• MERTK 10461 Druggable GenomeClinically Actionable

    Alternate Names:

    10461
    MER PROTO-ONCOGENE, TYROSINE KINASE
    MERTK
    MER
    RP38
    Tyro12
    c-Eyk
    c-mer
    604705
    7027
    ENSG00000153208
    OTTHUMG00000131278
    1837
    Q12866
    MERTK_HUMAN
    TYROSINE-PROTEIN KINASE MER
    8331
    NP_006334
    NM_006343
    PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER PRECURSOR (EC 2.7.1.112) (C-MER) (RECEPTOR TYROSINE KINASE MERTK). [SOURCE:UNIPROT/SWISSPROT;ACC:Q12866]
    T55781

    Gene Info:

    Uniprot Status Swiss-Prot
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Human Readable Name KINASE
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR001245
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    GuideToPharmacology Gene Category Name Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family
    GuideToPharmacology Gene Category ID 328
    Initial Gene Query MER
    Counted Citations from 1950-2000 991
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 1.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 1.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 1.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 1.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction In a biochemical enzyme activity assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

    • Version: 101_38

    Alternate Names:
    MERTK Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    10461 Entrez Gene Id
    MERTK Uniprot Gene Name
    TYROSINE-PROTEIN KINASE MER Uniprot Protein Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Human Readable Name KINASE

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: February-2014

    Alternate Names:
    10461 Entrez Gene ID

    Gene Info:
    Initial Gene Query MER
    Counted Citations from 1950-2000 991

    Gene Categories:
    KINASE

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    MERTK Display Id
    PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER PRECURSOR (EC 2.7.1.112) (C-MER) (RECEPTOR TYROSINE KINASE MERTK). [SOURCE:UNIPROT/SWISSPROT;ACC:Q12866] Description
    ENSG00000153208 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    7027 HUGO Gene ID
    7027 HUGO Gene Symbol
    MER proto-oncogene, tyrosine kinase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family
    GuideToPharmacology Gene Category ID 328

    Publications:

    • Version: 14-September-2020

    Alternate Names:
    10461 Entrez Gene ID
    8331 CIViC Gene ID

    Gene Info:

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000153208 Gene Symbol
    MERTK Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000153208 Ensembl Gene ID
    c-Eyk Human Protein Atlas Gene Synonym
    mer Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    10461 Gene ID
    MER dGene Synonym
    RP38 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    MERTK TTD Gene Abbreviation
    T55781 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Tyrosine-protein kinase Mer Gene Name
    Q12866 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: