DGIdb - MGAM Gene Record

MGAM 8972 Druggable Genome

Alternate Names:

8972
MALTASE-GLUCOAMYLASE
MGAM
MG
MGA
154360
7043
ENSG00000257335
OTTHUMG00000158395
O43451
ENSG00000257335; ENSG00000259858
MGA_HUMAN
ENSG00000179087
MALTASE-GLUCOAMYLASE, INTESTINAL [INCLUDES: MALTASE (EC 3.2.1.20) (ALPHA-GLUCOSIDASE); GLUCOAMYLASE (EC 3.2.1.3) (GLUCAN 1,4-ALPHA- GLUCOSIDASE)]. [SOURCE:UNIPROT/SWISSPROT;ACC:O43451]
Glucan 1,4-alpha-glucosidase
Alpha-glucosidase
Glucoamylase
Maltase
Maltase-glucoamylase, intestinal
MGAML
ENSG00000259858
Intestinal maltase-glucoamylase
T92777

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.2.1
Target Subclass	3.2.1
Transmembrane Helix Count	1
Target Main Class	Enzymes
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Acc	IPR000322
Interpro Name	Glycoside hydrolase, family 31
Interpro Short Name	Glyco_hydro_31
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Nishioka T et al., 1998, Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis., J Nat Prod
Satoh et al., 2006, An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients., Metab. Clin. Exp.
Matsumura et al., 2009, Effects of changeover from voglibose to acarbose on postprandial triglycerides in type 2 diabetes mellitus patients., Adv Ther
Fujimori et al., 2009, Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats., Eur. J. Pharmacol.
Abe et al., 2010, Combination therapy with mitiglinide and voglibose improves glycemic control in type 2 diabetic patients on hemodialysis., Expert Opin Pharmacother
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Iwasa et al., 2010, Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits., J. Cardiovasc. Pharmacol.
Rossi et al., 2006, Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives., FEBS J.
Fukaya et al., 2009, The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats., Eur. J. Pharmacol.
Mooradian et al., 1999, Drug therapy of postprandial hyperglycaemia., Drugs
Zhang et al., 2006, Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease., Genet. Med.
Okumiya et al., 2006, A new diagnostic assay for glycogen storage disease type II in mixed leukocytes., Mol. Genet. Metab.
Yamagishi et al., 2009, Clinical utility of acarbose, an alpha-glucosidase inhibitor in cardiometabolic disorders., Curr. Drug Metab.
Gelb et al., Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders., J. Inherit. Metab. Dis.
Suresh Babu K et al., 2004, Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson., Bioorg Med Chem Lett

VOGLIBOSE MGAM

Interaction Score: 55.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name voglibose,Basen

Novel drug target Established target

PMIDs:
16713439 19568704 19281809 20025554 11752352 20351564

Sources:
TdgClinicalTrial TEND TTD
MIGLITOL MGAM

Interaction Score: 14.43

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352 16817895 19818342 9951949

Sources:
TdgClinicalTrial TEND TTD
RESVERATROL 4'-METHYL ETHER MGAM

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15203173

Sources:
DTC
ACARBOSE MGAM

Interaction Score: 7.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name acarbose,Glucobay

PMIDs:
16702880 16359900 19275550 11752352 16763908

Sources:
TdgClinicalTrial TEND TTD
ALGLUCOSIDASE ALFA MGAM

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CELGOSIVIR MGAM

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SALACINOL MGAM

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MALTOSE MGAM

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DUVOGLUSTAT MGAM

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BAICALEIN MGAM

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9834167

Sources:
DTC

Ensembl: ENSG00000257335
- Version: 101_38
Alternate Names:

MGAM Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: O43451
- Version: January-2014
Alternate Names:

MGAM Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.2.1

Publications:
HopkinsGroom: O43451
- Version: 11-September-2012
Alternate Names:

MGAM Uniprot Gene Name

8972 Entrez Gene Id

ENSG00000257335 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: O43451
- Version: 01-August-2011
Alternate Names:

8972 Entrez Gene Id

O43451 Uniprot Accession

MGA_HUMAN Uniprot Id

Gene Info:

Target Subclass 3.2.1

Transmembrane Helix Count 1

Target Main Class Enzymes

Publications:

RussLampel: ENSG00000179087

Version: 26-July-2011

Alternate Names:

ENSG00000179087 Ensembl Gene Id

MALTASE-GLUCOAMYLASE, INTESTINAL [INCLUDES: MALTASE (EC 3.2.1.20) (ALPHA-GLUCOSIDASE); GLUCOAMYLASE (EC 3.2.1.3) (GLUCAN 1,4-ALPHA- GLUCOSIDASE)]. [SOURCE:UNIPROT/SWISSPROT;ACC:O43451] Description

MGAM Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TTD: Intestinal maltase-glucoamylase

Version: 2020.06.01

Alternate Names:

MGAM TTD Gene Abbreviation

T92777 TTD Target ID

Gene Info:

Publications:

Trask LE et al., 2014, Treatment with novel galactomannan derivative reduces 2-hour postprandial glucose excursions in individuals with type 2 diabetes treated with oral medications and/or insulin., J Diabetes Sci Technol

DTC: MGAM

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Nishioka T et al., 1998, Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis., J Nat Prod

Suresh Babu K et al., 2004, Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000257335
- Version: 31-May-2017
Alternate Names:

ENSG00000257335 Gene Symbol

MGAM Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: MGAM
- Version: 01-February-2022
Alternate Names:

Maltase-glucoamylase, intestinal Gene Name

O43451 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Trial Name	voglibose,Basen
Novel drug target	Established target

MGAM	Uniprot Gene Name
8972	Entrez Gene Id
ENSG00000257335	Ensembl Gene Id

antagonist (inhibitory)
inhibitor (inhibitory)

MGAM Gene Record

MGAM 8972 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name voglibose,Basen Novel drug target Established target

PMIDs: 16713439 19568704 19281809 20025554 11752352 20351564

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752352 16817895 19818342 9951949

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15203173

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name acarbose,Glucobay

PMIDs: 16702880 16359900 19275550 11752352 16763908

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9834167

Sources: DTC

Ensembl: ENSG00000257335

Alternate Names: MGAM Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: O43451

Alternate Names: MGAM Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.2.1

Publications:

HopkinsGroom: O43451

Alternate Names: MGAM Uniprot Gene Name 8972 Entrez Gene Id ENSG00000257335 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: O43451

Alternate Names: 8972 Entrez Gene Id O43451 Uniprot Accession MGA_HUMAN Uniprot Id

Gene Info: Target Subclass 3.2.1 Transmembrane Helix Count 1 Target Main Class Enzymes

Publications:

RussLampel: ENSG00000179087

Alternate Names: ENSG00000179087 Ensembl Gene Id MALTASE-GLUCOAMYLASE, INTESTINAL [INCLUDES: MALTASE (EC 3.2.1.20) (ALPHA-GLUCOSIDASE); GLUCOAMYLASE (EC 3.2.1.3) (GLUCAN 1,4-ALPHA- GLUCOSIDASE)]. [SOURCE:UNIPROT/SWISSPROT;ACC:O43451] Description MGAM Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Intestinal maltase-glucoamylase

Alternate Names: MGAM TTD Gene Abbreviation T92777 TTD Target ID

Gene Info:

Publications: Trask LE et al., 2014, Treatment with novel galactomannan derivative reduces 2-hour postprandial glucose excursions in individuals with type 2 diabetes treated with oral medications and/or insulin., J Diabetes Sci Technol

DTC: MGAM

Alternate Names:

Gene Info:

Publications: Nishioka T et al., 1998, Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis., J Nat Prod Suresh Babu K et al., 2004, Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000257335

Alternate Names: ENSG00000257335 Gene Symbol MGAM Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name voglibose,Basen

Novel drug target Established target

PMIDs:
16713439 19568704 19281809 20025554 11752352 20351564

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352 16817895 19818342 9951949

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
15203173

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name acarbose,Glucobay

PMIDs:
16702880 16359900 19275550 11752352 16763908

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
9834167

Sources:
DTC

Alternate Names:

MGAM Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

MGAM Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.2.1

Alternate Names:

MGAM Uniprot Gene Name

8972 Entrez Gene Id

ENSG00000257335 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

8972 Entrez Gene Id

O43451 Uniprot Accession

MGA_HUMAN Uniprot Id

Gene Info:

Target Subclass 3.2.1

Transmembrane Helix Count 1

Target Main Class Enzymes

Alternate Names:

ENSG00000179087 Ensembl Gene Id

MALTASE-GLUCOAMYLASE, INTESTINAL [INCLUDES: MALTASE (EC 3.2.1.20) (ALPHA-GLUCOSIDASE); GLUCOAMYLASE (EC 3.2.1.3) (GLUCAN 1,4-ALPHA- GLUCOSIDASE)]. [SOURCE:UNIPROT/SWISSPROT;ACC:O43451] Description

MGAM Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MGAM TTD Gene Abbreviation

T92777 TTD Target ID

Publications:

Trask LE et al., 2014, Treatment with novel galactomannan derivative reduces 2-hour postprandial glucose excursions in individuals with type 2 diabetes treated with oral medications and/or insulin., J Diabetes Sci Technol

Publications:

Nishioka T et al., 1998, Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis., J Nat Prod

Suresh Babu K et al., 2004, Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson., Bioorg Med Chem Lett

Alternate Names:

ENSG00000257335 Gene Symbol

MGAM Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Maltase-glucoamylase, intestinal Gene Name

O43451 UniProt ID

Gene Categories:

ENZYME