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NOS2 Gene Record

  • Summary
  • Interactions
  • Claims
  • NOS2 4843 Druggable Genome

    Alternate Names:

    4843
    NITRIC OXIDE SYNTHASE 2
    NOS2
    HEP-NOS
    INOS
    NOS
    NOS2A
    163730
    7873
    ENSG00000007171
    OTTHUMG00000132445
    P35228
    NOS2_HUMAN
    NITRIC OXIDE SYNTHASE, INDUCIBLE
    NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) (HEPATOCYTE NOS) (HEP-NOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P35228]
    PA164724093
    Nitric-oxide synthase inducible
    T02703

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:1.14.13.39
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Name Oxidoreductase FAD/NAD(P)-binding
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name OxRdtase_FAD/NAD-bd
    Interpro Acc IPR001433
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Hazell, 2002, Astrocytes and manganese neurotoxicity., Neurochem. Int.
    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    Nayeem et al., Ischemic and pharmacological induction of delayed cellular protection in iNOS gene-disrupted mice myocytes., Pol J Pharmacol
    Ha et al., 2006, Fluoxetine increases the nitric oxide production via nuclear factor kappa B-mediated pathway in BV2 murine microglial cells., Neurosci. Lett.
    Richette et al., 2007, Oestrogens inhibit interleukin 1beta-mediated nitric oxide synthase expression in articular chondrocytes through nuclear factor-kappa B impairment., Ann. Rheum. Dis.
    Nishida CR et al., 2008, Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase., J Med Chem
    Gahm et al., 2005, Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine., Acta Neurochir (Wien)
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
    Wickley et al., 2006, Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes., Anesthesiology
    Trubiani et al., 2005, NF-kappaB and NOS may play a role in human RPMI-8402 cell apoptosis., Cell Biol. Int.
    Zarrindast et al., 2002, Role of nitric oxide in systemic effect of theophylline on mouse body temperature., Eur. J. Pharmacol.
    Nanashima K et al., 2012, Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients., Tuberculosis (Edinb)
    Fu et al., 2005, A reduction of endogenous asymmetric dimethylarginine contributes to the effect of captopril on endothelial dysfunction induced by homocysteine in rats., Eur. J. Pharmacol.
  • PIMAGEDINE   NOS2

    Interaction Score: 7.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10592235 17016423 17139284 11752352


    Sources:
    TTD

  • BANOXANTRONE   NOS2

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18681417


    Sources:
    DTC

  • ALT-2074   NOS2

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GW-274150   NOS2

    Interaction Score: 2.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • KD7040   NOS2

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name KD7040
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TILARGININE   NOS2

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name tilarginine acetate

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • BENZODIAZEPINE   NOS2

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12106778


    Sources:
    NCI

  • DIMETHYL SULFOXIDE   NOS2

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15919216


    Sources:
    NCI

  • CAPTOPRIL   NOS2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15680268


    Sources:
    NCI

  • ISONIAZID   NOS2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22341855


    Sources:
    PharmGKB

  • DIAZOXIDE   NOS2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12856829


    Sources:
    NCI

  • NIMODIPINE   NOS2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16044358


    Sources:
    NCI

  • RIFAMPIN   NOS2

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22341855


    Sources:
    PharmGKB

  • THEOPHYLLINE   NOS2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12223230


    Sources:
    NCI

  • DOXYCYCLINE   NOS2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenomeClinicalTrial

  • FLUOXETINE   NOS2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16413968


    Sources:
    NCI

  • PROPOFOL   NOS2

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16645450


    Sources:
    NCI

  • ESTRADIOL   NOS2

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17068060


    Sources:
    NCI

  • IBUPROFEN   NOS2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25502615


    Sources:
    PharmGKB

  • DOXORUBICIN   NOS2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21048526


    Sources:
    PharmGKB

  • CURCUMIN   NOS2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000007171

    • Version: 101_38

    Alternate Names:
    NOS2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P35228

    • Version: January-2014

    Alternate Names:
    NOS2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.13.39

    Publications:

  • HopkinsGroom: P35228

    • Version: 11-September-2012

    Alternate Names:
    NOS2 Uniprot Gene Name
    NITRIC OXIDE SYNTHASE, INDUCIBLE Uniprot Protein Name
    ENSG00000007171 Ensembl Gene Id

    Gene Info:
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Name Oxidoreductase FAD/NAD(P)-binding

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000007171

    • Version: 26-July-2011

    Alternate Names:
    NOS2A Display Id
    ENSG00000007171 Ensembl Gene Id
    NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) (HEPATOCYTE NOS) (HEP-NOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P35228] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: NOS2

    • Version: 18-August-2020

    Alternate Names:
    PA164724093 PharmGKB ID

    Gene Info:

    Publications:
    Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
    Nanashima K et al., 2012, Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients., Tuberculosis (Edinb)
    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics

  • TTD: Nitric-oxide synthase inducible

    • Version: 2020.06.01

    Alternate Names:
    NOS2 TTD Gene Abbreviation
    T02703 TTD Target ID

    Gene Info:

    Publications:
    Letari O et al., 2010, Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice., Cancer Chemother Pharmacol

  • NCI: NOS2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Hazell, 2002, Astrocytes and manganese neurotoxicity., Neurochem. Int.
    Wickley et al., 2006, Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes., Anesthesiology
    Fu et al., 2005, A reduction of endogenous asymmetric dimethylarginine contributes to the effect of captopril on endothelial dysfunction induced by homocysteine in rats., Eur. J. Pharmacol.

  • DTC: NOS2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Nishida CR et al., 2008, Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase., J Med Chem

  • HingoraniCasas: ENSG00000007171

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000007171 Gene Symbol
    NOS2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • MyCancerGenomeClinicalTrial: NOS2

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21