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MGAM Gene Record

  • Summary
  • Interactions
  • Claims
  • MGAM 8972 Druggable Genome

    Alternate Names:

    8972
    MALTASE-GLUCOAMYLASE
    MGAM
    MG
    MGA
    154360
    7043
    ENSG00000257335
    OTTHUMG00000158395
    O43451
    ENSG00000257335; ENSG00000259858
    MGA_HUMAN
    ENSG00000179087
    MALTASE-GLUCOAMYLASE, INTESTINAL [INCLUDES: MALTASE (EC 3.2.1.20) (ALPHA-GLUCOSIDASE); GLUCOAMYLASE (EC 3.2.1.3) (GLUCAN 1,4-ALPHA- GLUCOSIDASE)]. [SOURCE:UNIPROT/SWISSPROT;ACC:O43451]
    Glucan 1,4-alpha-glucosidase
    Alpha-glucosidase
    Glucoamylase
    Maltase
    Maltase-glucoamylase, intestinal
    MGAML
    ENSG00000259858
    Intestinal maltase-glucoamylase
    T92777

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.2.1
    Target Subclass 3.2.1
    Transmembrane Helix Count 1
    Target Main Class Enzymes
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Acc IPR000322
    Interpro Name Glycoside hydrolase, family 31
    Interpro Short Name Glyco_hydro_31
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Nishioka T et al., 1998, Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis., J Nat Prod
    Satoh et al., 2006, An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients., Metab. Clin. Exp.
    Matsumura et al., 2009, Effects of changeover from voglibose to acarbose on postprandial triglycerides in type 2 diabetes mellitus patients., Adv Ther
    Fujimori et al., 2009, Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats., Eur. J. Pharmacol.
    Abe et al., 2010, Combination therapy with mitiglinide and voglibose improves glycemic control in type 2 diabetic patients on hemodialysis., Expert Opin Pharmacother
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Iwasa et al., 2010, Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits., J. Cardiovasc. Pharmacol.
    Rossi et al., 2006, Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives., FEBS J.
    Fukaya et al., 2009, The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats., Eur. J. Pharmacol.
    Mooradian et al., 1999, Drug therapy of postprandial hyperglycaemia., Drugs
    Zhang et al., 2006, Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease., Genet. Med.
    Okumiya et al., 2006, A new diagnostic assay for glycogen storage disease type II in mixed leukocytes., Mol. Genet. Metab.
    Yamagishi et al., 2009, Clinical utility of acarbose, an alpha-glucosidase inhibitor in cardiometabolic disorders., Curr. Drug Metab.
    Gelb et al., Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders., J. Inherit. Metab. Dis.
    Suresh Babu K et al., 2004, Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson., Bioorg Med Chem Lett
  • VOGLIBOSE   MGAM

    Interaction Score: 55.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name voglibose,Basen
    Novel drug target Established target

    PMIDs:
    16713439 19568704 19281809 20025554 11752352 20351564


    Sources:
    TdgClinicalTrial TEND TTD

  • MIGLITOL   MGAM

    Interaction Score: 14.43

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752352 16817895 19818342 9951949


    Sources:
    TdgClinicalTrial TEND TTD

  • RESVERATROL 4'-METHYL ETHER   MGAM

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15203173


    Sources:
    DTC

  • ACARBOSE   MGAM

    Interaction Score: 7.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name acarbose,Glucobay

    PMIDs:
    16702880 16359900 19275550 11752352 16763908


    Sources:
    TdgClinicalTrial TEND TTD

  • ALGLUCOSIDASE ALFA   MGAM

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CELGOSIVIR   MGAM

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SALACINOL   MGAM

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MALTOSE   MGAM

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DUVOGLUSTAT   MGAM

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BAICALEIN   MGAM

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9834167


    Sources:
    DTC

  • Ensembl: ENSG00000257335

    • Version: 101_38

    Alternate Names:
    MGAM Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: O43451

    • Version: January-2014

    Alternate Names:
    MGAM Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.2.1

    Publications:

  • HopkinsGroom: O43451

    • Version: 11-September-2012

    Alternate Names:
    MGAM Uniprot Gene Name
    8972 Entrez Gene Id
    ENSG00000257335 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: O43451

    • Version: 01-August-2011

    Alternate Names:
    8972 Entrez Gene Id
    O43451 Uniprot Accession
    MGA_HUMAN Uniprot Id

    Gene Info:
    Target Subclass 3.2.1
    Transmembrane Helix Count 1
    Target Main Class Enzymes

    Publications:

  • RussLampel: ENSG00000179087

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000179087 Ensembl Gene Id
    MALTASE-GLUCOAMYLASE, INTESTINAL [INCLUDES: MALTASE (EC 3.2.1.20) (ALPHA-GLUCOSIDASE); GLUCOAMYLASE (EC 3.2.1.3) (GLUCAN 1,4-ALPHA- GLUCOSIDASE)]. [SOURCE:UNIPROT/SWISSPROT;ACC:O43451] Description
    MGAM Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Intestinal maltase-glucoamylase

    • Version: 2020.06.01

    Alternate Names:
    MGAM TTD Gene Abbreviation
    T92777 TTD Target ID

    Gene Info:

    Publications:
    Trask LE et al., 2014, Treatment with novel galactomannan derivative reduces 2-hour postprandial glucose excursions in individuals with type 2 diabetes treated with oral medications and/or insulin., J Diabetes Sci Technol

  • DTC: MGAM

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Nishioka T et al., 1998, Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis., J Nat Prod
    Suresh Babu K et al., 2004, Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000257335

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000257335 Gene Symbol
    MGAM Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: MGAM

    • Version: 01-February-2022

    Alternate Names:
    Maltase-glucoamylase, intestinal Gene Name
    O43451 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21