DGIdb - MYC Gene Record

MYC 4609 Clinically Actionable

Alternate Names:

4609
MYC PROTO-ONCOGENE, BHLH TRANSCRIPTION FACTOR
MYC
MRTL
MYCC
bHLHe39
c-Myc
190080
7553
ENSG00000136997
OTTHUMG00000128475
3737
P01106
Myc proto-oncogene protein

Gene Info:

Target Class	Miscellaneous
Target Subclass	Transcription factor
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer
Rabizadeh et al., 1993, Rapid alteration of c-myc and c-jun expression in leukemic cells induced to differentiate by a butyric acid prodrug., FEBS Lett.
Verwanger et al., 1998, Expression kinetics of the (proto) oncogenes c-myc and bcl-2 following photodynamic treatment of normal and transformed human fibroblasts with 5-aminolaevulinic acid-stimulated endogenous protoporphyrin IX., J. Photochem. Photobiol. B, Biol.
Prochownik et al., Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation., Nature
Woynarowski et al., 2000, Region-specific DNA damage by AT-specific DNA-reactive drugs is predicted by drug binding specificity., Biochemistry
Sen et al., 2017, CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib., Cancer Res.
Aller et al., 1986, Selective increase of c-myc mRNA levels by methylglyoxal-bis (guanylhydrazone) and novobiocin in serum-stimulated fibroblasts., J. Cell. Physiol.
Burdman et al., 2001, Bromocriptine and the expression of c-myc and c-fos in human prolactinomas., Neurol. Res.
Lepique et al., 2000, Signal transduction in G0/G1-arrested mouse Y1 adrenocortical cells stimulated by ACTH and FGF2., Endocr. Res.
Toffoli et al., 1989, In K562 leukemia cells treated with doxorubicin and hemin, a decrease in c-myc mRNA expression correlates with loss of self-renewal capability but not with erythroid differentiation., Leuk. Res.
Bepler et al., 1986, Additive and differential biological activity of alpha-interferon A, difluoromethylornithine, and their combination on established human lung cancer cell lines., Cancer Res.
French et al., 1991, Queuine, a tRNA anticodon wobble base, maintains the proliferative and pluripotent potential of HL-60 cells in the presence of the differentiating agent 6-thioguanine., Proc. Natl. Acad. Sci. U.S.A.
Zhu et al., 1999, Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc., Biochem. Pharmacol.
Salleh et al., 2004, Gene expression profiling of p53(+/-) knockout and wild-type mice following diethylstilbestrol administration., IUBMB Life
Hsiao et al., 1996, Comparison of transformation by manganese sulfate and 5-azacytidine in Rat 6 cells overexpressing the c-myc oncogene., Carcinogenesis
Kawano et al., Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect., Anticancer Res.
Xu et al., 2005, The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines., Int. J. Mol. Med.
Díez et al., 1997, Quinapril inhibits c-Myc expression and normalizes smooth muscle cell proliferation in spontaneously hypertensive rats., Am. J. Hypertens.
Weinberg et al., 1991, Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression., Cancer Res.
Weinberg et al., 1992, Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation., Blood
Ohta et al., 2001, Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells., J. Clin. Endocrinol. Metab.
Domínguez-Cáceres et al., 2004, Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells., Oncogene
Chung et al., 2001, Requirement of de novo protein synthesis for aminopterin-induced apoptosis in a mouse myeloma cell line., Immunol. Lett.
Molis et al., 1995, Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer., J. Pineal Res.
Magnaldo et al., 1986, The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts., J. Biol. Chem.
Liu et al., 1997, Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine., Carcinogenesis
Weng et al., 2002, C-mycprotein expression upregulated by 2-(3-estrone-N-ethyl piperazine-methyl) tetracycline in bone., Yao Xue Xue Bao
Li et al., 2000, [Effect of estrogen on the expression of c-myc protein of bone in mice]., Wei Sheng Yan Jiu
Morris et al., 1997, Decreased C-MYC and BCL2 expression correlates with methylprednisolone-mediated inhibition of Raji lymphoma growth., Biochem. Mol. Med.
Saunders et al., 1993, Inhibition of c-myc in breast and ovarian carcinoma cells by 1,25-dihydroxyvitamin D3, retinoic acid and dexamethasone., Anticancer Drugs
Beer et al., 2004, Randomized study of high-dose pulse calcitriol or placebo prior to radical prostatectomy., Cancer Epidemiol. Biomarkers Prev.
Takemura et al., 1992, Effect of verapamil on the class I major histocompatibility complex antigen expression in K562 chronic myelogenous leukemia cells treated with recombinant human interferon-gamma., Cancer Lett.
Colletta et al., 1986, Induction of the c-fos oncogene by thyrotropic hormone in rat thyroid cells in culture., Science
Heldin et al., 1988, Epidermal growth factor, but not thyrotropin, stimulates the expression of c-fos and c-myc messenger ribonucleic acid in porcine thyroid follicle cells in primary culture., Endocrinology
McKeage, 2001, Lobaplatin: a new antitumour platinum drug., Expert Opin Investig Drugs
Wilson et al., 2002, Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention., Cancer Res.
Chong et al., 2017, Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer., Gut

BIZELESIN MYC

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10933811

Sources:
NCI
LOBAPLATIN MYC

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11116285

Sources:
NCI
AMINOPTERIN MYC

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11410244

Sources:
NCI
MITOGUAZONE MYC

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3528175

Sources:
NCI
ADOZELESIN MYC

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10933811

Sources:
NCI
ACIVICIN MYC

Interaction Score: 1.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1997162 1596574

Sources:
NCI
PREXASERTIB MYC

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28490518

Sources:
CIViC
QUINAPRIL MYC

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9370386

Sources:
NCI
HYPOXANTHINE MYC

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3528863

Sources:
NCI
THYROTROPIN MYC

Interaction Score: 0.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3726540 3125035

Sources:
NCI
NOVOBIOCIN MYC

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3528175

Sources:
NCI
AMIFOSTINE MYC

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9450496

Sources:
NCI
ESTRONE MYC

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12567859 12520970

Sources:
NCI
GLUTAMINE MYC

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16898871

Sources:
NCI
CALCITRIOL MYC

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8490200 15598784

Sources:
NCI
AN-9 MYC

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8348968

Sources:
NCI
AMG-900 MYC

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers
ANTIBIOTIC MYC

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2654492

Sources:
NCI
IBRUTINIB MYC

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28830912

Sources:
CIViC
METHYLPREDNISOLONE MYC

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9169090

Sources:
NCI
BROMOCRIPTINE MYC

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11680511

Sources:
NCI
SULINDAC MYC

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12414619

Sources:
NCI
DINACICLIB MYC

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers
THROMBIN MYC

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3023371

Sources:
NCI
TROGLITAZONE MYC

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11344222

Sources:
NCI
PROTOPORPHYRIN MYC

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9868803

Sources:
NCI
MELATONIN MYC

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7629697

Sources:
NCI
THIOGUANINE MYC

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1988936

Sources:
NCI
OLAPARIB MYC

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28490518

Sources:
CIViC
DIETHYLSTILBESTROL MYC

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15545218

Sources:
NCI
VERAPAMIL MYC

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1511424

Sources:
NCI
AZACITIDINE MYC

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9006118

Sources:
NCI
INDOMETHACIN MYC

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10403534

Sources:
NCI
CHEMBL35482 MYC

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11196459

Sources:
NCI
CETUXIMAB MYC

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3085922

Sources:
NCI
LITHIUM MYC

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15286700

Sources:
NCI
VORINOSTAT MYC

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15583844

Sources:
NCI
IMATINIB MYC

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15517875

Sources:
NCI
ALISERTIB MYC

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers
CISPLATIN MYC

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28490518

Sources:
CIViC

Ensembl: ENSG00000136997
- Version: 101_38
Alternate Names:

MYC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P01106
- Version: January-2014
Alternate Names:

MYC Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Transcription factor

Publications:

CIViC: MYC

Version: 14-September-2020

Alternate Names:

4609 Entrez Gene ID

3737 CIViC Gene ID

Gene Info:

Publications:

Delmore et al., 2011, BET bromodomain inhibition as a therapeutic strategy to target c-Myc., Cell

Sen et al., 2017, CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib., Cancer Res.

Chong et al., 2017, Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer., Gut

NCI: MYC

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer

Verwanger et al., 1998, Expression kinetics of the (proto) oncogenes c-myc and bcl-2 following photodynamic treatment of normal and transformed human fibroblasts with 5-aminolaevulinic acid-stimulated endogenous protoporphyrin IX., J. Photochem. Photobiol. B, Biol.

Aller et al., 1986, Selective increase of c-myc mRNA levels by methylglyoxal-bis (guanylhydrazone) and novobiocin in serum-stimulated fibroblasts., J. Cell. Physiol.

Tempus: MYC
- Version: 11-November-2018
Alternate Names:

MYC Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: MYC
- Version: 01-February-2022
Alternate Names:

Myc proto-oncogene protein Gene Name

P01106 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
ClearityFoundationBiomarkers: MYC
- Version: 26-July-2013
Alternate Names:

Gene Info:

Publications:
MskImpact: MYC
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: MYC
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: MYC
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: MYC
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

MYC Gene Record

MYC 4609 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10933811

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11116285

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11410244

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3528175

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10933811

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1997162 1596574

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28490518

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9370386

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3528863

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3726540 3125035

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3528175

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9450496

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12567859 12520970

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16898871

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8490200 15598784

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8348968

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationBiomarkers

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2654492

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
10933811

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11116285

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11410244

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3528175

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10933811

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1997162 1596574

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
28490518

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
9370386

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3528863

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3726540 3125035

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3528175

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9450496

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12567859 12520970

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16898871

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8490200 15598784

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8348968

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers

Interaction Types & Directionality:

n/a

PMIDs:
2654492

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
28830912

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
9169090

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11680511

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12414619

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers

Interaction Types & Directionality:

n/a

PMIDs:
3023371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11344222

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9868803

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7629697