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NOTCH4 Gene Record

  • Summary
  • Interactions
  • Claims
  • NOTCH4 4855 Druggable GenomeClinically Actionable

    Alternate Names:

    4855
    NOTCH 4
    NOTCH4
    INT3
    164951
    7884
    ENSG00000204301
    OTTHUMG00000031044
    Notch Pathway
    PA31686
    Notch-4 receptor
    T49453
    notch receptor 4

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Cheng L et al., 2018, The minor alleles HCP5 rs3099844 A and PSORS1C1 rs3131003 G are associated with allopurinol-induced severe cutaneous adverse reactions in Han Chinese: a multicentre retrospective case-control clinical study., Br J Dermatol
  • CRENIGACESTAT   NOTCH4

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NIROGACESTAT   NOTCH4

    Interaction Score: 3.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • RG-4733   NOTCH4

    Interaction Score: 3.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • ALLOPURINOL   NOTCH4

    Interaction Score: 1.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29193002


    Sources:
    PharmGKB

  • Ensembl: ENSG00000204301

    • Version: 101_38

    Alternate Names:
    NOTCH4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: NOTCH4

    • Version: 18-August-2020

    Alternate Names:
    PA31686 PharmGKB ID

    Gene Info:

    Publications:
    Cheng L et al., 2018, The minor alleles HCP5 rs3099844 A and PSORS1C1 rs3131003 G are associated with allopurinol-induced severe cutaneous adverse reactions in Han Chinese: a multicentre retrospective case-control clinical study., Br J Dermatol

  • HingoraniCasas: ENSG00000204301

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000204301 Gene Symbol
    NOTCH4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • MyCancerGenome: NOTCH4

    • Version: 20-Jun-2017

    Alternate Names:
    4855 Entrez Gene Id
    NOTCH4 MyCancerGenome Gene Symbol
    Notch Pathway MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • GO: NOTCH4

    • Version: 01-February-2022

    Alternate Names:
    INT3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • TTD: Notch-4 receptor

    • Version: 2020.06.01

    Alternate Names:
    NOTCH4 TTD Gene Abbreviation
    T49453 TTD Target ID

    Gene Info:

    Publications:

  • MskImpact: NOTCH4

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: NOTCH4

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21