK-356278   PDE4B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LIRIMILAST   PDE4B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • HT-0712   PDE4B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • IBUDILAST   PDE4B

    Interaction Score: 0.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ibudilast, MN-166, AV411
    Novel drug target Established target

    PMIDs:
    16313925


    Sources:
    TdgClinicalTrial

  • CDC-801   PDE4B

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • INAMRINONE   PDE4B

    Interaction Score: 0.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • CAFFEINE   PDE4B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17514358 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • THEOPHYLLINE   PDE4B

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name ADC4022, low-dose inhaled theophylline
    Mechanism of Interaction Phosphodiesterase 4 inhibitor

    PMIDs:
    15639300


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PENTOXIFYLLINE   PDE4B

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name pentoxifylline, EHT0201
    Novel drug target Established target
    Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • FLAVOXATE HYDROCHLORIDE   PDE4B

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMINOPHYLLINE   PDE4B

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXTRIPHYLLINE   PDE4B

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEOPHYLLINE SODIUM GLYCINATE   PDE4B

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMLEXANOX   PDE4B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETAZOLATE   PDE4B

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name EHT 0202
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ALCOHOL   PDE4B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • RESVERATROL   PDE4B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SRT501
    Novel drug target Established target
    Trial Name Resveratrol

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • DIPYRIDAMOLE   PDE4B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000184588

    • Version: 101_38

    Alternate Names:
    PDE4B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q07343

    • Version: 01-August-2011

    Alternate Names:
    PDE4B_HUMAN Uniprot Id
    5142 Entrez Gene Id
    Q07343 Uniprot Accession

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 3.1.4.17

    Publications:

  • TdgClinicalTrial: Q07343

    • Version: January-2014

    Alternate Names:
    PDE4B Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.1.4.17

    Publications:

  • RussLampel: ENSG00000184588

    • Version: 26-July-2011

    Alternate Names:
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC 3.1.4.17) (DPDE4) (PDE32). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07343] Description
    ENSG00000184588 Ensembl Gene Id
    PDE4B Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q07343

    • Version: 11-September-2012

    Alternate Names:
    PDE4B_HUMAN Uniprot Id
    5142 Entrez Gene Id
    PDE4B Uniprot Gene Name

    Gene Info:
    Interpro Acc IPR002073
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: PDE4B

    • Version: 18-August-2020

    Alternate Names:
    PA33129 PharmGKB ID

    Gene Info:

    Publications:
    Zhou H et al., 2020, Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits., Nat Neurosci

  • TTD: Phosphodiesterase 4B

    • Version: 2020.06.01

    Alternate Names:
    PDE4B TTD Gene Abbreviation
    T10265 TTD Target ID

    Gene Info:

    Publications:
    Giembycz MA, 2008, Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?, Br J Pharmacol
    Stocchi F, 2014, Therapy for Parkinson's disease: what is in the pipeline?, Neurotherapeutics

  • ChemblInteractions: DPDE4

    • Version: chembl_23

    Alternate Names:
    DPDE4 GENE_SYMBOL
    PDE4B GENE_SYMBOL
    cAMP-specific 3',5'-cyclic phosphodiesterase 4B UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000184588

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000184588 Gene Symbol
    PDE4B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DTC: PDE4B

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21