DGIdb - MET Gene Record

MET 4233 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

4233
MET PROTO-ONCOGENE, RECEPTOR TYROSINE KINASE
MET
AUTS9
DFNB97
HGFR
RCCP2
c-Met
164860
7029
ENSG00000105976
OTTHUMG00000023299
MET_HUMAN
P08581
HEPATOCYTE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (MET PROTO- ONCOGENE TYROSINE KINASE) (C-MET) (HGF RECEPTOR) (HGF-SF RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08581]
HEPATOCYTE GROWTH FACTOR RECEPTOR
1815
BE0000915
PA30763
SF receptor
HGF receptor
Tyrosine-protein kinase Met
Scatter factor receptor
Proto-oncogene c-Met
HGF/SF receptor
52
NP_000236
NM_000245
T40474

Gene Info:

Initial Gene Query	MET
Counted Citations from 1950-2000	4560
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	KINASE
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Acc	IPR001245
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
CancerCommons Reported Gene Name	MET
CancerCommons Reported Gene Name	MET, VEGFRs, Axl, Tie2, Ron
GuideToPharmacology Gene Category Name	Type X RTKs: HGF (hepatocyte growth factor) receptor family
GuideToPharmacology Gene Category ID	325
Target Class	Receptors
Target Subclass	EC:2.7.10.1
Gene Biotype	PROTEIN_CODING

