DGIdb - NT5C2 Gene Record

NT5C2 22978 Clinically ActionableDrug Resistance

Alternate Names:

22978
5'-NUCLEOTIDASE, CYTOSOLIC II
NT5C2
GMP
NT5B
PNT5
SPG45
SPG65
cN-II
600417
8022
ENSG00000076685
OTTHUMG00000018981
P49902
9189
PA31801
Cytosolic purine 5'-nucleotidase

Gene Info:

Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
CLINICALLY ACTIONABLE
ENZYME

Publications:

Vispo E et al., 2013, Genetic determinants of idiopathic noncirrhotic portal hypertension in HIV-infected patients., Clin Infect Dis
Khatri A et al., 2014, SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours., Br J Cancer
Mitra AK et al., 2012, Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors., Pharmacogenomics
Meyer JA et al., 2013, Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia., Nat Genet
Tzoneva et al., 2013, Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL., Nat. Med.
Brouwer C et al., 2005, Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment., Clin Chim Acta

DIDANOSINE NT5C2

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23315321

Sources:
PharmGKB
MERCAPTOPURINE NT5C2

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23377183 23377281 15990089

Sources:
CIViC PharmGKB
THIOGUANINE NT5C2

Interaction Score: 1.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23377183 23377281

Sources:
CIViC
GEMCITABINE NT5C2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24300978 22838949

Sources:
PharmGKB
CYTARABINE NT5C2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000076685
- Version: 101_38
Alternate Names:

NT5C2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: NT5C2

Version: 18-August-2020

Alternate Names:

PA31801 PharmGKB ID

Gene Info:

Publications:

Vispo E et al., 2013, Genetic determinants of idiopathic noncirrhotic portal hypertension in HIV-infected patients., Clin Infect Dis

Mitra AK et al., 2012, Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors., Pharmacogenomics

Khatri A et al., 2014, SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours., Br J Cancer

CIViC: NT5C2

Version: 14-September-2020

Alternate Names:

22978 Entrez Gene ID

9189 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Meyer JA et al., 2013, Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia., Nat Genet

Tzoneva et al., 2013, Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL., Nat. Med.

HumanProteinAtlas: NT5C2
- Version: 19.3
Alternate Names:

ENSG00000076685 Ensembl Gene ID

cN-II Human Protein Atlas Gene Synonym

GMP Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: NT5C2
- Version: 11-November-2018
Alternate Names:

NT5C2 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: NT5C2
- Version: 01-February-2022
Alternate Names:

Cytosolic purine 5'-nucleotidase Gene Name

P49902 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
FoundationOneGenes: NT5C2
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: NT5C2
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

ENSG00000076685	Ensembl Gene ID
cN-II	Human Protein Atlas Gene Synonym
GMP	Human Protein Atlas Gene Synonym

NT5C2 Gene Record

NT5C2 22978 Clinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DIDANOSINE NT5C2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23315321

Sources: PharmGKB

MERCAPTOPURINE NT5C2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23377183 23377281 15990089

Sources: CIViC PharmGKB

THIOGUANINE NT5C2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23377183 23377281

Sources: CIViC

GEMCITABINE NT5C2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24300978 22838949

Sources: PharmGKB

CYTARABINE NT5C2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000076685

Alternate Names: NT5C2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: NT5C2

Alternate Names: PA31801 PharmGKB ID

Gene Info:

CIViC: NT5C2

Alternate Names: 22978 Entrez Gene ID 9189 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications: Meyer JA et al., 2013, Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia., Nat Genet Tzoneva et al., 2013, Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL., Nat. Med.

HumanProteinAtlas: NT5C2

Alternate Names: ENSG00000076685 Ensembl Gene ID cN-II Human Protein Atlas Gene Synonym GMP Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

Tempus: NT5C2

Alternate Names: NT5C2 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: NT5C2

Alternate Names: Cytosolic purine 5'-nucleotidase Gene Name P49902 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

FoundationOneGenes: NT5C2

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: NT5C2

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
23315321

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23377183 23377281 15990089

Sources:
CIViC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23377183 23377281

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
24300978 22838949

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

NT5C2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA31801 PharmGKB ID

Alternate Names:

22978 Entrez Gene ID

9189 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Meyer JA et al., 2013, Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia., Nat Genet

Tzoneva et al., 2013, Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL., Nat. Med.

Alternate Names:

ENSG00000076685 Ensembl Gene ID

cN-II Human Protein Atlas Gene Synonym

GMP Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

NT5C2 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Cytosolic purine 5'-nucleotidase Gene Name

P49902 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE