DGIdb - NOS2 Gene Record

NOS2 4843 Druggable Genome

Alternate Names:

4843
NITRIC OXIDE SYNTHASE 2
NOS2
HEP-NOS
INOS
NOS
NOS2A
163730
7873
ENSG00000007171
OTTHUMG00000132445
P35228
NOS2_HUMAN
NITRIC OXIDE SYNTHASE, INDUCIBLE
NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) (HEPATOCYTE NOS) (HEP-NOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P35228]
PA164724093
Nitric-oxide synthase inducible
T02703

Gene Info:

Target Class	Enzymes
Target Subclass	EC:1.14.13.39
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Name	Oxidoreductase FAD/NAD(P)-binding
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	OxRdtase_FAD/NAD-bd
Interpro Acc	IPR001433
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Hazell, 2002, Astrocytes and manganese neurotoxicity., Neurochem. Int.
Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
Nayeem et al., Ischemic and pharmacological induction of delayed cellular protection in iNOS gene-disrupted mice myocytes., Pol J Pharmacol
Ha et al., 2006, Fluoxetine increases the nitric oxide production via nuclear factor kappa B-mediated pathway in BV2 murine microglial cells., Neurosci. Lett.
Richette et al., 2007, Oestrogens inhibit interleukin 1beta-mediated nitric oxide synthase expression in articular chondrocytes through nuclear factor-kappa B impairment., Ann. Rheum. Dis.
Nishida CR et al., 2008, Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase., J Med Chem
Gahm et al., 2005, Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine., Acta Neurochir (Wien)
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
Wickley et al., 2006, Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes., Anesthesiology
Trubiani et al., 2005, NF-kappaB and NOS may play a role in human RPMI-8402 cell apoptosis., Cell Biol. Int.
Zarrindast et al., 2002, Role of nitric oxide in systemic effect of theophylline on mouse body temperature., Eur. J. Pharmacol.
Nanashima K et al., 2012, Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients., Tuberculosis (Edinb)
Fu et al., 2005, A reduction of endogenous asymmetric dimethylarginine contributes to the effect of captopril on endothelial dysfunction induced by homocysteine in rats., Eur. J. Pharmacol.

PIMAGEDINE NOS2

Interaction Score: 7.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235 17016423 17139284 11752352

Sources:
TTD
BANOXANTRONE NOS2

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18681417

Sources:
DTC
ALT-2074 NOS2

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GW-274150 NOS2

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
KD7040 NOS2

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name KD7040

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
TILARGININE NOS2

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name tilarginine acetate

PMIDs:
None found

Sources:
TdgClinicalTrial
BENZODIAZEPINE NOS2

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12106778

Sources:
NCI
DIMETHYL SULFOXIDE NOS2

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15919216

Sources:
NCI
CAPTOPRIL NOS2

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15680268

Sources:
NCI
ISONIAZID NOS2

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22341855

Sources:
PharmGKB
DIAZOXIDE NOS2

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12856829

Sources:
NCI
NIMODIPINE NOS2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16044358

Sources:
NCI
RIFAMPIN NOS2

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22341855

Sources:
PharmGKB
THEOPHYLLINE NOS2

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12223230

Sources:
NCI
DOXYCYCLINE NOS2

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial
FLUOXETINE NOS2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16413968

Sources:
NCI
PROPOFOL NOS2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16645450

Sources:
NCI
ESTRADIOL NOS2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17068060

Sources:
NCI
IBUPROFEN NOS2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25502615

Sources:
PharmGKB
DOXORUBICIN NOS2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21048526

Sources:
PharmGKB
CURCUMIN NOS2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000007171
- Version: 101_38
Alternate Names:

NOS2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P35228
- Version: January-2014
Alternate Names:

NOS2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.13.39

Publications:
HopkinsGroom: P35228
- Version: 11-September-2012
Alternate Names:

NOS2 Uniprot Gene Name

NITRIC OXIDE SYNTHASE, INDUCIBLE Uniprot Protein Name

ENSG00000007171 Ensembl Gene Id

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Interpro Name Oxidoreductase FAD/NAD(P)-binding

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000007171

Version: 26-July-2011

Alternate Names:

NOS2A Display Id

ENSG00000007171 Ensembl Gene Id

NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) (HEPATOCYTE NOS) (HEP-NOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P35228] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: NOS2

Version: 18-August-2020

Alternate Names:

PA164724093 PharmGKB ID

Gene Info:

Publications:

Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics

Nanashima K et al., 2012, Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients., Tuberculosis (Edinb)

Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics

TTD: Nitric-oxide synthase inducible

Version: 2020.06.01

Alternate Names:

NOS2 TTD Gene Abbreviation

T02703 TTD Target ID

Gene Info:

Publications:

Letari O et al., 2010, Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice., Cancer Chemother Pharmacol

NCI: NOS2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Hazell, 2002, Astrocytes and manganese neurotoxicity., Neurochem. Int.

Wickley et al., 2006, Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes., Anesthesiology

Fu et al., 2005, A reduction of endogenous asymmetric dimethylarginine contributes to the effect of captopril on endothelial dysfunction induced by homocysteine in rats., Eur. J. Pharmacol.

DTC: NOS2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Nishida CR et al., 2008, Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase., J Med Chem
HingoraniCasas: ENSG00000007171
- Version: 31-May-2017
Alternate Names:

ENSG00000007171 Gene Symbol

NOS2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenomeClinicalTrial: NOS2
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:

NOS2	Uniprot Gene Name
NITRIC OXIDE SYNTHASE, INDUCIBLE	Uniprot Protein Name
ENSG00000007171	Ensembl Gene Id

NOS2A	Display Id
ENSG00000007171	Ensembl Gene Id
NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) (HEPATOCYTE NOS) (HEP-NOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P35228]	Description

Trial Name	KD7040
Novel drug target	Novel Target

Novel drug target	Novel Target
Trial Name	tilarginine acetate

NOS2 Gene Record

NOS2 4843 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10592235 17016423 17139284 11752352

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18681417

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name KD7040 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name tilarginine acetate

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12106778

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15919216

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15680268

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22341855

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12856829

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16044358

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22341855

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12223230

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenomeClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16413968

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16645450

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17068060

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10592235 17016423 17139284 11752352

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
18681417

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name KD7040

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name tilarginine acetate

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
12106778

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15919216

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15680268

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22341855

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12856829

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16044358

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22341855

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12223230

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
16413968

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16645450

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17068060

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25502615

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21048526

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

NOS2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

NOS2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.13.39

Alternate Names:

NOS2 Uniprot Gene Name

NITRIC OXIDE SYNTHASE, INDUCIBLE Uniprot Protein Name

ENSG00000007171 Ensembl Gene Id

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Interpro Name Oxidoreductase FAD/NAD(P)-binding

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NOS2A Display Id

ENSG00000007171 Ensembl Gene Id

NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) (HEPATOCYTE NOS) (HEP-NOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P35228] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA164724093 PharmGKB ID

Alternate Names:

NOS2 TTD Gene Abbreviation

T02703 TTD Target ID

Publications:

Letari O et al., 2010, Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice., Cancer Chemother Pharmacol

Publications:

Nishida CR et al., 2008, Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase., J Med Chem

Alternate Names:

ENSG00000007171 Gene Symbol

NOS2 Ensembl Id