DGIdb - NR1H4 Gene Record

NR1H4 9971 Druggable Genome

Alternate Names:

9971
NUCLEAR RECEPTOR SUBFAMILY 1 GROUP H MEMBER 4
NR1H4
BAR
FXR
HRR-1
HRR1
PFIC5
RIP14
603826
7967
ENSG00000012504
OTTHUMG00000170359
RETINOID X RECEPTOR-INTERACTING PROTEIN 14
RXR-INTERACTING PROTEIN 14
BILE ACID RECEPTOR
FARNESOL RECEPTOR HRR-1
Q96RI1
FARNESOID X-ACTIVATED RECEPTOR
NR1H4_HUMAN
BILE ACID RECEPTOR (FARNESOID X-ACTIVATED RECEPTOR) (FARNESOL RECEPTOR HRR-1) (RETINOID X RECEPTOR-INTERACTING PROTEIN 14) (RXR-INTERACTING PROTEIN 14). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96RI1]
T51426

Gene Info:

Initial Gene Query	NR1H4
Counted Citations from 1950-2000	792
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000536
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Target Class	Receptors
Target Subclass	Nuclear receptor
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

KINASE
NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Nam SJ et al., 2007, Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity., J Nat Prod
Katona BW et al., 2007, Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids., J Med Chem
Grienke U et al., 2011, Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum., Bioorg Med Chem
Choi H et al., 2011, Tuberatolides, potent FXR antagonists from the Korean marine tunicate Botryllus tuberatus., J Nat Prod
Lin HR et al., 2014, Cryptochinones from Cryptocarya chinensis act as farnesoid X receptor agonists., Bioorg Med Chem Lett
De Marino S et al., 2011, Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors., J Med Chem
Di Leva FS et al., 2013, Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands., J Med Chem
D'Amore C et al., 2014, Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors., J Med Chem
Gioiello A et al., 2011, Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine., Bioorg Med Chem
Festa C et al., 2014, Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands., J Med Chem
Bass JY et al., 2011, Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene., Bioorg Med Chem Lett
Schuster D et al., 2011, Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation., Bioorg Med Chem
Sepe V et al., 2014, Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)., J Med Chem
Sepe V et al., 2012, Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei., J Med Chem
Sepe V et al., 2011, Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor., J Med Chem
Yu DD et al., 2013, Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery., Bioorg Med Chem

OBETICHOLIC ACID NR1H4

Interaction Score: 4.76

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Bile acid receptor FXR agonist

PMIDs:
24387325 21459580 25247751

Sources:
DTC ChemblInteractions
GANODERMANONTRIOL NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22014750

Sources:
DTC
YEZOQUINOLIDE NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21142112

Sources:
DTC
CRYPTOCHINONE B NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25127166

Sources:
DTC
LUCIDUMOL A NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22014750

Sources:
DTC
CHEMBL476302 NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21256005

Sources:
DTC
ERGOSTEROL PEROXIDE NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22014750

Sources:
DTC
GANODERIC ACID TR NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22014750

Sources:
DTC
TUBERATOLIDE B NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21142112

Sources:
DTC
7-O-METHYLCRYPTOCHINONE B NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25127166

Sources:
DTC
CRYPTOCHINONE A NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25127166

Sources:
DTC
TUBERATOLIDE A NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21142112

Sources:
DTC
(S)-SARGACHROMENOL NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21142112

Sources:
DTC
7-O-METHYLCRYPTOCHINONE A NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25127166

Sources:
DTC
2'-EPI-TUBERATOLIDE B NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21142112

Sources:
DTC
(R)-SARGACHROMENOL NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21142112

Sources:
DTC
GANODERIOL F NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22014750

Sources:
DTC
CHEMBL269105 NR1H4

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17988093

Sources:
DTC
CHENODIOL NR1H4

Interaction Score: 1.63

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Bile acid receptor FXR agonist

Direct Interaction yes

PMIDs:
21459580 17963371 22018919 25162837 22014750 22126372 21309576 25247751 24387325

Sources:
DTC ChemblInteractions TTD
CONICASTEROL D NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
TUROFEXORATE ISOPROPYL NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Bile acid receptor FXR agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CONICASTEROL E NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22126372

Sources:
DTC
THEONELLASTEROL B NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
THEONELLASTEROL E NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
PX-102 NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Bile acid receptor FXR agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEONELLASTEROL G NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
CONICASTEROL B NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
SUVANINE'S SODIUM SALT NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23656455

Sources:
DTC
THEONELLASTEROL C NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
TROPIFEXOR NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
TTD
THEONELLASTEROL F NR1H4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
FLUSILAZOLE NR1H4

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
URSODIOL NR1H4

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Bile acid receptor FXR agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDRAMETHYLNON NR1H4

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUOXASTROBIN NR1H4

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIBUTYLCHLOROSTANNANE NR1H4

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUAZINAM NR1H4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIFENOCONAZOLE NR1H4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GUGGULSTERONE NR1H4

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
LITHOCHOLIC ACID NR1H4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17963371

Sources:
DTC
IMIPRAMINE HYDROCHLORIDE NR1H4

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SAQUINAVIR MESYLATE NR1H4

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIMODIPINE NR1H4

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23688559

Sources:
DTC
PHENOLPHTHALEIN NR1H4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
3R14S-OCHRATOXIN A NR1H4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLENE BLUE NR1H4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZO(K)FLUORANTHENE NR1H4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 NR1H4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PENTABROMOPHENOL NR1H4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZEARALENONE NR1H4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL184450 NR1H4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PENTACHLOROPHENOL NR1H4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL297304 NR1H4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENAZOPYRIDINE HYDROCHLORIDE NR1H4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICHLOROPHEN NR1H4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLIOQUINOL NR1H4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MELPHALAN NR1H4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOCONAZOLE NR1H4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RALOXIFENE HYDROCHLORIDE NR1H4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THIMEROSAL NR1H4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APIGENIN NR1H4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIETHYLSTILBESTROL NR1H4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HOMIDIUM BROMIDE NR1H4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOXORUBICIN HYDROCHLORIDE NR1H4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN NR1H4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000012504
- Version: 101_38
Alternate Names:

NR1H4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: NR1H4
- Version: February-2014
Alternate Names:

9971 Entrez Gene ID

Gene Info:

Initial Gene Query NR1H4

Counted Citations from 1950-2000 792

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TdgClinicalTrial: Q96RI1
- Version: January-2014
Alternate Names:

NR1H4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:

RussLampel: ENSG00000012504

Version: 26-July-2011

Alternate Names:

NR1H4 Display Id

BILE ACID RECEPTOR (FARNESOID X-ACTIVATED RECEPTOR) (FARNESOL RECEPTOR HRR-1) (RETINOID X RECEPTOR-INTERACTING PROTEIN 14) (RXR-INTERACTING PROTEIN 14). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96RI1] Description

ENSG00000012504 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q96RI1
- Version: 11-September-2012
Alternate Names:

NR1H4_HUMAN Uniprot Id

9971 Entrez Gene Id

ENSG00000012504 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Human Readable Name NUCLEAR HORMONE RECEPTOR

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:

DTC: NR1H4

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Nam SJ et al., 2007, Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity., J Nat Prod

Lin HR et al., 2014, Cryptochinones from Cryptocarya chinensis act as farnesoid X receptor agonists., Bioorg Med Chem Lett

Grienke U et al., 2011, Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum., Bioorg Med Chem

HingoraniCasas: ENSG00000012504
- Version: 31-May-2017
Alternate Names:

ENSG00000012504 Gene Symbol

NR1H4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: BAR
- Version: chembl_23
Alternate Names:

FXR GENE_SYMBOL

HRR1 GENE_SYMBOL

RIP14 GENE_SYMBOL

Gene Info:

Publications:
GO: NR1H4
- Version: 01-February-2022
Alternate Names:

BAR GO Gene Synonym

FXR GO Gene Synonym

HRR1 GO Gene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
dGene: NR1H4
- Version: 27-Jun-2013
Alternate Names:

9971 Gene ID

BAR dGene Synonym

FXR dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TTD: Farnesoid X-activated receptor
- Version: 2020.06.01
Alternate Names:

FXR TTD Gene Abbreviation

T51426 TTD Target ID

Gene Info:

Publications:
Pharos: NR1H4
- Version: 01-February-2022
Alternate Names:

Bile acid receptor Gene Name

Q96RI1 UniProt ID

Gene Info:

Gene Categories:

KINASE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

Publications:

Direct Interaction	yes
Mechanism of Interaction	Bile acid receptor FXR agonist

NR1H4	Display Id
BILE ACID RECEPTOR (FARNESOID X-ACTIVATED RECEPTOR) (FARNESOL RECEPTOR HRR-1) (RETINOID X RECEPTOR-INTERACTING PROTEIN 14) (RXR-INTERACTING PROTEIN 14). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96RI1]	Description
ENSG00000012504	Ensembl Gene Id

NR1H4_HUMAN	Uniprot Id
9971	Entrez Gene Id
ENSG00000012504	Ensembl Gene Id

NR1H4 Gene Record

NR1H4 9971 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Bile acid receptor FXR agonist

PMIDs: 24387325 21459580 25247751

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22014750

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21142112

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25127166

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22014750

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21256005

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22014750

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22014750

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21142112

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25127166

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25127166

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21142112

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21142112

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25127166

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21142112

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21142112

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22014750

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17988093

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Bile acid receptor FXR agonist Direct Interaction yes

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Bile acid receptor FXR agonist

PMIDs:
24387325 21459580 25247751

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22014750

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21142112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25127166

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22014750

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21256005

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22014750

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22014750

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21142112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25127166

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25127166

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21142112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21142112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25127166

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21142112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21142112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22014750

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17988093

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Bile acid receptor FXR agonist

Direct Interaction yes

PMIDs:
21459580 17963371 22018919 25162837 22014750 22126372 21309576 25247751 24387325

Sources:
DTC ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Bile acid receptor FXR agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22126372

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Bile acid receptor FXR agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a