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PCSK1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PCSK1 5122 Druggable Genome

    Alternate Names:

    5122
    PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 1
    PCSK1
    BMIQ12
    NEC1
    PC1
    PC3
    SPC3
    162150
    8743
    ENSG00000175426
    OTTHUMG00000122089
    P29120
    PC1/3

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Marcinkiewicz et al., 1994, Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets., Endocrinology
    Alarcón et al., 1995, Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus., J. Clin. Invest.
    Yaoi et al., 2003, Expression and localization of prohormone convertase PC1 in the calcitonin-producing cells of the bullfrog ultimobranchial gland., J. Histochem. Cytochem.
  • CALCITONIN   PCSK1

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14566018


    Sources:
    NCI

  • INSULIN   PCSK1

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7925129 7883951


    Sources:
    NCI

  • Ensembl: ENSG00000175426

    • Version: 101_38

    Alternate Names:
    PCSK1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: PCSK1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Mania-Farnell et al., 1996, Differential modulation of prohormone convertase mRNA by second messenger activators in two cholecystokinin-producing cell lines., Peptides
    Alarcón et al., 1995, Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus., J. Clin. Invest.
    Marcinkiewicz et al., 1994, Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets., Endocrinology

  • HingoraniCasas: ENSG00000175426

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000175426 Gene Symbol
    PCSK1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: PCSK1

    • Version: 19.3

    Alternate Names:
    ENSG00000175426 Ensembl Gene ID
    NEC1 Human Protein Atlas Gene Synonym
    PC1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • dGene: PCSK1

    • Version: 27-Jun-2013

    Alternate Names:
    5122 Gene ID
    BMIQ12 dGene Synonym
    NEC1 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21