4988 |
OPIOID RECEPTOR MU 1 |
OPRM1 |
LMOR |
M-OR-1 |
MOP |
MOR |
MOR1 |
OPRM |
600018 |
8156 |
ENSG00000112038 |
OTTHUMG00000015870 |
P35372 |
OPRM_HUMAN |
MU-TYPE OPIOID RECEPTOR |
Mu opiate receptor |
Mu opioid receptor |
hMOP |
MOR-1 |
319 |
NP_000905 |
NM_000914 |
μ receptor |
MU-TYPE OPIOID RECEPTOR (MOR-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35372] |
BE0000770 |
PA31945 |
Target Subclass | GPCR |
Target Main Class | Receptors |
Transmembrane Helix Count | 7 |
Target Subclass | Rhodopsin |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Type | Family |
Interpro Acc | IPR000276 |
Uniprot Status | Swiss-Prot |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Receptors |
GuideToPharmacology Gene Category Name | Opioid receptors |
GuideToPharmacology Gene Category ID | 50 |
Gene Biotype | PROTEIN_CODING |
KINASE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
partial agonist (activating) |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor partial agonist |
Trial Name | - |
partial agonist (activating) |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Details of the Assay for Interaction | Competition binding assay- the calculated K<sub>i</sub> varies depending on the radioligand used. |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Full agonist |
agonist (activating) |
Trial Name | ZX002, hydrocodone bitartrate |
Novel drug target | Established target |
Trial Name | PTI-701 |
agonist (activating) |
antagonist (inhibitory) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
Trial Name | TD-1211 |
Novel drug target | Established target |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
Novel drug target | Established target |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
agonist (activating) |
partial antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Partial agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
Specific Action of the Ligand | Agonist |
agonist (activating) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Agonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | True |
Direct Interaction? | False |
agonist (activating) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
Details of the Assay for Interaction | Displacement of [<sup>3</sup>H]DAMGO from human μ opioid receptors expressed in CHO cells |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Trial Name | REN-213 |
Trial Name | buprenorphine + naloxone,Suboxone |
Novel drug target | Established target |
partial agonist (activating) |
agonist (activating) |
Novel drug target | Established target |
Trial Name | - |
Specific Action of the Ligand | Full agonist |
agonist (activating) |
Trial Name | COL-003, sustained release oxycodone |
Novel drug target | Established target |
Trial Name | PTI-801,Oxytrex |
partial agonist (activating) |
agonist (activating) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Partial agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Biased agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Novel drug target | Established target |
Trial Name | NKTR-181 |
Details of the Assay for Interaction | Competitive membrane binding assay measuring displacement [3H]naloxone from human μ receptors expressed by CHO cells. |
partial agonist (activating) |
Mechanism of Interaction | Mu opioid receptor partial agonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor antagonist |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
Specific Action of the Ligand | Agonist |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Agonist |
agonist (activating) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
partial agonist (activating) |
Mechanism of Interaction | Mu opioid receptor partial agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
Details of the Assay for Interaction | Radioligand binding assay |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor antagonist |
agonist (activating) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Full agonist |
agonist (activating) |
Trial Name | ALO-01, morphine sulfate and naltrexone hydrochloride,Embeda, Kadian NT |
Novel drug target | Established target |
Trial Name | intranasal morphine,Rylomine |
antagonist (inhibitory) |
agonist (activating) |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Agonist |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | KP201 (prodrug of hydrocodone) |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
agonist (activating) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Agonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
OPRM1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
OPRM1 | Gene Symbol |
MOR | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
4988 | Entrez Gene Id |
MU-TYPE OPIOID RECEPTOR | Uniprot Protein Name |
ENSG00000112038 | Ensembl Gene Id |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Type | Family |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
P35372 | Uniprot Accession |
OPRM1 | Gene Symbol |
4988 | Entrez Gene Id |
Target Subclass | GPCR |
Target Main Class | Receptors |
Transmembrane Helix Count | 7 |
OPRM1 | Display Id |
ENSG00000112038 | Ensembl Gene Id |
MU-TYPE OPIOID RECEPTOR (MOR-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35372] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
8156 | HUGO Gene ID |
8156 | HUGO Gene Symbol |
opioid receptor mu 1 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Opioid receptors |
GuideToPharmacology Gene Category ID | 50 |
G PROTEIN COUPLED RECEPTOR |
PA31945 | PharmGKB ID |
OPRM1 | DrugBank Gene Name |
P35372 | UniProt Accession |
4988 | Entrez Gene Id |
ENSG00000112038 | Gene Symbol |
OPRM1 | Ensembl Id |
DRUGGABLE GENOME |
MOR1 | GENE_SYMBOL |
OPRM1 | GENE_SYMBOL |
Mu-type opioid receptor | UNIPROT |
Mu-type opioid receptor | Gene Name |
P35372 | UniProt ID |
KINASE, G PROTEIN COUPLED RECEPTOR |
MOR1 | GO Gene Synonym |
G PROTEIN COUPLED RECEPTOR |
4988 | Gene ID |
LMOR | dGene Synonym |
M-OR-1 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |