• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

NOS1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NOS1 4842 Druggable Genome

    Alternate Names:

    4842
    NITRIC OXIDE SYNTHASE 1
    NOS1
    IHPS1
    N-NOS
    NC-NOS
    NOS
    bNOS
    nNOS
    163731
    7872
    ENSG00000089250
    OTTHUMG00000137376
    P29475
    NOS1_HUMAN
    NITRIC OXIDE SYNTHASE, BRAIN
    NITRIC-OXIDE SYNTHASE, BRAIN (EC 1.14.13.39) (NOS, TYPE I) (NEURONAL NOS) (N-NOS) (NNOS) (CONSTITUTIVE NOS) (NC-NOS) (BNOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P29475]
    PA252
    Nitric-oxide synthase brain
    T16117

    Gene Info:

    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001433
    Interpro Short Name OxRdtase_FAD/NAD-bd
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Oxidoreductase FAD/NAD(P)-binding
    Target Class Enzymes
    Target Subclass EC:1.14.13.39
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    Elfline et al., 2004, Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze., Neuropsychopharmacology
    Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry
    Singh et al., 2000, Castration increases and androgens decrease nitric oxide synthase activity in the brain: physiologic implications., Proc. Natl. Acad. Sci. U.S.A.
    Solano et al., 2006, Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice., Reprod. Fertil. Dev.
    Ni et al., 2001, Effect of salt loading on nitric oxide synthase expression in normotensive rats., Am. J. Hypertens.
    Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol
    Weiner et al., 1994, Induction of calcium-dependent nitric oxide synthases by sex hormones., Proc. Natl. Acad. Sci. U.S.A.
    Aliev et al., 2000, Decreased constitutive nitric oxide synthase, but increased inducible nitric oxide synthase and endothelin-1 immunoreactivity in aortic endothelial cells of donryu rats on a cholesterol-enriched diet., Anat. Rec.
    Tuettenberg et al., 2001, Nitric oxide modulates cerebral blood flow stimulation by acetazolamide in the rat cortex: a laser Doppler scanning study., Neurosci. Lett.
    Sun et al., 1996, Protective effect of interleukin-1 receptor antagonist on oleic acid-induced lung injury., Chin. Med. J.
    Sara et al., 2004, The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle., Eur. J. Pharmacol.
    Farkas-Szallasi et al., 1995, Increased levels of GMAP, VIP and nitric oxide synthase, and their mRNAs, in lumbar dorsal root ganglia of the rat following systemic resiniferatoxin treatment., Neuroreport
    Aoki et al., 2006, mTOR pathway inhibition attenuates skeletal muscle growth induced by stretching., Cell Tissue Res.
    Ren et al., 2005, [Effects of glycosides of Tripterygium wilfordii, methyltestosterone and zhuanggushenjin capsule on nitric oxide synthase in rat testes]., Zhonghua Nan Ke Xue
    Lu et al., 1998, [Effect of nitric oxide release on epileptiform discharge in CA1 area of hippocampal slices]., Sheng Li Xue Bao
    Alvarez et al., 2005, Inhibition of bacillus Calmette-Guérin-induced nitric oxide in bladder tumor cells may improve BCG treatment., Int. J. Mol. Med.
    Sterin-Borda et al., Involvement of nitric oxide synthase and protein kinase C activation on chagasic antibodies action upon cardiac contractility., Mol. Cell. Biochem.
    Rawls et al., 2006, Baclofen and NOS inhibitors interact to evoke synergistic hypothermia in rats., Life Sci.
    Rawls et al., 2004, Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor., Eur. J. Pharmacol.
    Zarrindast et al., 2002, Role of nitric oxide in systemic effect of theophylline on mouse body temperature., Eur. J. Pharmacol.
    Afonso et al., 2006, Carvedilol action is dependent on endogenous production of nitric oxide., Am. J. Hypertens.
    Garner et al., 1999, Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents., Cancer Res.
    Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
    Wickley et al., 2006, Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes., Anesthesiology
    Fernández et al., 1997, Influence of hyperthyroidism on the activity of liver nitric oxide synthase in the rat., Nitric Oxide
    Oka et al., 2003, Gabapentin blocks L-type and P/Q-type Ca2+ channels involved in depolarization-stimulated nitric oxide synthase activity in primary cultures of neurons from mouse cerebral cortex., Pharm. Res.
    St-Pierre et al., 2004, Rosiglitazone increases extravasation of macromolecules and endothelial nitric oxide synthase in skeletal muscles of the fructose-fed rat model., Biochem. Pharmacol.
    Christopher et al., 2002, Idoxifene causes endothelium-dependent, nitric oxide-mediated vasorelaxation in male rats., Eur. J. Pharmacol.
    Shankar et al., 2001, Involvement of nitric oxide in the antiaggregatory effect of enalapril., Methods Find Exp Clin Pharmacol
    Verma et al., 2004, Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells., J. Surg. Res.
    Birnbaum et al., 2005, Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury., Cardiovasc. Res.
    Kuo et al., 1995, Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide., Surgery
    Karmeli et al., 2000, Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats., Eur J Gastroenterol Hepatol
    Sullivan et al., 2002, Functional NOS 1 in the rat mesenteric arterial bed., Am. J. Physiol. Heart Circ. Physiol.
  • RESINIFERATOXIN   NOS1

    Interaction Score: 1.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8595209


    Sources:
    NCI

  • THIOURACIL   NOS1

    Interaction Score: 1.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10967532


    Sources:
    NCI

  • TIRAPAZAMINE   NOS1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10213502


    Sources:
    NCI

  • IDOXIFENE   NOS1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12098595


    Sources:
    NCI

  • PENICILLIN G POTASSIUM   NOS1

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11367745


    Sources:
    NCI

  • METHYLTESTOSTERONE   NOS1

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15934456


    Sources:
    NCI

  • BENZODIAZEPINE   NOS1

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15136793


    Sources:
    NCI

  • BACLOFEN   NOS1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16137704 15476754


    Sources:
    NCI

  • ANAKINRA   NOS1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9206098


    Sources:
    NCI

  • AZITHROMYCIN   NOS1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14730107


    Sources:
    NCI

  • PRAZOSIN   NOS1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9322222


    Sources:
    NCI

  • CIMETIDINE   NOS1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7543704


    Sources:
    NCI

  • ACETAZOLAMIDE   NOS1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11711216


    Sources:
    NCI

  • NIMESULIDE   NOS1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10741939


    Sources:
    NCI

  • BCG VACCINE   NOS1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16142388


    Sources:
    NCI

  • VOLANESORSEN SODIUM   NOS1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11243307


    Sources:
    NCI

  • CLARITHROMYCIN   NOS1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14730107


    Sources:
    NCI

  • PHENYLEPHRINE   NOS1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12124213


    Sources:
    NCI

  • CARVEDILOL   NOS1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16580580


    Sources:
    NCI

  • PRASTERONE   NOS1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16836960


    Sources:
    NCI

  • ENALAPRIL   NOS1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11712645


    Sources:
    NCI

  • ROSIGLITAZONE   NOS1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15130775


    Sources:
    NCI

  • ANDROSTANOLONE   NOS1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10725371


    Sources:
    NCI

  • THEOPHYLLINE   NOS1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12223230


    Sources:
    NCI

  • STAUROSPORINE   NOS1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8901458


    Sources:
    NCI

  • CAFFEINE   NOS1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15556151


    Sources:
    NCI

  • GABAPENTIN   NOS1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12817894


    Sources:
    NCI

  • PROPOFOL   NOS1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16645450


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   NOS1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9466951


    Sources:
    NCI

  • IBUPROFEN   NOS1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25502615


    Sources:
    PharmGKB

  • PRAVASTATIN   NOS1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15126084


    Sources:
    NCI

  • TESTOSTERONE   NOS1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7515189


    Sources:
    NCI

  • SIROLIMUS   NOS1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16408196


    Sources:
    NCI

  • ATORVASTATIN   NOS1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15639473


    Sources:
    NCI

  • EPIRUBICIN   NOS1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOXORUBICIN   NOS1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21048526


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   NOS1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUOROURACIL   NOS1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000089250

    • Version: 101_38

    Alternate Names:
    NOS1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P29475

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000089250 Ensembl Gene Id
    NITRIC OXIDE SYNTHASE, BRAIN Uniprot Protein Name
    NOS1_HUMAN Uniprot Id

    Gene Info:
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000089250

    • Version: 26-July-2011

    Alternate Names:
    NITRIC-OXIDE SYNTHASE, BRAIN (EC 1.14.13.39) (NOS, TYPE I) (NEURONAL NOS) (N-NOS) (NNOS) (CONSTITUTIVE NOS) (NC-NOS) (BNOS). [SOURCE:UNIPROT/SWISSPROT;ACC:P29475] Description
    ENSG00000089250 Ensembl Gene Id
    NOS1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P29475

    • Version: January-2014

    Alternate Names:
    NOS1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.13.39

    Publications:

  • PharmGKB: NOS1

    • Version: 18-August-2020

    Alternate Names:
    PA252 PharmGKB ID

    Gene Info:

    Publications:
    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics

  • NCI: NOS1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Elfline et al., 2004, Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze., Neuropsychopharmacology
    Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry
    Solano et al., 2006, Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice., Reprod. Fertil. Dev.

  • HingoraniCasas: ENSG00000089250

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000089250 Gene Symbol
    NOS1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Nitric-oxide synthase brain

    • Version: 2020.06.01

    Alternate Names:
    NOS1 TTD Gene Abbreviation
    T16117 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21