DGIdb - NF2 Gene Record

NF2 4771 Clinically ActionableDrug Resistance

Alternate Names:

4771
NEUROFIBROMIN 2
NF2
ACN
BANF
SCH
607379
7773
ENSG00000186575
OTTHUMG00000030727
3870
P35240
Merlin

Gene Info:

Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
KINASE
DRUG RESISTANCE
CLINICALLY ACTIONABLE

Publications:

Sheffield et al., 2015, Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing., PLoS ONE
Mukherjee et al., 2009, Human schwannomas express activated platelet-derived growth factor receptors and c-kit and are growth inhibited by Gleevec (Imatinib Mesylate)., Cancer Res.
Rackemann et al., 1990, Uncemented press-fit total knee arthroplasty., J Arthroplasty
Hochart et al., 2015, Bevacizumab decreases vestibular schwannomas growth rate in children and teenagers with neurofibromatosis type 2., J. Neurooncol.
Plotkin et al., 2009, Hearing improvement after bevacizumab in patients with neurofibromatosis type 2., N. Engl. J. Med.
Plotkin et al., 2012, Bevacizumab for progressive vestibular schwannoma in neurofibromatosis type 2: a retrospective review of 31 patients., Otol. Neurotol.
Garcia-Rendueles et al., 2015, NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition., Cancer Discov
Goutagny et al., 2015, Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas., J. Neurooncol.
Karajannis et al., 2014, Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas., Neuro-oncology
Watkin et al., 1989, Sequential combination chemotherapy and radiotherapy in locally advanced non-small cell carcinoma of the bronchus., Respir Med
Baumslag, Trace metal studies in Bushman hair., Arch. Environ. Health
Karajannis et al., 2012, Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas., Neuro-oncology
Moulder et al., 2015, Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancer., Ann. Oncol.

TEMSIROLIMUS NF2

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25878190

Sources:
CIViC
EVEROLIMUS NF2

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family MTOR inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
25567352 24311643 2556735

Sources:
CIViC CGI
LAPATINIB NF2

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family ERBB2 inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
973739 22844108

Sources:
CGI
BEVACIZUMAB NF2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family VEGFR mAb inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
26022982 19587327 22805104

Sources:
CGI
OCTREOTIDE NF2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Everolimus;Octreotide

Drug family MTOR inhibitor;Somatostatin analog

Alteration NF2:del

PMIDs:
None found

Sources:
CGI
AR-42 NF2

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family HDAC inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
None found

Sources:
CGI
SELUMETINIB NF2

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26359368

Sources:
CIViC
IMATINIB NF2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family BCR-ABL inhibitor 1st gen&KIT inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
19509233 2290085

Sources:
CGI
CARBOPLATIN NF2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25798586

Sources:
CIViC
CETUXIMAB NF2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Erlotinib;Cetuximab

Drug family EGFR inhibitor 1st gen;EGFR mAb inhibitor

Alteration NF2:del;EGFR:.

PMIDs:
None found

Sources:
CGI
ERLOTINIB NF2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family EGFR inhibitor 1st gen

Alteration NF2:del

Alteration NF2:.

PMIDs:
None found

Sources:
CGI
CISPLATIN NF2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25798586

Sources:
CIViC

Ensembl: ENSG00000186575
- Version: 101_38
Alternate Names:

NF2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

CIViC: NF2

Version: 14-September-2020

Alternate Names:

4771 Entrez Gene ID

3870 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Sheffield et al., 2015, Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing., PLoS ONE

Garcia-Rendueles et al., 2015, NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition., Cancer Discov

Moulder et al., 2015, Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancer., Ann. Oncol.

CGI: NF2

Version: 27-September-2017

Alternate Names:

Gene Info:

Publications:

Karajannis et al., 2014, Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas., Neuro-oncology

Watkin et al., 1989, Sequential combination chemotherapy and radiotherapy in locally advanced non-small cell carcinoma of the bronchus., Respir Med

Mukherjee et al., 2009, Human schwannomas express activated platelet-derived growth factor receptors and c-kit and are growth inhibited by Gleevec (Imatinib Mesylate)., Cancer Res.

Pharos: NF2
- Version: 03-September-2020
Alternate Names:

Merlin Gene Name

P35240 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: NF2
- Version: 05-September-2020
Alternate Names:

SCH GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR

Publications:
Tempus: NF2
- Version: 11-November-2018
Alternate Names:

NF2 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
MskImpact: NF2
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: NF2
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: NF2
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: NF2
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Drug family	VEGFR mAb inhibitor
Alteration	NF2:del
Alteration	NF2:.

combination therapy	Everolimus;Octreotide
Drug family	MTOR inhibitor;Somatostatin analog
Alteration	NF2:del

Drug family	BCR-ABL inhibitor 1st gen&KIT inhibitor
Alteration	NF2:del
Alteration	NF2:.

combination therapy	Erlotinib;Cetuximab
Drug family	EGFR inhibitor 1st gen;EGFR mAb inhibitor
Alteration	NF2:del;EGFR:.

Drug family	EGFR inhibitor 1st gen
Alteration	NF2:del
Alteration	NF2:.

NF2 Gene Record

NF2 4771 Clinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25878190

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info: Drug family MTOR inhibitor Alteration NF2:del Alteration NF2:.

PMIDs: 25567352 24311643 2556735

Sources: CIViC CGI

Interaction Types & Directionality: n/a

Interaction Info: Drug family ERBB2 inhibitor Alteration NF2:del Alteration NF2:.

PMIDs: 973739 22844108

Sources: CGI

Interaction Types & Directionality: n/a

Interaction Info: Drug family VEGFR mAb inhibitor Alteration NF2:del Alteration NF2:.

PMIDs: 26022982 19587327 22805104

Sources: CGI

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Everolimus;Octreotide Drug family MTOR inhibitor;Somatostatin analog Alteration NF2:del

PMIDs: None found

Sources: CGI

Interaction Types & Directionality: n/a

Interaction Info: Drug family HDAC inhibitor Alteration NF2:del Alteration NF2:.

PMIDs: None found

Sources: CGI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26359368

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info: Drug family BCR-ABL inhibitor 1st gen&KIT inhibitor Alteration NF2:del Alteration NF2:.

PMIDs: 19509233 2290085

Sources: CGI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25798586

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Erlotinib;Cetuximab Drug family EGFR inhibitor 1st gen;EGFR mAb inhibitor Alteration NF2:del;EGFR:.

PMIDs: None found

Sources: CGI

Interaction Types & Directionality: n/a

Interaction Info: Drug family EGFR inhibitor 1st gen Alteration NF2:del Alteration NF2:.

PMIDs: None found

Sources: CGI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25798586

Sources: CIViC

Ensembl: ENSG00000186575

Alternate Names: NF2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

CIViC: NF2

Alternate Names: 4771 Entrez Gene ID 3870 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

CGI: NF2

Alternate Names:

Gene Info:

Pharos: NF2

Alternate Names: Merlin Gene Name P35240 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

GO: NF2

Alternate Names: SCH GO Gene Synonym

Gene Info:

Gene Categories: TUMOR SUPPRESSOR

Publications:

Tempus: NF2

Alternate Names: NF2 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
25878190

Sources:
CIViC

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family MTOR inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
25567352 24311643 2556735

Sources:
CIViC CGI

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family ERBB2 inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
973739 22844108

Sources:
CGI

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family VEGFR mAb inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
26022982 19587327 22805104

Sources:
CGI

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Everolimus;Octreotide

Drug family MTOR inhibitor;Somatostatin analog

Alteration NF2:del

PMIDs:
None found

Sources:
CGI

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family HDAC inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
None found

Sources:
CGI

Interaction Types & Directionality:

n/a

PMIDs:
26359368

Sources:
CIViC

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family BCR-ABL inhibitor 1st gen&KIT inhibitor

Alteration NF2:del

Alteration NF2:.

PMIDs:
19509233 2290085

Sources:
CGI

Interaction Types & Directionality:

n/a

PMIDs:
25798586

Sources:
CIViC

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Erlotinib;Cetuximab

Drug family EGFR inhibitor 1st gen;EGFR mAb inhibitor

Alteration NF2:del;EGFR:.

PMIDs:
None found

Sources:
CGI

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family EGFR inhibitor 1st gen

Alteration NF2:del

Alteration NF2:.

PMIDs:
None found

Sources:
CGI

Interaction Types & Directionality:

n/a

PMIDs:
25798586

Sources:
CIViC

Alternate Names:

NF2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

4771 Entrez Gene ID

3870 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Alternate Names:

Merlin Gene Name

P35240 UniProt ID

Gene Categories:

KINASE

Alternate Names:

SCH GO Gene Synonym

Gene Categories:

TUMOR SUPPRESSOR

Alternate Names:

NF2 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE