DGIdb - NOS1 Gene Record

NOS1 4842 Druggable Genome

Alternate Names:

4842
NITRIC OXIDE SYNTHASE 1
NOS1
IHPS1
N-NOS
NC-NOS
NOS
bNOS
nNOS
163731
7872
ENSG00000089250
OTTHUMG00000137376
P29475
NOS1_HUMAN
NITRIC OXIDE SYNTHASE, BRAIN
NITRIC-OXIDE SYNTHASE, BRAIN (EC 1.14.13.39) (NOS, TYPE I) (NEURONAL NOS) (N-NOS) (NNOS) (CONSTITUTIVE NOS) (NC-NOS) (BNOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P29475]
PA252
Nitric-oxide synthase brain
T16117

Gene Info:

Interpro Type	Domain
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Acc	IPR001433
Interpro Short Name	OxRdtase_FAD/NAD-bd
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Oxidoreductase FAD/NAD(P)-binding
Target Class	Enzymes
Target Subclass	EC:1.14.13.39
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
Elfline et al., 2004, Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze., Neuropsychopharmacology
Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry
Singh et al., 2000, Castration increases and androgens decrease nitric oxide synthase activity in the brain: physiologic implications., Proc. Natl. Acad. Sci. U.S.A.
Solano et al., 2006, Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice., Reprod. Fertil. Dev.
Ni et al., 2001, Effect of salt loading on nitric oxide synthase expression in normotensive rats., Am. J. Hypertens.
Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol
Weiner et al., 1994, Induction of calcium-dependent nitric oxide synthases by sex hormones., Proc. Natl. Acad. Sci. U.S.A.
Aliev et al., 2000, Decreased constitutive nitric oxide synthase, but increased inducible nitric oxide synthase and endothelin-1 immunoreactivity in aortic endothelial cells of donryu rats on a cholesterol-enriched diet., Anat. Rec.
Tuettenberg et al., 2001, Nitric oxide modulates cerebral blood flow stimulation by acetazolamide in the rat cortex: a laser Doppler scanning study., Neurosci. Lett.
Sun et al., 1996, Protective effect of interleukin-1 receptor antagonist on oleic acid-induced lung injury., Chin. Med. J.
Sara et al., 2004, The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle., Eur. J. Pharmacol.
Farkas-Szallasi et al., 1995, Increased levels of GMAP, VIP and nitric oxide synthase, and their mRNAs, in lumbar dorsal root ganglia of the rat following systemic resiniferatoxin treatment., Neuroreport
Aoki et al., 2006, mTOR pathway inhibition attenuates skeletal muscle growth induced by stretching., Cell Tissue Res.
Ren et al., 2005, [Effects of glycosides of Tripterygium wilfordii, methyltestosterone and zhuanggushenjin capsule on nitric oxide synthase in rat testes]., Zhonghua Nan Ke Xue
Lu et al., 1998, [Effect of nitric oxide release on epileptiform discharge in CA1 area of hippocampal slices]., Sheng Li Xue Bao
Alvarez et al., 2005, Inhibition of bacillus Calmette-Guérin-induced nitric oxide in bladder tumor cells may improve BCG treatment., Int. J. Mol. Med.
Sterin-Borda et al., Involvement of nitric oxide synthase and protein kinase C activation on chagasic antibodies action upon cardiac contractility., Mol. Cell. Biochem.
Rawls et al., 2006, Baclofen and NOS inhibitors interact to evoke synergistic hypothermia in rats., Life Sci.
Rawls et al., 2004, Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor., Eur. J. Pharmacol.
Zarrindast et al., 2002, Role of nitric oxide in systemic effect of theophylline on mouse body temperature., Eur. J. Pharmacol.
Afonso et al., 2006, Carvedilol action is dependent on endogenous production of nitric oxide., Am. J. Hypertens.
Garner et al., 1999, Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents., Cancer Res.
Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
Wickley et al., 2006, Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes., Anesthesiology
Fernández et al., 1997, Influence of hyperthyroidism on the activity of liver nitric oxide synthase in the rat., Nitric Oxide
Oka et al., 2003, Gabapentin blocks L-type and P/Q-type Ca2+ channels involved in depolarization-stimulated nitric oxide synthase activity in primary cultures of neurons from mouse cerebral cortex., Pharm. Res.
St-Pierre et al., 2004, Rosiglitazone increases extravasation of macromolecules and endothelial nitric oxide synthase in skeletal muscles of the fructose-fed rat model., Biochem. Pharmacol.
Christopher et al., 2002, Idoxifene causes endothelium-dependent, nitric oxide-mediated vasorelaxation in male rats., Eur. J. Pharmacol.
Shankar et al., 2001, Involvement of nitric oxide in the antiaggregatory effect of enalapril., Methods Find Exp Clin Pharmacol
Verma et al., 2004, Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells., J. Surg. Res.
Birnbaum et al., 2005, Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury., Cardiovasc. Res.
Kuo et al., 1995, Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide., Surgery
Karmeli et al., 2000, Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats., Eur J Gastroenterol Hepatol
Sullivan et al., 2002, Functional NOS 1 in the rat mesenteric arterial bed., Am. J. Physiol. Heart Circ. Physiol.

RESINIFERATOXIN NOS1

Interaction Score: 1.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8595209

Sources:
NCI
THIOURACIL NOS1

Interaction Score: 1.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10967532

Sources:
NCI
TIRAPAZAMINE NOS1

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10213502

Sources:
NCI
IDOXIFENE NOS1

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12098595

Sources:
NCI
PENICILLIN G POTASSIUM NOS1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11367745

Sources:
NCI
METHYLTESTOSTERONE NOS1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15934456

Sources:
NCI
BENZODIAZEPINE NOS1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15136793

Sources:
NCI
BACLOFEN NOS1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16137704 15476754

Sources:
NCI
ANAKINRA NOS1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9206098

Sources:
NCI
AZITHROMYCIN NOS1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14730107

Sources:
NCI
PRAZOSIN NOS1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9322222

Sources:
NCI
CIMETIDINE NOS1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7543704

Sources:
NCI
ACETAZOLAMIDE NOS1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11711216

Sources:
NCI
NIMESULIDE NOS1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10741939

Sources:
NCI
BCG VACCINE NOS1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16142388

Sources:
NCI
VOLANESORSEN SODIUM NOS1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11243307

Sources:
NCI
CLARITHROMYCIN NOS1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14730107

Sources:
NCI
PHENYLEPHRINE NOS1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12124213

Sources:
NCI
CARVEDILOL NOS1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16580580

Sources:
NCI
PRASTERONE NOS1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16836960

Sources:
NCI
ENALAPRIL NOS1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11712645

Sources:
NCI
ROSIGLITAZONE NOS1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15130775

Sources:
NCI
ANDROSTANOLONE NOS1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10725371

Sources:
NCI
THEOPHYLLINE NOS1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12223230

Sources:
NCI
STAUROSPORINE NOS1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8901458

Sources:
NCI
CAFFEINE NOS1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15556151

Sources:
NCI
GABAPENTIN NOS1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12817894

Sources:
NCI
PROPOFOL NOS1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16645450

Sources:
NCI
LIOTHYRONINE SODIUM NOS1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9466951

Sources:
NCI
IBUPROFEN NOS1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25502615

Sources:
PharmGKB
PRAVASTATIN NOS1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15126084

Sources:
NCI
TESTOSTERONE NOS1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7515189

Sources:
NCI
SIROLIMUS NOS1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16408196

Sources:
NCI
ATORVASTATIN NOS1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15639473

Sources:
NCI
EPIRUBICIN NOS1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DOXORUBICIN NOS1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21048526

Sources:
PharmGKB
CYCLOPHOSPHAMIDE NOS1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FLUOROURACIL NOS1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000089250
- Version: 101_38
Alternate Names:

NOS1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P29475
- Version: 11-September-2012
Alternate Names:

ENSG00000089250 Ensembl Gene Id

NITRIC OXIDE SYNTHASE, BRAIN Uniprot Protein Name

NOS1_HUMAN Uniprot Id

Gene Info:

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000089250

Version: 26-July-2011

Alternate Names:

NITRIC-OXIDE SYNTHASE, BRAIN (EC 1.14.13.39) (NOS, TYPE I) (NEURONAL NOS) (N-NOS) (NNOS) (CONSTITUTIVE NOS) (NC-NOS) (BNOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P29475] Description

ENSG00000089250 Ensembl Gene Id

NOS1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P29475
- Version: January-2014
Alternate Names:

NOS1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.13.39

Publications:

PharmGKB: NOS1

Version: 18-August-2020

Alternate Names:

PA252 PharmGKB ID

Gene Info:

Publications:

Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics

Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics

NCI: NOS1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Elfline et al., 2004, Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze., Neuropsychopharmacology

Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry

Solano et al., 2006, Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice., Reprod. Fertil. Dev.

HingoraniCasas: ENSG00000089250
- Version: 31-May-2017
Alternate Names:

ENSG00000089250 Gene Symbol

NOS1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Nitric-oxide synthase brain
- Version: 2020.06.01
Alternate Names:

NOS1 TTD Gene Abbreviation

T16117 TTD Target ID

Gene Info:

Publications:

ENSG00000089250	Ensembl Gene Id
NITRIC OXIDE SYNTHASE, BRAIN	Uniprot Protein Name
NOS1_HUMAN	Uniprot Id

NITRIC-OXIDE SYNTHASE, BRAIN (EC 1.14.13.39) (NOS, TYPE I) (NEURONAL NOS) (N-NOS) (NNOS) (CONSTITUTIVE NOS) (NC-NOS) (BNOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P29475]	Description
ENSG00000089250	Ensembl Gene Id
NOS1	Display Id

NOS1 Gene Record

NOS1 4842 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8595209

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10967532

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10213502

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12098595

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11367745

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15934456

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15136793

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16137704 15476754

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9206098

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14730107

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9322222

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7543704

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11711216

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10741939

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16142388

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11243307

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14730107

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12124213

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
8595209

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10967532

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10213502

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12098595

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11367745

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15934456

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15136793

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16137704 15476754

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9206098

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14730107

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9322222

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7543704

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11711216

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10741939

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16142388

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11243307

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14730107

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12124213

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16580580

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16836960

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11712645

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15130775

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10725371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12223230

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8901458

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15556151

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12817894