DGIdb - MAPK14 Gene Record

MAPK14 1432 Druggable Genome

Alternate Names:

1432
MITOGEN-ACTIVATED PROTEIN KINASE 14
MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
600289
6876
ENSG00000112062
OTTHUMG00000159806
MITOGEN-ACTIVATED PROTEIN KINASE 14 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA) (MAP KINASE P38 ALPHA) (CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN) (CSAID BINDING PROTEIN) (CSBP) (MAX-INTERACTING PROTEIN 2) (MAP KINASE MXI2
MAP kinase 14
Stress-activated protein kinase 2a
Mitogen-activated protein kinase p38 alpha
MAX-interacting protein 2
MAP kinase MXI2
MAP kinase p38 alpha
Cytokine suppressive anti-inflammatory drug-binding protein
CSAID-binding protein
MAPK 14
MK14_HUMAN
Q16539
BE0001019
1499
NP_001306
NM_001315
PA30621
p38 alpha
T65864

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002290
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Human Readable Name	KINASE
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Target Class	Enzymes
Target Subclass	EC:2.7.11.24
GuideToPharmacology Gene Category Name	p38 subfamily
GuideToPharmacology Gene Category ID	519
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod
Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
Goldstein DM et al., 2011, Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase., J Med Chem
Angell RM et al., 2008, Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes., Bioorg Med Chem Lett
Bagley MC et al., 2008, Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells., Bioorg Med Chem Lett
Goldstein et al., 2006, Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase., J. Med. Chem.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Gollob et al., 1999, The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation., J. Immunol.
Laufer S et al., 2009, Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase., Bioorg Med Chem Lett
Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
Chen et al., 2003, Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection., J. Neurochem.
Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
Kneidinger M et al., 2008, The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils., Blood
Arena S et al., 2007, Genetic targeting of the kinase activity of the Met receptor in cancer cells., Proc Natl Acad Sci U S A
Singhal et al., 2002, Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis., J. Immunol.
Duffy JP et al., 2011, The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor., ACS Med Chem Lett
Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett
Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
Noh et al., 2000, Haloperidol-induced neuronal apoptosis: role of p38 and c-Jun-NH(2)-terminal protein kinase., J. Neurochem.
De Paiva et al., 2006, Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye., Exp. Eye Res.
Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod
Abu Thaher B et al., 2009, Role of the hydrogen bonding heteroatom-Lys53 interaction between the p38alpha mitogen-activated protein (MAP) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors., J Med Chem
Cappellini et al., 2005, Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation., Apoptosis
Bogatcheva et al., 2007, Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction., Am. J. Physiol. Lung Cell Mol. Physiol.
Lee et al., 2006, Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis., Biochim. Biophys. Acta
Niiya et al., 2004, Involvement of ERK1/2 and p38 MAP kinase in doxorubicin-induced uPA expression in human RC-K8 lymphoma and NCI-H69 small cell lung carcinoma cells., Oncology
Olajide OA et al., 2013, Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition., Eur J Med Chem
Ito et al., 2000, p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells., Hypertension
Kozawa et al., 2000, Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase., J. Cell. Biochem.
Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
Das et al., 2006, Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J. Pharmacol. Exp. Ther.
Shan et al., 1999, Distinct roles of JNKs/p38 MAP kinase and ERKs in apoptosis and survival of HCD-57 cells induced by withdrawal or addition of erythropoietin., Blood
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

RO-3201195 MAPK14

Interaction Score: 3.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
18539026 16509574 10592235

Sources:
DTC DrugBank ChemblInteractions
CHEMBL193156 MAPK14

Interaction Score: 2.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL29641 MAPK14

Interaction Score: 2.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL85860 MAPK14

Interaction Score: 2.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL87277 MAPK14

Interaction Score: 2.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL94417 MAPK14

Interaction Score: 2.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL305178 MAPK14

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL564912 MAPK14

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
SD-0006 MAPK14

Interaction Score: 1.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
10592235

Sources:
DrugBank ChemblInteractions
2-CHLOROPHENOL MAPK14

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL522579 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL258202 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL195450 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL425616 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL371491 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL194009 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL194322 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL257341 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL559401 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL478649 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL237127 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL252128 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL492265 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL197277 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL273158 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL199237 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1233024 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL193264 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL410668 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL191598 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL379760 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL195393 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
GW607117X MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL380373 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL365776 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL494072 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL590753 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL96741 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
ACUMAPIMOD MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
GSK-610677 MAPK14

Interaction Score: 1.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
NEFLAMAPIMOD MAPK14

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
24900264 10592235 17659871

Sources:
DTC TTD DrugBank GuideToPharmacology ChemblInteractions
RALIMETINIB MAPK14

Interaction Score: 0.75

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial GuideToPharmacology ChemblInteractions
LOSMAPIMOD MAPK14

Interaction Score: 0.75

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Direct Interaction? True

PMIDs:
None found

Sources:
TTD GuideToPharmacology ChemblInteractions
TALMAPIMOD MAPK14

Interaction Score: 0.6

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
19195885

Sources:
DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
CHEMBL522387 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
KC-706 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEO-15520 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SB-85635 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AZD-7624 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LY-3007113 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AVE-9940 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PS-516895 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FX-005 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL261641 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17595299

Sources:
DTC
DILMAPIMOD MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name SB-681323

Mechanism of Interaction MAP kinase p38 alpha inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial TTD GuideToPharmacology ChemblInteractions
PG-760564 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
SCIO-323 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
TA-5493 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
GW775608X MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18602262

Sources:
DTC
PH-797804 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
10592235

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
AZD-6703 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SC-80036 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
AMG-548 MAPK14

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BMS-582949 MAPK14

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions
ARRY-797 MAPK14

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Trial Name ARRY-797

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CRYPTOLEPINE HYDROCHLORIDE MAPK14

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23507189

Sources:
DTC
VX-702 MAPK14

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
SEMAPIMOD MAPK14

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Trial Name CPSI-2364

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
PAMAPIMOD MAPK14

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Details of the Assay for Interaction In a biochemical assay.

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
DIHYDROTANSHINONE I MAPK14

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26339922

Sources:
DTC
MILTIRONE MAPK14

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26339922

Sources:
DTC
CHEMBL8483 MAPK14

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18566250

Sources:
DTC
XANTHOHUMOL MAPK14

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22111577

Sources:
DTC
RWJ-67657 MAPK14

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
R-1487 MAPK14

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

PMIDs:
21375264

Sources:
DrugBank ChemblInteractions
OPHIOBOLIN O MAPK14

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22130129

Sources:
DTC
DORAMAPIMOD MAPK14

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
18602262 17139284 17016423

Sources:
DTC DrugBank GuideToPharmacology ChemblInteractions
KERACYANIN MAPK14

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17360708

Sources:
DTC
PF-03715455 MAPK14

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Binding

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
METHOXSALEN MAPK14

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15711930

Sources:
NCI
CHEMBL1951415 MAPK14

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical kinase assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PEXMETINIB MAPK14

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ARRY-614

Novel drug target Novel Target

Mechanism of Interaction MAP kinase p38 alpha inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions
RHAMNETIN MAPK14

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24397781

Sources:
DTC
VASOPRESSIN MAPK14

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10679516 11029753

Sources:
NCI
SB-203580 MAPK14

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25692815 19301816 17659871

Sources:
DTC
EPOETIN BETA MAPK14

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10590051

Sources:
NCI
DOXYCYCLINE MAPK14

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16643899

Sources:
NCI
2-METHOXYESTRADIOL MAPK14

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17012370

Sources:
NCI
SB-220025 MAPK14

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
PIRFENIDONE MAPK14

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pirfenidone,Esbriet , Deskar, Pirespa

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
TAK-715 MAPK14

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
CHEMBL1236539 MAPK14

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
ALDESLEUKIN MAPK14

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10201984

Sources:
NCI
MORPHINE MAPK14

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11937560

Sources:
NCI
SB-202190 MAPK14

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22951114

Sources:
DTC
CI-1040 MAPK14

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LITHIUM MAPK14

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12558976

Sources:
NCI
DASATINIB MAPK14

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18180381

Sources:
DTC DrugBank
CHEMBL406845 MAPK14

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB MAPK14

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20124951

Sources:
DTC PharmGKB
DOXORUBICIN MAPK14

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16905201 15557793

Sources:
NCI
RESVERATROL MAPK14

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16525036

Sources:
NCI
AST-487 MAPK14

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HALOPERIDOL MAPK14

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11080184

Sources:
NCI
CHEMBL1997335 MAPK14

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OSI-632 MAPK14

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 MAPK14

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VANDETANIB MAPK14

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEFITINIB MAPK14

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINIFANIB MAPK14

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 MAPK14

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB MAPK14

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOSTAMATINIB MAPK14

Interaction Score: 0.0

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000112062
- Version: 101_38
Alternate Names:

MAPK14 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q16539
- Version: January-2014
Alternate Names:

MAPK14 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:
HopkinsGroom: Q16539
- Version: 11-September-2012
Alternate Names:

MAPK14 Uniprot Gene Name

Q16539 Uniprot Accession

MK14_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR002290

Human Readable Name DRUGGABLE GENOME

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000112062

Version: 26-July-2011

Alternate Names:

MITOGEN-ACTIVATED PROTEIN KINASE 14 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA) (MAP KINASE P38 ALPHA) (CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN) (CSAID BINDING PROTEIN) (CSBP) (MAX-INTERACTING PROTEIN 2) (MAP KINASE MXI2 Description

ENSG00000112062 Ensembl Gene Id

MAPK14 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 1432
- Version: 29-September-2020
Alternate Names:

6876 HUGO Gene ID

6876 HUGO Gene Symbol

mitogen-activated protein kinase 14 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name p38 subfamily

GuideToPharmacology Gene Category ID 519

Gene Categories:

ENZYME

Publications:
PharmGKB: MAPK14
- Version: 18-August-2020
Alternate Names:

PA30621 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

DrugBank: BE0001019

Version: 5.1.7

Alternate Names:

MAPK14 DrugBank Gene Name

Q16539 UniProt Accession

1432 Entrez Gene Id

Gene Info:

Publications:

Kneidinger M et al., 2008, The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils., Blood

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

NCI: MAPK14

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Cappellini et al., 2005, Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation., Apoptosis

Daly et al., 1999, NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways., Oncogene

McGillicuddy et al., 2006, TGF-beta1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells., Vascul. Pharmacol.

DTC: MAPK14

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bagley MC et al., 2008, Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells., Bioorg Med Chem Lett

Goldstein et al., 2006, Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase., J. Med. Chem.

Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science

HingoraniCasas: ENSG00000112062
- Version: 31-May-2017
Alternate Names:

ENSG00000112062 Gene Symbol

MAPK14 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CSBP
- Version: chembl_23
Alternate Names:

CSAID-binding protein UNIPROT

CSBP1 GENE_SYMBOL

CSBP2 GENE_SYMBOL

Gene Info:

Publications:
Pharos: MAPK14
- Version: 03-September-2020
Alternate Names:

Mitogen-activated protein kinase 14 Gene Name

Q16539 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
GO: MAPK14
- Version: 05-September-2020
Alternate Names:

CSBP GO Gene Synonym

CSBP1 GO Gene Synonym

CSBP2 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: MAPK14
- Version: 27-Jun-2013
Alternate Names:

1432 Gene ID

CSBP dGene Synonym

CSBP1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Stress-activated protein kinase 2a
- Version: 2020.06.01
Alternate Names:

p38 alpha TTD Gene Abbreviation

T65864 TTD Target ID

Gene Info:

Publications:
ClearityFoundationClinicalTrial: MAPK14
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	MAP kinase p38 alpha inhibitor
Direct Interaction	yes

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Novel drug target	Novel Target
Trial Name	SB-681323
Mechanism of Interaction	MAP kinase p38 alpha inhibitor

Details of the Assay for Interaction	In a biochemical kinase assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Trial Name	ARRY-614
Novel drug target	Novel Target
Mechanism of Interaction	MAP kinase p38 alpha inhibitor

Trial Name	pirfenidone,Esbriet , Deskar, Pirespa
Novel drug target	Novel Target

MAPK14	Uniprot Gene Name
Q16539	Uniprot Accession
MK14_HUMAN	Uniprot Id

MITOGEN-ACTIVATED PROTEIN KINASE 14 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA) (MAP KINASE P38 ALPHA) (CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN) (CSAID BINDING PROTEIN) (CSBP) (MAX-INTERACTING PROTEIN 2) (MAP KINASE MXI2	Description
ENSG00000112062	Ensembl Gene Id
MAPK14	Display Id

6876	HUGO Gene ID
6876	HUGO Gene Symbol
mitogen-activated protein kinase 14	HUGO Gene Name

MAPK14	DrugBank Gene Name
Q16539	UniProt Accession
1432	Entrez Gene Id

CSAID-binding protein	UNIPROT
CSBP1	GENE_SYMBOL
CSBP2	GENE_SYMBOL

Mitogen-activated protein kinase 14	Gene Name
Q16539	UniProt ID

MAPK14 Gene Record

MAPK14 1432 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

PMIDs: 18539026 16509574 10592235

Sources: DTC DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

PMIDs: 10592235

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
18539026 16509574 10592235

Sources:
DTC DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

PMIDs:
10592235

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank