2475 |
MECHANISTIC TARGET OF RAPAMYCIN KINASE |
MTOR |
FRAP |
FRAP1 |
FRAP2 |
RAFT1 |
RAPT1 |
SKS |
601231 |
3942 |
ENSG00000198793 |
OTTHUMG00000002001 |
P42345 |
FRAP_HUMAN |
MTOR_HUMAN |
SERINE/THREONINE-PROTEIN KINASE MTOR |
FKBP12-rapamycin complex-associated protein |
Rapamycin and FKBP12 target 1 |
FK506-binding protein 12-rapamycin complex-associated protein 1 |
Rapamycin target protein 1 |
Mechanistic target of rapamycin |
Mammalian target of rapamycin |
FKBP12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN (FK506-BINDING PROTEIN 12- RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1) (RAPAMYCIN TARGET PROTEIN) (RAPT1) (MAMMALIAN TARGET OF RAPAMYCIN) (MTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P42345] |
2073 |
PA28360 |
T75243 |
Target Main Class | Enzymes |
Target Subclass | 2.7.11.1 |
CancerCommons Reported Gene Name | PI3K/mTOR |
CancerCommons Reported Gene Name | mTOR |
CancerCommons Reported Gene Name | TORC |
Interpro Acc | IPR000403 |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | PHOSPHATIDYLINOSITOL 3 KINASE |
Interpro Type | Domain |
Interpro Name | Phosphatidylinositol 3-/4-kinase, catalytic domain |
Uniprot Status | Swiss-Prot |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | PI3/4_kinase_cat_dom |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.1 |
Gene Biotype | PROTEIN_CODING |
KINASE |
SERINE THREONINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
PHOSPHATIDYLINOSITOL 3 KINASE |
CLINICALLY ACTIONABLE |
ENZYME |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
Reported Cancer Type | Lung |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Trial Name | Ridaforolimus |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Notes | |
Reported Cancer Type | Lung |
Trial Name | temsirolimus, CCI-779,Torisel |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
Reported Cancer Type | Lung |
inhibitor (inhibitory) |
Variant Effect | gain-of-function |
Pathway | activation |
Clinical Status | case report |
potentiator |
Trial Name | pimecrolimus, ASM 981,Elidel |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Trial Name | OSI-027 |
inhibitor (inhibitory) |
Trial Name | LCP-Siro, sirolimus |
Novel drug target | Established target |
Trial Name | sirolimus, rapamycin,Perceiva |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
Reported Cancer Type | Melanoma |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Reported Cancer Type | Melanoma |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase mTOR inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Reported Cancer Type | Lung |
inhibitor (inhibitory) |
MTOR | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000198793 | Ensembl Gene Id |
FKBP12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN (FK506-BINDING PROTEIN 12- RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1) (RAPAMYCIN TARGET PROTEIN) (RAPT1) (MAMMALIAN TARGET OF RAPAMYCIN) (MTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P42345] | Description |
FRAP1 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
2475 | Entrez Gene Id |
FRAP_HUMAN | Uniprot Id |
FRAP1 | Gene Symbol |
Target Main Class | Enzymes |
Target Subclass | 2.7.11.1 |
MTOR | Gene Symbol |
FRAP1 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.1 |
2475 | Entrez Gene ID |
CancerCommons Reported Gene Name | PI3K/mTOR |
CancerCommons Reported Gene Name | mTOR |
CancerCommons Reported Gene Name | TORC |
P42345 | Uniprot Accession |
2475 | Entrez Gene Id |
ENSG00000198793 | Ensembl Gene Id |
Interpro Acc | IPR000403 |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | PHOSPHATIDYLINOSITOL 3 KINASE |
DRUGGABLE GENOME, PHOSPHATIDYLINOSITOL 3 KINASE |
PA28360 | PharmGKB ID |
2475 | Entrez Gene ID |
2073 | CIViC Gene ID |
DRUG RESISTANCE |
mTOR | TTD Gene Abbreviation |
T75243 | TTD Target ID |
2475 | Entrez Gene Id |
MTOR | MyCancerGenome Gene Symbol |
mTOR | MyCancerGenome Reported Gene Name |
ENSG00000198793 | Gene Symbol |
MTOR | Ensembl Id |
DRUGGABLE GENOME |
FRAP1 | GENE_SYMBOL |
FRAP2 | GENE_SYMBOL |
RAFT1 | GENE_SYMBOL |
MTOR | Gene Symbol |
2475 | OncoKB Entrez Id |
FRAP1 | OncoKB Gene Synonym |
RAFT1 | OncoKB Gene Synonym |
FRAP | GO Gene Synonym |
FRAP1 | GO Gene Synonym |
FRAP2 | GO Gene Synonym |
KINASE, SERINE THREONINE KINASE |
MTOR | Gene Symbol |
CLINICALLY ACTIONABLE |
2475 | Gene ID |
FRAP | dGene Synonym |
FRAP1 | dGene Synonym |
KINASE, SERINE THREONINE KINASE |
Serine/threonine-protein kinase mTOR | Gene Name |
P42345 | UniProt ID |
KINASE, ENZYME |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |