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METAP2 Gene Record

  • Summary
  • Interactions
  • Claims
  • METAP2 10988 Druggable Genome

    Alternate Names:

    10988
    METHIONYL AMINOPEPTIDASE 2
    METAP2
    MAP2
    MNPEP
    p67eIF2
    601870
    16672
    ENSG00000111142
    OTTHUMG00000170280
    Methionine aminopeptidase 2
    MetAP 2
    p67
    MAP 2
    Peptidase M
    Initiation factor 2-associated 67 kDa glycoprotein
    P50579
    1573
    NM_006838
    NP_006829
    BE0001534
    AMPM2_HUMAN
    METHIONINE AMINOPEPTIDASE 2 (EC 3.4.11.18) (METAP 2) (PEPTIDASE M 2) (INITIATION FACTOR 2 ASSOCIATED 67 KDA GLYCOPROTEIN) (P67) (P67EIF2). [SOURCE:UNIPROT/SWISSPROT;ACC:P50579]
    T75596

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.4.11.18
    GuideToPharmacology Gene Category Name M24: Methionyl aminopeptidase
    GuideToPharmacology Gene Category ID 746
    Human Readable Name PROTEASE
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Name Peptidase M24, structural domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000994
    Interpro Short Name Pept_M24_structural-domain
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    KINASE
    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Shim et al., 2010, Effect of nitroxoline on angiogenesis and growth of human bladder cancer., J. Natl. Cancer Inst.
    Sheppard et al., 2006, Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding., J. Med. Chem.
    Upadhya et al., 2006, System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae., Antimicrob. Agents Chemother.
    Hu et al., 2006, Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression., Proc. Natl. Acad. Sci. U.S.A.
    Addlagatta et al., 2006, Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase., Protein Sci.
    Nonato et al., 2006, Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Bioorg. Med. Chem. Lett.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
  • CHEMBL354739   METAP2

    Interaction Score: 14.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • BELORANIB   METAP2

    Interaction Score: 10.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ZGN-433
    Novel drug target Novel Target
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD GuideToPharmacology

  • PPI-2458   METAP2

    Interaction Score: 10.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name PPI-2458

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank

  • CHEMBL378927   METAP2

    Interaction Score: 7.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1234268   METAP2

    Interaction Score: 7.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16540317


    Sources:
    DrugBank

  • CHEMBL230172   METAP2

    Interaction Score: 7.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL380394   METAP2

    Interaction Score: 7.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL212522   METAP2

    Interaction Score: 7.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • OVALICIN   METAP2

    Interaction Score: 7.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL352764   METAP2

    Interaction Score: 7.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • FUMAGILLIN   METAP2

    Interaction Score: 3.55

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    11752352


    Sources:
    DrugBank

  • TERT-BUTANOL   METAP2

    Interaction Score: 2.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • METHIONINE   METAP2

    Interaction Score: 2.13

    Interaction Types & Directionality:
    product of

    Interaction Info:

    PMIDs:
    16789740 16917013 17114291 16823043 16540317


    Sources:
    DrugBank

  • O-CHLOROACETYLCARBAMOYLFUMAGILLOL   METAP2

    Interaction Score: 1.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • NITROXOLINE   METAP2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21088277


    Sources:
    DrugBank

  • TOSEDOSTAT   METAP2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Aminopeptidases inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000111142

    • Version: 101_38

    Alternate Names:
    METAP2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P50579

    • Version: January-2014

    Alternate Names:
    METAP2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.11.18

    Publications:

  • HopkinsGroom: P50579

    • Version: 11-September-2012

    Alternate Names:
    AMPM2_HUMAN Uniprot Id
    10988 Entrez Gene Id
    METAP2 Uniprot Gene Name

    Gene Info:
    Human Readable Name PROTEASE
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000111142

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000111142 Ensembl Gene Id
    METAP2 Display Id
    METHIONINE AMINOPEPTIDASE 2 (EC 3.4.11.18) (METAP 2) (PEPTIDASE M 2) (INITIATION FACTOR 2 ASSOCIATED 67 KDA GLYCOPROTEIN) (P67) (P67EIF2). [SOURCE:UNIPROT/SWISSPROT;ACC:P50579] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 10988

    • Version: 29-September-2020

    Alternate Names:
    16672 HUGO Gene ID
    16672 HUGO Gene Symbol
    methionyl aminopeptidase 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name M24: Methionyl aminopeptidase
    GuideToPharmacology Gene Category ID 746

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0001534

    • Version: 5.1.7

    Alternate Names:
    METAP2 DrugBank Gene Name
    P50579 UniProt Accession
    10988 Entrez Gene Id

    Gene Info:

    Publications:
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Nonato et al., 2006, Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Bioorg. Med. Chem. Lett.

  • HingoraniCasas: ENSG00000111142

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000111142 Gene Symbol
    METAP2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: MNPEP

    • Version: chembl_23

    Alternate Names:
    P67EIF2 GENE_SYMBOL
    METAP2 GENE_SYMBOL
    Methionine aminopeptidase 2 UNIPROT

    Gene Info:

    Publications:

  • Pharos: METAP2

    • Version: 03-September-2020

    Alternate Names:
    Methionine aminopeptidase 2 Gene Name
    P50579 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • dGene: METAP2

    • Version: 27-Jun-2013

    Alternate Names:
    10988 Gene ID
    MAP2 dGene Synonym
    MNPEP dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Methionine aminopeptidase 2

    • Version: 2020.06.01

    Alternate Names:
    METAP2 TTD Gene Abbreviation
    T75596 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21