DGIdb - NQO2 Gene Record

NQO2 4835 Druggable Genome

Alternate Names:

4835
N-RIBOSYLDIHYDRONICOTINAMIDE:QUINONE REDUCTASE 2
NQO2
DHQV
DIA6
NMOR2
QR2
160998
7856
ENSG00000124588
OTTHUMG00000014130
P16083
NQO2_HUMAN
PA31745
Quinone reductase 2
T75498
Ribosyldihydronicotinamide dehydrogenase [quinone]

Gene Info:

Target Main Class	Enzymes
Target Subclass	1.10.99.2
Target Class	Enzymes
Target Subclass	EC:1.10.99.2
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Nolan KA et al., 2010, In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)., Bioorg Med Chem Lett
Radogna et al., 2009, Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes., Toxicol. Appl. Pharmacol.
Michaelis S et al., 2012, Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2)., J Med Chem
Kwiek et al., 2004, Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines., Biochemistry
Celli et al., 2006, NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs., Biochem. Pharmacol.
Boutin et al., 2005, Quinone reductase 2 substrate specificity and inhibition pharmacology., Chem. Biol. Interact.
Foster et al., 1999, Crystal structure of human quinone reductase type 2, a metalloflavoprotein., Biochemistry
Long et al., 2002, Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity., J. Biol. Chem.
Kalra S et al., 2018, Association of CYP2C192 and ALDH1A11/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol
Jamieson D et al., 2011, Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy., Pharmacogenet Genomics

CARICOTAMIDE NQO2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name CB1954/EP-0152R, NQO2 prodrug therapy,Prolarix

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
CHEMBL1287895 NQO2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1288281 NQO2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1287866 NQO2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1288253 NQO2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1287867 NQO2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL476968 NQO2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1983317 NQO2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
DABIGATRAN NQO2

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22494098

Sources:
DTC
MENADIONE NQO2

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15078100 16765324 15733542 10433694 12351651

Sources:
TEND
C-1311 NQO2

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MELATONIN NQO2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19463840

Sources:
TTD
CYCLOPHOSPHAMIDE NQO2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 21946896

Sources:
PharmGKB
DOXORUBICIN NQO2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 21946896

Sources:
PharmGKB
IMATINIB NQO2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22494098

Sources:
DTC

Ensembl: ENSG00000124588
- Version: 101_38
Alternate Names:

NQO2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P16083
- Version: 01-August-2011
Alternate Names:

ENSG00000124588 Ensembl Gene Id

P16083 Uniprot Accession

NQO2_HUMAN Uniprot Id

Gene Info:

Target Main Class Enzymes

Target Subclass 1.10.99.2

Publications:
TdgClinicalTrial: P16083
- Version: January-2014
Alternate Names:

NQO2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.10.99.2

Publications:

PharmGKB: NQO2

Version: 18-August-2020

Alternate Names:

PA31745 PharmGKB ID

Gene Info:

Publications:

Kalra S et al., 2018, Association of CYP2C192 and ALDH1A11/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol

Jamieson D et al., 2011, Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy., Pharmacogenet Genomics

DTC: NQO2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Nolan KA et al., 2010, In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)., Bioorg Med Chem Lett

Michaelis S et al., 2012, Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2)., J Med Chem

HingoraniCasas: ENSG00000124588
- Version: 31-May-2017
Alternate Names:

ENSG00000124588 Gene Symbol

NQO2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Quinone reductase 2
- Version: 2020.06.01
Alternate Names:

NQO2 TTD Gene Abbreviation

T75498 TTD Target ID

Gene Info:

Publications:
Pharos: NQO2
- Version: 01-February-2022
Alternate Names:

Ribosyldihydronicotinamide dehydrogenase [quinone] Gene Name

P16083 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Trial Name	CB1954/EP-0152R, NQO2 prodrug therapy,Prolarix
Novel drug target	Established target

ENSG00000124588	Ensembl Gene Id
P16083	Uniprot Accession
NQO2_HUMAN	Uniprot Id

Ribosyldihydronicotinamide dehydrogenase [quinone]	Gene Name
P16083	UniProt ID

NQO2 Gene Record

NQO2 4835 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name CB1954/EP-0152R, NQO2 prodrug therapy,Prolarix Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22494098

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15078100 16765324 15733542 10433694 12351651

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19463840

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 21946896

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 21946896

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22494098

Sources: DTC

Ensembl: ENSG00000124588

Alternate Names: NQO2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P16083

Alternate Names: ENSG00000124588 Ensembl Gene Id P16083 Uniprot Accession NQO2_HUMAN Uniprot Id

Gene Info: Target Main Class Enzymes Target Subclass 1.10.99.2

Publications:

TdgClinicalTrial: P16083

Alternate Names: NQO2 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.10.99.2

Publications:

PharmGKB: NQO2

Alternate Names: PA31745 PharmGKB ID

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name CB1954/EP-0152R, NQO2 prodrug therapy,Prolarix

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22494098

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15078100 16765324 15733542 10433694 12351651

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
19463840

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
29938344 21946896

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29938344 21946896

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22494098

Sources:
DTC

Alternate Names:

NQO2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000124588 Ensembl Gene Id

P16083 Uniprot Accession

NQO2_HUMAN Uniprot Id

Gene Info:

Target Main Class Enzymes

Target Subclass 1.10.99.2

Alternate Names:

NQO2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.10.99.2

Alternate Names:

PA31745 PharmGKB ID

Alternate Names:

ENSG00000124588 Gene Symbol

NQO2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NQO2 TTD Gene Abbreviation

T75498 TTD Target ID

Alternate Names:

Ribosyldihydronicotinamide dehydrogenase [quinone] Gene Name

P16083 UniProt ID

Gene Categories:

ENZYME