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MPO Gene Record

  • Summary
  • Interactions
  • Claims
  • MPO 4353 Druggable Genome

    Alternate Names:

    4353
    MYELOPEROXIDASE
    MPO
    606989
    7218
    ENSG00000005381
    OTTHUMG00000178922
    P05164
    MYELOPEROXIDASE PRECURSOR (EC 1.11.1.7) (MPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P05164]
    PERM_HUMAN
    T23471

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name Haem_peroxidase_animal
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Haem peroxidase, animal
    Interpro Acc IPR002007
    Interpro Type Family
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Candelario-Jalil et al., 2007, Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats., J. Neurochem.
    Jorgenson et al., 1991, Chromatin structural analysis of the 5' end and contiguous flanking region of the myeloperoxidase gene., Blood
    Doğan et al., 2004, Effect of fludarabine on leukocyte functions., Chemotherapy
    Pedersen et al., 1996, Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking., Am. J. Respir. Crit. Care Med.
    Zuurbier et al., 1990, Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase., Biochem. Pharmacol.
    Krumholz et al., 1993, The influence of fentanyl and alfentanil on functions of human polymorphonuclear leukocytes in vitro., Acta Anaesthesiol Scand
    Kettle et al., 1992, Oxidative metabolism of amsacrine by the neutrophil enzyme myeloperoxidase., Biochem. Pharmacol.
    Brügger-Andersen et al., 2007, The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin and D-dimer in acute myocardial infarction., Thromb. Res.
    Yu et al., 2006, Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1., J. Leukoc. Biol.
    Iakovleva et al., [In vitro induced activity of polymorphonuclear leukocyte myeloperoxidase at different stages of opisthorchis invasion and at stages of a different rehabilitative period]., Med Parazitol (Mosk)
    Kapuścińska et al., 2004, [Cytofluorimetric assay for evaluation of CD16 receptor expression and myeloperoxidase (MPO) activity of neutrophils in patients with psoriasis vulgaris treated with PUVA]., Wiad. Lek.
    Sener et al., 2004, Octreotide ameliorates alendronate-induced gastric injury., Peptides
    Zeis, 1988, Antimycobacterial drugs and the production of reactive oxidants by polymorphonuclear leucocytes in vitro., Chemotherapy
    Türközkan et al., 1993, Biochemical investigation of leukocyte functions during lithium therapy., Int. J. Biochem.
    Anderson et al., 1980, Effects of sulfamethoxazole and trimethoprim on human neutrophil and lymphocyte functions in vitro: in vivo effects of co-trimoxazole., Antimicrob. Agents Chemother.
    Ruggeri RB et al., 2015, Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases., J Med Chem
    Behbehani et al., 1996, Properties of a projection pathway from the medial preoptic nucleus to the midbrain periaqueductal gray of the rat and its role in the regulation of cardiovascular function., Brain Res.
    Nosál' et al., 2006, On the pharmacology and toxicology of neutrophils., Neuro Endocrinol. Lett.
    Anderson et al., 1981, Prevention of peroxidase mediated inhibition of neutrophil motility and lymphocyte transformation by levamisole, OMPI, sodium aurothiomalate, indomethacin and tolmetin in vitro., Int. J. Immunopharmacol.
  • ASULACRINE   MPO

    Interaction Score: 6.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1333205


    Sources:
    NCI

  • TENECTEPLASE   MPO

    Interaction Score: 3.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16650886


    Sources:
    NCI

  • TOLMETIN   MPO

    Interaction Score: 2.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6266970


    Sources:
    NCI

  • DIMETHYL SULFOXIDE   MPO

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1845843


    Sources:
    NCI

  • PYRAZINAMIDE   MPO

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2832129


    Sources:
    NCI

  • PSORALEN   MPO

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15865234


    Sources:
    NCI

  • OCTREOTIDE   MPO

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15003363


    Sources:
    NCI

  • TRIMETHOPRIM   MPO

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7425598


    Sources:
    NCI

  • DOXYCYCLINE   MPO

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14564835


    Sources:
    NCI

  • NIMESULIDE   MPO

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17176264


    Sources:
    NCI

  • LORATADINE   MPO

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17159802


    Sources:
    NCI

  • LIDOCAINE   MPO

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8973808


    Sources:
    NCI

  • PROPYLTHIOURACIL   MPO

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26509551


    Sources:
    DTC

  • FLUTAMIDE   MPO

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16330533


    Sources:
    NCI

  • FLUDARABINE   MPO

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15608444


    Sources:
    NCI

  • DICLOFENAC   MPO

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2173589


    Sources:
    NCI

  • THEOPHYLLINE   MPO

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8630596


    Sources:
    NCI

  • FENTANYL   MPO

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8391745


    Sources:
    NCI

  • LITHIUM   MPO

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8224362


    Sources:
    NCI

  • Ensembl: ENSG00000005381

    • Version: 101_38

    Alternate Names:
    MPO Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P05164

    • Version: 11-September-2012

    Alternate Names:
    PERM_HUMAN Uniprot Id
    4353 Entrez Gene Id
    MPO Uniprot Gene Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Short Name Haem_peroxidase_animal
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000005381

    • Version: 26-July-2011

    Alternate Names:
    MPO Display Id
    MYELOPEROXIDASE PRECURSOR (EC 1.11.1.7) (MPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P05164] Description
    ENSG00000005381 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: MPO

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Jorgenson et al., 1991, Chromatin structural analysis of the 5' end and contiguous flanking region of the myeloperoxidase gene., Blood
    Kettle et al., 1992, Oxidative metabolism of amsacrine by the neutrophil enzyme myeloperoxidase., Biochem. Pharmacol.
    Brügger-Andersen et al., 2007, The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin and D-dimer in acute myocardial infarction., Thromb. Res.

  • DTC: MPO

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Ruggeri RB et al., 2015, Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases., J Med Chem

  • HingoraniCasas: ENSG00000005381

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000005381 Gene Symbol
    MPO Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: MPO

    • Version: 19.3

    Alternate Names:
    P05164 UniProt ID
    ENSG00000005381 Ensembl Gene ID
    Myeloperoxidase Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Myeloperoxidase

    • Version: 2020.06.01

    Alternate Names:
    MPO TTD Gene Abbreviation
    T23471 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: MPO

    • Version: 01-February-2022

    Alternate Names:
    Myeloperoxidase Gene Name
    P05164 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21