(31 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
TYROSINE KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Zick et al., 2017, Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients., Medicine (Baltimore)
Patnaik et al., 2014, Phase I ficlatuzumab monotherapy or with erlotinib for refractory advanced solid tumours and multiple myeloma., Br. J. Cancer
Phillip et al., 2013, Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines., J Hematol Oncol
Awad et al., 2016, MET Exon 14 Mutations in Non-Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met Overexpression., J. Clin. Oncol.
Lorenzato et al., 2002, Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion., Cancer Res.
Secrier et al., 2016, Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance., Nat. Genet.
Heist et al., 2016, Acquired Resistance to Crizotinib in NSCLC with MET Exon 14 Skipping., J Thorac Oncol
Tanizaki et al., 2011, MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations., J Thorac Oncol
Bahcall et al., 2016, Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer., Cancer Discov
Bardelli et al., 1998, Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth., Proc. Natl. Acad. Sci. U.S.A.
Forde et al., 2012, Crizotinib in the treatment of non-small-cell lung cancer., Expert Opin Pharmacother
Moro-Sibilot D et al., 2019, Crizotinib in c-MET- or ROS1-positive NSCLC: results of the AcSé phase II trial., Ann Oncol
Du et al., 2016, Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors., Nat. Med.
Frampton et al., 2015, Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors., Cancer Discov
Le et al., 2015, Detection of Crizotinib-Sensitive Lung Adenocarcinomas With MET, ALK, and ROS1 Genomic Alterations via Comprehensive Genomic Profiling., Clin Lung Cancer
Chi et al., 2012, Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor., J. Clin. Oncol.
Landi L et al., 2019, Crizotinib in <i>MET</i>-Deregulated or <i>ROS1</i>-Rearranged Pretreated Non-Small Cell Lung Cancer (METROS): A Phase II, Prospective, Multicenter, Two-Arms Trial., Clin Cancer Res
Wiesweg M et al., 2020, Clinical response to crizotinib and emergence of resistance in lung adenocarcinoma harboring a MET c-Cbl binding site mutation., Lung Cancer
Dalinka et al., 1975, The radiology of osseous and articular infection., CRC Crit Rev Clin Radiol Nucl Med
Paik et al., 2015, Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping., Cancer Discov
Ou et al., 2011, Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification., J Thorac Oncol
Zou et al., 2007, An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms., Cancer Res.
Pietrantonio et al., 2016, MET-Driven Resistance to Dual EGFR and BRAF Blockade May Be Overcome by Switching from EGFR to MET Inhibition in BRAF-Mutated Colorectal Cancer., Cancer Discov
Pfefferle et al., 2016, Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers., Dis Model Mech
Ou SH, 2011, Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond., Drug Des Devel Ther
Drilon A et al., 2020, Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration., Nat Med
Shen et al., 2015, c-Myc alterations confer therapeutic response and acquired resistance to c-Met inhibitors in MET-addicted cancers., Cancer Res.
Palma et al., 2014, Durable Response to Crizotinib in a MET-Amplified, KRAS-Mutated Carcinoma of Unknown Primary., Case Rep Oncol
Engstrom et al., 2017, Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-Mediated Resistance to Type I MET Inhibitors in Nonclinical Models., Clin. Cancer Res.
Qi et al., 2011, Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors., Cancer Res.
Mahjoubi L et al., 2016, A never-smoker lung adenocarcinoma patient with a MET exon 14 mutation (D1028N) and a rapid partial response after crizotinib., Invest New Drugs
Ou et al., 2016, High MET amplification level as a resistance mechanism to osimertinib (AZD9291) in a patient that symptomatically responded to crizotinib treatment post-osimertinib progression., Lung Cancer
MacConaill et al., 2014, Prospective enterprise-level molecular genotyping of a cohort of cancer patients., J Mol Diagn
Chabon et al., 2016, Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients., Nat Commun
Lu et al., 2017, MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma., Cancer Res.
Bardelli et al., 2013, Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer., Cancer Discov
Kwak et al., 2015, Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer., Cancer Discov
Choi et al., 2004, Molecular mechanisms of heptaplatin effective against cisplatin-resistant cancer cell lines: less involvement of metallothionein., Cancer Cell Int.
Togashi et al., 2015, MET gene exon 14 deletion created using the CRISPR/Cas9 system enhances cellular growth and sensitivity to a MET inhibitor., Lung Cancer
Olivero et al., 1999, Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family., Int. J. Cancer
Zhu YC et al., 2018, Identification of a novel crizotinib-sensitive MET-ATXN7L1 gene fusion variant in lung adenocarcinoma by next generation sequencing., Ann Oncol
Li et al., 2017, Acquired MET Y1248H and D1246N Mutations Mediate Resistance to MET Inhibitors in Non-Small Cell Lung Cancer., Clin. Cancer Res.
Chu LP et al., 2019, MET Genomic Alterations in Head and Neck Squamous Cell Carcinoma (HNSCC): Rapid Response to Crizotinib in a Patient with HNSCC with a Novel <i>MET</i> R1004G Mutation., Oncologist
Maulik et al., 2002, Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition., Cytokine Growth Factor Rev.
Choueiri et al., 2017, Biomarker-Based Phase II Trial of Savolitinib in Patients With Advanced Papillary Renal Cell Cancer., J. Clin. Oncol.
Lee J et al., 2019, Tumor Genomic Profiling Guides Patients with Metastatic Gastric Cancer to Targeted Treatment: The VIKTORY Umbrella Trial., Cancer Discov
Schuller et al., 2015, The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models., Clin. Cancer Res.
Spigel et al., 2013, Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer., J. Clin. Oncol.
Shah et al., 2017, Effect of Fluorouracil, Leucovorin, and Oxaliplatin With or Without Onartuzumab in HER2-Negative, MET-Positive Gastroesophageal Adenocarcinoma: The METGastric Randomized Clinical Trial., JAMA Oncol
Catenacci et al., 2011, Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence., Cancer Discov
Merchant et al., 2013, Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent., Proc. Natl. Acad. Sci. U.S.A.
Cheng et al., 2015, Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma., Cancer Res.
Qu et al., 2014, Antitumor activity of selective MEK1/2 inhibitor AZD6244 in combination with PI3K/mTOR inhibitor BEZ235 in gefitinib-resistant NSCLC xenograft models., J. Exp. Clin. Cancer Res.
Falchook et al., 2015, Dual antiangiogenic inhibition: a phase I dose escalation and expansion trial targeting VEGF-A and VEGFR in patients with advanced solid tumors., Invest New Drugs
Busnena BA et al., 2013, Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer., Bioorg Med Chem
Dorsch D et al., 2015, Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors., Bioorg Med Chem Lett
Paik PK et al., 2020, Tepotinib in Non-Small-Cell Lung Cancer with <i>MET</i> Exon 14 Skipping Mutations., N Engl J Med
Medová M et al., 2013, The novel ATP-competitive inhibitor of the MET hepatocyte growth factor receptor EMD1214063 displays inhibitory activity against selected MET-mutated variants., Mol Cancer Ther
Choueiri et al., 2013, Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma., J. Clin. Oncol.
Hudkins RL et al., 2012, Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agent., J Med Chem
Nakagawa et al., 2010, E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models., Cancer Sci.
Minuti et al., 2012, Increased MET and HGF gene copy numbers are associated with trastuzumab failure in HER2-positive metastatic breast cancer., Br. J. Cancer
Rosen et al., 2017, A First-in-Human Phase I Study of a Bivalent MET Antibody, Emibetuzumab (LY2875358), as Monotherapy and in Combination with Erlotinib in Advanced Cancer., Clin. Cancer Res.
Wang et al., 2017, ABBV-399, a c-Met Antibody-Drug Conjugate that Targets Both MET-Amplified and c-Met-Overexpressing Tumors, Irrespective of MET Pathway Dependence., Clin. Cancer Res.
Yao et al., 2017, Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS., Nature
Wolf J et al., 2020, Capmatinib in <i>MET</i> Exon 14-Mutated or <i>MET</i>-Amplified Non-Small-Cell Lung Cancer., N Engl J Med
Hong JY et al., 2011, Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa., J Nat Prod
Fujita et al., 2013, The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profile., Mol. Cancer Ther.
Egile et al., 2015, The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer., Mol. Cancer Ther.
Zhang D et al., 2013, Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors., Bioorg Med Chem
Engelman et al., 2007, MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling., Science
Rho et al., 2014, MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation., Cancer Res.
Shien et al., 2013, Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells., Cancer Res.
Yamaoka et al., 2016, Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI-Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation., Mol. Cancer Ther.
Smith et al., 2015, Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2., Mol. Cancer Ther.
Piao et al., 2016, Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models., Neuro-oncology
Kwon et al., 2015, Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment., Oncogene
McDermott U et al., 2007, Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling., Proc Natl Acad Sci U S A
Ninomiya K et al., 2018, MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib., Sci Rep
Ortiz-Cuaran et al., 2016, Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors., Clin. Cancer Res.
Dai et al., 2012, Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation., Clin. Exp. Metastasis
Dai et al., 2010, BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro., Mol. Cancer Ther.
Hugo et al., 2015, Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance., Cell
Dabir et al., 2014, RET mutation and expression in small-cell lung cancer., J Thorac Oncol
Hong DS et al., 2015, A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors., Oncotarget
Sameni et al., 2016, Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models., Clin. Cancer Res.
Kurzrock et al., 2011, Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer., J. Clin. Oncol.
Goyal et al., 2017, A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma., Cancer
Nakatani M et al., 2017, The Anti-tumor Effect of Cabozantinib on Ovarian Clear Cell Carcinoma <i>In Vitro</i> and <i>In Vivo</i>., Anticancer Res
Yakes et al., 2011, Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth., Mol. Cancer Ther.
Moores et al., 2016, A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors., Cancer Res.
Yang SP et al., 2012, Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity., J Med Chem
Foster et al., 2015, The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models., Mol. Cancer Ther.
Liu et al., 2014, LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth., Clin. Cancer Res.
Larsen CA et al., 2009, Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies., J Med Chem
Arena S et al., 2007, Genetic targeting of the kinase activity of the Met receptor in cancer cells., Proc Natl Acad Sci U S A
Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

TIVANTINIB MET

Interaction Score: 3.85

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Reported Cancer Type Lung, Prostate

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
CancerCommons TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions
TEPOTINIB MET

Interaction Score: 3.85

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
25736998 32469185 24061647

Sources:
DTC CIViC TTD GuideToPharmacology ChemblInteractions
ONARTUZUMAB MET

Interaction Score: 2.89

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Indication/Tumor Type esophagus adenocarcinoma

Indication/Tumor Type gastroesophageal junction adenocarcinoma

Response Type no benefit

PMIDs:
24101053 27918764 22389872 23882082

Sources:
CancerCommons JAX-CKB TdgClinicalTrial CIViC TALC MyCancerGenome GuideToPharmacology ChemblInteractions
SAVOLITINIB MET

Interaction Score: 2.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
28644771 31315834 27694386 25779944 28396313

Sources:
JAX-CKB CIViC TTD COSMIC GuideToPharmacology ChemblInteractions

EMIBETUZUMAB MET

Interaction Score: 2.41

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Details of the Assay for Interaction binding constant for hMET extracellular domain measured using proprietary BIACore® technology

Specific Action of the Ligand Binding

Endogenous Drug? False

PMIDs:
27803065 25231402

Sources:
JAX-CKB TTD GuideToPharmacology

CAPMATINIB MET

Interaction Score: 2.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Indication/Tumor Type lung large cell carcinoma

Response Type sensitive

PMIDs:
28783719 27694386 25971938 28765324 15494073 32877583 28396313

Sources:
CancerCommons OncoKB JAX-CKB CIViC TTD DrugBank COSMIC TALC MyCancerGenome GuideToPharmacology ChemblInteractions
AMG-208 MET

Interaction Score: 1.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
26155941

Sources:
DrugBank ChemblInteractions
TELISOTUZUMAB MET

Interaction Score: 1.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Phase I

PMIDs:
None found

Sources:
JAX-CKB TTD ChemblInteractions
TELISOTUZUMAB VEDOTIN MET

Interaction Score: 1.44

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type sensitive

Approval Status Phase I

PMIDs:
27573171

Sources:
JAX-CKB TTD
SGX-523 MET

Interaction Score: 1.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DrugBank GuideToPharmacology ChemblInteractions
CRIZOTINIB MET

Interaction Score: 1.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
26729443 12460923 27595477 27343442 21716144 27694386 9826708 22594847 31584608 26779812 25971938 25922291 22162573 31416808 31809977 1104268 25971939 21623265 28514312 17483355 27325282 27149990 22162641 31932802 26483207 25232318 28765324 21266357 26892698 10592235 27393507 25157968 27283993 28522754 23729478 26432108 15494073 26547802 10417759 30339198 28396313 31391294 11750879

Sources:
ClearityFoundationBiomarkers MyCancerGenomeClinicalTrial OncoKB PharmGKB DoCM JAX-CKB TdgClinicalTrial CIViC TTD DrugBank COSMIC TALC MyCancerGenome GuideToPharmacology ChemblInteractions CGI
CHEMBL509101 MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL462712 MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL561660 MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL527066 MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL503090 MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
EUCALYPTIN A MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22934600

Sources:
DTC
MACROCARPAL B MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22934600

Sources:
DTC
GALLOCATECHIN GALLATE MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19839593

Sources:
DTC
MACROCARPAL A MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22934600

Sources:
DTC
EMD-1204831 MET

Interaction Score: 0.96

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
(-)-OLEOCANTHAL MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23403296

Sources:
DTC
PF-04217903 MET

Interaction Score: 0.96

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
DTC TTD COSMIC TALC MyCancerGenome ChemblInteractions
JNJ-38877605 MET

Interaction Score: 0.96

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
SAR-125844 MET

Interaction Score: 0.96

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Indication/Tumor Type lung cancer

PMIDs:
25504634

Sources:
JAX-CKB TTD ChemblInteractions
TYROSOL SINAPATE MET

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23403296

Sources:
DTC
GOLVATINIB MET

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

Details of the Assay for Interaction Measured as inhibition of c-MET phosphorylation in MKN45 cells

PMIDs:
19832844

Sources:
JAX-CKB TTD GuideToPharmacology ChemblInteractions
OSIMERTINIB MET

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

Approval Status Preclinical

Response Type resistant

Evidence Type Actionable

PMIDs:
27694386 29386539 27393507 27252416

Sources:
OncoKB JAX-CKB CIViC CGI
CHEMBL261641 MET

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17595299 23403296

Sources:
DTC
JNJ-61186372 MET

Interaction Score: 0.72

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type sensitive

Approval Status Preclinical - Cell line xenograft

PMIDs:
27216193

Sources:
JAX-CKB GuideToPharmacology
TAS-115 MET

Interaction Score: 0.72

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

Indication/Tumor Type stomach cancer

PMIDs:
24140932

Sources:
JAX-CKB ChemblInteractions
PHA-665752 MET

Interaction Score: 0.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

combination therapy Gefitinib + PHA-665752

Indication/Tumor Type non-small cell lung carcinoma

Response Type sensitive

PMIDs:
18077425 24165158 21266357 23542356

Sources:
DTC JAX-CKB GuideToPharmacology
BMS-777607 MET

Interaction Score: 0.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
22286523 20515943 28396313

Sources:
JAX-CKB TTD MyCancerGenome GuideToPharmacology ChemblInteractions
CABOZANTINIB MET

Interaction Score: 0.6

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
27694386 26432786 21606412 25971939 28192597 29061793 21926191 28396313

Sources:
ClearityFoundationClinicalTrial MyCancerGenomeClinicalTrial OncoKB JAX-CKB TdgClinicalTrial CIViC TTD DrugBank TALC MyCancerGenome GuideToPharmacology CGI
GLESATINIB MET

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Reported Cancer Type Lung

Trial Name MGCD265

PMIDs:
27694386 28765324 15494073

Sources:
CancerCommons JAX-CKB TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology
NAQUOTINIB MET

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29386539

Sources:
CIViC
MK-8033 MET

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
EMI-137 MET

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

Details of the Assay for Interaction <i>In vitro</i> fluorescence polarization assay.

Specific Action of the Ligand Binding

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
COMETRIQ MET

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

PMIDs:
None found

Sources:
CancerCommons
APRATOXIN F MET

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BMS-698769 MET

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
AMG-337 MET

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
AMUVATINIB MET

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

Trial Name MP-470

PMIDs:
24326130

Sources:
JAX-CKB TdgClinicalTrial DrugBank TALC MyCancerGenome ChemblInteractions
FICLATUZUMAB MET

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type multiple myeloma

Response Type predicted – sensitive

Approval Status Phase I

PMIDs:
24901237

Sources:
JAX-CKB
ALTIRATINIB MET

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Approval Status Preclinical

PMIDs:
26285778 26965451 24362531

Sources:
JAX-CKB TTD GuideToPharmacology ChemblInteractions
K-252A MET

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
FORETINIB MET

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Approval Status Preclinical

combination therapy Foretinib + Rucaparib

Evidence Type Actionable

PMIDs:
23213094 26779812

Sources:
CancerCommons JAX-CKB TdgClinicalTrial CIViC TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions
EPICATECHIN GALLATE MET

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19839593

Sources:
DTC
BPI-9016 MET

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALVESPIMYCIN MET

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type predicted – sensitive

Approval Status Preclinical - Cell line xenograft

PMIDs:
26483207

Sources:
JAX-CKB
LY-3164530 MET

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CMX-2043 MET

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CABOZANTINIB S-MALATE MET

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BMS-794833 MET

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
BMS-817378 MET

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
YUANHUADINE MET

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21916433

Sources:
DTC
ENSARTINIB MET

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Result from DiscoveRx KINOMEscan® selectivity screen.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ROCILETINIB MET

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Alteration MET:amp

Drug family [EGFR inhibitor 3rd gen]

PMIDs:
None found

Sources:
CGI
ARRY-300 MET

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MK-2461 MET

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD MyCancerGenome GuideToPharmacology ChemblInteractions
MERESTINIB MET

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of <i>in vitro</i> biochemical activity by EMD Millipore assay.

Direct Interaction? False

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
GANETESPIB MET

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type predicted – sensitive

Approval Status Preclinical - Cell culture

PMIDs:
26483207

Sources:
JAX-CKB
AFATINIB MET

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type lung adenocarcinoma

Response Type sensitive

Approval Status Clinical Study

PMIDs:
27694386

Sources:
JAX-CKB
VELIPARIB MET

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type triple-receptor negative breast cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
26779812

Sources:
JAX-CKB
MGCD-265 MET

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRASTUZUMAB MET

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Response Type sensitive

combination therapy Crizotinib + Trastuzumab + Paclitaxel

combination therapy Trastuzumab + Fluorouracil + Leucovorin + Oxaliplatin

PMIDs:
22850551 26432108

Sources:
JAX-CKB CGI
BMS-754807 MET

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19778024

Sources:
DTC
SITRAVATINIB MET

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical enzyme activity assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology
LAPATINIB MET

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family ERBB2 inhibitor

Alteration MET:amp;ERBB2:amp

combination therapy Crizotinib + Lapatinib

PMIDs:
27595477 26432108

Sources:
JAX-CKB CGI
CHEMBL399530 MET

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PANITUMUMAB MET

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy JNJ 38877605 + Panitumumab

Indication/Tumor Type colorectal cancer

Response Type sensitive

PMIDs:
23729478

Sources:
JAX-CKB CGI
VEMURAFENIB MET

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Alteration MET:amp;BRAF:V600E

Drug family BRAF inhibitor;EGFR mAb inhibitor

combination therapy Vemurafenib;Panitumumab

PMIDs:
27325282 26359985

Sources:
CIViC CGI
GEFITINIB MET

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Approval Status Preclinical - Cell culture

combination therapy Gefitinib + NPS-1034

Approval Status Preclinical - Cell line xenograft

PMIDs:
23993328 17463250 24165158 23542356 27612490

Sources:
DTC OncoKB JAX-CKB CIViC
ALECTINIB MET

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CRENOLANIB MET

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial
SELUMETINIB MET

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Selumetinib + BEZ235

Indication/Tumor Type non-small cell lung carcinoma

Response Type sensitive

PMIDs:
25952648 24939055

Sources:
JAX-CKB CIViC
ERLOTINIB MET

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Onartuzumab + Erlotinib

Indication/Tumor Type non-small cell lung carcinoma

Response Type conflicting

PMIDs:
27694386 27803065 24101053

Sources:
DTC OncoKB JAX-CKB
CEP-11981 MET

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22148921

Sources:
DTC
BRIGATINIB MET

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
PILARALISIB MET

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type melanoma

Response Type sensitive

Approval Status Preclinical

PMIDs:
25637314

Sources:
JAX-CKB
BEVACIZUMAB MET

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Altiratinib + Bevacizumab

Indication/Tumor Type glioblastoma multiforme

Response Type sensitive

PMIDs:
26965451 26432108 25363205

Sources:
JAX-CKB
TRAMETINIB MET

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy INC280 + Trametinib

Indication/Tumor Type collecting duct carcinoma

Response Type sensitive

PMIDs:
28783719 25952648

Sources:
JAX-CKB CIViC
TANESPIMYCIN MET

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measuring downstream uPA-plasmin inhibition.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
LEUCOVORIN MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Trastuzumab + Fluorouracil + Leucovorin + Oxaliplatin

Indication/Tumor Type gastric adenocarcinoma

Response Type resistant

PMIDs:
26432108

Sources:
JAX-CKB
EPIGALOCATECHIN GALLATE MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19839593

Sources:
DTC
OLAPARIB MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type triple-receptor negative breast cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
26779812

Sources:
JAX-CKB
DACTOLISIB MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type sensitive

Approval Status Preclinical

PMIDs:
24939055

Sources:
DTC JAX-CKB
PONATINIB MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type lung small cell carcinoma

Response Type sensitive

Approval Status Preclinical

PMIDs:
25122427

Sources:
JAX-CKB
CETUXIMAB MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

Response Type sensitive

combination therapy Cetuximab + JNJ 38877605

Approval Status Preclinical - Cell culture

PMIDs:
23729478

Sources:
JAX-CKB CIViC
RUCAPARIB MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type breast cancer

combination therapy Foretinib + Rucaparib

Approval Status Preclinical - Cell line xenograft

PMIDs:
26779812

Sources:
JAX-CKB
CHEMBL202721 MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CAPECITABINE MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

Response Type resistant

Evidence Type Actionable

Approval Status Clinical Study

PMIDs:
26432108

Sources:
JAX-CKB
OXALIPLATIN MET

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Bevacizumab + Capecitabine + Oxaliplatin + Trastuzumab

Indication/Tumor Type gastric adenocarcinoma

Response Type resistant

PMIDs:
26432108

Sources:
JAX-CKB
CHEMBL546797 MET

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PACLITAXEL MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type gastric adenocarcinoma

combination therapy Crizotinib + Trastuzumab + Paclitaxel

Evidence Type Actionable

PMIDs:
28514312 26432108

Sources:
JAX-CKB
IMATINIB MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Imatinib + Carboplatin + Paclitaxel

Indication/Tumor Type melanoma

Response Type sensitive

PMIDs:
28514312

Sources:
JAX-CKB
CHEMBL541400 MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBOPLATIN MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Imatinib + Carboplatin + Paclitaxel

Indication/Tumor Type melanoma

Response Type sensitive

PMIDs:
28514312

Sources:
JAX-CKB
DASATINIB MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type predicted – sensitive

Approval Status Preclinical - Cell culture

PMIDs:
26483207

Sources:
JAX-CKB
CHEMBL1997335 MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SNS-314 MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Bevacizumab + Sorafenib

Indication/Tumor Type gastrointestinal stromal tumor

Response Type sensitive

PMIDs:
25363205

Sources:
JAX-CKB
OSI-632 MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAZOPANIB MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PALBOCICLIB MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUOROURACIL MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Trastuzumab + Fluorouracil + Leucovorin + Oxaliplatin

Indication/Tumor Type gastric adenocarcinoma

Response Type resistant

PMIDs:
26432108

Sources:
JAX-CKB
ENTRECTINIB MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINIFANIB MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 MET

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 MET

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 MET

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 MET

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB MET

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB MET

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOSTAMATINIB MET

Interaction Score: 0.0

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000105976
- Version: 101_38
Alternate Names:

MET Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P08581
- Version: January-2014
Alternate Names:

MET Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.10.1

Publications:
CancerCommons: MET
- Version: 25-July-2013
Alternate Names:

4233 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name MET

CancerCommons Reported Gene Name MET, VEGFRs, Axl, Tie2, Ron

Publications:
BaderLabGenes: MET
- Version: February-2014
Alternate Names:

4233 Entrez Gene ID

Gene Info:

Initial Gene Query MET

Counted Citations from 1950-2000 4560

Gene Categories:

KINASE

Publications:
HopkinsGroom: P08581
- Version: 11-September-2012
Alternate Names:

MET_HUMAN Uniprot Id

4233 Entrez Gene Id

P08581 Uniprot Accession

Gene Info:

Human Readable Name KINASE

Interpro Type Domain

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000105976

Version: 26-July-2011

Alternate Names:

ENSG00000105976 Ensembl Gene Id

MET Display Id

HEPATOCYTE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (MET PROTO- ONCOGENE TYROSINE KINASE) (C-MET) (HGF RECEPTOR) (HGF-SF RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08581] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 4233
- Version: 29-September-2020
Alternate Names:

7029 HUGO Gene ID

7029 HUGO Gene Symbol

MET proto-oncogene, receptor tyrosine kinase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Type X RTKs: HGF (hepatocyte growth factor) receptor family

GuideToPharmacology Gene Category ID 325

Publications:

JAX-CKB: MET

Version: 27-September-2017

Alternate Names:

4233 CKB Entrez Id

MET CKB Gene Synonym

AUTS9 CKB Gene Synonym

Gene Info:

Publications:

Zick et al., 2017, Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients., Medicine (Baltimore)

Bardelli et al., 2013, Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer., Cancer Discov

Engelman et al., 2007, MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling., Science

PharmGKB: MET

Version: 18-August-2020

Alternate Names:

PA30763 PharmGKB ID

Gene Info:

Publications:

Ou SH, 2011, Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond., Drug Des Devel Ther

CIViC: MET

Version: 14-September-2020

Alternate Names:

4233 Entrez Gene ID

52 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Bardelli et al., 2013, Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer., Cancer Discov

Lee J et al., 2019, Tumor Genomic Profiling Guides Patients with Metastatic Gastric Cancer to Targeted Treatment: The VIKTORY Umbrella Trial., Cancer Discov

Bahcall et al., 2016, Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer., Cancer Discov

DrugBank: BE0000915

Version: 5.1.7

Alternate Names:

MET DrugBank Gene Name

P08581 UniProt Accession

4233 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Hong DS et al., 2015, A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors., Oncotarget

Forde et al., 2012, Crizotinib in the treatment of non-small-cell lung cancer., Expert Opin Pharmacother

CGI: MET

Version: 27-September-2017

Alternate Names:

Gene Info:

Publications:

Minuti et al., 2012, Increased MET and HGF gene copy numbers are associated with trastuzumab failure in HER2-positive metastatic breast cancer., Br. J. Cancer

Kwak et al., 2015, Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer., Cancer Discov

DoCM: MET

Version: 27-September-2017

Alternate Names:

Gene Info:

Publications:

Lorenzato et al., 2002, Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion., Cancer Res.

