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NRG1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NRG1 3084 Druggable GenomeClinically ActionableDrug Resistance

    Alternate Names:

    3084
    NEUREGULIN 1
    NRG1
    ARIA
    GGF
    GGF2
    HGL
    HRG
    HRG1
    HRGA
    MST131
    MSTP131
    NDF
    NRG1-IT2
    SMDF
    142445
    7997
    ENSG00000157168
    OTTHUMG00000163918
    2593
    PA31776
    Q02297
    Pro-neuregulin-1, membrane-bound isoform

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    KINASE
    GROWTH FACTOR
    DRUG RESISTANCE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Labriola et al., 2003, Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells., Mol. Cell. Biol.
    Balañá et al., 1999, Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas., Oncogene
    Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med
    Heining C et al., 2018, <i>NRG1</i> Fusions in <i>KRAS</i> Wild-Type Pancreatic Cancer., Cancer Discov
    Jones MR et al., 2019, <i>NRG1</i> Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in <i>KRAS</i> Wild-Type Pancreatic Ductal Adenocarcinoma., Clin Cancer Res
    Jones MR et al., 2017, Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer., Ann Oncol
    Gay ND et al., 2017, Durable Response to Afatinib in Lung Adenocarcinoma Harboring NRG1 Gene Fusions., J Thorac Oncol
    Cheema PK et al., 2017, A Case of Invasive Mucinous Pulmonary Adenocarcinoma with a CD74-NRG1 Fusion Protein Targeted with Afatinib., J Thorac Oncol
    Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation
    Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.
    Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer
    Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.
    Vellon et al., 2007, Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner., Differentiation
    Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.
    Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med
    Sheng et al., 2010, An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells., Cancer Cell
    Mendell et al., 2015, Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer., EBioMedicine
    Wilson et al., 2011, Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers., Cancer Cell
    Leung et al., 2015, Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer., Oncotarget
    Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.
    Hirata et al., 2007, Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration., Acta Neuropathol.
    Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science
    Zhong et al., 2008, Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors., J. Neurosci.
    Akinmade et al., 2008, Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells., Br. J. Cancer
  • PATRITUMAB   NRG1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26137564


    Sources:
    CIViC

  • SERIBANTUMAB   NRG1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20227043


    Sources:
    CIViC

  • AFATINIB   NRG1

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29802158 31068372 28950338 28502724 29169524


    Sources:
    CIViC

  • PERTUZUMAB   NRG1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29802158


    Sources:
    CIViC

  • BUPIVACAINE   NRG1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17294200


    Sources:
    NCI

  • LAPATINIB   NRG1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21840482 25691057


    Sources:
    CIViC

  • ALTEPLASE   NRG1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11679632


    Sources:
    NCI

  • WORTMANNIN   NRG1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10559227


    Sources:
    NCI

  • ISOPROTERENOL   NRG1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14732742


    Sources:
    NCI

  • CETUXIMAB   NRG1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21900593


    Sources:
    CIViC PharmGKB

  • PANITUMUMAB   NRG1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PROGESTERONE   NRG1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12529413 10597237


    Sources:
    NCI

  • COLCHICINE   NRG1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7666195


    Sources:
    NCI

  • ERLOTINIB   NRG1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29802158


    Sources:
    CIViC

  • NICOTINE   NRG1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18784291


    Sources:
    NCI

  • GENISTEIN   NRG1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17539658


    Sources:
    NCI

  • TAMOXIFEN   NRG1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18283314


    Sources:
    NCI

  • VINCRISTINE   NRG1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17999741


    Sources:
    NCI

  • ASPIRIN   NRG1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10921413


    Sources:
    NCI

  • CARBOPLATIN   NRG1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23390248


    Sources:
    CIViC

  • GEMCITABINE   NRG1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23390248


    Sources:
    CIViC

  • DEXAMETHASONE   NRG1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7599067


    Sources:
    NCI

  • PACLITAXEL   NRG1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23390248


    Sources:
    CIViC

  • CISPLATIN   NRG1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23390248


    Sources:
    CIViC

  • Ensembl: ENSG00000157168

    • Version: 101_38

    Alternate Names:
    NRG1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: NRG1

    • Version: 14-September-2020

    Alternate Names:
    3084 Entrez Gene ID
    2593 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Meetze et al., 2015, Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models., Clin. Cancer Res.
    Sheng et al., 2010, An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells., Cancer Cell
    Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

  • NCI: NRG1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation
    Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer
    Fukazawa et al., 2003, Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt., J. Mol. Cell. Cardiol.

  • HingoraniCasas: ENSG00000157168

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000157168 Gene Symbol
    NRG1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: NRG1

    • Version: 18-August-2020

    Alternate Names:
    PA31776 PharmGKB ID

    Gene Info:

    Publications:

  • GO: NRG1

    • Version: 01-February-2022

    Alternate Names:
    GGF GO Gene Synonym
    HGL GO Gene Synonym
    HRGA GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

  • Tempus: NRG1

    • Version: 11-November-2018

    Alternate Names:
    NRG1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: NRG1

    • Version: 01-February-2022

    Alternate Names:
    Pro-neuregulin-1, membrane-bound isoform Gene Name
    Q02297 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • CarisMolecularIntelligence: NRG1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: NRG1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21