DGIdb - MPO Gene Record

MPO 4353 Druggable Genome

Alternate Names:

4353
MYELOPEROXIDASE
MPO
606989
7218
ENSG00000005381
OTTHUMG00000178922
P05164
MYELOPEROXIDASE PRECURSOR (EC 1.11.1.7) (MPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P05164]
PERM_HUMAN
T23471

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	Haem_peroxidase_animal
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Haem peroxidase, animal
Interpro Acc	IPR002007
Interpro Type	Family
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Candelario-Jalil et al., 2007, Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats., J. Neurochem.
Jorgenson et al., 1991, Chromatin structural analysis of the 5' end and contiguous flanking region of the myeloperoxidase gene., Blood
Doğan et al., 2004, Effect of fludarabine on leukocyte functions., Chemotherapy
Pedersen et al., 1996, Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking., Am. J. Respir. Crit. Care Med.
Zuurbier et al., 1990, Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase., Biochem. Pharmacol.
Krumholz et al., 1993, The influence of fentanyl and alfentanil on functions of human polymorphonuclear leukocytes in vitro., Acta Anaesthesiol Scand
Kettle et al., 1992, Oxidative metabolism of amsacrine by the neutrophil enzyme myeloperoxidase., Biochem. Pharmacol.
Brügger-Andersen et al., 2007, The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin and D-dimer in acute myocardial infarction., Thromb. Res.
Yu et al., 2006, Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1., J. Leukoc. Biol.
Iakovleva et al., [In vitro induced activity of polymorphonuclear leukocyte myeloperoxidase at different stages of opisthorchis invasion and at stages of a different rehabilitative period]., Med Parazitol (Mosk)
Kapuścińska et al., 2004, [Cytofluorimetric assay for evaluation of CD16 receptor expression and myeloperoxidase (MPO) activity of neutrophils in patients with psoriasis vulgaris treated with PUVA]., Wiad. Lek.
Sener et al., 2004, Octreotide ameliorates alendronate-induced gastric injury., Peptides
Zeis, 1988, Antimycobacterial drugs and the production of reactive oxidants by polymorphonuclear leucocytes in vitro., Chemotherapy
Türközkan et al., 1993, Biochemical investigation of leukocyte functions during lithium therapy., Int. J. Biochem.
Anderson et al., 1980, Effects of sulfamethoxazole and trimethoprim on human neutrophil and lymphocyte functions in vitro: in vivo effects of co-trimoxazole., Antimicrob. Agents Chemother.
Ruggeri RB et al., 2015, Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases., J Med Chem
Behbehani et al., 1996, Properties of a projection pathway from the medial preoptic nucleus to the midbrain periaqueductal gray of the rat and its role in the regulation of cardiovascular function., Brain Res.
Nosál' et al., 2006, On the pharmacology and toxicology of neutrophils., Neuro Endocrinol. Lett.
Anderson et al., 1981, Prevention of peroxidase mediated inhibition of neutrophil motility and lymphocyte transformation by levamisole, OMPI, sodium aurothiomalate, indomethacin and tolmetin in vitro., Int. J. Immunopharmacol.

ASULACRINE MPO

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1333205

Sources:
NCI
TENECTEPLASE MPO

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16650886

Sources:
NCI
TOLMETIN MPO

Interaction Score: 2.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6266970

Sources:
NCI
DIMETHYL SULFOXIDE MPO

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1845843

Sources:
NCI
PYRAZINAMIDE MPO

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2832129

Sources:
NCI
PSORALEN MPO

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15865234

Sources:
NCI
OCTREOTIDE MPO

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15003363

Sources:
NCI
TRIMETHOPRIM MPO

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7425598

Sources:
NCI
DOXYCYCLINE MPO

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14564835

Sources:
NCI
NIMESULIDE MPO

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17176264

Sources:
NCI
LORATADINE MPO

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17159802

Sources:
NCI
LIDOCAINE MPO

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8973808

Sources:
NCI
PROPYLTHIOURACIL MPO

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26509551

Sources:
DTC
FLUTAMIDE MPO

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16330533

Sources:
NCI
FLUDARABINE MPO

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15608444

Sources:
NCI
DICLOFENAC MPO

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2173589

Sources:
NCI
THEOPHYLLINE MPO

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8630596

Sources:
NCI
FENTANYL MPO

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8391745

Sources:
NCI
LITHIUM MPO

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8224362

Sources:
NCI

Ensembl: ENSG00000005381
- Version: 101_38
Alternate Names:

MPO Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P05164
- Version: 11-September-2012
Alternate Names:

PERM_HUMAN Uniprot Id

4353 Entrez Gene Id

MPO Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Short Name Haem_peroxidase_animal

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000005381
- Version: 26-July-2011
Alternate Names:

MPO Display Id

MYELOPEROXIDASE PRECURSOR (EC 1.11.1.7) (MPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P05164] Description

ENSG00000005381 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: MPO

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Jorgenson et al., 1991, Chromatin structural analysis of the 5' end and contiguous flanking region of the myeloperoxidase gene., Blood

Kettle et al., 1992, Oxidative metabolism of amsacrine by the neutrophil enzyme myeloperoxidase., Biochem. Pharmacol.

Brügger-Andersen et al., 2007, The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin and D-dimer in acute myocardial infarction., Thromb. Res.

DTC: MPO

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Ruggeri RB et al., 2015, Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases., J Med Chem

HingoraniCasas: ENSG00000005381
- Version: 31-May-2017
Alternate Names:

ENSG00000005381 Gene Symbol

MPO Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: MPO
- Version: 19.3
Alternate Names:

P05164 UniProt ID

ENSG00000005381 Ensembl Gene ID

Myeloperoxidase Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Myeloperoxidase
- Version: 2020.06.01
Alternate Names:

MPO TTD Gene Abbreviation

T23471 TTD Target ID

Gene Info:

Publications:
Pharos: MPO
- Version: 01-February-2022
Alternate Names:

Myeloperoxidase Gene Name

P05164 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

MPO	Display Id
MYELOPEROXIDASE PRECURSOR (EC 1.11.1.7) (MPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P05164]	Description
ENSG00000005381	Ensembl Gene Id

P05164	UniProt ID
ENSG00000005381	Ensembl Gene ID
Myeloperoxidase	Human Protein Atlas Gene Description

MPO Gene Record

MPO 4353 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1333205

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16650886

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6266970

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1845843

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2832129

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15865234

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15003363

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7425598

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14564835

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17176264

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17159802

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8973808

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26509551

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16330533

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15608444

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2173589

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8630596

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8391745

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
1333205

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16650886

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6266970

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1845843

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2832129

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15865234

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15003363

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7425598

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14564835

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17176264

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17159802

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8973808

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26509551

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16330533

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15608444

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2173589

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8630596

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8391745

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8224362

Sources:
NCI

Alternate Names:

MPO Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PERM_HUMAN Uniprot Id

4353 Entrez Gene Id

MPO Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Short Name Haem_peroxidase_animal

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MPO Display Id

MYELOPEROXIDASE PRECURSOR (EC 1.11.1.7) (MPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P05164] Description

ENSG00000005381 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

Ruggeri RB et al., 2015, Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases., J Med Chem

Alternate Names:

ENSG00000005381 Gene Symbol

MPO Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

P05164 UniProt ID

ENSG00000005381 Ensembl Gene ID

Myeloperoxidase Human Protein Atlas Gene Description

Gene Categories:

ENZYME

Alternate Names:

MPO TTD Gene Abbreviation

T23471 TTD Target ID

Alternate Names:

Myeloperoxidase Gene Name

P05164 UniProt ID

Gene Categories:

ENZYME