DGIdb - NR5A1 Gene Record

NR5A1 2516 Druggable Genome

Alternate Names:

2516
NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 1
NR5A1
AD4BP
ELP
FTZ1
FTZF1
POF7
SF-1
SF1
SPGF8
SRXX4
SRXY3
hSF-1
184757
7983
ENSG00000136931
OTTHUMG00000020655
Q13285
STEROIDOGENIC FACTOR 1
STF1_HUMAN
STEROIDOGENIC FACTOR 1 (STF-1) (SF-1) (ADRENAL 4 BINDING PROTEIN) (STEROID HORMONE RECEPTOR AD4BP) (FUSHI TARAZU FACTOR HOMOLOG 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13285]

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000536
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME

Publications:

Gummow et al., 2006, Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex., Mol. Endocrinol.
Kelly et al., 2005, Coregulatory protein-orphan nuclear receptor interactions in the human adrenal cortex., J. Endocrinol.
Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.
Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology
Manna et al., 2001, Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function., Endocrinology
Wojtecka-Lukasik et al., 1984, Effects of neutral proteases from human leukocytes on plasma fibronectin., Thromb. Res.
Walther et al., 2006, Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells., Reprod. Biol. Endocrinol.
Kelly et al., 2004, Modulation of steroidogenic enzymes by orphan nuclear transcriptional regulation may control diverse production of cortisol and androgens in the human adrenal., J. Endocrinol.
Wehrenberg et al., 1994, Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary., Proc. Natl. Acad. Sci. U.S.A.

CHEMBL597670 NR5A1

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CORTICOTROPIN NR5A1

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12530657 12239114

Sources:
NCI
OXYTOCIN NR5A1

Interaction Score: 1.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8108428

Sources:
NCI
HEPARIN NR5A1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6372156

Sources:
NCI
LIOTHYRONINE SODIUM NR5A1

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11145595

Sources:
NCI
CHEMBL35482 NR5A1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17176485

Sources:
NCI
HYDROCORTISONE NR5A1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16002533

Sources:
NCI
INSULIN NR5A1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15128284

Sources:
NCI
DEXAMETHASONE NR5A1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16857744

Sources:
NCI

Ensembl: ENSG00000136931
- Version: 101_38
Alternate Names:

NR5A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000136931

Version: 26-July-2011

Alternate Names:

STEROIDOGENIC FACTOR 1 (STF-1) (SF-1) (ADRENAL 4 BINDING PROTEIN) (STEROID HORMONE RECEPTOR AD4BP) (FUSHI TARAZU FACTOR HOMOLOG 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13285] Description

ENSG00000136931 Ensembl Gene Id

NR5A1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q13285
- Version: 11-September-2012
Alternate Names:

2516 Entrez Gene Id

Q13285 Uniprot Accession

STEROIDOGENIC FACTOR 1 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Interpro Type Domain

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:

NCI: NR5A1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Gummow et al., 2006, Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex., Mol. Endocrinol.

Kelly et al., 2005, Coregulatory protein-orphan nuclear receptor interactions in the human adrenal cortex., J. Endocrinol.

Wehrenberg et al., 1994, Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary., Proc. Natl. Acad. Sci. U.S.A.

HingoraniCasas: ENSG00000136931
- Version: 31-May-2017
Alternate Names:

ENSG00000136931 Gene Symbol

NR5A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: NR5A1
- Version: 01-February-2022
Alternate Names:

AD4BP GO Gene Synonym

FTZF1 GO Gene Synonym

SF1 GO Gene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
dGene: NR5A1
- Version: 27-Jun-2013
Alternate Names:

2516 Gene ID

AD4BP dGene Synonym

ELP dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
DTC: NR5A1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

STEROIDOGENIC FACTOR 1 (STF-1) (SF-1) (ADRENAL 4 BINDING PROTEIN) (STEROID HORMONE RECEPTOR AD4BP) (FUSHI TARAZU FACTOR HOMOLOG 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13285]	Description
ENSG00000136931	Ensembl Gene Id
NR5A1	Display Id

2516	Entrez Gene Id
Q13285	Uniprot Accession
STEROIDOGENIC FACTOR 1	Uniprot Protein Name

NR5A1 Gene Record

NR5A1 2516 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12530657 12239114

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8108428

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6372156

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11145595

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17176485

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16002533

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15128284

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16857744

Sources: NCI

Ensembl: ENSG00000136931

Alternate Names: NR5A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000136931

Alternate Names: STEROIDOGENIC FACTOR 1 (STF-1) (SF-1) (ADRENAL 4 BINDING PROTEIN) (STEROID HORMONE RECEPTOR AD4BP) (FUSHI TARAZU FACTOR HOMOLOG 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13285] Description ENSG00000136931 Ensembl Gene Id NR5A1 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: Q13285

Alternate Names: 2516 Entrez Gene Id Q13285 Uniprot Accession STEROIDOGENIC FACTOR 1 Uniprot Protein Name

Gene Info: Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Interpro Type Domain

Gene Categories: NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:

NCI: NR5A1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000136931

Alternate Names: ENSG00000136931 Gene Symbol NR5A1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: NR5A1

Alternate Names: AD4BP GO Gene Synonym FTZF1 GO Gene Synonym SF1 GO Gene Synonym

Gene Info:

Gene Categories: NUCLEAR HORMONE RECEPTOR

Publications:

dGene: NR5A1

Alternate Names: 2516 Gene ID AD4BP dGene Synonym ELP dGene Synonym

Gene Info:

Gene Categories: NUCLEAR HORMONE RECEPTOR

Publications:

DTC: NR5A1

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12530657 12239114

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8108428

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6372156

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11145595

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17176485

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16002533

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15128284

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16857744

Sources:
NCI

Alternate Names:

NR5A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

STEROIDOGENIC FACTOR 1 (STF-1) (SF-1) (ADRENAL 4 BINDING PROTEIN) (STEROID HORMONE RECEPTOR AD4BP) (FUSHI TARAZU FACTOR HOMOLOG 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13285] Description

ENSG00000136931 Ensembl Gene Id

NR5A1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

2516 Entrez Gene Id

Q13285 Uniprot Accession

STEROIDOGENIC FACTOR 1 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Interpro Type Domain

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Alternate Names:

ENSG00000136931 Gene Symbol

NR5A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

AD4BP GO Gene Synonym

FTZF1 GO Gene Synonym

SF1 GO Gene Synonym

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Alternate Names:

2516 Gene ID

AD4BP dGene Synonym

ELP dGene Synonym

Gene Categories:

NUCLEAR HORMONE RECEPTOR