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NF1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NF1 4763 Clinically ActionableDrug Resistance

    Alternate Names:

    4763
    NEUROFIBROMIN 1
    NF1
    NFNS
    VRNF
    WSS
    613113
    7765
    ENSG00000196712
    OTTHUMG00000132871
    3867

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUG RESISTANCE
    CLINICALLY ACTIONABLE

    Publications:

    Woodfield et al., 2016, Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression., BMC Cancer
    Dombi et al., 2016, Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas., N. Engl. J. Med.
    Fangusaro J et al., 2019, Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial., Lancet Oncol
    Winoto et al., 1989, A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor alpha locus., EMBO J.
    Nissan et al., 2014, Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence., Cancer Res.
    Hayashi T et al., 2018, <i>RASA1</i> and <i>NF1</i> are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition., Clin Cancer Res
    Whittaker et al., 2013, A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition., Cancer Discov
    Savarese et al., beta-Adrenergic receptor decrease in diabetic rat hearts., Life Sci.
    Maertens et al., 2013, Elucidating distinct roles for NF1 in melanomagenesis., Cancer Discov
  • BINIMETINIB   NF1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26925841


    Sources:
    ClearityFoundationBiomarkers CIViC

  • COBIMETINIB   NF1

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers OncoKB

  • TRAMETINIB   NF1

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2524381 24576830 29127119


    Sources:
    ClearityFoundationBiomarkers CIViC OncoKB

  • SELUMETINIB   NF1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28029918 31151904


    Sources:
    ClearityFoundationBiomarkers CIViC

  • PIMASERTIB   NF1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers

  • DABRAFENIB   NF1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23171796


    Sources:
    CIViC

  • VEMURAFENIB   NF1

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23288408 231718


    Sources:
    CIViC

  • SIROLIMUS   NF1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23171796


    Sources:
    CIViC

  • Ensembl: ENSG00000196712

    • Version: 101_38

    Alternate Names:
    NF1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: NF1

    • Version: 14-September-2020

    Alternate Names:
    4763 Entrez Gene ID
    3867 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Maertens et al., 2013, Elucidating distinct roles for NF1 in melanomagenesis., Cancer Discov
    Dombi et al., 2016, Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas., N. Engl. J. Med.
    Fangusaro J et al., 2019, Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial., Lancet Oncol

  • OncoKB: NF1

    • Version: 23-July-2020

    Alternate Names:
    4763 OncoKB Entrez Id
    WSS OncoKB Gene Synonym
    NFNS OncoKB Gene Synonym

    Gene Info:

    Publications:

  • Tempus: NF1

    • Version: 11-November-2018

    Alternate Names:
    NF1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • ClearityFoundationBiomarkers: NF1

    • Version: 26-July-2013

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: NF1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: NF1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: NF1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: NF1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21