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NTF3 Gene Record

  • Summary
  • Interactions
  • Claims
  • NTF3 4908 Druggable Genome

    Alternate Names:

    4908
    NEUROTROPHIN 3
    NTF3
    HDNF
    NGF-2
    NGF2
    NT-3
    NT3
    162660
    8023
    ENSG00000185652
    OTTHUMG00000168649

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME

    Publications:

    Lindholm et al., 1994, Brain-derived neurotrophic factor and neurotrophin-4 increase neurotrophin-3 expression in the rat hippocampus., Int. J. Dev. Neurosci.
    Ceccatelli et al., 1991, Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment., Proc. Natl. Acad. Sci. U.S.A.
    Musselman et al., Preliminary evidence of phenytoin-induced alterations in embryonic gene expression in a mouse model., Reprod. Toxicol.
    Ursø et al., 1999, Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes., J. Biol. Chem.
    Koh et al., 1995, Potentiated necrosis of cultured cortical neurons by neurotrophins., Science
    Shin-young et al., 2007, Nicotine inhibits bFGF-induced neurite outgrowth through suppression of NO synthesis in H19-7 cells., Neurochem. Res.
    He et al., 2000, Intracellular Ca(2+) and Ca(2+)/calmodulin-dependent kinase II mediate acute potentiation of neurotransmitter release by neurotrophin-3., J. Cell Biol.
    Malcangio et al., 2000, Intrathecally injected neurotrophins and the release of substance P from the rat isolated spinal cord., Eur. J. Neurosci.
    Malcangio et al., 1997, Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord., J. Neurosci.
    Park et al., 2006, ERK-mediated production of neurotrophic factors by astrocytes promotes neuronal stem cell differentiation by erythropoietin., Biochem. Biophys. Res. Commun.
    Good et al., 2001, Neurotrophin-3 inhibits HCO absorption via a cAMP-dependent pathway in renal thick ascending limb., Am. J. Physiol., Cell Physiol.
    Leingärtner et al., 1994, Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons., J. Biol. Chem.
    Sano, 2001, Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons., Neuropharmacology
    Vizzard, 2000, Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction., Exp. Neurol.
    Iwata et al., 1996, Neurotrophin-3 increases the DNA-binding activities of several transcription factors in a mouse osteoblastic cell line., Biochim. Biophys. Acta
    Becker et al., 2008, Expression of mRNA of neurotrophic factors and their receptors are significantly altered after subchronic ketamine treatment., Med Chem
  • NALOXONE   NTF3

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9334418


    Sources:
    NCI

  • PILOCARPINE   NTF3

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7747601


    Sources:
    NCI

  • INOSITOL   NTF3

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10811820


    Sources:
    NCI

  • CAPSAICIN   NTF3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10651868


    Sources:
    NCI

  • NIMODIPINE   NTF3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7725105


    Sources:
    NCI

  • ALTEPLASE   NTF3

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8630334


    Sources:
    NCI

  • EPOETIN ALFA   NTF3

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16337149


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   NTF3

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8288635


    Sources:
    NCI

  • PHENYTOIN   NTF3

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7841657


    Sources:
    NCI

  • COLCHICINE   NTF3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1946455


    Sources:
    NCI

  • NICOTINE   NTF3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17268847


    Sources:
    NCI

  • GENISTEIN   NTF3

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11698238


    Sources:
    NCI

  • INSULIN   NTF3

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10521479


    Sources:
    NCI

  • RISPERIDONE   NTF3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18473918


    Sources:
    NCI

  • VINCRISTINE   NTF3

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11378165


    Sources:
    NCI

  • CYCLOPHOSPHAMIDE   NTF3

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10683293


    Sources:
    NCI

  • Ensembl: ENSG00000185652

    • Version: 101_38

    Alternate Names:
    NTF3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: NTF3

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ceccatelli et al., 1991, Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment., Proc. Natl. Acad. Sci. U.S.A.
    Koh et al., 1995, Potentiated necrosis of cultured cortical neurons by neurotrophins., Science
    Park et al., 2006, ERK-mediated production of neurotrophic factors by astrocytes promotes neuronal stem cell differentiation by erythropoietin., Biochem. Biophys. Res. Commun.

  • HingoraniCasas: ENSG00000185652

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000185652 Gene Symbol
    NTF3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: NTF3

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21