• MST1R 4486 Druggable GenomeClinically Actionable

    Alternate Names:

    4486
    MACROPHAGE STIMULATING 1 RECEPTOR
    MST1R
    CD136
    CDw136
    NPCA3
    PTK8
    RON
    600168
    7381
    ENSG00000164078
    OTTHUMG00000156709
    Macrophage-stimulating protein receptor alpha chain
    p185-Ron
    MSP receptor
    CD_antigen=CD136
    Macrophage-stimulating protein receptor
    Protein-tyrosine kinase 8
    Macrophage-stimulating protein receptor beta chain
    MACROPHAGE-STIMULATING PROTEIN RECEPTOR PRECURSOR (EC 2.7.1.112) (MSP RECEPTOR) (P185-RON) (CDW136) (CD136 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q04912]
    Q04912
    RON_HUMAN
    1816
    NP_002438
    NM_001244937
    T01973
    SEA

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:2.7.10.1
    GuideToPharmacology Gene Category Name Type X RTKs: HGF (hepatocyte growth factor) receptor family
    GuideToPharmacology Gene Category ID 325
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001245
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Interpro Type Domain
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 1.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Macrophage-stimulating protein receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name MGCD265
    Novel drug target Novel Target

    PMIDs:
    None found


  • Interaction Score: 0.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 0.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Macrophage-stimulating protein receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19778024


    Sources:
    DTC

  • Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of <i>in vitro</i> biochemical activity by EMD Millipore assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

    • Version: 101_38

    Alternate Names:
    MST1R Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: January-2014

    Alternate Names:
    MST1R Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.10.1

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    MACROPHAGE-STIMULATING PROTEIN RECEPTOR PRECURSOR (EC 2.7.1.112) (MSP RECEPTOR) (P185-RON) (CDW136) (CD136 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q04912] Description
    ENSG00000164078 Ensembl Gene Id
    MST1R Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    RON_HUMAN Uniprot Id
    4486 Entrez Gene Id
    MACROPHAGE-STIMULATING PROTEIN RECEPTOR ALPHA CHAIN Uniprot Protein Name

    Gene Info:
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001245

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    7381 HUGO Gene ID
    7381 HUGO Gene Symbol
    macrophage stimulating 1 receptor HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Type X RTKs: HGF (hepatocyte growth factor) receptor family
    GuideToPharmacology Gene Category ID 325

    Publications:

    • Version: 02-September-2020
    • Version: 12-May-2016

    Alternate Names:
    RON Gene Symbol

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164078 Gene Symbol
    MST1R Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    RON GENE_SYMBOL
    MST1R GENE_SYMBOL
    Macrophage-stimulating protein receptor UNIPROT

    Gene Info:

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000164078 Ensembl Gene ID
    CD136 Human Protein Atlas Gene Synonym
    CDw136 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, ENZYME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    4486 Gene ID
    CD136 dGene Synonym
    CDw136 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

  • Alternate Names:
    RON TTD Gene Abbreviation
    T01973 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    PTK8 GO Gene Synonym
    RON GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Macrophage-stimulating protein receptor Gene Name
    Q04912 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: