DGIdb - MAPK14 Gene Record

MAPK14 1432 Druggable Genome

Alternate Names:

1432
MITOGEN-ACTIVATED PROTEIN KINASE 14
MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
600289
6876
ENSG00000112062
OTTHUMG00000159806
MITOGEN-ACTIVATED PROTEIN KINASE 14 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA) (MAP KINASE P38 ALPHA) (CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN) (CSAID BINDING PROTEIN) (CSBP) (MAX-INTERACTING PROTEIN 2) (MAP KINASE MXI2
MAP kinase 14
Stress-activated protein kinase 2a
Mitogen-activated protein kinase p38 alpha
MAX-interacting protein 2
MAP kinase MXI2
MAP kinase p38 alpha
Cytokine suppressive anti-inflammatory drug-binding protein
CSAID-binding protein
MAPK 14
MK14_HUMAN
Q16539
BE0001019
1499
Q13093
PLA<sub>2</sub>-G7
NP_001306
NM_001315
TTDC00201
CSAID BINDING PROTEIN
MAP KINASE P38
MAP KINASE P38ALPHA
CRK1
P38 MITOGEN-ACTIVATED PROTEIN KINASE ALPHA
P38 MITOGEN ACTIVATED PROTEIN KINASE
MITOGEN-ACTIVATED PROTEIN KINASE P38
CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN
PA30621
p38 alpha
T65864

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002290
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Human Readable Name	KINASE
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Target Class	Enzymes
Target Subclass	EC:2.7.11.24
GuideToPharmacology Gene Category Name	p38 subfamily
GuideToPharmacology Gene Category ID	519
GuideToPharmacology Gene Type	enzyme
Is VIP	false
Has Variant Annotation	false
Human Readable Name	SERINE THREONINE KINASE
Gene Biotype	PROTEIN_CODING

(13 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
KINASE
SERINE THREONINE KINASE
NEUTRAL ZINC METALLOPEPTIDASE
PROTEASE
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod
Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
Goldstein DM et al., 2011, Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase., J Med Chem
Angell RM et al., 2008, Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes., Bioorg Med Chem Lett
Goldstein et al., 2006, Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase., J. Med. Chem.
Bagley MC et al., 2008, Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells., Bioorg Med Chem Lett
Gollob et al., 1999, The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation., J. Immunol.
Laufer S et al., 2009, Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase., Bioorg Med Chem Lett
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
Chen et al., 2003, Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection., J. Neurochem.
Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
Kneidinger M et al., 2008, The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils., Blood
Arena S et al., 2007, Genetic targeting of the kinase activity of the Met receptor in cancer cells., Proc Natl Acad Sci U S A
Singhal et al., 2002, Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis., J. Immunol.
Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett
Duffy JP et al., 2011, The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor., ACS Med Chem Lett
Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
Noh et al., 2000, Haloperidol-induced neuronal apoptosis: role of p38 and c-Jun-NH(2)-terminal protein kinase., J. Neurochem.
De Paiva et al., 2006, Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye., Exp. Eye Res.
Abu Thaher B et al., 2009, Role of the hydrogen bonding heteroatom-Lys53 interaction between the p38alpha mitogen-activated protein (MAP) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors., J Med Chem
Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod
Cappellini et al., 2005, Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation., Apoptosis
Bogatcheva et al., 2007, Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction., Am. J. Physiol. Lung Cell Mol. Physiol.
Lee et al., 2006, Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis., Biochim. Biophys. Acta
Niiya et al., 2004, Involvement of ERK1/2 and p38 MAP kinase in doxorubicin-induced uPA expression in human RC-K8 lymphoma and NCI-H69 small cell lung carcinoma cells., Oncology
Olajide OA et al., 2013, Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition., Eur J Med Chem
Kozawa et al., 2000, Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase., J. Cell. Biochem.
Ito et al., 2000, p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells., Hypertension
Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
Das et al., 2006, Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J. Pharmacol. Exp. Ther.
Shan et al., 1999, Distinct roles of JNKs/p38 MAP kinase and ERKs in apoptosis and survival of HCD-57 cells induced by withdrawal or addition of erythropoietin., Blood
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

DORAMAPIMOD MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:

Angell RM et al., 2008, Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes., Bioorg Med Chem Lett

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

TALMAPIMOD MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Publications:

Laufer S et al., 2009, Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase., Bioorg Med Chem Lett
PH-797804 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NEFLAMAPIMOD MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

Publications:

Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett

Duffy JP et al., 2011, The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor., ACS Med Chem Lett

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

LOSMAPIMOD MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Direct Interaction? True

Publications:
AMG-548 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
SC-80036 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:
SEMAPIMOD MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Trial Name CPSI-2364

Publications:
AZD-6703 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
RWJ-67657 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
chembl:CHEMBL1236539 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Publications:
GSK-610677 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
TA-5493 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:
SCIO-323 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:
PG-760564 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:
RALIMETINIB MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:
DILMAPIMOD MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name SB-681323

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:
VX-702 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:
PEXMETINIB MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ARRY-614

Novel drug target Novel Target

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:
FX-005 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
chembl:CHEMBL1951415 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical kinase assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Publications:
PS-516895 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
AVE-9940 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
BMS-582949 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

Publications:
LY-3007113 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
PAMAPIMOD MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Details of the Assay for Interaction In a biochemical assay.

