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MYC Gene Record

  • Summary
  • Interactions
  • Claims
  • MYC 4609 Clinically Actionable

    Alternate Names:

    4609
    MYC PROTO-ONCOGENE, BHLH TRANSCRIPTION FACTOR
    MYC
    MRTL
    MYCC
    bHLHe39
    c-Myc
    190080
    7553
    ENSG00000136997
    OTTHUMG00000128475
    3737
    P01106
    Myc proto-oncogene protein

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Transcription factor
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer
    Rabizadeh et al., 1993, Rapid alteration of c-myc and c-jun expression in leukemic cells induced to differentiate by a butyric acid prodrug., FEBS Lett.
    Verwanger et al., 1998, Expression kinetics of the (proto) oncogenes c-myc and bcl-2 following photodynamic treatment of normal and transformed human fibroblasts with 5-aminolaevulinic acid-stimulated endogenous protoporphyrin IX., J. Photochem. Photobiol. B, Biol.
    Prochownik et al., Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation., Nature
    Woynarowski et al., 2000, Region-specific DNA damage by AT-specific DNA-reactive drugs is predicted by drug binding specificity., Biochemistry
    Sen et al., 2017, CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib., Cancer Res.
    Aller et al., 1986, Selective increase of c-myc mRNA levels by methylglyoxal-bis (guanylhydrazone) and novobiocin in serum-stimulated fibroblasts., J. Cell. Physiol.
    Burdman et al., 2001, Bromocriptine and the expression of c-myc and c-fos in human prolactinomas., Neurol. Res.
    Lepique et al., 2000, Signal transduction in G0/G1-arrested mouse Y1 adrenocortical cells stimulated by ACTH and FGF2., Endocr. Res.
    Toffoli et al., 1989, In K562 leukemia cells treated with doxorubicin and hemin, a decrease in c-myc mRNA expression correlates with loss of self-renewal capability but not with erythroid differentiation., Leuk. Res.
    Bepler et al., 1986, Additive and differential biological activity of alpha-interferon A, difluoromethylornithine, and their combination on established human lung cancer cell lines., Cancer Res.
    French et al., 1991, Queuine, a tRNA anticodon wobble base, maintains the proliferative and pluripotent potential of HL-60 cells in the presence of the differentiating agent 6-thioguanine., Proc. Natl. Acad. Sci. U.S.A.
    Zhu et al., 1999, Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc., Biochem. Pharmacol.
    Salleh et al., 2004, Gene expression profiling of p53(+/-) knockout and wild-type mice following diethylstilbestrol administration., IUBMB Life
    Hsiao et al., 1996, Comparison of transformation by manganese sulfate and 5-azacytidine in Rat 6 cells overexpressing the c-myc oncogene., Carcinogenesis
    Kawano et al., Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect., Anticancer Res.
    Xu et al., 2005, The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines., Int. J. Mol. Med.
    Díez et al., 1997, Quinapril inhibits c-Myc expression and normalizes smooth muscle cell proliferation in spontaneously hypertensive rats., Am. J. Hypertens.
    Weinberg et al., 1991, Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression., Cancer Res.
    Weinberg et al., 1992, Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation., Blood
    Ohta et al., 2001, Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells., J. Clin. Endocrinol. Metab.
    Domínguez-Cáceres et al., 2004, Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells., Oncogene
    Chung et al., 2001, Requirement of de novo protein synthesis for aminopterin-induced apoptosis in a mouse myeloma cell line., Immunol. Lett.
    Molis et al., 1995, Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer., J. Pineal Res.
    Magnaldo et al., 1986, The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts., J. Biol. Chem.
    Liu et al., 1997, Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine., Carcinogenesis
    Weng et al., 2002, C-mycprotein expression upregulated by 2-(3-estrone-N-ethyl piperazine-methyl) tetracycline in bone., Yao Xue Xue Bao
    Li et al., 2000, [Effect of estrogen on the expression of c-myc protein of bone in mice]., Wei Sheng Yan Jiu
    Morris et al., 1997, Decreased C-MYC and BCL2 expression correlates with methylprednisolone-mediated inhibition of Raji lymphoma growth., Biochem. Mol. Med.
    Saunders et al., 1993, Inhibition of c-myc in breast and ovarian carcinoma cells by 1,25-dihydroxyvitamin D3, retinoic acid and dexamethasone., Anticancer Drugs
    Beer et al., 2004, Randomized study of high-dose pulse calcitriol or placebo prior to radical prostatectomy., Cancer Epidemiol. Biomarkers Prev.
    Takemura et al., 1992, Effect of verapamil on the class I major histocompatibility complex antigen expression in K562 chronic myelogenous leukemia cells treated with recombinant human interferon-gamma., Cancer Lett.
    Colletta et al., 1986, Induction of the c-fos oncogene by thyrotropic hormone in rat thyroid cells in culture., Science
    Heldin et al., 1988, Epidermal growth factor, but not thyrotropin, stimulates the expression of c-fos and c-myc messenger ribonucleic acid in porcine thyroid follicle cells in primary culture., Endocrinology
    McKeage, 2001, Lobaplatin: a new antitumour platinum drug., Expert Opin Investig Drugs
    Wilson et al., 2002, Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention., Cancer Res.
    Chong et al., 2017, Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer., Gut
  • BIZELESIN   MYC

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10933811


    Sources:
    NCI

  • LOBAPLATIN   MYC

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11116285


    Sources:
    NCI

  • AMINOPTERIN   MYC

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11410244


    Sources:
    NCI

  • MITOGUAZONE   MYC

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3528175


    Sources:
    NCI

  • ADOZELESIN   MYC

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10933811


    Sources:
    NCI

  • ACIVICIN   MYC

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1997162 1596574


    Sources:
    NCI

  • PREXASERTIB   MYC

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28490518


    Sources:
    CIViC

  • QUINAPRIL   MYC

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9370386


    Sources:
    NCI

  • HYPOXANTHINE   MYC

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3528863


    Sources:
    NCI

  • THYROTROPIN   MYC

    Interaction Score: 0.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3726540 3125035


    Sources:
    NCI

  • NOVOBIOCIN   MYC

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3528175


    Sources:
    NCI

  • AMIFOSTINE   MYC

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9450496


    Sources:
    NCI

  • ESTRONE   MYC

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12567859 12520970


    Sources:
    NCI

  • GLUTAMINE   MYC

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16898871


    Sources:
    NCI

  • CALCITRIOL   MYC

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8490200 15598784


    Sources:
    NCI

  • AN-9   MYC

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8348968


    Sources:
    NCI

  • AMG-900   MYC

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers

  • ANTIBIOTIC   MYC

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2654492


    Sources:
    NCI

  • IBRUTINIB   MYC

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28830912


    Sources:
    CIViC

  • METHYLPREDNISOLONE   MYC

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9169090


    Sources:
    NCI

  • BROMOCRIPTINE   MYC

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11680511


    Sources:
    NCI

  • SULINDAC   MYC

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12414619


    Sources:
    NCI

  • DINACICLIB   MYC

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers

  • THROMBIN   MYC

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3023371


    Sources:
    NCI

  • TROGLITAZONE   MYC

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11344222


    Sources:
    NCI

  • PROTOPORPHYRIN   MYC

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9868803


    Sources:
    NCI

  • MELATONIN   MYC

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7629697


    Sources:
    NCI

  • THIOGUANINE   MYC

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1988936


    Sources:
    NCI

  • OLAPARIB   MYC

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28490518


    Sources:
    CIViC

  • DIETHYLSTILBESTROL   MYC

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15545218


    Sources:
    NCI

  • VERAPAMIL   MYC

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1511424


    Sources:
    NCI

  • AZACITIDINE   MYC

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9006118


    Sources:
    NCI

  • INDOMETHACIN   MYC

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10403534


    Sources:
    NCI

  • CHEMBL35482   MYC

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11196459


    Sources:
    NCI

  • CETUXIMAB   MYC

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3085922


    Sources:
    NCI

  • LITHIUM   MYC

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15286700


    Sources:
    NCI

  • VORINOSTAT   MYC

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15583844


    Sources:
    NCI

  • IMATINIB   MYC

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15517875


    Sources:
    NCI

  • ALISERTIB   MYC

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers

  • CISPLATIN   MYC

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28490518


    Sources:
    CIViC

  • Ensembl: ENSG00000136997

    • Version: 101_38

    Alternate Names:
    MYC Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P01106

    • Version: January-2014

    Alternate Names:
    MYC Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Transcription factor

    Publications:

  • CIViC: MYC

    • Version: 14-September-2020

    Alternate Names:
    4609 Entrez Gene ID
    3737 CIViC Gene ID

    Gene Info:

    Publications:
    Delmore et al., 2011, BET bromodomain inhibition as a therapeutic strategy to target c-Myc., Cell
    Sen et al., 2017, CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib., Cancer Res.
    Chong et al., 2017, Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer., Gut

  • NCI: MYC

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer
    Verwanger et al., 1998, Expression kinetics of the (proto) oncogenes c-myc and bcl-2 following photodynamic treatment of normal and transformed human fibroblasts with 5-aminolaevulinic acid-stimulated endogenous protoporphyrin IX., J. Photochem. Photobiol. B, Biol.
    Aller et al., 1986, Selective increase of c-myc mRNA levels by methylglyoxal-bis (guanylhydrazone) and novobiocin in serum-stimulated fibroblasts., J. Cell. Physiol.

  • Tempus: MYC

    • Version: 11-November-2018

    Alternate Names:
    MYC Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: MYC

    • Version: 01-February-2022

    Alternate Names:
    Myc proto-oncogene protein Gene Name
    P01106 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • ClearityFoundationBiomarkers: MYC

    • Version: 26-July-2013

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: MYC

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: MYC

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: MYC

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: MYC

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21