• PCSK9 255738 Druggable Genome

    Alternate Names:

    255738
    PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
    PCSK9
    FH3
    HCHOLA3
    LDLCQ1
    NARC-1
    NARC1
    PC9
    607786
    20001
    ENSG00000169174
    OTTHUMG00000008136
    2388
    NM_174936
    Q8NBP7
    NP_777596
    SUBTILISIN/KEXIN-LIKE PROTEASE PC9
    NEURAL APOPTOSIS-REGULATED CONVERTASE 1
    Proprotein convertase 9
    PA38617
    T62206
    FHCL3
    PSEC0052

    Gene Info:

    GuideToPharmacology Gene Category Name S8: Subtilisin
    GuideToPharmacology Gene Category ID 755
    Target Class Enzymes
    Target Subclass EC:3.4.21.-
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    PROTEASE
    DRUGGABLE GENOME
    ENZYME
  • Interaction Score: 31.9

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Subtilisin/kexin type 9 inhibitor
    Direct Interaction yes
    Details of the Assay for Interaction Affinity for hPCSK9 measured using proprietary BIACore® technology.

    PMIDs:
    None found


  • Interaction Score: 26.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Subtilisin/kexin type 9 inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

  • Interaction Score: 10.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Subtilisin/kexin type 9 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 10.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 10.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Dissociation equilibrium constant for wild-type hPCSK9, measured using proprietary BIACore® technology.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 2.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

    • Version: 101_38

    Alternate Names:
    PCSK9 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: January-2014

    Alternate Names:
    PCSK9 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.21.-

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    20001 HUGO Gene ID
    20001 HUGO Gene Symbol
    proprotein convertase subtilisin/kexin type 9 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name S8: Subtilisin
    GuideToPharmacology Gene Category ID 755

    Gene Categories:
    ENZYME

    Publications:

    • Version: chembl_23

    Alternate Names:
    NARC1 GENE_SYMBOL
    PCSK9 GENE_SYMBOL
    Proprotein convertase subtilisin/kexin type 9 UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000169174 Gene Symbol
    PCSK9 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 18-August-2020

    Alternate Names:
    PA38617 PharmGKB ID

    Gene Info:

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    255738 Gene ID
    FH3 dGene Synonym
    HCHOLA3 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • Alternate Names:
    PCSK9 TTD Gene Abbreviation
    T62206 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    NARC1 GO Gene Synonym
    PSEC0052 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications: