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OXTR Gene Record

  • Summary
  • Interactions
  • Claims
  • OXTR 5021 Druggable Genome

    Alternate Names:

    5021
    OXYTOCIN RECEPTOR
    OXTR
    OT-R
    167055
    8529
    ENSG00000180914
    OTTHUMG00000090537
    P30559
    OXYR_HUMAN
    OXYTOCIN RECEPTOR (OT-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P30559]
    OTR
    T84486

    Gene Info:

    Target Subclass Rhodopsin
    Target Main Class Receptors
    Target Subclass GPCR
    Transmembrane Helix Count 7
    Target Class Receptors
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000276
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Takagi et al., 2002, Bovine retained placenta: hormonal concentrations in fetal and maternal placenta., Placenta
    Akerlund et al., 1999, Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women., Br J Obstet Gynaecol
    Kim SH et al., 2016, The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G(αi) signalling., Mol Cell Endocrinol
    Reversi A et al., 2005, The oxytocin receptor antagonist atosiban inhibits cell growth via a "biased agonist" mechanism., J Biol Chem
    Lamont RF, 2003, The development and introduction of anti-oxytocic tocolytics., BJOG
    Pierzynski P, 2011, Oxytocin and vasopressin V(1A) receptors as new therapeutic targets in assisted reproduction., Reprod Biomed Online
    Hixon et al., 1987, Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F-2 alpha secretion in sheep., J. Reprod. Fertil.
    Gimpl et al., 2005, Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin., Eur. J. Pharmacol.
    Engstrøm et al., 1998, Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradation., Eur. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Frantz et al., 2010, Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxytocin receptor agonist., J. Med. Chem.
    Spyranti et al., 2010, In position 7 L- and D-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights., Amino Acids
    Ahn et al., In vivo activity of the potent oxytocin antagonist on uterine activity in the rat., In Vivo
    Gimpl et al., 2008, Oxytocin receptors: ligand binding, signalling and cholesterol dependence., Prog. Brain Res.
    Furman et al., 2011, Variant in oxytocin receptor gene is associated with amygdala volume., Psychoneuroendocrinology
    Fitts et al., 2003, Effects of central oxytocin receptor blockade on water and saline intake, mean arterial pressure, and c-Fos expression in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Wiśniewski K et al., 2014, New, potent, and selective peptidic oxytocin receptor agonists., J Med Chem
    Johnson et al., 1991, The regulation of oxytocin receptor binding in the ventromedial hypothalamic nucleus by testosterone and its metabolites., Endocrinology
  • CARBETOCIN   OXTR

    Interaction Score: 14.27

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15740719 9760035 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • EPELSIBAN   OXTR

    Interaction Score: 9.51

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Oxytocin receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • RETOSIBAN   OXTR

    Interaction Score: 9.51

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Oxytocin receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • BARUSIBAN   OXTR

    Interaction Score: 9.51

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Oxytocin receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • FE 202767   OXTR

    Interaction Score: 9.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Oxytocin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ATOSIBAN   OXTR

    Interaction Score: 5.95

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10519430 26586210 15705593 12763125


    Sources:
    TTD

  • OXYTOCIN   OXTR

    Interaction Score: 4.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name TI-001, intranasal oxytocin
    Novel drug target Established target
    Mechanism of Interaction Oxytocin receptor agonist

    PMIDs:
    20104850 20108008 15646817 18655883 21208749


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • DESMOPRESSIN   OXTR

    Interaction Score: 3.57

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    24874785


    Sources:
    DTC TTD

  • RELCOVAPTAN   OXTR

    Interaction Score: 2.85

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Oxytocin receptor antagonist
    Direct Interaction yes

    PMIDs:
    21130036 10519430


    Sources:
    ChemblInteractions

  • SODIUM CHLORIDE   OXTR

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12907413


    Sources:
    NCI

  • ESTRADIOL   OXTR

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3033233


    Sources:
    NCI

  • TESTOSTERONE   OXTR

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1846593


    Sources:
    NCI

  • PROGESTERONE   OXTR

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12061859


    Sources:
    NCI

  • Ensembl: ENSG00000180914

    • Version: 101_38

    Alternate Names:
    OXTR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P30559

    • Version: 11-September-2012

    Alternate Names:
    OXTR Uniprot Gene Name
    ENSG00000180914 Ensembl Gene Id
    OXYR_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Short Name 7TM_GPCR_Rhodpsn

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: P30559

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000180914 Ensembl Gene Id
    5021 Entrez Gene Id
    P30559 Uniprot Accession

    Gene Info:
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Target Subclass GPCR

    Publications:

  • TdgClinicalTrial: P30559

    • Version: January-2014

    Alternate Names:
    OXTR Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • RussLampel: ENSG00000180914

    • Version: 26-July-2011

    Alternate Names:
    OXYTOCIN RECEPTOR (OT-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P30559] Description
    OXTR Display Id
    ENSG00000180914 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: OXTR

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Takagi et al., 2002, Bovine retained placenta: hormonal concentrations in fetal and maternal placenta., Placenta
    Hixon et al., 1987, Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F-2 alpha secretion in sheep., J. Reprod. Fertil.
    Fitts et al., 2003, Effects of central oxytocin receptor blockade on water and saline intake, mean arterial pressure, and c-Fos expression in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.

  • DTC: OXTR

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wiśniewski K et al., 2014, New, potent, and selective peptidic oxytocin receptor agonists., J Med Chem

  • ChemblInteractions: OXTR

    • Version: chembl_23

    Alternate Names:
    OXTR GENE_SYMBOL
    Oxytocin receptor UNIPROT
    OT-R UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000180914

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000180914 Gene Symbol
    OXTR Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: OXTR

    • Version: 27-Jun-2013

    Alternate Names:
    5021 Gene ID
    OT-R dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Oxytocin receptor

    • Version: 2020.06.01

    Alternate Names:
    OTR TTD Gene Abbreviation
    T84486 TTD Target ID

    Gene Info:

    Publications:

  • GO: OXTR

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21