DGIdb - NQO1 Gene Record

NQO1 1728 Druggable Genome

Alternate Names:

1728
NAD(P)H QUINONE DEHYDROGENASE 1
NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
125860
2874
ENSG00000181019
OTTHUMG00000137575
P15559
Quinone reductase 1
Phylloquinone reductase
NAD(P)H:quinone oxidoreductase 1
Menadione reductase
DT-diaphorase
Azoreductase
NAD(P)H dehydrogenase [quinone] 1
PA31744
NQO1_HUMAN
T52389

Gene Info:

Target Class	Enzymes
Target Subclass	EC:1.6.5.5
Target Subclass	1.6.5.2
Target Main Class	Enzymes
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Ip et al., 2000, Schisandrin B protects against menadione-induced hepatotoxicity by enhancing DT-diaphorase activity., Mol. Cell. Biochem.
Chiou et al., 1999, DT-diaphorase protects against menadione-induced oxidative stress., Toxicology
Munday et al., 1999, Effect of butylated hydroxyanisole on the toxicity of 2-hydroxy-1,4-naphthoquinone to rats., Chem. Biol. Interact.
Munday et al., 1999, Effect of inducers of DT-diaphorase on the toxicity of 2-methyl- and 2-hydroxy-1,4-naphthoquinone to rats., Chem. Biol. Interact.
Kishi et al., 2002, Effect of dicumarol, a Nad(P)h: quinone acceptor oxidoreductase 1 (DT-diaphorase) inhibitor on ubiquinone redox cycling in cultured rat hepatocytes., Free Radic. Res.
Nolan KA et al., 2010, In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)., Bioorg Med Chem Lett
Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J
Ross D, 2005, Functions and distribution of NQO1 in human bone marrow: potential clues to benzene toxicity., Chem Biol Interact
Moffit et al., 2007, Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen., Toxicology
Asher et al., 2003, P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1., Proc. Natl. Acad. Sci. U.S.A.
Preusch et al., 1990, Vitamin K1 2,3-epoxide and quinone reduction: mechanism and inhibition., Free Radic. Res. Commun.
Chen et al., 1999, Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling., Mol. Pharmacol.
Arriagada et al., 2000, Studies of aminochrome toxicity in a mouse derived neuronal cell line: is this toxicity mediated via glutamate transmission?, Amino Acids
Floreani et al., 2000, Protective action of cardiac DT-diaphorase against menadione toxicity in guinea pig isolated atria., Biochem. Pharmacol.
Joseph et al., 2000, A unique cytosolic activity related but distinct from NQO1 catalyses metabolic activation of mitomycin C., Br. J. Cancer
Jaiswal, 2000, Characterization and partial purification of microsomal NAD(P)H:quinone oxidoreductases., Arch. Biochem. Biophys.
Andreani A et al., 2010, Antitumor activity and COMPARE analysis of bis-indole derivatives., Bioorg Med Chem
Hariani GD et al., 2014, Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics., BMC Res Notes
Wong TW et al., 2000, The decrease of mitochondrial NADH dehydrogenease and drug induced apoptosis in doxorubicin resistant A431 cells., Life Sci
Vásquez-Vivar J et al., 1997, Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin., Biochemistry
Korashy et al., 2007, Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection., Cancer Lett.
Luo Z et al., 2017, Identification of novel variants associated with warfarin stable dosage by use of a two-stage extreme phenotype strategy., J Thromb Haemost
Pourgholi L et al., 2016, Gene polymorphisms and the risk of warfarin-induced bleeding complications at therapeutic international normalized ratio (INR)., Toxicol Appl Pharmacol
Chung JE et al., 2015, Effects of NAD(P)H quinone oxidoreductase 1 polymorphisms on stable warfarin doses in Korean patients with mechanical cardiac valves., Eur J Clin Pharmacol
Cavallari LH et al., 2011, Association of apolipoprotein E genotype with duration of time to achieve a stable warfarin dose in African-American patients., Pharmacotherapy
Geng R et al., 2014, Oxidative stress-related genetic polymorphisms are associated with the prognosis of metastatic gastric cancer patients treated with epirubicin, oxaliplatin and 5-fluorouracil combination chemotherapy., PLoS One
Khrunin AV et al., 2014, Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer., Pharmacogenomics
Jamieson D et al., 2011, Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy., Pharmacogenet Genomics
Kolesar JM et al., 2011, The NQO12/2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer., Oncol Rep
Fagerholm R et al., 2008, NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer., Nat Genet
Siegel D et al., 2001, Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1., Mol Pharmacol
Siegel D et al., 1999, Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1., Pharmacogenetics
Moran et al., 1999, A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity., Proc. Natl. Acad. Sci. U.S.A.
Kolesar JM et al., 2002, Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue., Int J Oncol

BENZENE NQO1

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15935810

Sources:
PharmGKB
VATIQUINONE NQO1

Interaction Score: 5.89

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Quinone reductase 1 modulator

Direct Interaction yes

Trial Name EPI-743

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
DICUMAROL NQO1

Interaction Score: 3.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
14634213 2113031 10419545 10949919 10874136 10755406 10683249

Sources:
NCI PharmGKB
CHEMBL1287866 NQO1

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL476968 NQO1

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1288253 NQO1

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1287895 NQO1

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1983317 NQO1

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1288281 NQO1

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
CHEMBL1287867 NQO1

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21074425

Sources:
DTC
SULFORAPHANE NQO1

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20395150

Sources:
DTC
MENADIONE NQO1

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10939639 10614691 10190578 10654840 12069105

Sources:
TEND
ITRACONAZOLE NQO1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17923278

Sources:
NCI
WARFARIN NQO1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27740732 27581200 26257249 21923605

Sources:
PharmGKB
HYDROQUINONE NQO1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10393963

Sources:
NCI
FLUOROURACIL NQO1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25545243 24533712 21946896 21479364 18511948 11160862 10208650

Sources:
PharmGKB
OXALIPLATIN NQO1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24924344

Sources:
PharmGKB
ACETAMINOPHEN NQO1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17188792

Sources:
NCI
DOXORUBICIN NQO1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10954045 9333325

Sources:
PharmGKB
IMATINIB NQO1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30237583

Sources:
PharmGKB
CISPLATIN NQO1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12370763

Sources:
PharmGKB

Ensembl: ENSG00000181019
- Version: 101_38
Alternate Names:

NQO1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P15559
- Version: 01-August-2011
Alternate Names:

1728 Entrez Gene Id

P15559 Uniprot Accession

NQO1_HUMAN Uniprot Id

Gene Info:

Target Subclass 1.6.5.2

Target Main Class Enzymes

Publications:
TdgClinicalTrial: P15559
- Version: January-2014
Alternate Names:

NQO1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.6.5.5

Publications:

PharmGKB: NQO1

Version: 18-August-2020

Alternate Names:

PA31744 PharmGKB ID

Gene Info:

Publications:

Ross D, 2005, Functions and distribution of NQO1 in human bone marrow: potential clues to benzene toxicity., Chem Biol Interact

Hariani GD et al., 2014, Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics., BMC Res Notes

Pourgholi L et al., 2016, Gene polymorphisms and the risk of warfarin-induced bleeding complications at therapeutic international normalized ratio (INR)., Toxicol Appl Pharmacol

TTD: Quinone reductase 1
- Version: 2020.06.01
Alternate Names:

NQO1 TTD Gene Abbreviation

T52389 TTD Target ID

Gene Info:

Publications:

Gueven N et al., 2013, Therapeutic strategies for Leber's hereditary optic neuropathy: A current update., Intractable Rare Dis Res

NCI: NQO1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Moffit et al., 2007, Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen., Toxicology

Asher et al., 2003, P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1., Proc. Natl. Acad. Sci. U.S.A.

Anwar et al., 2002, Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1., J. Biol. Chem.

DTC: NQO1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Andreani A et al., 2010, Antitumor activity and COMPARE analysis of bis-indole derivatives., Bioorg Med Chem

Nolan KA et al., 2010, In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000181019
- Version: 31-May-2017
Alternate Names:

ENSG00000181019 Gene Symbol

NQO1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: DIA4
- Version: chembl_23
Alternate Names:

NMOR1 GENE_SYMBOL

NQO1 GENE_SYMBOL

NAD(P)H dehydrogenase [quinone] 1 UNIPROT

Gene Info:

Publications:
Tempus: NQO1
- Version: 11-November-2018
Alternate Names:

NQO1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: NQO1
- Version: 01-February-2022
Alternate Names:

NAD(P)H dehydrogenase [quinone] 1 Gene Name

P15559 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Mechanism of Interaction	Quinone reductase 1 modulator
Direct Interaction	yes
Trial Name	EPI-743

1728	Entrez Gene Id
P15559	Uniprot Accession
NQO1_HUMAN	Uniprot Id

NMOR1	GENE_SYMBOL
NQO1	GENE_SYMBOL
NAD(P)H dehydrogenase [quinone] 1	UNIPROT

NQO1 Gene Record

NQO1 1728 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15935810

Sources: PharmGKB

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Quinone reductase 1 modulator Direct Interaction yes Trial Name EPI-743

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 14634213 2113031 10419545 10949919 10874136 10755406 10683249

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21074425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20395150

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10939639 10614691 10190578 10654840 12069105

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17923278

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27740732 27581200 26257249 21923605

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10393963

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25545243 24533712 21946896 21479364 18511948 11160862 10208650

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24924344

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17188792

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
15935810

Sources:
PharmGKB

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Quinone reductase 1 modulator

Direct Interaction yes

Trial Name EPI-743

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
14634213 2113031 10419545 10949919 10874136 10755406 10683249

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21074425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20395150

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10939639 10614691 10190578 10654840 12069105

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
17923278

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
27740732 27581200 26257249 21923605

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10393963

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25545243 24533712 21946896 21479364 18511948 11160862 10208650

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24924344

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17188792

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10954045 9333325

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30237583

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12370763

Sources:
PharmGKB

Alternate Names:

NQO1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

1728 Entrez Gene Id

P15559 Uniprot Accession

NQO1_HUMAN Uniprot Id

Gene Info:

Target Subclass 1.6.5.2

Target Main Class Enzymes

Alternate Names:

NQO1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.6.5.5

Alternate Names:

PA31744 PharmGKB ID

Alternate Names:

NQO1 TTD Gene Abbreviation

T52389 TTD Target ID

Publications:

Gueven N et al., 2013, Therapeutic strategies for Leber's hereditary optic neuropathy: A current update., Intractable Rare Dis Res

Publications:

Andreani A et al., 2010, Antitumor activity and COMPARE analysis of bis-indole derivatives., Bioorg Med Chem

Nolan KA et al., 2010, In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)., Bioorg Med Chem Lett

Alternate Names:

ENSG00000181019 Gene Symbol

NQO1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NMOR1 GENE_SYMBOL

NQO1 GENE_SYMBOL

NAD(P)H dehydrogenase [quinone] 1 UNIPROT

Alternate Names:

NQO1 Gene Symbol