DGIdb - NRG1 Gene Record

NRG1 3084 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

3084
NEUREGULIN 1
NRG1
ARIA
GGF
GGF2
HGL
HRG
HRG1
HRGA
MST131
MSTP131
NDF
NRG1-IT2
SMDF
142445
7997
ENSG00000157168
OTTHUMG00000163918
2593
PA31776
Q02297
Pro-neuregulin-1, membrane-bound isoform

Gene Info:

Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

KINASE
GROWTH FACTOR
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Labriola et al., 2003, Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells., Mol. Cell. Biol.
Balañá et al., 1999, Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas., Oncogene
Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med
Heining C et al., 2018, <i>NRG1</i> Fusions in <i>KRAS</i> Wild-Type Pancreatic Cancer., Cancer Discov
Jones MR et al., 2019, <i>NRG1</i> Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in <i>KRAS</i> Wild-Type Pancreatic Ductal Adenocarcinoma., Clin Cancer Res
Jones MR et al., 2017, Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer., Ann Oncol
Gay ND et al., 2017, Durable Response to Afatinib in Lung Adenocarcinoma Harboring NRG1 Gene Fusions., J Thorac Oncol
Cheema PK et al., 2017, A Case of Invasive Mucinous Pulmonary Adenocarcinoma with a CD74-NRG1 Fusion Protein Targeted with Afatinib., J Thorac Oncol
Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation
Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.
Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer
Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.
Vellon et al., 2007, Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner., Differentiation
Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.
Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med
Sheng et al., 2010, An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells., Cancer Cell
Mendell et al., 2015, Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer., EBioMedicine
Wilson et al., 2011, Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers., Cancer Cell
Leung et al., 2015, Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer., Oncotarget
Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.
Hirata et al., 2007, Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration., Acta Neuropathol.
Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science
Zhong et al., 2008, Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors., J. Neurosci.
Akinmade et al., 2008, Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells., Br. J. Cancer

PATRITUMAB NRG1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26137564

Sources:
CIViC
SERIBANTUMAB NRG1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20227043

Sources:
CIViC
AFATINIB NRG1

Interaction Score: 1.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29802158 31068372 28950338 28502724 29169524

Sources:
CIViC
PERTUZUMAB NRG1

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29802158

Sources:
CIViC
BUPIVACAINE NRG1

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17294200

Sources:
NCI
LAPATINIB NRG1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21840482 25691057

Sources:
CIViC
ALTEPLASE NRG1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11679632

Sources:
NCI
WORTMANNIN NRG1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10559227

Sources:
NCI
ISOPROTERENOL NRG1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14732742

Sources:
NCI
CETUXIMAB NRG1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21900593

Sources:
CIViC PharmGKB
PANITUMUMAB NRG1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PROGESTERONE NRG1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12529413 10597237

Sources:
NCI
COLCHICINE NRG1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7666195

Sources:
NCI
ERLOTINIB NRG1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29802158

Sources:
CIViC
NICOTINE NRG1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18784291

Sources:
NCI
GENISTEIN NRG1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17539658

Sources:
NCI
TAMOXIFEN NRG1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18283314

Sources:
NCI
VINCRISTINE NRG1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17999741

Sources:
NCI
ASPIRIN NRG1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10921413

Sources:
NCI
CARBOPLATIN NRG1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23390248

Sources:
CIViC
GEMCITABINE NRG1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23390248

Sources:
CIViC
DEXAMETHASONE NRG1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7599067

Sources:
NCI
PACLITAXEL NRG1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23390248

Sources:
CIViC
CISPLATIN NRG1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23390248

Sources:
CIViC

Ensembl: ENSG00000157168
- Version: 101_38
Alternate Names:

NRG1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

CIViC: NRG1

Version: 14-September-2020

Alternate Names:

3084 Entrez Gene ID

2593 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Meetze et al., 2015, Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models., Clin. Cancer Res.

Sheng et al., 2010, An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells., Cancer Cell

Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

NCI: NRG1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation

Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer

Fukazawa et al., 2003, Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt., J. Mol. Cell. Cardiol.

HingoraniCasas: ENSG00000157168
- Version: 31-May-2017
Alternate Names:

ENSG00000157168 Gene Symbol

NRG1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: NRG1
- Version: 18-August-2020
Alternate Names:

PA31776 PharmGKB ID

Gene Info:

Publications:
GO: NRG1
- Version: 01-February-2022
Alternate Names:

GGF GO Gene Synonym

HGL GO Gene Synonym

HRGA GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:
Tempus: NRG1
- Version: 11-November-2018
Alternate Names:

NRG1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: NRG1
- Version: 01-February-2022
Alternate Names:

Pro-neuregulin-1, membrane-bound isoform Gene Name

Q02297 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
CarisMolecularIntelligence: NRG1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: NRG1
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Pro-neuregulin-1, membrane-bound isoform	Gene Name
Q02297	UniProt ID

NRG1 Gene Record

NRG1 3084 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26137564

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20227043

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29802158 31068372 28950338 28502724 29169524

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29802158

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17294200

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21840482 25691057

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11679632

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10559227

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14732742

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21900593

Sources: CIViC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12529413 10597237

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7666195

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29802158

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18784291

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17539658

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18283314

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17999741

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
26137564

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
20227043

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
29802158 31068372 28950338 28502724 29169524

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
29802158

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
17294200

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21840482 25691057

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
11679632

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10559227

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14732742

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21900593

Sources:
CIViC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12529413 10597237

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7666195

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29802158

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
18784291

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17539658

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18283314

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17999741

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10921413

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23390248

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
23390248

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
7599067

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23390248

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
23390248

Sources:
CIViC

Alternate Names:

NRG1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

3084 Entrez Gene ID

2593 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Alternate Names:

ENSG00000157168 Gene Symbol

NRG1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA31776 PharmGKB ID

Alternate Names:

GGF GO Gene Synonym

HGL GO Gene Synonym

HRGA GO Gene Synonym