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NF2 Gene Record

  • Summary
  • Interactions
  • Claims
  • NF2 4771 Clinically ActionableDrug Resistance

    Alternate Names:

    4771
    NEUROFIBROMIN 2
    NF2
    ACN
    BANF
    SCH
    607379
    7773
    ENSG00000186575
    OTTHUMG00000030727
    3870
    merlin-1
    NF2, MOESIN-EZRIN-RADIXIN LIKE (MERLIN) TUMOR SUPPRESSOR
    P35240
    Merlin

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    KINASE
    DRUG RESISTANCE
    CLINICALLY ACTIONABLE

    Publications:

    Sheffield et al., 2015, Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing., PLoS ONE
    Garcia-Rendueles et al., 2015, NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition., Cancer Discov
    Goutagny et al., 2015, Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas., J. Neurooncol.
    Watkin et al., 1989, Sequential combination chemotherapy and radiotherapy in locally advanced non-small cell carcinoma of the bronchus., Respir Med
    Karajannis et al., 2014, Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas., Neuro-oncology
    Moulder et al., 2015, Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancer., Ann. Oncol.
  • TEMSIROLIMUS   NF2

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25878190


    Sources:
    CIViC

  • EVEROLIMUS   NF2

    Interaction Score: 1.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25567352 2556735 24311643


    Sources:
    CIViC

  • SELUMETINIB   NF2

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26359368


    Sources:
    CIViC

  • CARBOPLATIN   NF2

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25798586


    Sources:
    CIViC

  • CISPLATIN   NF2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25798586


    Sources:
    CIViC

  • Ensembl: ENSG00000186575

    • Version: 101_38

    Alternate Names:
    NF2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: NF2

    • Version: 14-September-2020

    Alternate Names:
    4771 Entrez Gene ID
    3870 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Sheffield et al., 2015, Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing., PLoS ONE
    Garcia-Rendueles et al., 2015, NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition., Cancer Discov
    Moulder et al., 2015, Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancer., Ann. Oncol.

  • GO: NF2

    • Version: 01-February-2022

    Alternate Names:
    SCH GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications:

  • Tempus: NF2

    • Version: 11-November-2018

    Alternate Names:
    NF2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: NF2

    • Version: 01-February-2022

    Alternate Names:
    Merlin Gene Name
    P35240 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: NF2

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: NF2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: NF2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: NF2

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21