Publications:
AZD-7624 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
SB-85635 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
TAK-715 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

Publications:
LEO-15520 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:
ARRY-797 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Trial Name ARRY-797

Publications:
ACUMAPIMOD MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

Publications:
PF-03715455 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Binding

Publications:
KC-706 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:

R-1487 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:

Goldstein DM et al., 2011, Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase., J Med Chem

RO-3201195 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:

Goldstein et al., 2006, Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase., J. Med. Chem.

Bagley MC et al., 2008, Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells., Bioorg Med Chem Lett

SD-0006 MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
FOSTAMATINIB MAPK14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
PIRFENIDONE MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pirfenidone,Esbriet , Deskar, Pirespa

Novel drug target Novel Target

Publications:
SORAFENIB MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
2-CHLOROPHENOL MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
RHAMNETIN MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod
OPHIOBOLIN O MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett

ALDESLEUKIN MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Gollob et al., 1999, The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation., J. Immunol.

GW775608X MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Angell RM et al., 2008, Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes., Bioorg Med Chem Lett
XANTHOHUMOL MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod

LITHIUM MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chen et al., 2003, Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection., J. Neurochem.

MILTIRONE MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
DASATINIB MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kneidinger M et al., 2008, The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils., Blood
chembl:CHEMBL261641 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Arena S et al., 2007, Genetic targeting of the kinase activity of the Met receptor in cancer cells., Proc Natl Acad Sci U S A
MORPHINE MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Singhal et al., 2002, Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis., J. Immunol.
DIHYDROTANSHINONE I MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
chembl:CHEMBL8483 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
HALOPERIDOL MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Noh et al., 2000, Haloperidol-induced neuronal apoptosis: role of p38 and c-Jun-NH(2)-terminal protein kinase., J. Neurochem.
DOXYCYCLINE MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

De Paiva et al., 2006, Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye., Exp. Eye Res.

SB-203580 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett

Abu Thaher B et al., 2009, Role of the hydrogen bonding heteroatom-Lys53 interaction between the p38alpha mitogen-activated protein (MAP) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors., J Med Chem

Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod

METHOXSALEN MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Cappellini et al., 2005, Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation., Apoptosis

2-METHOXYESTRADIOL MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bogatcheva et al., 2007, Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction., Am. J. Physiol. Lung Cell Mol. Physiol.

DOXORUBICIN MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lee et al., 2006, Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis., Biochim. Biophys. Acta

Niiya et al., 2004, Involvement of ERK1/2 and p38 MAP kinase in doxorubicin-induced uPA expression in human RC-K8 lymphoma and NCI-H69 small cell lung carcinoma cells., Oncology

CRYPTOLEPINE HYDROCHLORIDE MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Olajide OA et al., 2013, Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition., Eur J Med Chem

VASOPRESSIN MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kozawa et al., 2000, Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase., J. Cell. Biochem.

Ito et al., 2000, p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells., Hypertension

SB-202190 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
KERACYANIN MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem

RESVERATROL MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Das et al., 2006, Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J. Pharmacol. Exp. Ther.

EPOETIN BETA MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Shan et al., 1999, Distinct roles of JNKs/p38 MAP kinase and ERKs in apoptosis and survival of HCD-57 cells induced by withdrawal or addition of erythropoietin., Blood
chembl:CHEMBL111456 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GEFITINIB MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
OSI-632 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
AST-487 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RO-316233 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
VANDETANIB MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RG-1530 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
LINIFANIB MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL388582 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL371720 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PD-0166285 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ILORASERTIB MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
STAUROSPORINONE MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL327127 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL492634 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL608532 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL186526 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL28324 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL115769 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL406845 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL373011 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL111364 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL1997335 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL574059 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL387748 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL96741 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CI-1040 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL113419 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL590753 MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000112062
- Version: 101_38
Alternate Names:

MAPK14 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q16539
- Version: January-2014
Alternate Names:

MAPK14 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:
GuideToPharmacologyGenes: 1499
- Version: 4-March-2015
Alternate Names:

mitogen-activated protein kinase 14 HUGO Gene Name

6876 HUGO Gene ID

MAPK14 Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name p38 subfamily

GuideToPharmacology Gene Category ID 519

GuideToPharmacology Gene Type enzyme

Gene Categories:

SERINE THREONINE KINASE, KINASE

Publications:
HopkinsGroom: Q16539
- Version: 11-September-2012
Alternate Names:

MAPK14 Uniprot Gene Name

Q16539 Uniprot Accession

MK14_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR002290

Human Readable Name DRUGGABLE GENOME

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000112062

Version: 26-July-2011

Alternate Names:

MITOGEN-ACTIVATED PROTEIN KINASE 14 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA) (MAP KINASE P38 ALPHA) (CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN) (CSAID BINDING PROTEIN) (CSBP) (MAX-INTERACTING PROTEIN 2) (MAP KINASE MXI2 Description

ENSG00000112062 Ensembl Gene Id

MAPK14 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: MAPK14
- Version: 18-August-2020
Alternate Names:

PA30621 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

DrugBank: BE0001019

Version: 5.1.7

Alternate Names:

MAPK14 DrugBank Gene Name

Q16539 UniProt Accession

1432 Entrez Gene Id

Gene Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: MAPK14

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Cappellini et al., 2005, Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation., Apoptosis

Daly et al., 1999, NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways., Oncogene

McGillicuddy et al., 2006, TGF-beta1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells., Vascul. Pharmacol.

DTC: MAPK14

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bagley MC et al., 2008, Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells., Bioorg Med Chem Lett

Goldstein et al., 2006, Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase., J. Med. Chem.

Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science

HingoraniCasas: ENSG00000112062
- Version: 31-May-2017
Alternate Names:

ENSG00000112062 Gene Symbol

MAPK14 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CSBP
- Version: chembl_23
Alternate Names:

CSBP1 GENE_SYMBOL

CSBP2 GENE_SYMBOL

CSPB1 GENE_SYMBOL

Gene Info:

Publications:
GuideToPharmacologyInteractions: ENSG00000112062
- Version: 20-July-2020
Alternate Names:

mitogen-activated protein kinase 14 GuideToPharmacology Name

Q16539 UniProtKB ID

Gene Info:

Publications:
TTD: Stress-activated protein kinase 2a
- Version: 2020.06.01
Alternate Names:

p38 alpha TTD Gene Abbreviation

T65864 TTD Target ID

Gene Info:

Publications:
Pharos: MAPK14
- Version: 03-September-2020
Alternate Names:

Mitogen-activated protein kinase 14 Gene Name

Q16539 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
GO: MAPK14
- Version: 05-September-2020
Alternate Names:

CSBP GO Gene Synonym

CSBP1 GO Gene Synonym

CSBP2 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: MAPK14
- Version: 27-Jun-2013
Alternate Names:

1432 Gene ID

CSBP dGene Synonym

CSBP1 dGene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, KINASE

Publications:
ClearityFoundationClinicalTrial: MAPK14
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Mechanism of Interaction	MAP kinase p38 alpha inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

Novel drug target	Novel Target
Trial Name	SB-681323
Mechanism of Interaction	MAP kinase p38 alpha inhibitor

Trial Name	ARRY-614
Novel drug target	Novel Target
Mechanism of Interaction	MAP kinase p38 alpha inhibitor

Details of the Assay for Interaction	In a biochemical kinase assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Trial Name	pirfenidone,Esbriet , Deskar, Pirespa
Novel drug target	Novel Target

mitogen-activated protein kinase 14	HUGO Gene Name
6876	HUGO Gene ID
MAPK14	Gene Symbol

MAPK14	Uniprot Gene Name
Q16539	Uniprot Accession
MK14_HUMAN	Uniprot Id

MITOGEN-ACTIVATED PROTEIN KINASE 14 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA) (MAP KINASE P38 ALPHA) (CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN) (CSAID BINDING PROTEIN) (CSBP) (MAX-INTERACTING PROTEIN 2) (MAP KINASE MXI2	Description
ENSG00000112062	Ensembl Gene Id
MAPK14	Display Id

MAPK14	DrugBank Gene Name
Q16539	UniProt Accession
1432	Entrez Gene Id

mitogen-activated protein kinase 14	GuideToPharmacology Name
Q16539	UniProtKB ID

Mitogen-activated protein kinase 14	Gene Name
Q16539	UniProt ID

MAPK14 Gene Record

MAPK14 1432 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

Publications: Laufer S et al., 2009, Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase., Bioorg Med Chem Lett

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes Direct Interaction? True

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction MAP kinase p38 alpha inhibitor Trial Name CPSI-2364

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Novel Target Trial Name SB-681323 Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ARRY-614 Novel drug target Novel Target Mechanism of Interaction MAP kinase p38 alpha inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction In a biochemical kinase assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Publications:

Laufer S et al., 2009, Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase., Bioorg Med Chem Lett

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Direct Interaction? True

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Trial Name CPSI-2364

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name SB-681323

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ARRY-614

Novel drug target Novel Target

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical kinase assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Details of the Assay for Interaction In a biochemical assay.

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Trial Name ARRY-797

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Binding

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes