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NPR1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NPR1 4881 Druggable Genome

    Alternate Names:

    4881
    NATRIURETIC PEPTIDE RECEPTOR 1
    NPR1
    ANPRA
    ANPa
    GUC2A
    GUCY2A
    NPRA
    108960
    7943
    ENSG00000169418
    OTTHUMG00000037085
    P16066
    ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1
    ANPRA_HUMAN
    ANP-A
    NPR-A
    ANPR-A
    Guanylate cyclase A
    Atrial natriuretic peptide receptor type A
    GC-A
    ATRIAL NATRIURETIC PEPTIDE RECEPTOR A
    ATRIAL NATRIURETIC PEPTIDE RECEPTOR A PRECURSOR (ANP-A) (ANPRA) (GC-A) (GUANYLATE CYCLASE) (EC 4.6.1.2) (NPR-A) (ATRIAL NATRIURETIC PEPTIDE A-TYPE RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P16066]
    T71230

    Gene Info:

    Interpro Acc IPR001245
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Type Domain
    Interpro Acc IPR001170
    Interpro Short Name Ntpep_rcpt
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name A/G_cyclase
    Interpro Name Natriuretic peptide receptor
    Interpro Acc IPR001054
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Human Readable Name KINASE
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase
    Target Subclass RGC
    Target Main Class Receptors
    Transmembrane Helix Count 1
    Target Subclass Kinase
    Target Class Receptors
    Target Subclass EC:4.6.1.2
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUGGABLE GENOME

    Publications:

    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Fortin et al., 2006, Role of cyclic GMP and calcineurin in homologous and heterologous desensitization of natriuretic peptide receptor-A., Can. J. Physiol. Pharmacol.
    Madhani et al., 2006, Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo., Br. J. Pharmacol.
    Steinmetz et al., 2004, Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice., Regul. Pept.
    Bauersachs, 2009, Aminoethyl nitrate--the novel super nitrate?, Br. J. Pharmacol.
    Madhani et al., 2003, Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling., Br. J. Pharmacol.
    Edelson JD et al., 2013, In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator., Pulm Pharmacol Ther
  • PL-3994   NPR1

    Interaction Score: 23.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name PL-3994
    Novel drug target Established target

    PMIDs:
    23154072


    Sources:
    TdgClinicalTrial TTD

  • NITROPRUSSIDE   NPR1

    Interaction Score: 12.88

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16902599 17016498 15093694


    Sources:
    TdgClinicalTrial TEND

  • NESIRITIDE   NPR1

    Interaction Score: 12.88

    Interaction Types & Directionality:
    agonist (activating)
    binder

    Interaction Info:
    Mechanism of Interaction Atrial natriuretic peptide receptor A agonist
    Direct Interaction yes
    Trial Name nesiritide ,Natrecor

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • ATACIGUAT   NPR1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ULARITIDE   NPR1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CENDERITIDE   NPR1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ISOSORBIDE MONONITRATE   NPR1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • NITROGLYCERIN   NPR1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MQX-503, nitroglycerin 0.9% topical cream,Vascana
    Novel drug target Established target

    PMIDs:
    19732062 12890708


    Sources:
    TdgClinicalTrial TEND

  • Ensembl: ENSG00000169418

    • Version: 101_38

    Alternate Names:
    NPR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000169418

    • Version: 26-July-2011

    Alternate Names:
    ATRIAL NATRIURETIC PEPTIDE RECEPTOR A PRECURSOR (ANP-A) (ANPRA) (GC-A) (GUANYLATE CYCLASE) (EC 4.6.1.2) (NPR-A) (ATRIAL NATRIURETIC PEPTIDE A-TYPE RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P16066] Description
    NPR1 Display Id
    ENSG00000169418 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P16066

    • Version: January-2014

    Alternate Names:
    NPR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass EC:4.6.1.2

    Publications:

  • TEND: P16066

    • Version: 01-August-2011

    Alternate Names:
    NPR1 Gene Symbol
    P16066 Uniprot Accession
    ANPRA_HUMAN Uniprot Id

    Gene Info:
    Target Subclass RGC
    Target Main Class Receptors
    Transmembrane Helix Count 1

    Publications:

  • HopkinsGroom: P16066

    • Version: 11-September-2012

    Alternate Names:
    ANPRA_HUMAN Uniprot Id
    ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1 Uniprot Protein Name
    4881 Entrez Gene Id

    Gene Info:
    Interpro Acc IPR001245
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • TTD: Atrial natriuretic peptide receptor A

    • Version: 2020.06.01

    Alternate Names:
    NPR1 TTD Gene Abbreviation
    T71230 TTD Target ID

    Gene Info:

    Publications:
    Edelson JD et al., 2013, In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator., Pulm Pharmacol Ther

  • HingoraniCasas: ENSG00000169418

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000169418 Gene Symbol
    NPR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ANPRA

    • Version: chembl_23

    Alternate Names:
    ANPRA GENE_SYMBOL
    NPR1 GENE_SYMBOL
    Atrial natriuretic peptide receptor 1 UNIPROT

    Gene Info:

    Publications:

  • Pharos: NPR1

    • Version: 01-February-2022

    Alternate Names:
    Atrial natriuretic peptide receptor 1 Gene Name
    P16066 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21