Bardelli et al., 1998, Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth., Proc. Natl. Acad. Sci. U.S.A.

Dalinka et al., 1975, The radiology of osseous and articular infection., CRC Crit Rev Clin Radiol Nucl Med

DTC: MET

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

McDermott U et al., 2007, Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling., Proc Natl Acad Sci U S A

Yang SP et al., 2012, Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity., J Med Chem

Dorsch D et al., 2015, Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors., Bioorg Med Chem Lett

TALC: MET
- Version: 12-May-2016
Alternate Names:

MET Gene Symbol

Gene Info:

Publications:
TALC: HGFR
- Version: 12-May-2016
Alternate Names:

HGFR Gene Symbol

Gene Info:

Publications:
MyCancerGenome: MET
- Version: 20-Jun-2017
Alternate Names:

4233 Entrez Gene Id

MET MyCancerGenome Gene Symbol

MET MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000105976
- Version: 31-May-2017
Alternate Names:

ENSG00000105976 Gene Symbol

MET Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: C-MET
- Version: 12-May-2016
Alternate Names:

C-MET Gene Symbol

Gene Info:

Publications:
ChemblInteractions: MET
- Version: chembl_23
Alternate Names:

MET GENE_SYMBOL

Hepatocyte growth factor receptor UNIPROT

HGF/SF receptor UNIPROT

Gene Info:

Publications:
OncoKB: MET
- Version: 23-July-2020
Alternate Names:

4233 OncoKB Entrez Id

RCCP2 OncoKB Gene Synonym

HGFR OncoKB Gene Synonym

Gene Info:

Publications:
Pharos: MET
- Version: 03-September-2020
Alternate Names:

Hepatocyte growth factor receptor Gene Name

P08581 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
Tempus: MET
- Version: 11-November-2018
Alternate Names:

MET Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: MET
- Version: 27-Jun-2013
Alternate Names:

4233 Gene ID

AUTS9 dGene Synonym

HGFR dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Proto-oncogene c-Met
- Version: 2020.06.01
Alternate Names:

MET TTD Gene Abbreviation

T40474 TTD Target ID

Gene Info:

Publications:
MyCancerGenomeClinicalTrial: MET
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
MskImpact: MET
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationBiomarkers: MET
- Version: 26-July-2013
Alternate Names:

Gene Info:

Publications:
ClearityFoundationClinicalTrial: MET
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
ClearityFoundationClinicalTrial: C-MET
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: MET
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: MET
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: MET
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE, TYROSINE KINASE

Publications:
Oncomine: MET
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
COSMIC: MET
- Version: 4-Sep-2020
Alternate Names:

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Notes
Reported Cancer Type	Lung, Prostate
Specific Action of the Ligand	Inhibition

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Indication/Tumor Type	esophagus adenocarcinoma
Indication/Tumor Type	gastroesophageal junction adenocarcinoma
Response Type	no benefit

Details of the Assay for Interaction	binding constant for hMET extracellular domain measured using proprietary BIACore® technology
Specific Action of the Ligand	Binding
Endogenous Drug?	False

Reported Cancer Type	Melanoma
Indication/Tumor Type	lung large cell carcinoma
Response Type	sensitive

Mechanism of Interaction	Hepatocyte growth factor receptor inhibitor
Direct Interaction	yes

Indication/Tumor Type	Advanced Solid Tumor
Response Type	sensitive
Approval Status	Phase I

Indication/Tumor Type	non-small cell lung carcinoma
Response Type	sensitive
Approval Status	Phase I

Approval Status	Preclinical
Response Type	resistant
Evidence Type	Actionable

combination therapy	Gefitinib + PHA-665752
Indication/Tumor Type	non-small cell lung carcinoma
Response Type	sensitive

Details of the Assay for Interaction	<i>In vitro</i> fluorescence polarization assay.
Specific Action of the Ligand	Binding
Endogenous Drug?	False

Indication/Tumor Type	multiple myeloma
Response Type	predicted – sensitive
Approval Status	Phase I

Details of the Assay for Interaction	Result from DiscoveRx KINOMEscan® selectivity screen.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Details of the Assay for Interaction	Inhibition of <i>in vitro</i> biochemical activity by EMD Millipore assay.
Direct Interaction?	False
Endogenous Drug?	False

Indication/Tumor Type	lung adenocarcinoma
Response Type	sensitive
Approval Status	Clinical Study

Indication/Tumor Type	triple-receptor negative breast cancer
Response Type	sensitive
Approval Status	Preclinical

Details of the Assay for Interaction	In a biochemical enzyme activity assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Drug family	ERBB2 inhibitor
Alteration	MET:amp;ERBB2:amp
combination therapy	Crizotinib + Lapatinib

combination therapy	JNJ 38877605 + Panitumumab
Indication/Tumor Type	colorectal cancer
Response Type	sensitive

Alteration	MET:amp;BRAF:V600E
Drug family	BRAF inhibitor;EGFR mAb inhibitor
combination therapy	Vemurafenib;Panitumumab

MET Gene Record

MET 4233 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Reported Cancer Type Lung, Prostate Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: CancerCommons TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 25736998 32469185 24061647

Sources: DTC CIViC TTD GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Indication/Tumor Type esophagus adenocarcinoma Indication/Tumor Type gastroesophageal junction adenocarcinoma Response Type no benefit

PMIDs: 24101053 27918764 22389872 23882082

Sources: CancerCommons JAX-CKB TdgClinicalTrial CIViC TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 28644771 31315834 27694386 25779944 28396313

Sources: JAX-CKB CIViC TTD COSMIC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info: Details of the Assay for Interaction binding constant for hMET extracellular domain measured using proprietary BIACore&reg; technology Specific Action of the Ligand Binding Endogenous Drug? False

PMIDs: 27803065 25231402

Sources: JAX-CKB TTD GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Melanoma Indication/Tumor Type lung large cell carcinoma Response Type sensitive

PMIDs: 28783719 27694386 25971938 28765324 15494073 32877583 28396313

Sources: CancerCommons OncoKB JAX-CKB CIViC TTD DrugBank COSMIC TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Hepatocyte growth factor receptor inhibitor Direct Interaction yes

PMIDs: 26155941

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Indication/Tumor Type Advanced Solid Tumor Response Type sensitive Approval Status Phase I

PMIDs: None found

Sources: JAX-CKB TTD ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type non-small cell lung carcinoma Response Type sensitive Approval Status Phase I

PMIDs: 27573171

Sources: JAX-CKB TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Sources: ClearityFoundationBiomarkers MyCancerGenomeClinicalTrial OncoKB PharmGKB DoCM JAX-CKB TdgClinicalTrial CIViC TTD DrugBank COSMIC TALC MyCancerGenome GuideToPharmacology ChemblInteractions CGI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22934600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22934600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19839593

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Reported Cancer Type Lung, Prostate

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
CancerCommons TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
25736998 32469185 24061647

Sources:
DTC CIViC TTD GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Indication/Tumor Type esophagus adenocarcinoma

Indication/Tumor Type gastroesophageal junction adenocarcinoma

Response Type no benefit

PMIDs:
24101053 27918764 22389872 23882082

Sources:
CancerCommons JAX-CKB TdgClinicalTrial CIViC TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
28644771 31315834 27694386 25779944 28396313

Sources:
JAX-CKB CIViC TTD COSMIC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Details of the Assay for Interaction binding constant for hMET extracellular domain measured using proprietary BIACore® technology

Specific Action of the Ligand Binding

Endogenous Drug? False

PMIDs:
27803065 25231402

Sources:
JAX-CKB TTD GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Indication/Tumor Type lung large cell carcinoma

Response Type sensitive

PMIDs:
28783719 27694386 25971938 28765324 15494073 32877583 28396313

Sources:
CancerCommons OncoKB JAX-CKB CIViC TTD DrugBank COSMIC TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
26155941

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Phase I

PMIDs:
None found

Sources:
JAX-CKB TTD ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type sensitive

Approval Status Phase I

PMIDs:
27573171

Sources:
JAX-CKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Sources:
ClearityFoundationBiomarkers MyCancerGenomeClinicalTrial OncoKB PharmGKB DoCM JAX-CKB TdgClinicalTrial CIViC TTD DrugBank COSMIC TALC MyCancerGenome GuideToPharmacology ChemblInteractions CGI

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
22934600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22934600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19839593

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22934600

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23403296

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Approval Status	Preclinical - Cell culture
combination therapy	Gefitinib + NPS-1034
Approval Status	Preclinical - Cell line xenograft

combination therapy	Selumetinib + BEZ235
Indication/Tumor Type	non-small cell lung carcinoma
Response Type	sensitive

combination therapy	Onartuzumab + Erlotinib
Indication/Tumor Type	non-small cell lung carcinoma
Response Type	conflicting

combination therapy	Altiratinib + Bevacizumab
Indication/Tumor Type	glioblastoma multiforme
Response Type	sensitive

combination therapy	INC280 + Trametinib
Indication/Tumor Type	collecting duct carcinoma
Response Type	sensitive

Details of the Assay for Interaction	Measuring downstream uPA-plasmin inhibition.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

combination therapy	Trastuzumab + Fluorouracil + Leucovorin + Oxaliplatin
Indication/Tumor Type	gastric adenocarcinoma
Response Type	resistant

Indication/Tumor Type	lung small cell carcinoma
Response Type	sensitive
Approval Status	Preclinical

Indication/Tumor Type	breast cancer
combination therapy	Foretinib + Rucaparib
Approval Status	Preclinical - Cell line xenograft

combination therapy	Bevacizumab + Capecitabine + Oxaliplatin + Trastuzumab
Indication/Tumor Type	gastric adenocarcinoma
Response Type	resistant