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NR5A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NR5A1 2516 Druggable Genome

    Alternate Names:

    2516
    NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 1
    NR5A1
    AD4BP
    ELP
    FTZ1
    FTZF1
    POF7
    SF-1
    SF1
    SPGF8
    SRXX4
    SRXY3
    hSF-1
    184757
    7983
    ENSG00000136931
    OTTHUMG00000020655
    Q13285
    STEROIDOGENIC FACTOR 1
    STF1_HUMAN
    STEROIDOGENIC FACTOR 1 (STF-1) (SF-1) (ADRENAL 4 BINDING PROTEIN) (STEROID HORMONE RECEPTOR AD4BP) (FUSHI TARAZU FACTOR HOMOLOG 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13285]

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000536
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Gummow et al., 2006, Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex., Mol. Endocrinol.
    Kelly et al., 2005, Coregulatory protein-orphan nuclear receptor interactions in the human adrenal cortex., J. Endocrinol.
    Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.
    Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology
    Manna et al., 2001, Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function., Endocrinology
    Wojtecka-Lukasik et al., 1984, Effects of neutral proteases from human leukocytes on plasma fibronectin., Thromb. Res.
    Walther et al., 2006, Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells., Reprod. Biol. Endocrinol.
    Kelly et al., 2004, Modulation of steroidogenic enzymes by orphan nuclear transcriptional regulation may control diverse production of cortisol and androgens in the human adrenal., J. Endocrinol.
    Wehrenberg et al., 1994, Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary., Proc. Natl. Acad. Sci. U.S.A.
  • CHEMBL597670   NR5A1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CORTICOTROPIN   NR5A1

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12530657 12239114


    Sources:
    NCI

  • OXYTOCIN   NR5A1

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8108428


    Sources:
    NCI

  • HEPARIN   NR5A1

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6372156


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   NR5A1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11145595


    Sources:
    NCI

  • CHEMBL35482   NR5A1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17176485


    Sources:
    NCI

  • HYDROCORTISONE   NR5A1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16002533


    Sources:
    NCI

  • INSULIN   NR5A1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15128284


    Sources:
    NCI

  • DEXAMETHASONE   NR5A1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16857744


    Sources:
    NCI

  • Ensembl: ENSG00000136931

    • Version: 101_38

    Alternate Names:
    NR5A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000136931

    • Version: 26-July-2011

    Alternate Names:
    STEROIDOGENIC FACTOR 1 (STF-1) (SF-1) (ADRENAL 4 BINDING PROTEIN) (STEROID HORMONE RECEPTOR AD4BP) (FUSHI TARAZU FACTOR HOMOLOG 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13285] Description
    ENSG00000136931 Ensembl Gene Id
    NR5A1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q13285

    • Version: 11-September-2012

    Alternate Names:
    2516 Entrez Gene Id
    Q13285 Uniprot Accession
    STEROIDOGENIC FACTOR 1 Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • NCI: NR5A1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Gummow et al., 2006, Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex., Mol. Endocrinol.
    Kelly et al., 2005, Coregulatory protein-orphan nuclear receptor interactions in the human adrenal cortex., J. Endocrinol.
    Wehrenberg et al., 1994, Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary., Proc. Natl. Acad. Sci. U.S.A.

  • HingoraniCasas: ENSG00000136931

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000136931 Gene Symbol
    NR5A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: NR5A1

    • Version: 01-February-2022

    Alternate Names:
    AD4BP GO Gene Synonym
    FTZF1 GO Gene Synonym
    SF1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: NR5A1

    • Version: 27-Jun-2013

    Alternate Names:
    2516 Gene ID
    AD4BP dGene Synonym
    ELP dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • DTC: NR5A1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21