• Interaction Score: 5.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 5.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Thrombopoietin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 5.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Agonist

  • Interaction Score: 4.52

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Thrombopoietin receptor agonist
    Direct Interaction yes
    Direct Interaction? True

  • Interaction Score: 4.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Promacta
    Novel drug target Established target
    Specific Action of the Ligand Agonist

  • Interaction Score: 2.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ruxolitinib + TGX-221
    Indication/Tumor Type Advanced Solid Tumor
    Response Type sensitive

    PMIDs:
    24251790


    Sources:
    JAX-CKB

  • Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type myelofibrosis
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    23748344


    Sources:
    JAX-CKB

  • Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Response Type sensitive
    combination therapy GDC-0941 + Ruxolitinib
    Indication/Tumor Type Advanced Solid Tumor

    PMIDs:
    24251790


    Sources:
    JAX-CKB

  • Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type myelofibrosis
    Response Type sensitive
    Approval Status Phase II

    PMIDs:
    21725052


    Sources:
    JAX-CKB

  • Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy BEZ235 + Ruxolitinib
    Indication/Tumor Type Advanced Solid Tumor
    Response Type sensitive

    PMIDs:
    24251790


    Sources:
    JAX-CKB