DGIdb - PDE3A Gene Record

PDE3A 5139 Druggable Genome

Alternate Names:

5139
PHOSPHODIESTERASE 3A
PDE3A
CGI-PDE
CGI-PDE A
CGI-PDE-A
HTNB
123805
8778
ENSG00000172572
OTTHUMG00000168962
Q14432
PDE3A_HUMAN
PDE3
PHOSPHODIESTERASE 3
CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A
Cyclic GMP-inhibited phosphodiesterase A
CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A (EC 3.1.4.17) (CYCLIC GMP INHIBITED PHOSPHODIESTERASE A) (CGI-PDE A). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14432]
PA33126
T33754
T88975

Gene Info:

Target Subclass	3.1.4
Transmembrane Helix Count	6
Target Main Class	Enzymes
Target Class	Enzymes
Target Subclass	EC:3.1.4
Target Subclass	EC:3.1.4.17
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Interpro Short Name	PDEase_catalytic_dom
Interpro Acc	IPR002073
Uniprot Evidence	1: Evidence at protein level
Interpro Name	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Schrör, 2002, The pharmacology of cilostazol., Diabetes Obes Metab
Mokry et al., 2008, Influence of selective inhibitors of phosphodiesterase 3 and 4 on cough and airway reactivity., J. Physiol. Pharmacol.
Hong et al., 2006, Cilostazol: therapeutic potential against focal cerebral ischemic damage., Curr. Pharm. Des.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Parkkonen et al., 2008, Phosphodiesterase 4 inhibitors delay human eosinophil and neutrophil apoptosis in the absence and presence of salbutamol., Pulm Pharmacol Ther
Yoshida H et al., 2012, K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model., PLoS One
Kajikawa et al., 2006, Changes in submaxillary gland gene expression in F344 rats by multiple dosing of theophylline., Exp. Anim.
Wu et al., 2004, KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels., Br. J. Pharmacol.
Rickards et al., 2003, Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation., J. Vet. Pharmacol. Ther.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Venuti et al., 1988, Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline., J. Med. Chem.
An R et al., 2019, PDE3A inhibitor anagrelide activates death signaling pathway genes and synergizes with cell death-inducing cytokines to selectively inhibit cancer cell growth., Am J Cancer Res
Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension
Hirota et al., 2002, Spasmolytic effects of colforsin daropate on serotonin-induced pulmonary hypertension and bronchoconstriction in dogs., Acta Anaesthesiol Scand
Lefièvre et al., 2002, Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa., Biol. Reprod.
Küthe et al., 2000, Gene expression of the phosphodiesterases 3A and 5A in human corpus cavernosum penis., Eur. Urol.
Zhang et al., 2002, Identification of interaction sites of cyclic nucleotide phosphodiesterase type 3A with milrinone and cilostazol using molecular modeling and site-directed mutagenesis., Mol. Pharmacol.
Shakur et al., 2002, Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart., Cardiovasc Drugs Ther
Cone et al., 1999, Comparison of the effects of cilostazol and milrinone on intracellular cAMP levels and cellular function in platelets and cardiac cells., J. Cardiovasc. Pharmacol.
Sandroni et al., 2006, Enoximone in cardiac arrest caused by propranolol: two case reports., Acta Anaesthesiol Scand
Boldt et al., 2007, Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone., Expert Opin Pharmacother
Kucuk et al., 2009, Effects of amrinone in an experimental model of hepatic ischemia-reperfusion injury., J. Surg. Res.
Kobayashi et al., 2002, Effects of amrinone on hepatic ischemia-reperfusion injury in rats., J. Hepatol.
Ko et al., 2009, Myocardial cyclic AMP augmentation with high-dose PDEIII inhibitor in terminal warm blood cardioplegia., Ann Thorac Cardiovasc Surg

ANAGRELIDE PDE3A

Interaction Score: 17.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17016423 17139284 11752352 2846839 31598394

Sources:
TTD
MILRINONE PDE3A

Interaction Score: 13.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12135876 10859452 12181427 12652111 11752352 10511123

Sources:
TdgClinicalTrial TEND TTD
K-134 PDE3A

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23110051

Sources:
TTD
ENOXIMONE PDE3A

Interaction Score: 3.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16987374 17714066

Sources:
TdgClinicalTrial TEND TTD
INAMRINONE LACTATE PDE3A

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MILRINONE LACTATE PDE3A

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BEMORADAN PDE3A

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CILOSTAZOL PDE3A

Interaction Score: 2.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3A inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12180353 19218671 16472148 11752352 18282775

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ANAGRELIDE HYDROCHLORIDE PDE3A

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE PDE3A

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
16651698 15237094 12887610

Sources:
ChemblInteractions TTD
TIPELUKAST PDE3A

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
OLPRINONE PDE3A

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AMINOPHYLLINE PDE3A

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
11939921 11752352

Sources:
ChemblInteractions TTD
INAMRINONE PDE3A

Interaction Score: 1.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18468627 12076859 19901885 11752352

Sources:
TdgClinicalTrial TEND
THEOPHYLLINE PDE3A

Interaction Score: 0.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Trial Name ADC4022, low-dose inhaled theophylline

PMIDs:
16651698 15237094 12887610

Sources:
TdgClinicalTrial ChemblInteractions TEND
VESNARINONE PDE3A

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DYPHYLLINE PDE3A

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3A inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE SODIUM GLYCINATE PDE3A

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROCHLOROTHIAZIDE PDE3A

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
PENTOXIFYLLINE PDE3A

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE3A

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000172572
- Version: 101_38
Alternate Names:

PDE3A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000172572

Version: 26-July-2011

Alternate Names:

PDE3A Display Id

CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A (EC 3.1.4.17) (CYCLIC GMP INHIBITED PHOSPHODIESTERASE A) (CGI-PDE A). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14432] Description

ENSG00000172572 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: Q14432
- Version: 01-August-2011
Alternate Names:

PDE3A_HUMAN Uniprot Id

PDE3A Gene Symbol

ENSG00000172572 Ensembl Gene Id

Gene Info:

Target Subclass 3.1.4

Transmembrane Helix Count 6

Target Main Class Enzymes

Publications:
TdgClinicalTrial: Q14432
- Version: January-2014
Alternate Names:

PDE3A Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.4

Target Subclass EC:3.1.4.17

Publications:
HopkinsGroom: Q14432
- Version: 11-September-2012
Alternate Names:

PDE3A_HUMAN Uniprot Id

5139 Entrez Gene Id

PDE3A Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Type Domain

Interpro Short Name PDEase_catalytic_dom

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: PDE3A
- Version: 18-August-2020
Alternate Names:

PA33126 PharmGKB ID

Gene Info:

Publications:

Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension
TTD: Phosphodiesterase 3
- Version: 2020.06.01
Alternate Names:

PDE3 TTD Gene Abbreviation

T33754 TTD Target ID

Gene Info:

Publications:

Yoshida H et al., 2012, K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model., PLoS One
HingoraniCasas: ENSG00000172572
- Version: 31-May-2017
Alternate Names:

ENSG00000172572 Gene Symbol

PDE3A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PDE3A
- Version: chembl_23
Alternate Names:

PDE3A GENE_SYMBOL

cGMP-inhibited 3',5'-cyclic phosphodiesterase A UNIPROT

Cyclic GMP-inhibited phosphodiesterase A UNIPROT

Gene Info:

Publications:
TTD: Phosphodiesterase 3A
- Version: 2020.06.01
Alternate Names:

PDE3A TTD Gene Abbreviation

T88975 TTD Target ID

Gene Info:

Publications:
Pharos: PDE3A
- Version: 01-February-2022
Alternate Names:

cGMP-inhibited 3',5'-cyclic phosphodiesterase A Gene Name

Q14432 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Mechanism of Interaction	Phosphodiesterase 3A inhibitor
Direct Interaction	yes

Mechanism of Interaction	Phosphodiesterase 3 inhibitor
Direct Interaction	yes

Mechanism of Interaction	3',5'-cyclic phosphodiesterase inhibitor
Direct Interaction	yes

PDE3A	Display Id
CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A (EC 3.1.4.17) (CYCLIC GMP INHIBITED PHOSPHODIESTERASE A) (CGI-PDE A). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14432]	Description
ENSG00000172572	Ensembl Gene Id

PDE3A_HUMAN	Uniprot Id
PDE3A	Gene Symbol
ENSG00000172572	Ensembl Gene Id

PDE3A	GENE_SYMBOL
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	UNIPROT
Cyclic GMP-inhibited phosphodiesterase A	UNIPROT

cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Gene Name
Q14432	UniProt ID

Novel drug target	Established target
Trial Name	-

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

PDE3A Gene Record

PDE3A 5139 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17016423 17139284 11752352 2846839 31598394

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 12135876 10859452 12181427 12652111 11752352 10511123

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23110051

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 16987374 17714066

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 3A inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 3A inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 3A inhibitor Direct Interaction yes Trial Name -

PMIDs: 12180353 19218671 16472148 11752352 18282775

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs: 16651698 15237094 12887610

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs: 11939921 11752352

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 18468627 12076859 19901885 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 3 inhibitor Trial Name ADC4022, low-dose inhaled theophylline

PMIDs: 16651698 15237094 12887610

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 3A inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17016423 17139284 11752352 2846839 31598394

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12135876 10859452 12181427 12652111 11752352 10511123

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
23110051

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16987374 17714066

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3A inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12180353 19218671 16472148 11752352 18282775

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
16651698 15237094 12887610

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
11939921 11752352

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18468627 12076859 19901885 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Trial Name ADC4022, low-dose inhaled theophylline

PMIDs:
16651698 15237094 12887610

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3A inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

PDE3A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PDE3A Display Id

CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A (EC 3.1.4.17) (CYCLIC GMP INHIBITED PHOSPHODIESTERASE A) (CGI-PDE A). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14432] Description

ENSG00000172572 Ensembl Gene Id