1432 |
MITOGEN-ACTIVATED PROTEIN KINASE 14 |
MAPK14 |
CSBP |
CSBP1 |
CSBP2 |
CSPB1 |
EXIP |
Mxi2 |
PRKM14 |
PRKM15 |
RK |
SAPK2A |
p38 |
p38ALPHA |
600289 |
6876 |
ENSG00000112062 |
OTTHUMG00000159806 |
MITOGEN-ACTIVATED PROTEIN KINASE 14 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA) (MAP KINASE P38 ALPHA) (CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN) (CSAID BINDING PROTEIN) (CSBP) (MAX-INTERACTING PROTEIN 2) (MAP KINASE MXI2 |
MAP kinase 14 |
Stress-activated protein kinase 2a |
Mitogen-activated protein kinase p38 alpha |
MAX-interacting protein 2 |
MAP kinase MXI2 |
MAP kinase p38 alpha |
Cytokine suppressive anti-inflammatory drug-binding protein |
CSAID-binding protein |
MAPK 14 |
MK14_HUMAN |
Q16539 |
BE0001019 |
1499 |
NP_001306 |
NM_001315 |
PA30621 |
p38 alpha |
T65864 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR002290 |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Ser/Thr_dual-sp_kinase_dom |
Human Readable Name | KINASE |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.24 |
GuideToPharmacology Gene Category Name | p38 subfamily |
GuideToPharmacology Gene Category ID | 519 |
Gene Biotype | PROTEIN_CODING |
KINASE |
SERINE THREONINE KINASE |
DRUGGABLE GENOME |
ENZYME |
TRANSCRIPTION FACTOR |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
Direct Interaction? | True |
inhibitor (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Novel drug target | Novel Target |
Trial Name | SB-681323 |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
inhibitor (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
Trial Name | ARRY-797 |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Trial Name | CPSI-2364 |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
Details of the Assay for Interaction | In a biochemical assay. |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
Specific Action of the Ligand | Binding |
inhibitor (inhibitory) |
Details of the Assay for Interaction | In a biochemical kinase assay. |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Trial Name | ARRY-614 |
Novel drug target | Novel Target |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
n/a |
Trial Name | pirfenidone,Esbriet , Deskar, Pirespa |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
Direct Interaction | yes |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
MAPK14 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
MAPK14 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.24 |
MAPK14 | Uniprot Gene Name |
Q16539 | Uniprot Accession |
MK14_HUMAN | Uniprot Id |
Interpro Acc | IPR002290 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Type | Domain |
KINASE, DRUGGABLE GENOME |
MITOGEN-ACTIVATED PROTEIN KINASE 14 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA) (MAP KINASE P38 ALPHA) (CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN) (CSAID BINDING PROTEIN) (CSBP) (MAX-INTERACTING PROTEIN 2) (MAP KINASE MXI2 | Description |
ENSG00000112062 | Ensembl Gene Id |
MAPK14 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
6876 | HUGO Gene ID |
6876 | HUGO Gene Symbol |
mitogen-activated protein kinase 14 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | p38 subfamily |
GuideToPharmacology Gene Category ID | 519 |
ENZYME |
PA30621 | PharmGKB ID |
MAPK14 | DrugBank Gene Name |
Q16539 | UniProt Accession |
1432 | Entrez Gene Id |
ENSG00000112062 | Gene Symbol |
MAPK14 | Ensembl Id |
DRUGGABLE GENOME |
CSAID-binding protein | UNIPROT |
CSBP1 | GENE_SYMBOL |
CSBP2 | GENE_SYMBOL |
Mitogen-activated protein kinase 14 | Gene Name |
Q16539 | UniProt ID |
KINASE, TRANSCRIPTION FACTOR |
CSBP | GO Gene Synonym |
CSBP1 | GO Gene Synonym |
CSBP2 | GO Gene Synonym |
SERINE THREONINE KINASE |
1432 | Gene ID |
CSBP | dGene Synonym |
CSBP1 | dGene Synonym |
KINASE, SERINE THREONINE KINASE |
p38 alpha | TTD Gene Abbreviation |
T65864 | TTD Target ID |