DGIdb - MGMT Gene Record

MGMT 4255 Druggable GenomeClinically Actionable

Alternate Names:

4255
O-6-METHYLGUANINE-DNA METHYLTRANSFERASE
MGMT
156569
7059
ENSG00000170430
OTTHUMG00000019261
34
PA239
O-6-methylguanine-DNA-alkyltransferase
T24587
P16455
Methylated-DNA--protein-cysteine methyltransferase

Gene Info:

Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DNA REPAIR
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Preuss et al., 1996, Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs., Int. J. Cancer
Okamoto et al., 2002, O(6)-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives., Jpn. J. Cancer Res.
Maki et al., 2005, Role of O6-methylguanine-DNA methyltransferase and effect of O6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines., Oral Oncol.
Chen et al., 1994, O6-methylguanine-DNA methyltransferase in ovarian malignancy and its correlation with postoperative response to chemotherapy., Gynecol. Oncol.
Fang et al., 2005, Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy., Clin. Cancer Res.
Brown CC et al., 2014, Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines., Pharmacogenomics
Watanabe et al., 2011, O6-methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma., Brain Tumor Pathol
Kreth et al., 2011, O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation., PLoS ONE
Chinot et al., 2007, Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide., J. Clin. Oncol.
Rapkins et al., 2015, The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide., Neuro-oncology
Hegi et al., 2005, MGMT gene silencing and benefit from temozolomide in glioblastoma., N. Engl. J. Med.
Barvaux et al., 2004, Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase., Mol. Cancer Ther.
Herrlinger U et al., 2019, Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial., Lancet
von Wronski et al., 1994, Effect of 5-azacytidine on expression of the human DNA repair enzyme O6-methylguanine-DNA methyltransferase., Carcinogenesis
Ma et al., Immunohistochemical analysis of DNA mismatch repair protein and O6-methylguanine-DNA methyltransferase in melanoma metastases in relation to clinical response to DTIC-based chemotherapy., Oncol. Rep.
Zhu R et al., 2012, Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase., Bioorg Med Chem Lett
Pauly GT et al., 2008, Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine., J Med Chem
Mirzayans et al., 1992, Cytotoxic and mutagenic effects of methylnitrosourea in two human fetal fibroblast strains differing in O6-methylguanine-DNA methyltransferase activity., Carcinogenesis
Badawi, 1998, O6-methylguanine and O6-methylguanine-DNA [corrected] methyltransferase activity in tissues of BDF-1 mice treated with antiparasitic drugs., Toxicol. Lett.
Kokkinakis et al., 1997, Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents., Cancer Res.
Kuo et al., 2006, DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors., J. Pharmacol. Exp. Ther.
Christmann et al., 2001, Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT., Int. J. Cancer
Esteller et al., 2000, Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents., N. Engl. J. Med.

CHEMBL485756 MGMT

Interaction Score: 9.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22932317 18973327

Sources:
DTC
FOTEMUSTINE MGMT

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11279615

Sources:
NCI
LOMUSTINE MGMT

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9393761 30782343

Sources:
NCI CIViC
EXATECAN MESYLATE MGMT

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11802813

Sources:
NCI
TEMOZOLOMIDE MGMT

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24444404 21331613 21365007 17442989 25910840 15758010 15486188 30782343

Sources:
NCI CIViC PharmGKB
6-O-BENZYLGUANINE MGMT

Interaction Score: 1.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18973327 22932317

Sources:
DTC
MAFOSFAMIDE MGMT

Interaction Score: 1.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8621235

Sources:
NCI
IRINOTECAN HYDROCHLORIDE MGMT

Interaction Score: 0.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11802813

Sources:
NCI
IFOSFAMIDE MGMT

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8621235

Sources:
NCI
CARMUSTINE MGMT

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11070098

Sources:
CIViC
CHLORAMBUCIL MGMT

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8621235

Sources:
NCI
DACARBAZINE MGMT

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12168066

Sources:
NCI
HYCANTHONE MGMT

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9609323

Sources:
NCI
MELPHALAN MGMT

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8621235

Sources:
NCI
THIOGUANINE MGMT

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1638685

Sources:
NCI
AZACITIDINE MGMT

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7511991

Sources:
NCI
CAMPTOTHECIN MGMT

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16258022

Sources:
NCI
GENISTEIN MGMT

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16203797

Sources:
NCI
CISPLATIN MGMT

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16043385 8314134

Sources:
NCI

Ensembl: ENSG00000170430
- Version: 101_38
Alternate Names:

MGMT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: MGMT
- Version: 18-August-2020
Alternate Names:

PA239 PharmGKB ID

Gene Info:

Publications:

Brown CC et al., 2014, Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines., Pharmacogenomics

CIViC: MGMT

Version: 14-September-2020

Alternate Names:

4255 Entrez Gene ID

34 CIViC Gene ID

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Herrlinger U et al., 2019, Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial., Lancet

Rapkins et al., 2015, The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide., Neuro-oncology

Hegi et al., 2005, MGMT gene silencing and benefit from temozolomide in glioblastoma., N. Engl. J. Med.

NCI: MGMT

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Preuss et al., 1996, Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs., Int. J. Cancer

Okamoto et al., 2002, O(6)-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives., Jpn. J. Cancer Res.

Ma et al., Immunohistochemical analysis of DNA mismatch repair protein and O6-methylguanine-DNA methyltransferase in melanoma metastases in relation to clinical response to DTIC-based chemotherapy., Oncol. Rep.

DTC: MGMT

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Zhu R et al., 2012, Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase., Bioorg Med Chem Lett

Pauly GT et al., 2008, Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine., J Med Chem

HingoraniCasas: ENSG00000170430
- Version: 31-May-2017
Alternate Names:

ENSG00000170430 Gene Symbol

MGMT Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: MGMT
- Version: 11-November-2018
Alternate Names:

MGMT Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: O-6-methylguanine-DNA-alkyltransferase
- Version: 2020.06.01
Alternate Names:

MGMT TTD Gene Abbreviation

T24587 TTD Target ID

Gene Info:

Publications:
Pharos: MGMT
- Version: 01-February-2022
Alternate Names:

Methylated-DNA--protein-cysteine methyltransferase Gene Name

P16455 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
ClearityFoundationBiomarkers: MGMT
- Version: 26-July-2013
Alternate Names:

Gene Info:

Publications:
GO: MGMT
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

DNA REPAIR

Publications:

Methylated-DNA--protein-cysteine methyltransferase	Gene Name
P16455	UniProt ID

MGMT Gene Record

MGMT 4255 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22932317 18973327

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11279615

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9393761 30782343

Sources: NCI CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11802813

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24444404 21331613 21365007 17442989 25910840 15758010 15486188 30782343

Sources: NCI CIViC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18973327 22932317

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8621235

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11802813

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8621235

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11070098

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8621235

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12168066

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9609323

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8621235

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1638685

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7511991

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16258022

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16203797

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
22932317 18973327

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11279615

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9393761 30782343

Sources:
NCI CIViC

Interaction Types & Directionality:

n/a

PMIDs:
11802813

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24444404 21331613 21365007 17442989 25910840 15758010 15486188 30782343

Sources:
NCI CIViC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18973327 22932317

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
8621235

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11802813

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8621235

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11070098

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
8621235

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12168066

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9609323

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8621235

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1638685

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7511991

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16258022

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16203797

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16043385 8314134

Sources:
NCI

Alternate Names:

MGMT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA239 PharmGKB ID

Publications:

Brown CC et al., 2014, Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines., Pharmacogenomics

Alternate Names:

4255 Entrez Gene ID

34 CIViC Gene ID

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

ENSG00000170430 Gene Symbol

MGMT Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MGMT Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

MGMT TTD Gene Abbreviation

T24587 TTD Target ID

Alternate Names:

Methylated-DNA--protein-cysteine methyltransferase Gene Name

P16455 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

DNA REPAIR