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NME1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NME1 4830

    Alternate Names:

    4830
    NME/NM23 NUCLEOSIDE DIPHOSPHATE KINASE 1
    NME1
    AWD
    GAAD
    NB
    NBS
    NDKA
    NDPK-A
    NDPKA
    NM23
    NM23-H1
    156490
    7849
    ENSG00000239672
    OTTHUMG00000137474
    BE0003106
    P15531
    PA249
    Nucleoside diphosphate kinase A

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    KINASE

    Publications:

    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Huang et al., 2005, Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells., J. Nutr.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    She YM et al., 2003, Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry., Mol Cell Proteomics
    Smith SD et al., 2004, Using immobilized metal affinity chromatography, two-dimensional electrophoresis and mass spectrometry to identify hepatocellular proteins with copper-binding ability., J Proteome Res
    Buczynski G et al., 1990, Nucleoside diphosphate kinase from Xenopus oocytes; partial purification and characterization., Biochim Biophys Acta
  • DEOXYGUANOSINE TRIPHOSPHATE   NME1

    Interaction Score: 15.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • ADENOSINE PHOSPHONOACETIC ACID   NME1

    Interaction Score: 15.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • STAVUDINE TRIPHOSPHATE   NME1

    Interaction Score: 15.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL259724   NME1

    Interaction Score: 15.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL1232205   NME1

    Interaction Score: 15.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL405730   NME1

    Interaction Score: 15.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • SELENOCYSTEINE   NME1

    Interaction Score: 7.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • LYCOPENE   NME1

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16140886


    Sources:
    NCI

  • CHEMBL384759   NME1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • TENOFOVIR   NME1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ZIDOVUDINE   NME1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • LAMIVUDINE   NME1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ZINC CHLORIDE   NME1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    14534351 2176546


    Sources:
    DrugBank

  • COPPER   NME1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • METHYLDOPA   NME1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351


    Sources:
    DrugBank

  • Ensembl: ENSG00000239672

    • Version: 101_38

    Alternate Names:
    NME1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: NME1

    • Version: 18-August-2020

    Alternate Names:
    PA249 PharmGKB ID

    Gene Info:

    Publications:
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

  • DrugBank: BE0003106

    • Version: 5.1.7

    Alternate Names:
    NME1 DrugBank Gene Name
    P15531 UniProt Accession
    4830 Entrez Gene Id

    Gene Info:

    Publications:
    She YM et al., 2003, Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry., Mol Cell Proteomics
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

  • NCI: NME1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Huang et al., 2005, Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells., J. Nutr.

  • Pharos: NME1

    • Version: 03-September-2020

    Alternate Names:
    Nucleoside diphosphate kinase A Gene Name
    P15531 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21