• Interaction Score: 7.1

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? False

  • Interaction Score: 5.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Agonist

    PMIDs:
    23910990


  • Interaction Score: 3.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:


    Sources:
    DTC

  • Interaction Score: 3.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Binned data point measured in a luciferase transactivation assay in HEK293 cells expressing the hLXRβ ligand binding domain (aa 153-461)
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 3.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22579484


    Sources:
    DTC

  • Interaction Score: 3.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction LXR-beta agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 3.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

  • Interaction Score: 1.78

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction LXR-beta modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.78

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction LXR-beta agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.78

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

  • Interaction Score: 1.78

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction LXR-beta agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.78

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 1.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction LXR-beta agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23139635


    Sources:
    DrugBank

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23139635


    Sources:
    DrugBank

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31664190


    Sources:
    PharmGKB