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PDE4A Gene Record

  • Summary
  • Interactions
  • Claims
  • PDE4A 5141 Druggable Genome

    Alternate Names:

    5141
    PHOSPHODIESTERASE 4A
    PDE4A
    DPDE2
    PDE4
    PDE46
    600126
    8780
    ENSG00000065989
    OTTHUMG00000180411
    PHOSPHODIESTERASE 4
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A (EC 3.1.4.17) (DPDE2) (PDE46). [SOURCE:UNIPROT/SWISSPROT;ACC:P27815]
    P27815
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A
    PDE4A_HUMAN
    T47941
    T61744

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Subclass 3.1.4.17
    Target Main Class Enzymes
    Target Class Enzymes
    Target Subclass EC:3.1.4.17
    Interpro Name 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    Interpro Type Domain
    Interpro Short Name PDEase_catalytic_dom
    Interpro Acc IPR002073
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Ukena et al., 1985, Effects of enprofylline on A1 and A2 adenosine receptors., Eur. J. Pharmacol.
    Featherstone et al., 2004, Long-term hypothermic lung preservation: does adenosine A1 receptor antagonism have a role in ischemic preconditioning protection?, Interact Cardiovasc Thorac Surg
    Berg et al., 1987, Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study., Arch Int Pharmacodyn Ther
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Dulloo et al., 1991, Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue., Int J Obes
    Dar, 1990, Central adenosinergic system involvement in ethanol-induced motor incoordination in mice., J. Pharmacol. Exp. Ther.
    Usta et al., 2004, The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations., Prostaglandins Leukot. Essent. Fatty Acids
    Haider, 2003, Cyclic AMP level and phosphodiesterase activity during 17alpha,20beta-dihydroxy-4-pregnen-3-one induction and theophylline inhibition of oocyte maturation in the catfish, Clarias batrachus., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
    Wang et al., 2002, Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45., Acta Pharmacol. Sin.
    Lee et al., 2004, Modulation of thyroidal radioiodine uptake by theophylline., Exp. Mol. Pathol.
    Rickards et al., 2003, Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation., J. Vet. Pharmacol. Ther.
    Freund YR et al., 2012, Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center., FEBS Lett
    Iancu et al., 1979, Trials with xanthine derivatives in systemic treatment of psoriasis., Dermatologica
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Hariton, 1994, Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors., Eur. J. Pharmacol.
    Barone et al., 2008, Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and mice., Pharmacology
    Yagi et al., 2010, Ibudilast inhibits cerebral aneurysms by down-regulating inflammation-related molecules in the vascular wall of rats., Neurosurgery
    Huang et al., 2006, Preferential inhibition of human phosphodiesterase 4 by ibudilast., Life Sci.
    Yamazaki et al., 2011, Ibudilast, a mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery., Eur. J. Pharmacol.
    Bäumer et al., 2007, Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis., Inflamm Allergy Drug Targets
    Abdulrahim et al., 2015, Apremilast: a PDE4 inhibitor for the treatment of psoriatic arthritis., Expert Opin Pharmacother
    Afra TP et al., 2019, Apremilast in Psoriasis and Beyond: Big Hopes on a Small Molecule., Indian Dermatol Online J
    Giembycz MA, 2008, Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?, Br J Pharmacol
    Beeh et al., 2004, Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients., Lung
  • ENPROFYLLINE   PDE4A

    Interaction Score: 9.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    3002801 17670210 3446047 11752352 1885257 2262902


    Sources:
    TdgClinicalTrial TEND TTD

  • DYPHYLLINE   PDE4A

    Interaction Score: 2.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Phosphodiesterase 4 inhibitor

    PMIDs:
    225216 17016423 17139284 11752352 7925603


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • LOTAMILAST   PDE4A

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OGLEMILAST   PDE4A

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Oglemilast, GRC 3886
    Novel drug target Established target

    PMIDs:
    18660832


    Sources:
    TdgClinicalTrial TTD

  • AROFYLLINE   PDE4A

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • APREMILAST   PDE4A

    Interaction Score: 2.06

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name apremilast, CC-10004
    Mechanism of Interaction Phosphodiesterase 4 inhibitor

    PMIDs:
    17352685 25864487 30775293


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • MILRINONE   PDE4A

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • ROFLUMILAST   PDE4A

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Trial Name roflumilast, Daxas

    PMIDs:
    17726343


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • CRISABOROLE   PDE4A

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes
    Trial Name AN-2728

    PMIDs:
    22841723


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • OXTRIPHYLLINE   PDE4A

    Interaction Score: 1.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    15253881 12547256 12421478 15351234 12887610


    Sources:
    ChemblInteractions TTD

  • LIRIMILAST   PDE4A

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18660832


    Sources:
    TTD

  • PICLAMILAST   PDE4A

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15765929


    Sources:
    TTD

  • IBUDILAST   PDE4A

    Interaction Score: 1.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ibudilast, MN-166, AV411
    Novel drug target Established target

    PMIDs:
    20124930 16313925 21036126


    Sources:
    TdgClinicalTrial

  • GSK-356278   PDE4A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • REVAMILAST   PDE4A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TADALAFIL   PDE4A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • HT-0712   PDE4A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TOFIMILAST   PDE4A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • THEOPHYLLINE   PDE4A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name ADC4022, low-dose inhaled theophylline
    Mechanism of Interaction Phosphodiesterase 4 inhibitor

    PMIDs:
    15253881 12547256 12421478 15351234 12887610


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DENBUFYLLINE   PDE4A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MK-0873   PDE4A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CDC-801   PDE4A

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ROLIPRAM   PDE4A

    Interaction Score: 0.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FLAVOXATE HYDROCHLORIDE   PDE4A

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOXIFYLLINE   PDE4A

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name pentoxifylline, EHT0201
    Novel drug target Established target
    Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • THEOPHYLLINE SODIUM GLYCINATE   PDE4A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMINOPHYLLINE   PDE4A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMLEXANOX   PDE4A

    Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Phosphodiesterase 4 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIPYRIDAMOLE   PDE4A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor
    Direct Interaction yes
    Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ETAZOLATE   PDE4A

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name EHT 0202
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Ensembl: ENSG00000065989

    • Version: 101_38

    Alternate Names:
    PDE4A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P27815

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000065989 Ensembl Gene Id
    5141 Entrez Gene Id
    P27815 Uniprot Accession

    Gene Info:
    Target Subclass 3.1.4.17
    Target Main Class Enzymes

    Publications:

  • TdgClinicalTrial: P27815

    • Version: January-2014

    Alternate Names:
    PDE4A Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.1.4.17

    Publications:

  • HopkinsGroom: P27815

    • Version: 11-September-2012

    Alternate Names:
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A Uniprot Protein Name
    PDE4A Uniprot Gene Name
    ENSG00000065989 Ensembl Gene Id

    Gene Info:
    Interpro Name 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    Interpro Type Domain
    Interpro Short Name PDEase_catalytic_dom

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000065989

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000065989 Ensembl Gene Id
    PDE4A Display Id
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A (EC 3.1.4.17) (DPDE2) (PDE46). [SOURCE:UNIPROT/SWISSPROT;ACC:P27815] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Phosphodiesterase 4A

    • Version: 2020.06.01

    Alternate Names:
    PDE4A TTD Gene Abbreviation
    T61744 TTD Target ID

    Gene Info:

    Publications:
    Giembycz MA, 2008, Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?, Br J Pharmacol
    Stocchi F, 2014, Therapy for Parkinson's disease: what is in the pipeline?, Neurotherapeutics

  • HingoraniCasas: ENSG00000065989

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000065989 Gene Symbol
    PDE4A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: DPDE2

    • Version: chembl_23

    Alternate Names:
    DPDE2 GENE_SYMBOL
    PDE4A GENE_SYMBOL
    cAMP-specific 3',5'-cyclic phosphodiesterase 4A UNIPROT

    Gene Info:

    Publications:

  • TTD: Phosphodiesterase 4

    • Version: 2020.06.01

    Alternate Names:
    PDE4 TTD Gene Abbreviation
    T47941 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21