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NAT2 Gene Record

  • Summary
  • Interactions
  • Claims
  • NAT2 10 Druggable Genome

    Alternate Names:

    10
    N-ACETYLTRANSFERASE 2
    NAT2
    AAC2
    NAT-2
    PNAT
    612182
    7646
    ENSG00000156006
    OTTHUMG00000130826
    PA18
    Arylamine N-acetyltransferase 2
    P11245

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Pronko et al., 2002, Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposure., Pharmacol. Toxicol.
    Bertrand J et al., 2014, Dependence of efavirenz- and rifampicin-isoniazid-based antituberculosis treatment drug-drug interaction on CYP2B6 and NAT2 genetic polymorphisms: ANRS 12154 study in Cambodia., J Infect Dis
    Khrunin AV et al., 2014, Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer., Pharmacogenomics
    Walter et al., 1996, Effects of streptolysin O, polyriboinosinic-polyribocytidylic acid and combinations with cyclophosphamide on the hepatic arylamine N-acetyltransferase and cytochrome P450-dependent monooxygenases in rats., Pharmazie
    Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J
    Lu et al., 2002, The effect of paclitaxel on gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells., Food Chem. Toxicol.
    Chung et al., 1998, Effects of garlic compounds diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients., Am. J. Chin. Med.
    Chung, 1999, Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity in human bladder tumor cells., Drug Chem Toxicol
    Kuhn UD et al., 2010, Phenotyping with sulfasalazine - time dependence and relation to NAT2 pharmacogenetics., Int J Clin Pharmacol Ther
    Ma JJ et al., 2009, Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population., Clin Chim Acta
    Yamasaki Y et al., 2008, Pharmacogenetic characterization of sulfasalazine disposition based on NAT2 and ABCG2 (BCRP) gene polymorphisms in humans., Clin Pharmacol Ther
    Chung et al., 1998, Effects of aspirin on arylamine N-acetyltransferase activity in Klebsiella pneumoniae., Drug Chem Toxicol
    Kim JM et al., 2010, Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics., Pharmacogenomics
    Kummar S et al., 2013, Pharmacogenetically driven patient selection for a first-in-human phase I trial of batracylin in patients with advanced solid tumors and lymphomas., Cancer Chemother Pharmacol
    García-Martín E et al., 2015, Genetic determinants of metamizole metabolism modify the risk of developing anaphylaxis., Pharmacogenet Genomics
    Martínez C et al., 2014, Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole., Biochem Pharmacol
    Ho TT et al., 2019, Prolonged clonazepam-induced withdrawal symptoms in an NAT2 ultraslow acetylator., Pharmacogenomics
  • SULFAPYRIDINE   NAT2

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20040334 19560446 18167504


    Sources:
    PharmGKB

  • DIPYRONE   NAT2

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26111152 25241292


    Sources:
    PharmGKB

  • SOLITHROMYCIN   NAT2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMIFAMPRIDINE   NAT2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • DANIQUIDONE   NAT2

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23912694


    Sources:
    PharmGKB

  • SULFAMETHAZINE   NAT2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PROCAINAMIDE   NAT2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • GARLIC   NAT2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9862023 10234471


    Sources:
    NCI

  • EFAVIRENZ   NAT2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23990572


    Sources:
    PharmGKB

  • CLONAZEPAM   NAT2

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30520338


    Sources:
    PharmGKB

  • THALIDOMIDE   NAT2

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20038957


    Sources:
    PharmGKB

  • ASPIRIN   NAT2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9839158 20602614


    Sources:
    NCI PharmGKB

  • CYCLOPHOSPHAMIDE   NAT2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24533712 8774842


    Sources:
    NCI PharmGKB

  • PHENYTOIN   NAT2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOCETAXEL   NAT2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20038957


    Sources:
    PharmGKB

  • ALCOHOL   NAT2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12071337


    Sources:
    NCI

  • PACLITAXEL   NAT2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11955677


    Sources:
    NCI

  • CISPLATIN   NAT2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24533712


    Sources:
    PharmGKB

  • Ensembl: ENSG00000156006

    • Version: 101_38

    Alternate Names:
    NAT2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: NAT2

    • Version: 18-August-2020

    Alternate Names:
    PA18 PharmGKB ID

    Gene Info:

    Publications:
    Bertrand J et al., 2014, Dependence of efavirenz- and rifampicin-isoniazid-based antituberculosis treatment drug-drug interaction on CYP2B6 and NAT2 genetic polymorphisms: ANRS 12154 study in Cambodia., J Infect Dis
    Khrunin AV et al., 2014, Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer., Pharmacogenomics
    Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J

  • NCI: NAT2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Pronko et al., 2002, Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposure., Pharmacol. Toxicol.
    Chung, 1999, Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity in human bladder tumor cells., Drug Chem Toxicol
    Chung et al., 1998, Effects of garlic compounds diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients., Am. J. Chin. Med.

  • HingoraniCasas: ENSG00000156006

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000156006 Gene Symbol
    NAT2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: NAT2

    • Version: 01-February-2022

    Alternate Names:
    Arylamine N-acetyltransferase 2 Gene Name
    P11245 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • FDA: NAT2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21